JP2013533790A - 変形可能な物質を伴った調節眼内レンズ - Google Patents
変形可能な物質を伴った調節眼内レンズ Download PDFInfo
- Publication number
- JP2013533790A JP2013533790A JP2013518667A JP2013518667A JP2013533790A JP 2013533790 A JP2013533790 A JP 2013533790A JP 2013518667 A JP2013518667 A JP 2013518667A JP 2013518667 A JP2013518667 A JP 2013518667A JP 2013533790 A JP2013533790 A JP 2013533790A
- Authority
- JP
- Japan
- Prior art keywords
- transparent
- deformable material
- intraocular lens
- liquid
- providing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000463 material Substances 0.000 title claims abstract description 90
- 238000000034 method Methods 0.000 claims abstract description 24
- 239000013013 elastic material Substances 0.000 claims description 55
- 210000005252 bulbus oculi Anatomy 0.000 claims description 54
- 239000007788 liquid Substances 0.000 claims description 32
- 230000001886 ciliary effect Effects 0.000 claims description 16
- 239000002775 capsule Substances 0.000 claims description 15
- 210000003205 muscle Anatomy 0.000 claims description 15
- 239000012780 transparent material Substances 0.000 claims description 9
- 230000008531 maintenance mechanism Effects 0.000 claims description 3
- 210000003786 sclera Anatomy 0.000 claims description 3
- 210000001519 tissue Anatomy 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims 6
- 230000000452 restraining effect Effects 0.000 claims 1
- 210000000695 crystalline len Anatomy 0.000 description 69
- 241000219739 Lens Species 0.000 description 56
- 230000008859 change Effects 0.000 description 17
- 210000001508 eye Anatomy 0.000 description 11
- 201000010041 presbyopia Diseases 0.000 description 11
- 230000001105 regulatory effect Effects 0.000 description 11
- 230000004308 accommodation Effects 0.000 description 10
- 210000004087 cornea Anatomy 0.000 description 7
- 230000000694 effects Effects 0.000 description 4
- 229920000642 polymer Polymers 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000004438 eyesight Effects 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 208000002177 Cataract Diseases 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 208000001491 myopia Diseases 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000000750 progressive effect Effects 0.000 description 2
- 238000012552 review Methods 0.000 description 2
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047571 Visual impairment Diseases 0.000 description 1
- 210000002159 anterior chamber Anatomy 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004118 muscle contraction Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 230000005043 peripheral vision Effects 0.000 description 1
- 230000008288 physiological mechanism Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 208000029257 vision disease Diseases 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 230000004393 visual impairment Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0053—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in optical properties
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39862610P | 2010-06-29 | 2010-06-29 | |
| US61/398,626 | 2010-06-29 | ||
| PCT/US2011/042446 WO2012006186A2 (en) | 2010-06-29 | 2011-06-29 | Accommodating intraocular lens with deformable material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013533790A true JP2013533790A (ja) | 2013-08-29 |
| JP2013533790A5 JP2013533790A5 (enExample) | 2014-08-14 |
Family
ID=45441753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518667A Pending JP2013533790A (ja) | 2010-06-29 | 2011-06-29 | 変形可能な物質を伴った調節眼内レンズ |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20130110235A1 (enExample) |
| EP (1) | EP2588029A4 (enExample) |
| JP (1) | JP2013533790A (enExample) |
| CN (1) | CN103096837A (enExample) |
| AU (1) | AU2011276397A1 (enExample) |
| BR (1) | BR112012033762A2 (enExample) |
| CA (1) | CA2803893A1 (enExample) |
| RU (1) | RU2013103484A (enExample) |
