JP2013535209A5 - - Google Patents
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- Publication number
- JP2013535209A5 JP2013535209A5 JP2013522265A JP2013522265A JP2013535209A5 JP 2013535209 A5 JP2013535209 A5 JP 2013535209A5 JP 2013522265 A JP2013522265 A JP 2013522265A JP 2013522265 A JP2013522265 A JP 2013522265A JP 2013535209 A5 JP2013535209 A5 JP 2013535209A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- seq
- primer
- nucleic acid
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 150000007523 nucleic acids Chemical group 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108010067902 Peptide Library Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 230000006044 T cell activation Effects 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 3
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 3
- 239000007795 chemical reaction product Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008233 | 2010-08-06 | ||
| EP10008233.8 | 2010-08-06 | ||
| PCT/EP2011/063538 WO2012017081A1 (en) | 2010-08-06 | 2011-08-05 | Identification of t cell target antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197135A Division JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535209A JP2013535209A (ja) | 2013-09-12 |
| JP2013535209A5 true JP2013535209A5 (https=) | 2014-08-28 |
| JP6192537B2 JP6192537B2 (ja) | 2017-09-06 |
Family
ID=44023005
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013522265A Expired - Fee Related JP6192537B2 (ja) | 2010-08-06 | 2011-08-05 | Ｔ細胞の標的抗原の同定 |
| JP2016197135A Withdrawn JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197135A Withdrawn JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9678061B2 (https=) |
| EP (3) | EP2601521B1 (https=) |
| JP (2) | JP6192537B2 (https=) |
| CA (1) | CA2806440A1 (https=) |
| WO (1) | WO2012017081A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2726702T3 (es) | 2009-01-15 | 2019-10-08 | Adaptive Biotechnologies Corp | Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales |
| AU2012309830B2 (en) * | 2011-09-15 | 2017-03-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T cell receptors recognizing HLA-A1- or HLA-Cw7-restricted mage |
| US9824179B2 (en) * | 2011-12-09 | 2017-11-21 | Adaptive Biotechnologies Corp. | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| ES3011307T3 (en) * | 2012-02-23 | 2025-04-07 | Juno Therapeutics Gmbh | Chromatographic isolation of cells and other complex biological materials |
| EP3372694A1 (en) * | 2012-03-05 | 2018-09-12 | Adaptive Biotechnologies Corporation | Determining paired immune receptor chains from frequency matched subunits |
| HUE029357T2 (en) | 2012-05-08 | 2017-02-28 | Adaptive Biotechnologies Corp | Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions |
| US20140065629A1 (en) * | 2012-08-29 | 2014-03-06 | Israel Barken | Methods of treating diseases |
| US20140065098A1 (en) * | 2012-08-29 | 2014-03-06 | Israel Barken | Method to augment immune system in response to disease or injury |
| WO2015160439A2 (en) | 2014-04-17 | 2015-10-22 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US20140356318A1 (en) * | 2013-05-28 | 2014-12-04 | Israel Barken | Adoptive cell therapy with specific regulatory lymphocytes |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US11203783B2 (en) | 2013-11-21 | 2021-12-21 | Repertoire Genesis Incorporation | T cell receptor and B cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
| WO2015143558A1 (en) | 2014-03-27 | 2015-10-01 | British Columbia Cancer Agency Branch | T-cell epitope identification |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| SI3132247T1 (sl) | 2014-04-16 | 2021-12-31 | Juno Therapeutics Gmbh | Postopki, kompleti in naprava za povečanje populacije celic |
| CA2946312A1 (en) | 2014-04-23 | 2015-10-29 | Juno Therapeutics, Inc. | Methods for isolating, culturing, and genetically engineering immune cell populations for adoptive therapy |
| US10526391B2 (en) | 2014-07-22 | 2020-01-07 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| EP3277294B1 (en) | 2015-04-01 | 2024-05-15 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| EP3112375A1 (en) * | 2015-07-03 | 2017-01-04 | Ludwig-Maximilians-Universität München | Antigenic peptides for the diagnosis, therapy monitoring and/or treatment of psoriasis vulgaris |
| MX2018003534A (es) * | 2015-09-25 | 2019-04-25 | Abvitro Llc | Proceso de alto rendimiento para identificacion de blanco de receptor de celula t de secuencias de receptor de celula t apareadas de manera natural. |
| AU2016341529B2 (en) | 2015-10-22 | 2023-03-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| MX2018004875A (es) | 2015-10-22 | 2018-08-01 | Juno Therapeutics Gmbh | Metodos para cultivar celulas y kits y aparatos para ello. |
| EP3365453A2 (en) | 2015-10-22 | 2018-08-29 | Juno Therapeutics GmbH | Methods, kits, agents and apparatuses for transduction |
