JP2013535209A5 - - Google Patents
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- JP2013535209A5 JP2013535209A5 JP2013522265A JP2013522265A JP2013535209A5 JP 2013535209 A5 JP2013535209 A5 JP 2013535209A5 JP 2013522265 A JP2013522265 A JP 2013522265A JP 2013522265 A JP2013522265 A JP 2013522265A JP 2013535209 A5 JP2013535209 A5 JP 2013535209A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- seq
- primer
- nucleic acid
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 16
- 150000007523 nucleic acids Chemical group 0.000 claims 11
- 239000000427 antigen Substances 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091008874 T cell receptors Proteins 0.000 claims 8
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108010067902 Peptide Library Proteins 0.000 claims 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 4
- 230000006044 T cell activation Effects 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 4
- 102000006707 alpha-beta T-Cell Antigen Receptors Human genes 0.000 claims 3
- 108010087408 alpha-beta T-Cell Antigen Receptors Proteins 0.000 claims 3
- 239000007795 chemical reaction product Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 230000030741 antigen processing and presentation Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008233 | 2010-08-06 | ||
| EP10008233.8 | 2010-08-06 | ||
| PCT/EP2011/063538 WO2012017081A1 (en) | 2010-08-06 | 2011-08-05 | Identification of t cell target antigens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197135A Division JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013535209A JP2013535209A (ja) | 2013-09-12 |
| JP2013535209A5 true JP2013535209A5 (https=) | 2014-08-28 |
| JP6192537B2 JP6192537B2 (ja) | 2017-09-06 |
Family
ID=44023005
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013522265A Expired - Fee Related JP6192537B2 (ja) | 2010-08-06 | 2011-08-05 | Ｔ細胞の標的抗原の同定 |
| JP2016197135A Withdrawn JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016197135A Withdrawn JP2017038609A (ja) | 2010-08-06 | 2016-10-05 | Ｔ細胞の標的抗原の同定 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9678061B2 (https=) |
| EP (3) | EP2601521B1 (https=) |
| JP (2) | JP6192537B2 (https=) |
| CA (1) | CA2806440A1 (https=) |
| WO (1) | WO2012017081A1 (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2387627B1 (en) | 2009-01-15 | 2016-03-30 | Adaptive Biotechnologies Corporation | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| ES2834070T3 (es) | 2011-09-15 | 2021-06-16 | Us Health | Receptores de células T que reconocen MAGE restringido por HLA-A1 o HLA-Cw7 |
| US9824179B2 (en) * | 2011-12-09 | 2017-11-21 | Adaptive Biotechnologies Corp. | Diagnosis of lymphoid malignancies and minimal residual disease detection |
| RU2746407C1 (ru) | 2012-02-23 | 2021-04-13 | Стейдж Селл Терапеутикс Гмбх | Хроматографическое выделение клеток и других сложных биологических материалов |
| DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| CA2872468C (en) | 2012-05-08 | 2020-10-27 | Adaptive Biotechnologies Corporation | Compositions and methods for measuring and calibrating amplification bias in multiplexed pcr reactions |
| US20140065098A1 (en) * | 2012-08-29 | 2014-03-06 | Israel Barken | Method to augment immune system in response to disease or injury |
| US20140065629A1 (en) * | 2012-08-29 | 2014-03-06 | Israel Barken | Methods of treating diseases |
