JP2013534804A5 - - Google Patents

Info

Publication number

JP2013534804A5

JP2013534804A5 JP2013505074A JP2013505074A JP2013534804A5 JP 2013534804 A5 JP2013534804 A5 JP 2013534804A5 JP 2013505074 A JP2013505074 A JP 2013505074A JP 2013505074 A JP2013505074 A JP 2013505074A JP 2013534804 A5 JP2013534804 A5 JP 2013534804A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

residue

alk

position corresponding

Prior art date

2011-04-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 116
• 125000000539 amino acid group Chemical group 0.000 claims 116
• 102100033793 ALK tyrosine kinase receptor Human genes 0.000 claims 108
• 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 108
• 229920001184 polypeptide Polymers 0.000 claims 91
• 102000004196 processed proteins & peptides Human genes 0.000 claims 91
• 108090000765 processed proteins & peptides Proteins 0.000 claims 91
• 239000002157 polynucleotide Substances 0.000 claims 65
• 102000040430 polynucleotide Human genes 0.000 claims 65
• 108091033319 polynucleotide Proteins 0.000 claims 65
• 125000003275 alpha amino acid group Chemical group 0.000 claims 59
• 150000003384 small molecules Chemical class 0.000 claims 48
• 229940043355 kinase inhibitor Drugs 0.000 claims 47
• 239000003757 phosphotransferase inhibitor Substances 0.000 claims 47
• 239000002773 nucleotide Substances 0.000 claims 45
• 125000003729 nucleotide group Chemical group 0.000 claims 45
• 230000000694 effects Effects 0.000 claims 42
• 108091000080 Phosphotransferase Proteins 0.000 claims 37
• 102000020233 phosphotransferase Human genes 0.000 claims 37
• 230000035772 mutation Effects 0.000 claims 34
• 238000000034 method Methods 0.000 claims 29
• 229940122531 Anaplastic lymphoma kinase inhibitor Drugs 0.000 claims 28
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 28
• 239000012472 biological sample Substances 0.000 claims 26
• 206010028980 Neoplasm Diseases 0.000 claims 22
• 201000011510 cancer Diseases 0.000 claims 22
• 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 14
• 108020001507 fusion proteins Proteins 0.000 claims 14
• 102000037865 fusion proteins Human genes 0.000 claims 14
• 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 14
• 231100000590 oncogenic Toxicity 0.000 claims 13
• 230000002246 oncogenic effect Effects 0.000 claims 13
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims 11
• 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 7
• 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 7
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 7
• 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 7
• 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 7
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 7
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 7
• 239000003153 chemical reaction reagent Substances 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• 229940126069 ALK kinase inhibitor Drugs 0.000 claims 5
• 230000001594 aberrant effect Effects 0.000 claims 5
• 230000030279 gene silencing Effects 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 241001465754 Metazoa Species 0.000 claims 2
• 230000009261 transgenic effect Effects 0.000 claims 2
• 230000002159 abnormal effect Effects 0.000 claims 1
• 230000000711 cancerogenic effect Effects 0.000 claims 1
• 231100000315 carcinogenic Toxicity 0.000 claims 1
• 230000004927 fusion Effects 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 235000018102 proteins Nutrition 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 230000008685 targeting Effects 0.000 claims 1