| WO (1) | WO2012006186A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10835373B2 (en) | 2002-12-12 | 2020-11-17 | Alcon Inc. | Accommodating intraocular lenses and methods of use |
| IL161706A0 (en) | 2004-04-29 | 2004-09-27 | Nulens Ltd | Intraocular lens fixation device |
| WO2006103674A2 (en) | 2005-03-30 | 2006-10-05 | Nulens Ltd | Accommodating intraocular lens (aiol) assemblies, and discrete components therfor |
| US8968396B2 (en) | 2007-07-23 | 2015-03-03 | Powervision, Inc. | Intraocular lens delivery systems and methods of use |
| US8668734B2 (en) | 2010-07-09 | 2014-03-11 | Powervision, Inc. | Intraocular lens delivery devices and methods of use |
| US10299913B2 (en) | 2009-01-09 | 2019-05-28 | Powervision, Inc. | Accommodating intraocular lenses and methods of use |
| EP2473138A4 (en) | 2009-08-31 | 2017-08-16 | PowerVision, Inc. | Lens capsule size estimation |
| US8900298B2 (en) | 2010-02-23 | 2014-12-02 | Powervision, Inc. | Fluid for accommodating intraocular lenses |
| WO2011137191A1 (en) | 2010-04-27 | 2011-11-03 | Ramgopal Rao | Accommodating intraocular lens device |
| US9220590B2 (en) | 2010-06-10 | 2015-12-29 | Z Lens, Llc | Accommodative intraocular lens and method of improving accommodation |
| EP3685801B1 (en) | 2011-02-04 | 2025-01-22 | ForSight Vision6, Inc. | Intraocular accommodating lens |
| EP2688515B1 (en) | 2011-03-24 | 2021-05-19 | Alcon Inc. | Intraocular lens loading systems and methods of use |
| US10433949B2 (en) | 2011-11-08 | 2019-10-08 | Powervision, Inc. | Accommodating intraocular lenses |
| US9364318B2 (en) | 2012-05-10 | 2016-06-14 | Z Lens, Llc | Accommodative-disaccommodative intraocular lens |
| JP5936461B2 (ja) * | 2012-06-26 | 2016-06-22 | Hoya株式会社 | 眼内レンズ |
| ES2457840B1 (es) | 2012-09-28 | 2015-02-16 | Universidad De Murcia | Lente intraocular acomodativa de potencia variable y conjunto de lente intraocular acomodativa de potencia variable y anillo capsular |
| EP2967842B1 (en) | 2013-03-15 | 2020-11-04 | Alcon Inc. | Method of reconfiguring an intraocular lens for delivery to a delivery device |
| WO2015066532A1 (en) | 2013-11-01 | 2015-05-07 | Daniel Brady | Two-part accommodating intraocular lens device |
| EP3062741B1 (en) | 2013-11-01 | 2023-04-26 | Lensgen, Inc. | Accomodating intraocular lens device |
| WO2015134784A1 (en) * | 2014-03-06 | 2015-09-11 | Valdemar Portney | Multi-mode operating optic for presbyopia correction |
| EP3791827B8 (en) | 2014-03-28 | 2024-02-14 | ForSight Vision6, Inc. | Accommodating intraocular lens |
| MX381023B (es) * | 2014-04-18 | 2025-03-12 | Investmed Kft | Lente intraocular secundaria con porción óptica coaxial amplificadora. |
| US10004596B2 (en) | 2014-07-31 | 2018-06-26 | Lensgen, Inc. | Accommodating intraocular lens device |
| US10945832B2 (en) | 2014-09-22 | 2021-03-16 | Onpoint Vision, Inc. | Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method |
| US10299910B2 (en) | 2014-09-22 | 2019-05-28 | Kevin J. Cady | Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method |
| US10159562B2 (en) | 2014-09-22 | 2018-12-25 | Kevin J. Cady | Intraocular pseudophakic contact lenses and related systems and methods |
| US11938018B2 (en) | 2014-09-22 | 2024-03-26 | Onpoint Vision, Inc. | Intraocular pseudophakic contact lens (IOPCL) for treating age-related macular degeneration (AMD) or other eye disorders |
| US12447007B2 (en) | 2014-09-22 | 2025-10-21 | Onpoint Vision, Inc. | Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method |
| US11109957B2 (en) | 2014-09-22 | 2021-09-07 | Onpoint Vision, Inc. | Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method |
| EP3197462A4 (en) | 2014-09-23 | 2018-05-30 | Lensgen, Inc | Polymeric material for accommodating intraocular lenses |
| AU2016349532B2 (en) | 2015-11-06 | 2021-08-26 | Alcon Inc. | Accommodating intraocular lenses and methods of manufacturing |
| AU2016362384B2 (en) | 2015-12-01 | 2021-10-07 | Lensgen, Inc. | Accommodating intraocular lens device |