| US10150996B2 (en) | 2012-10-19 | 2018-12-11 | Adaptive Biotechnologies Corp. | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US20140356318A1 (en) * | 2013-05-28 | 2014-12-04 | Israel Barken | Adoptive cell therapy with specific regulatory lymphocytes |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| CN106103711A (zh) | 2013-11-21 | 2016-11-09 | 组库创世纪株式会社 | T细胞受体和b细胞受体库分析系统及其在治疗和诊断中的应用 |
| US10627411B2 (en) | 2014-03-27 | 2020-04-21 | British Columbia Cancer Agency Branch | T-cell epitope identification |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| BR112016024072B1 (pt) | 2014-04-16 | 2021-02-09 | Juno Therapeutics Gmbh | método in vitro de estimular uma população de células |
| RU2763795C2 (ru) | 2014-04-23 | 2022-01-11 | Джуно Терапьютикс, Инк. | Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии |
| WO2016014725A1 (en) | 2014-07-22 | 2016-01-28 | The University Of Notre Dame Du Lac | Molecular constructs and uses thereof |
| CA2966201A1 (en) | 2014-10-29 | 2016-05-06 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CA2976580A1 (en) | 2015-02-24 | 2016-09-01 | Adaptive Biotechnologies Corp. | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| AU2016242967B2 (en) | 2015-04-01 | 2021-07-01 | Adaptive Biotechnologies Corp. | Method of identifying human compatible T cell receptors specific for an antigenic target |
| EP3112375A1 (en) | 2015-07-03 | 2017-01-04 | Ludwig-Maximilians-Universität München | Antigenic peptides for the diagnosis, therapy monitoring and/or treatment of psoriasis vulgaris |
| JP7341661B2 (ja) * | 2015-09-25 | 2023-09-11 | アブビトロ， エルエルシー | ネイティブに対合するｔ細胞受容体配列のｔ細胞受容体標的識別のための高スループットプロセス |
| US11248238B2 (en) | 2015-10-22 | 2022-02-15 | Juno Therapeutics Gmbh | Methods, kits, agents and apparatuses for transduction |
| SG11201803330WA (en) | 2015-10-22 | 2018-05-30 | Juno Therapeutics Gmbh | Methods for culturing cells and kits and apparatus for same |
| JP7194020B2 (ja) | 2015-10-22 | 2022-12-21 | ジュノ セラピューティクス ゲーエムベーハー | 細胞の培養方法ならびにそのためのキットおよび装置 |
| EP3368691A4 (en) * | 2015-10-27 | 2019-04-03 | Arizona Board of Regents on behalf of Arizona State University | HIGH-SCREEN-TYPE IDENTIFICATION OF ANTIGENES AND EPITOPES FOR T-CELL DETECTION |
| CN108884140B (zh) | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| US20190227063A1 (en) * | 2016-09-16 | 2019-07-25 | Memorial Sloan Kettering Cancer Center | Methods and compositions for t-cell epitope screening |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CN110023497B (zh) | 2016-11-07 | 2021-07-13 | 杰诺维有限公司 | 用于t细胞受体合成和向tcr呈递细胞进行稳定的基因组整合的两部分装置 |
| EP3535387B1 (en) | 2016-11-07 | 2022-01-12 | Genovie AB | An engineered multi-component system for identification and characterisation of t-cell receptors and t-cell antigens |
| KR102606929B1 (ko) * | 2016-11-07 | 2023-11-27 | 제노비에 에이비 | 동족 항원과 t-세포 수용체 상호작용의 발견 및 특징규명을 위한 조작된 2-부분 세포 디바이스 |
| JP7339160B2 (ja) | 2017-04-27 | 2023-09-05 | ジュノ セラピューティクス ゲーエムベーハー | オリゴマー粒子試薬およびその使用方法 |
| WO2018213803A1 (en) * | 2017-05-19 | 2018-11-22 | Neon Therapeutics, Inc. | Immunogenic neoantigen identification |
| US20200308279A1 (en) | 2017-10-06 | 2020-10-01 | Oslo Universitetssykehus Hf | Chimeric antigen receptors |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| MX2020011023A (es) | 2018-04-19 | 2021-01-29 | Baylor College Medicine | Reprogramación de células t cd4 en células cd8 citotóxicas por expresión forzada de cd8ab y receptores de células t restringidos de clase 1. |
