JP2013533856A - 局所筋麻痺効果を有する非拡散型ボツリヌス毒素とその精製方法 - Google Patents
局所筋麻痺効果を有する非拡散型ボツリヌス毒素とその精製方法 Download PDFInfo
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- JP2013533856A JP2013533856A JP2013513102A JP2013513102A JP2013533856A JP 2013533856 A JP2013533856 A JP 2013533856A JP 2013513102 A JP2013513102 A JP 2013513102A JP 2013513102 A JP2013513102 A JP 2013513102A JP 2013533856 A JP2013533856 A JP 2013533856A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
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- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Anesthesiology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Virology (AREA)
Abstract
Description
Claims (3)
- 精製されたボツリヌス毒素A型製剤を、pHは4.5ないし6.5の範囲、
塩化ナトリウム(NaCl)の濃度を0.02ないし0.2Mに調節して添加した陰イオンイオン交換樹脂クロマトグラフィーを遂行して亜分画を分離する段階;及び
上記亜分画のうちA260/A280の値が0.4ないし0.6の水準を維持する非拡散性ボツリヌス毒素分画を収得する段階を含んでなることを特徴とする非拡散型ボツリヌス毒素の精製方法。 - 請求項1によって分離精製されたものであって、
毒素100U/ml当りZnイオンが少なくとも150ppb、Feイオンが少なくとも80ppb、Mgイオンが少なくとも140ppbで含まれることを特徴とする非拡散型ボツリヌス毒素。 - 請求項2の非拡散型ボツリヌス毒素をその半数致死量の1.5ないし3倍の量でマウスの右下肢に注射し、右下肢の筋肉と呼吸筋の麻痺有無と致死有無を判断することを特徴とする非拡散型ボツリヌス毒素を判別する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2010-0051076 | 2010-05-31 | ||
KR1020100051076A KR101134146B1 (ko) | 2010-05-31 | 2010-05-31 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
PCT/KR2011/003547 WO2011152618A2 (ko) | 2010-05-31 | 2011-05-13 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015094777A Division JP5998419B2 (ja) | 2010-05-31 | 2015-05-07 | 局所筋麻痺効果を有する非拡散型ボツリヌス毒素とその精製方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013533856A true JP2013533856A (ja) | 2013-08-29 |
JP5919608B2 JP5919608B2 (ja) | 2016-05-18 |
Family
ID=45067165
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP2013513102A Expired - Fee Related JP5919608B2 (ja) | 2010-05-31 | 2011-05-13 | 局所筋麻痺効果を有する非拡散型ボツリヌス毒素とその精製方法 |
JP2015094777A Expired - Fee Related JP5998419B2 (ja) | 2010-05-31 | 2015-05-07 | 局所筋麻痺効果を有する非拡散型ボツリヌス毒素とその精製方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015094777A Expired - Fee Related JP5998419B2 (ja) | 2010-05-31 | 2015-05-07 | 局所筋麻痺効果を有する非拡散型ボツリヌス毒素とその精製方法 |
Country Status (8)
Country | Link |
---|---|
US (3) | US9598683B2 (ja) |
EP (1) | EP2578228B1 (ja) |
JP (2) | JP5919608B2 (ja) |
KR (1) | KR101134146B1 (ja) |
CN (1) | CN102985102B (ja) |
AU (1) | AU2011262499B2 (ja) |
ES (1) | ES2659820T3 (ja) |
WO (1) | WO2011152618A2 (ja) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101134146B1 (ko) * | 2010-05-31 | 2012-04-19 | 메덱스젠 주식회사 | 국소 근마비 효과를 갖는 비확산형 보툴리눔 독소와 그의 정제방법 |
KR101775682B1 (ko) * | 2015-11-30 | 2017-09-06 | 주식회사 대웅 | 보툴리눔 독소의 제조방법 |
Citations (2)
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WO2008050866A1 (en) * | 2006-10-27 | 2008-05-02 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Preparation containing highly purified botulinum toxin type a derived from infant botulism pathogen |
WO2010078242A1 (en) * | 2008-12-31 | 2010-07-08 | Revance Therapeutics, Inc. | Injectable botulinum toxin formulations |
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US5939070A (en) * | 1996-10-28 | 1999-08-17 | Wisconsin Alumni Research Foundation | Hybrid botulinal neurotoxins |
EP1053014A4 (en) * | 1998-01-26 | 2004-11-10 | Univ Massachusetts | BIOLOGICALLY ACTIVE HEMAGGLUTININE TYPE A i (STRIDIUM BOTULINUM) AND METHOD FOR ITS USE |
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-
2010
- 2010-05-31 KR KR1020100051076A patent/KR101134146B1/ko active IP Right Grant
-
2011
- 2011-05-13 CN CN201180028634.2A patent/CN102985102B/zh not_active Expired - Fee Related
- 2011-05-13 US US13/700,867 patent/US9598683B2/en not_active Expired - Fee Related
- 2011-05-13 AU AU2011262499A patent/AU2011262499B2/en not_active Ceased
- 2011-05-13 JP JP2013513102A patent/JP5919608B2/ja not_active Expired - Fee Related
- 2011-05-13 ES ES11789976.5T patent/ES2659820T3/es active Active
- 2011-05-13 WO PCT/KR2011/003547 patent/WO2011152618A2/ko active Application Filing
- 2011-05-13 EP EP11789976.5A patent/EP2578228B1/en not_active Revoked
-
2015
- 2015-05-07 JP JP2015094777A patent/JP5998419B2/ja not_active Expired - Fee Related
-
2017
- 2017-02-01 US US15/422,083 patent/US20170145399A1/en not_active Abandoned
- 2017-02-01 US US15/422,129 patent/US10369235B2/en not_active Expired - Fee Related
Patent Citations (2)
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WO2008050866A1 (en) * | 2006-10-27 | 2008-05-02 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Preparation containing highly purified botulinum toxin type a derived from infant botulism pathogen |
WO2010078242A1 (en) * | 2008-12-31 | 2010-07-08 | Revance Therapeutics, Inc. | Injectable botulinum toxin formulations |
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Also Published As
Publication number | Publication date |
---|---|
EP2578228A2 (en) | 2013-04-10 |
US9598683B2 (en) | 2017-03-21 |
CN102985102A (zh) | 2013-03-20 |
US20130071331A1 (en) | 2013-03-21 |
EP2578228A4 (en) | 2013-10-02 |
US10369235B2 (en) | 2019-08-06 |
AU2011262499B2 (en) | 2015-01-22 |
KR101134146B1 (ko) | 2012-04-19 |
CN102985102B (zh) | 2016-06-08 |
ES2659820T3 (es) | 2018-03-19 |
WO2011152618A2 (ko) | 2011-12-08 |
EP2578228B1 (en) | 2017-11-15 |
WO2011152618A9 (ko) | 2012-03-22 |
AU2011262499A1 (en) | 2013-01-24 |
JP2015200659A (ja) | 2015-11-12 |
JP5919608B2 (ja) | 2016-05-18 |
JP5998419B2 (ja) | 2016-09-28 |
WO2011152618A3 (ko) | 2012-05-24 |
US20170143849A1 (en) | 2017-05-25 |
WO2011152618A4 (ko) | 2012-07-12 |
US20170145399A1 (en) | 2017-05-25 |
KR20110131572A (ko) | 2011-12-07 |
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