JP2013536871A5 - - Google Patents

Info

Publication number

JP2013536871A5

JP2013536871A5 JP2013527348A JP2013527348A JP2013536871A5 JP 2013536871 A5 JP2013536871 A5 JP 2013536871A5 JP 2013527348 A JP2013527348 A JP 2013527348A JP 2013527348 A JP2013527348 A JP 2013527348A JP 2013536871 A5 JP2013536871 A5 JP 2013536871A5

Authority

JP

Japan

Prior art keywords

oxygen

compound according

optionally substituted

bond

formula

Prior art date

2011-09-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 claims 14
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 10
• 239000001301 oxygen Substances 0.000 claims 10
• 229910052760 oxygen Inorganic materials 0.000 claims 10
• 125000002947 alkylene group Chemical group 0.000 claims 3
• 125000005529 alkyleneoxy group Chemical group 0.000 claims 3
• 239000001257 hydrogen Substances 0.000 claims 3
• 229910052739 hydrogen Inorganic materials 0.000 claims 3
• 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 208000031886 HIV Infections Diseases 0.000 claims 2
• 208000037357 HIV infectious disease Diseases 0.000 claims 2
• 125000005237 alkyleneamino group Chemical group 0.000 claims 2
• YLFIGGHWWPSIEG-UHFFFAOYSA-N aminoxyl Chemical compound [O]N YLFIGGHWWPSIEG-UHFFFAOYSA-N 0.000 claims 2
• 125000003710 aryl alkyl group Chemical group 0.000 claims 2
• 125000004474 heteroalkylene group Chemical group 0.000 claims 2
• 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical class C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
• 239000005977 Ethylene Substances 0.000 claims 1
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical class O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 125000000753 cycloalkyl group Chemical group 0.000 claims 1
• -1 cycloheteroalkyl Chemical group 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 125000004404 heteroalkyl group Chemical group 0.000 claims 1
• 125000001072 heteroaryl group Chemical group 0.000 claims 1
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
• 150000002431 hydrogen Chemical class 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Chemical class CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 claims 1
• 125000004805 propylene group Chemical class [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
• 125000003107 substituted aryl group Chemical group 0.000 claims 1
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
• 0 **N(*)C(*)*C(C(*)C(C(*)CC(O*)=C)=C)O* Chemical compound **N(*)C(*)*C(C(*)C(C(*)CC(O*)=C)=C)O* 0.000 description 6
• XZIJZSJDIXTUAI-NSSIIVRHSA-N CC(C)CC(CCC[C@H]([C@@H](CCC([O]([C@@H](CO1)[C@H]2[C@@H]1O[C@H]1[C@@H]2COC1)#C)=O)Cc1ccccc1)O)S(c(cc1)ccc1OC)(=O)=O Chemical compound CC(C)CC(CCC[C@H]([C@@H](CCC([O]([C@@H](CO1)[C@H]2[C@@H]1O[C@H]1[C@@H]2COC1)#C)=O)Cc1ccccc1)O)S(c(cc1)ccc1OC)(=O)=O XZIJZSJDIXTUAI-NSSIIVRHSA-N 0.000 description 2
• LJVPMSTVLPXTNI-OMUWLRAZSA-N CC(C)CC(CCC[C@H]([C@H](Cc1ccccc1)CNC([O]([C@@H](CO[C@H]1O[C@]2([N]#C)OCC3)[C@]1(C)[C@]23N=C)=C)=O)[O]=C)S(c(cc1)ccc1OC)(=O)=O Chemical compound CC(C)CC(CCC[C@H]([C@H](Cc1ccccc1)CNC([O]([C@@H](CO[C@H]1O[C@]2([N]#C)OCC3)[C@]1(C)[C@]23N=C)=C)=O)[O]=C)S(c(cc1)ccc1OC)(=O)=O LJVPMSTVLPXTNI-OMUWLRAZSA-N 0.000 description 1
• QIKONVXKHJXMOG-GUGHXQSSSA-N CC(C)CC(CCC[C@H]([C@H](Cc1ccccc1)NC(O[C@](CO[C@]1([N]#C)O[C@]2([N]#C)OCC[C@@]22N=C)([C@]12N=C)N=C)=O)O)S(c(cc1)ccc1OC)(=O)=O Chemical compound CC(C)CC(CCC[C@H]([C@H](Cc1ccccc1)NC(O[C@](CO[C@]1([N]#C)O[C@]2([N]#C)OCC[C@@]22N=C)([C@]12N=C)N=C)=O)O)S(c(cc1)ccc1OC)(=O)=O QIKONVXKHJXMOG-GUGHXQSSSA-N 0.000 description 1
• ALOOIZPMMQFAQE-GENCIFFESA-N C[C@@H](CO1)[C@@]2(C)[C@@H]1O[C@H]1[C@@H]2COC1 Chemical compound C[C@@H](CO1)[C@@]2(C)[C@@H]1O[C@H]1[C@@H]2COC1 ALOOIZPMMQFAQE-GENCIFFESA-N 0.000 description 1
• UFWLKKLLFQHVNL-ABRLLLAPSA-N C[C@@H](CO1)[C@H]2[C@@H]1O[C@H]1[C@@H]2OCC1 Chemical compound C[C@@H](CO1)[C@H]2[C@@H]1O[C@H]1[C@@H]2OCC1 UFWLKKLLFQHVNL-ABRLLLAPSA-N 0.000 description 1
• LWMBYUADXXMYPL-VVULQXIFSA-N C[C@H]1C[C@H]2O[C@H](COC3)[C@H]3[C@H]2C1 Chemical compound C[C@H]1C[C@H]2O[C@H](COC3)[C@H]3[C@H]2C1 LWMBYUADXXMYPL-VVULQXIFSA-N 0.000 description 1