| CN113474450A (zh) | 2018-08-09 | 2021-10-01 | 朱诺治疗学股份有限公司 | 产生工程化细胞的方法以及所述工程化细胞的组合物 |
| US20210301324A1 (en) * | 2018-08-24 | 2021-09-30 | Repertoire Genesis Incorporation | Method for analyzing functional subunit pair gene of t cell receptor and b cell receptor |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| CN114807125B (zh) * | 2022-05-20 | 2023-09-12 | 纳昂达(南京)生物科技有限公司 | 测序文库接头、测序文库及其构建方法、提升ngs建库连接效率的方法 |
| CN121100267A (zh) | 2022-12-09 | 2025-12-09 | 朱诺治疗学股份有限公司 | 使用全息成像预测细胞表型的机器学习方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6037135A (en) | 1992-08-07 | 2000-03-14 | Epimmune Inc. | Methods for making HLA binding peptides and their uses |
| US20010053523A1 (en) * | 1995-06-02 | 2001-12-20 | M&E Biotech A/S. | Method for identification of biologically active peptides and nucleic acids |
| JP2000505650A (ja) * | 1996-02-08 | 2000-05-16 | アメリカ合衆国 | 樹状突起細胞を形質転換し、そしてｔ細胞を活性化するための方法及び組成物 |
| WO1998046739A1 (fr) * | 1997-04-16 | 1998-10-22 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Molecules immunomodulatrices et leur procede de production |
| US6872518B2 (en) * | 1997-09-22 | 2005-03-29 | University Of Rochester | Methods for selecting polynucleotides encoding T cell epitopes |
| DE10009341A1 (de) * | 2000-02-22 | 2001-09-06 | Florian Kern | Verfahren zur antigen-spezifischen Stimulation von T-Lymphozyten |
| JP4812951B2 (ja) * | 2001-03-21 | 2011-11-09 | 一般財団法人化学及血清療法研究所 | 特異性不明のｔ細胞のクローン化法及びその認識ペプチドリガンドの同定方法 |
| ATE388448T1 (de) * | 2001-04-13 | 2008-03-15 | Inst Nat Sante Rech Med | Verfahren zur analyse von t-lymphozyten über die t-lymphozytrezeptoren eines organismus |
| US20030003485A1 (en) * | 2001-05-15 | 2003-01-02 | Ludwig Institute For Cancer Research | Methods for identifying antigens |
| WO2003068800A2 (en) | 2002-02-13 | 2003-08-21 | Ludwig Institute For Cancer Research | Isolated peptides which bind to hla molecules and uses thereof |
| JP2009515534A (ja) | 2005-11-10 | 2009-04-16 | ザ ユニヴァーシティー オヴ シカゴ | Ｈｃｖ−反応性ｔ細胞受容体 |
| JP5292550B2 (ja) | 2007-03-23 | 2013-09-18 | 静岡県 | Ｔ細胞レセプターβ鎖遺伝子及びα鎖遺伝子 |
| GB0712670D0 (en) * | 2007-06-29 | 2007-08-08 | King S College London | Isolated peptides and uses thereof |
| US9012148B2 (en) * | 2008-04-16 | 2015-04-21 | Jian Han | Method for evaluating and comparing immunorepertoires |
| US7892202B2 (en) | 2008-05-09 | 2011-02-22 | Merit Medical Systems, Inc. | System and method for inflation syringe with improved display |
| CN104195227B (zh) * | 2008-11-07 | 2017-04-12 | 适应生物技术公司 | 通过序列分析监测状况的方法 |
-
2011
- 2011-08-05 EP EP11739098.9A patent/EP2601521B1/en not_active Not-in-force
- 2011-08-05 JP JP2013522265A patent/JP6192537B2/ja not_active Expired - Fee Related
- 2011-08-05 WO PCT/EP2011/063538 patent/WO2012017081A1/en not_active Ceased
- 2011-08-05 EP EP15181740.0A patent/EP2982766B1/en not_active Not-in-force
- 2011-08-05 US US13/814,263 patent/US9678061B2/en not_active Expired - Fee Related
- 2011-08-05 CA CA2806440A patent/CA2806440A1/en not_active Abandoned
- 2011-08-05 EP EP18165023.5A patent/EP3376225A1/en not_active Withdrawn
-
2016
- 2016-10-05 JP JP2016197135A patent/JP2017038609A/ja not_active Withdrawn
-
2017
- 2017-05-05 US US15/587,636 patent/US20170240884A1/en not_active Abandoned
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