JP2013536864A5 - - Google Patents
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- Publication number
- JP2013536864A5 JP2013536864A5 JP2013527286A JP2013527286A JP2013536864A5 JP 2013536864 A5 JP2013536864 A5 JP 2013536864A5 JP 2013527286 A JP2013527286 A JP 2013527286A JP 2013527286 A JP2013527286 A JP 2013527286A JP 2013536864 A5 JP2013536864 A5 JP 2013536864A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- crystalline form
- thrombosis
- item
- stroke
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37933910P | 2010-09-01 | 2010-09-01 | |
| US61/379,339 | 2010-09-01 | ||
| US201161454396P | 2011-03-18 | 2011-03-18 | |
| US61/454,396 | 2011-03-18 | ||
| PCT/US2011/050057 WO2012031017A1 (en) | 2010-09-01 | 2011-08-31 | CRYSTALLINE FORMS OF A FACTOR Xa INHIBITOR |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015187427A Division JP2015232046A (ja) | 2010-09-01 | 2015-09-24 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2017221050A Division JP2018024709A (ja) | 2010-09-01 | 2017-11-16 | 第Ｘａ因子阻害剤の結晶形態 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013536864A JP2013536864A (ja) | 2013-09-26 |
| JP2013536864A5 true JP2013536864A5 (https=) | 2014-10-09 |
Family
ID=45773260
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013527286A Pending JP2013536864A (ja) | 2010-09-01 | 2011-08-31 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2015187427A Pending JP2015232046A (ja) | 2010-09-01 | 2015-09-24 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2017221050A Pending JP2018024709A (ja) | 2010-09-01 | 2017-11-16 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2019081907A Pending JP2019135258A (ja) | 2010-09-01 | 2019-04-23 | 第Ｘａ因子阻害剤の結晶形態 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015187427A Pending JP2015232046A (ja) | 2010-09-01 | 2015-09-24 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2017221050A Pending JP2018024709A (ja) | 2010-09-01 | 2017-11-16 | 第Ｘａ因子阻害剤の結晶形態 |
| JP2019081907A Pending JP2019135258A (ja) | 2010-09-01 | 2019-04-23 | 第Ｘａ因子阻害剤の結晶形態 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8946269B2 (https=) |
| EP (1) | EP2611779B1 (https=) |
| JP (4) | JP2013536864A (https=) |
| CN (1) | CN103261161B (https=) |
| AR (1) | AR082804A1 (https=) |
| AU (1) | AU2011295909B2 (https=) |
| CA (1) | CA2810004C (https=) |
| ES (1) | ES2603084T3 (https=) |
| IL (1) | IL224698A (https=) |
| NZ (1) | NZ608442A (https=) |
| PT (1) | PT2611779T (https=) |
| TW (1) | TW201221128A (https=) |
| WO (1) | WO2012031017A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8980876B2 (en) | 2010-10-28 | 2015-03-17 | The Procter & Gamble Company | Inhibition of microbial growth by aconitase inhibition |
| WO2013033370A1 (en) * | 2011-08-31 | 2013-03-07 | Portola Pharmaceuticals, Inc. | Prevention and treatment of thrombosis in medically ill patients |
| TWI686904B (zh) * | 2012-03-16 | 2020-03-01 | 美商樂仕特拉公司 | 光子材料中介層的方法及系統 |
| US9200268B2 (en) | 2012-12-27 | 2015-12-01 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| US20140346397A1 (en) | 2012-12-27 | 2014-11-27 | Portola Pharmaceuticals, Inc. | Compounds and methods for purification of serine proteases |
| CN104693114B (zh) * | 2013-12-10 | 2019-08-16 | 四川海思科制药有限公司 | 一种贝曲西班的改进的制备方法 |
| CN105085387A (zh) * | 2014-05-20 | 2015-11-25 | 四川海思科制药有限公司 | 贝曲西班盐及其制备方法和用途 |
| WO2017091757A1 (en) * | 2015-11-24 | 2017-06-01 | Portola Pharmaceuticals, Inc. | Isotopically enriched betrixaban |
| CN106995405A (zh) * | 2016-01-25 | 2017-08-01 | 重庆医药工业研究院有限责任公司 | 一种贝曲西班马来酸盐无定型物及其制备方法 |
| WO2017208169A1 (en) * | 2016-06-02 | 2017-12-07 | Dr. Reddy’S Laboratories Limited | Polymorphs of betrixaban & its maleate salt |
| EP3254674A1 (en) | 2016-06-08 | 2017-12-13 | Sandoz Ag | Pharmaceutical compositions of betrixaban maleate |
| EP3293174A1 (en) | 2016-09-09 | 2018-03-14 | Sandoz Ag | Crystalline salts of betrixaban |
| WO2018069936A1 (en) * | 2016-10-13 | 2018-04-19 | Mylan Laboratories Limited | Polymorphs and solid dispersion of betrixaban and methods for the preparation thereof |
| CN107382897B (zh) * | 2017-07-10 | 2021-05-04 | 浙江宏元药业股份有限公司 | 一种贝曲西班的中间体及其制备方法和应用 |
