JP2013534410A5 - - Google Patents

Info

Publication number

JP2013534410A5

JP2013534410A5 JP2013510459A JP2013510459A JP2013534410A5 JP 2013534410 A5 JP2013534410 A5 JP 2013534410A5 JP 2013510459 A JP2013510459 A JP 2013510459A JP 2013510459 A JP2013510459 A JP 2013510459A JP 2013534410 A5 JP2013534410 A5 JP 2013534410A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

antisense oligonucleotide

cell

glioma

drr

Prior art date

2011-05-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 239000008194 pharmaceutical composition Substances 0.000 claims 24
• 108091034117 Oligonucleotide Proteins 0.000 claims 23
• 239000000074 antisense oligonucleotide Substances 0.000 claims 21
• 238000012230 antisense oligonucleotides Methods 0.000 claims 21
• 206010018338 Glioma Diseases 0.000 claims 16
• 208000032612 Glial tumor Diseases 0.000 claims 15
• 210000004027 cell Anatomy 0.000 claims 14
• 210000004881 tumor cell Anatomy 0.000 claims 14
• 238000000034 method Methods 0.000 claims 11
• 108020004707 nucleic acids Proteins 0.000 claims 10
• 102000039446 nucleic acids Human genes 0.000 claims 10
• 150000007523 nucleic acids Chemical class 0.000 claims 10
• 230000001225 therapeutic effect Effects 0.000 claims 9
• 108020004414 DNA Proteins 0.000 claims 8
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 7
• 201000011510 cancer Diseases 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 7
• 230000003211 malignant effect Effects 0.000 claims 7
• 239000013598 vector Substances 0.000 claims 7
• 208000005017 glioblastoma Diseases 0.000 claims 5
• 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 4
• 108020004999 messenger RNA Proteins 0.000 claims 4
• 210000004498 neuroglial cell Anatomy 0.000 claims 4
• 238000011275 oncology therapy Methods 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 102000053602 DNA Human genes 0.000 claims 3
• 230000008595 infiltration Effects 0.000 claims 3
• 238000001764 infiltration Methods 0.000 claims 3
• 239000002773 nucleotide Substances 0.000 claims 3
• 125000003729 nucleotide group Chemical group 0.000 claims 3
• 108020000948 Antisense Oligonucleotides Proteins 0.000 claims 2
• 108020005544 Antisense RNA Proteins 0.000 claims 2
• 230000004709 cell invasion Effects 0.000 claims 2
• 238000002512 chemotherapy Methods 0.000 claims 2
• 230000000295 complement effect Effects 0.000 claims 2
• 239000003184 complementary RNA Substances 0.000 claims 2
• 230000003247 decreasing effect Effects 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 239000013604 expression vector Substances 0.000 claims 2
• 238000001415 gene therapy Methods 0.000 claims 2
• 238000009169 immunotherapy Methods 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 239000002777 nucleoside Substances 0.000 claims 2
• 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
• 238000001959 radiotherapy Methods 0.000 claims 2
• 239000000523 sample Substances 0.000 claims 2
• 238000011282 treatment Methods 0.000 claims 2
• 108091023037 Aptamer Proteins 0.000 claims 1
• 230000000692 anti-sense effect Effects 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 230000003111 delayed effect Effects 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 208000029824 high grade glioma Diseases 0.000 claims 1
• 201000011614 malignant glioma Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000004393 prognosis Methods 0.000 claims 1
• 238000002271 resection Methods 0.000 claims 1