| EP3463188B1 (en) | 2016-05-27 | 2023-04-26 | LensGen, Inc. | Lens oil having a narrow molecular weight distribution for intraocular lens devices |
| US10512535B2 (en) | 2016-08-24 | 2019-12-24 | Z Lens, Llc | Dual mode accommodative-disaccomodative intraocular lens |
| US11523898B2 (en) | 2016-10-28 | 2022-12-13 | Forsight Vision6, Inc. | Accommodating intraocular lens and methods of implantation |
| US11357619B2 (en) * | 2018-10-31 | 2022-06-14 | Verily Life Sciences Llc | Adjustable ophthalmic devices, systems, and methods of adjustment |
| US12336903B2 (en) | 2021-01-13 | 2025-06-24 | Forsight Vision6, Inc. | Variable thickness dynamic membrane for accommodating intraocular lenses |
| CN121313381B (zh) * | 2025-12-12 | 2026-03-10 | 中国人民解放军陆军军医大学第一附属医院 | 一种绷带镜 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008534111A (ja) * | 2005-03-30 | 2008-08-28 | ニューレンズ・リミテッド | 調節型眼内レンズ（ａｉｏｌ）アセンブリおよびそのための個別の構成要素 |
| US20100094412A1 (en) * | 2008-10-15 | 2010-04-15 | Doug Wensrich | Accommodating intraocular lens |
| JP2010517639A (ja) * | 2007-02-02 | 2010-05-27 | キー メディカル テクノロジーズ インコーポレイテッド | 界面の屈折調節レンズ（ｉｒａｌ） |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4242760A (en) * | 1979-06-11 | 1981-01-06 | Rainin Edgar A | Intraocular lens structure |
| US4328595A (en) * | 1979-08-30 | 1982-05-11 | Sheets John H | Intraocular lens |
| US4409691A (en) * | 1981-11-02 | 1983-10-18 | Levy Chauncey F | Focussable intraocular lens |
| US4435856A (en) * | 1982-04-14 | 1984-03-13 | Esperance Francis A L | Bifocal intraocular lens structure and spectacle actuation frame |
| US4892543A (en) * | 1989-02-02 | 1990-01-09 | Turley Dana F | Intraocular lens providing accomodation |
| US5489302A (en) * | 1994-05-24 | 1996-02-06 | Skottun; Bernt C. | Accommodating intraocular lens |
| IL145015A0 (en) * | 2001-08-21 | 2002-06-30 | Nun Yehoshua Ben | Accommodating lens |
| US7097660B2 (en) * | 2001-12-10 | 2006-08-29 | Valdemar Portney | Accommodating intraocular lens |
| JP4480766B2 (ja) * | 2004-10-13 | 2010-06-16 | ニューレンズ・リミテッド | 調節式眼内レンズ（ａｉｏｌ）及びそれを含んでいるａｉｏｌアッセンブリ |
| CN101646400A (zh) * | 2007-02-02 | 2010-02-10 | 关键医学技术有限公司 | 界面折射调节透镜（iral） |
| US8034106B2 (en) * | 2007-02-02 | 2011-10-11 | Adoptics Ag | Interfacial refraction accommodating lens (IRAL) |
| EP2315559B1 (en) * | 2008-07-24 | 2012-01-25 | Nulens Ltd | Accommodating intraocular lens (aiol) capsules |
| US8858627B1 (en) * | 2009-08-07 | 2014-10-14 | Richard L. Lindstrom | Accomodative intraocular lens |
-
2011
- 2011-06-29 CA CA2803893A patent/CA2803893A1/en not_active Abandoned
- 2011-06-29 EP EP11804203.5A patent/EP2588029A4/en not_active Withdrawn
- 2011-06-29 WO PCT/US2011/042446 patent/WO2012006186A2/en not_active Ceased
- 2011-06-29 CN CN2011800320150A patent/CN103096837A/zh active Pending
- 2011-06-29 AU AU2011276397A patent/AU2011276397A1/en not_active Abandoned
- 2011-06-29 RU RU2013103484/14A patent/RU2013103484A/ru not_active Application Discontinuation
- 2011-06-29 BR BR112012033762A patent/BR112012033762A2/pt not_active IP Right Cessation
- 2011-06-29 JP JP2013518667A patent/JP2013533790A/ja active Pending
- 2011-06-29 US US13/806,993 patent/US20130110235A1/en not_active Abandoned
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008534111A (ja) * | 2005-03-30 | 2008-08-28 | ニューレンズ・リミテッド | 調節型眼内レンズ（ａｉｏｌ）アセンブリおよびそのための個別の構成要素 |
| JP2010517639A (ja) * | 2007-02-02 | 2010-05-27 | キー メディカル テクノロジーズ インコーポレイテッド | 界面の屈折調節レンズ（ｉｒａｌ） |
| US20100094412A1 (en) * | 2008-10-15 | 2010-04-15 | Doug Wensrich | Accommodating intraocular lens |
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012033762A2 (pt) | 2018-02-27 |
| AU2011276397A1 (en) | 2013-02-14 |
| RU2013103484A (ru) | 2014-08-10 |
| CN103096837A (zh) | 2013-05-08 |
| CA2803893A1 (en) | 2012-01-12 |
| WO2012006186A2 (en) | 2012-01-12 |
| US20130110235A1 (en) | 2013-05-02 |
| EP2588029A4 (en) | 2014-11-19 |
| EP2588029A2 (en) | 2013-05-08 |
| WO2012006186A3 (en) | 2012-04-05 |
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