| EP3368691A4 (en) * | 2015-10-27 | 2019-04-03 | Arizona Board of Regents on behalf of Arizona State University | HIGH-SCREEN-TYPE IDENTIFICATION OF ANTIGENES AND EPITOPES FOR T-CELL DETECTION |
| EP4212547A1 (en) | 2015-12-03 | 2023-07-19 | Juno Therapeutics, Inc. | Modified chimeric receptors and related compositions and methods |
| WO2018053374A2 (en) * | 2016-09-16 | 2018-03-22 | Memorial Sloan Kettering Cancer Center | Methods and compositions for t-cell epitope screening |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| JP6803480B2 (ja) | 2016-11-07 | 2020-12-23 | ジェノヴィー エービーＧｅｎｏｖｉｅ Ａｂ | Ｔ細胞受容体の合成及びｔｃｒ提示細胞への安定なゲノム組込みのための二部分装置 |
| DK4039800T5 (da) | 2016-11-07 | 2024-07-29 | Genovie Ab | Konstrueret flerkomponentsystem til identifikation og karakterisering af t-cellreceptorer og t-cellantigener |
| EP3535290B1 (en) * | 2016-11-07 | 2024-01-10 | Genovie AB | An engineered two-part cellular device for discovery and characterisation of t-cell receptor interaction with cognate antigen |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| WO2018213803A1 (en) * | 2017-05-19 | 2018-11-22 | Neon Therapeutics, Inc. | Immunogenic neoantigen identification |
| WO2019069125A1 (en) | 2017-10-06 | 2019-04-11 | Oslo Universitetssykehus Hf | CHIMERIC ANTIGEN RECEPTORS |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CA3097396A1 (en) | 2018-04-19 | 2019-10-24 | Baylor College Of Medicine | Reprogramming cd4 t cells into cytotoxic cd8 cells by forced expression of cd8ab and class 1 restricted t cell receptors |
| US12516099B2 (en) | 2018-08-09 | 2026-01-06 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| TW202031888A (zh) * | 2018-08-24 | 2020-09-01 | 日商組庫創世紀股份有限公司 | T細胞受體及b細胞受體之功能性次單元成對基因之解析方法 |
| SG11202104355SA (en) | 2018-10-31 | 2021-05-28 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
| CN114807125B (zh) * | 2022-05-20 | 2023-09-12 | 纳昂达(南京)生物科技有限公司 | 测序文库接头、测序文库及其构建方法、提升ngs建库连接效率的方法 |
| WO2024124132A1 (en) | 2022-12-09 | 2024-06-13 | Juno Therapeutics, Inc. | Machine learning methods for predicting cell phenotype using holographic imaging |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037135A (en) | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| US20010053523A1 (en) * | 1995-06-02 | 2001-12-20 | M&E Biotech A/S. | Method for identification of biologically active peptides and nucleic acids |
| JP2000505650A (ja) * | 1996-02-08 | 2000-05-16 | アメリカ合衆国 | 樹状突起細胞を形質転換し、そしてｔ細胞を活性化するための方法及び組成物 |
| US6429286B1 (en) | 1997-04-16 | 2002-08-06 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Immunoregulatory molecules for costimulatory signal transduction |
| US6872518B2 (en) * | 1997-09-22 | 2005-03-29 | University Of Rochester | Methods for selecting polynucleotides encoding T cell epitopes |
| DE10009341A1 (de) * | 2000-02-22 | 2001-09-06 | Florian Kern | Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten |
| JP4812951B2 (ja) | 2001-03-21 | 2011-11-09 | 一般財団法人化学及血清療法研究所 | 特異性不明のｔ細胞のクローン化法及びその認識ペプチドリガンドの同定方法 |
| CA2445181A1 (fr) | 2001-04-13 | 2002-10-24 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Procede d'analyse des lymphocytes t par le biais des recepteurs des lymphocytes t d'un organisme |
| US20030003485A1 (en) * | 2001-05-15 | 2003-01-02 | Ludwig Institute For Cancer Research | Methods for identifying antigens |
| AU2003217384A1 (en) | 2002-02-13 | 2003-09-04 | Ludwig Institute For Cancer Research | Isolated peptides which bind to hla molecules and uses thereof |
| EP1976981A2 (en) | 2005-11-10 | 2008-10-08 | The University Of Chicago | Hcv-reactive t cell receptors |
| JP5292550B2 (ja) | 2007-03-23 | 2013-09-18 | 静岡県 | Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子 |
| GB0712670D0 (en) * | 2007-06-29 | 2007-08-08 | King S College London | Isolated peptides and uses thereof |
| AU2009244634B2 (en) * | 2008-04-16 | 2014-12-18 | iRepertoire, Inc. | Method for evaluating and comparing immunorepertoires |
| US7892202B2 (en) | 2008-05-09 | 2011-02-22 | Merit Medical Systems, Inc. | System and method for inflation syringe with improved display |
| EP2364368B1 (en) * | 2008-11-07 | 2014-01-15 | Sequenta, Inc. | Methods of monitoring conditions by sequence analysis |
-
2011
- 2011-08-05 EP EP11739098.9A patent/EP2601521B1/en not_active Not-in-force
- 2011-08-05 EP EP15181740.0A patent/EP2982766B1/en not_active Not-in-force
- 2011-08-05 US US13/814,263 patent/US9678061B2/en not_active Expired - Fee Related
- 2011-08-05 EP EP18165023.5A patent/EP3376225A1/en not_active Withdrawn
- 2011-08-05 WO PCT/EP2011/063538 patent/WO2012017081A1/en not_active Ceased
- 2011-08-05 CA CA2806440A patent/CA2806440A1/en not_active Abandoned
- 2011-08-05 JP JP2013522265A patent/JP6192537B2/ja not_active Expired - Fee Related
-
2016
- 2016-10-05 JP JP2016197135A patent/JP2017038609A/ja not_active Withdrawn
-
2017
- 2017-05-05 US US15/587,636 patent/US20170240884A1/en not_active Abandoned
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