| EP3510996A1 (en) * | 2018-01-11 | 2019-07-17 | Sandoz AG | Pharmaceutical compositions of betrixaban |
| CN108570003A (zh) * | 2018-06-01 | 2018-09-25 | 浙江宏元药业股份有限公司 | 一种贝曲西班马来酸盐的一水无定形及其制备方法 |
| CN113905715B (zh) | 2019-06-28 | 2025-04-15 | 宝洁公司 | 光增强处理方法 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9226238D0 (en) | 1992-12-16 | 1993-02-10 | Scherer Ltd R P | Encapsulation apparatus and process |
| US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
| US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
| WO2001051919A2 (en) * | 2000-01-07 | 2001-07-19 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| AU2001250783A1 (en) | 2000-02-29 | 2001-09-12 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
| US6627646B2 (en) | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
| DE10322469A1 (de) | 2003-05-19 | 2004-12-16 | Bayer Healthcare Ag | Heterocyclische Verbindungen |
| US7696352B2 (en) | 2004-06-18 | 2010-04-13 | Millennium Pharmaceuticals, Inc. | Factor Xa inhibitors |
| KR101195801B1 (ko) | 2004-06-18 | 2012-11-05 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | Ｘａ 인자 억제제 |
| NZ592533A (en) * | 2005-11-08 | 2012-08-31 | Millennium Pharm Inc | METHOD FOR THE PREPARATION OF N-(5-CHLORO-2-PYRIDINYL)-2-[[4-[(DIMETHYLAMINO) IMINOMETHYL] BENZOYL] AMINO]-5-METHOXY-BENZAMIDE, A FACTOR Xa INHIBITOR |
| MX2008014193A (es) | 2006-05-05 | 2009-03-31 | Millennium Pharm Inc | Inhibidores del factor xa. |
| US20080051578A1 (en) | 2006-08-24 | 2008-02-28 | Georg Dahmann | Substituted biaryls, process for their manufacture and use thereof as medicaments |
| ES2550057T3 (es) | 2006-11-02 | 2015-11-04 | Millennium Pharmaceuticals, Inc. | Métodos para sintetizar sales farmacéuticas de un inhibidor del Factor Xa |
| CN105193799A (zh) | 2006-12-08 | 2015-12-30 | 米伦纽姆医药公司 | 使用经口因子xa抑制剂治疗血栓形成的单位剂量调配物和方法 |
| JP2010515691A (ja) | 2007-01-05 | 2010-05-13 | ミレニアム・ファーマシューティカルズ・インコーポレイテッド | 第Ｘａ因子阻害剤 |
| EP2155195B1 (en) | 2007-04-13 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Combination anticoagulant therapy with a compound that acts as a factor Xa inhibitor |
| MX2009011755A (es) * | 2007-05-02 | 2010-02-12 | Portola Pharm Inc | Terapia de combinacion con un compuesto que actua como un inhibidor del receptor adp de plaquetas. |
| KR102069498B1 (ko) | 2007-09-28 | 2020-01-23 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 Ｘａ 저해제에 대한 안티도트 및 그것을 사용하는 방법 |
| EP2364165B1 (en) | 2008-11-14 | 2018-01-03 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same in combination with blood coagulating agents |
| CA2784904C (en) * | 2009-12-17 | 2017-10-10 | Millennium Pharmaceuticals, Inc. | Methods of synthesizing factor xa inhibitors |
| TW201240664A (en) | 2010-09-01 | 2012-10-16 | Portola Pharm Inc | Methods and formulations of treating thrombosis with betrixaban and a P-glycoprotein inhibitor |
-
2011
- 2011-08-30 TW TW100131157A patent/TW201221128A/zh unknown
- 2011-08-30 AR ARP110103159A patent/AR082804A1/es unknown
- 2011-08-31 WO PCT/US2011/050057 patent/WO2012031017A1/en not_active Ceased
- 2011-08-31 AU AU2011295909A patent/AU2011295909B2/en not_active Ceased
- 2011-08-31 EP EP11757467.3A patent/EP2611779B1/en not_active Not-in-force
- 2011-08-31 PT PT117574673T patent/PT2611779T/pt unknown
- 2011-08-31 NZ NZ60844211A patent/NZ608442A/en not_active IP Right Cessation
- 2011-08-31 US US13/223,023 patent/US8946269B2/en active Active
- 2011-08-31 CN CN201180052042.4A patent/CN103261161B/zh not_active Expired - Fee Related
- 2011-08-31 JP JP2013527286A patent/JP2013536864A/ja active Pending
- 2011-08-31 ES ES11757467.3T patent/ES2603084T3/es active Active
- 2011-08-31 CA CA2810004A patent/CA2810004C/en not_active Expired - Fee Related
-
2013
- 2013-02-13 IL IL224698A patent/IL224698A/en active IP Right Grant
-
2015
- 2015-09-24 JP JP2015187427A patent/JP2015232046A/ja active Pending
-
2017
- 2017-11-16 JP JP2017221050A patent/JP2018024709A/ja active Pending
-
2019
- 2019-04-23 JP JP2019081907A patent/JP2019135258A/ja active Pending
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