JP2013531651A - 線溶亢進を伴う凝固障害の処置 - Google Patents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
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- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2010/003541 WO2010142461A2 (en) | 2009-06-12 | 2010-06-14 | Treatment of coagulopathy with hyperfibrinolysis |
| EPPCT/EP2010/003541 | 2010-06-14 | ||
| PCT/EP2010/007632 WO2011157283A1 (en) | 2010-06-14 | 2010-12-15 | Treatment of coagulopathy with hyperfibrinolysis |
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| JP2013531651A true JP2013531651A (ja) | 2013-08-08 |
| JP2013531651A5 JP2013531651A5 (enExample) | 2014-11-06 |
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| MX355060B (es) | 2010-11-17 | 2018-04-03 | Chugai Pharmaceutical Co Ltd | Molecula multiespecifica de union a antigeno que tiene funcion alternativa a la funcion del factor viii de coagulacion sanguinea. |
| TWI831106B (zh) * | 2014-06-20 | 2024-02-01 | 日商中外製藥股份有限公司 | 用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物 |
| EP3449940B1 (en) | 2016-04-28 | 2025-11-19 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
| CA3035327A1 (en) | 2016-09-06 | 2018-03-15 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| CN107083357B (zh) * | 2017-06-16 | 2021-04-02 | 四川农业大学 | 一种诱导培养骨髓间充质干细胞的方法 |
| JP2019031486A (ja) * | 2017-08-04 | 2019-02-28 | 公立大学法人福島県立医科大学 | 新規ポリペプチド及びその用途 |
| CN107677834B (zh) * | 2017-09-25 | 2019-07-09 | 辽宁迈迪生物科技股份有限公司 | TAFIa含量的检测方法、用于检测TAFIa含量的试剂盒及二者的应用 |
| BR112020008393A2 (pt) | 2017-11-01 | 2020-11-03 | Chugai Seiyaku Kabushiki Kaisha | variante e isoforma de anticorpos com atividade biológica reduzida |
| CN111961137B (zh) * | 2020-08-27 | 2023-09-05 | 南开大学 | 仿生内皮细胞功能的融合蛋白及其应用 |
Citations (2)
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|---|---|---|---|---|
| WO1993025675A1 (en) * | 1992-06-10 | 1993-12-23 | Schering Aktiengesellschaft | Mutants of the epidermal growth factor domains of human thrombomodulin |
| JP2010512411A (ja) * | 2006-12-12 | 2010-04-22 | イーライ リリー アンド カンパニー | 可溶性トロンボモジュリン変異体を用いる急性腎不全の治療 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0816494A1 (en) | 1987-01-08 | 1998-01-07 | Asahi Kasei Kogyo Kabushiki Kaisha | DNA coding for a peptide promoting the activation of protein C by thrombin, and process for producing the same |
| US5256770A (en) | 1990-04-09 | 1993-10-26 | Schering Ag | Oxidation resistant thrombomodulin analogs |
| ES2170747T3 (es) | 1990-08-15 | 2002-08-16 | Paion Gmbh | Analogos superiores de trombomodulina para uso farmaceutico. |
| PT641215E (pt) | 1992-02-05 | 2004-09-30 | Paion Gmbh | Analogos de trombomodulina resistentes a proteases |
| EP1383885A4 (en) | 2001-04-04 | 2005-11-30 | American Diagnostica Inc | METHOD FOR PRODUCING A STABILIZED THROMBIN-ACTIVATED FIBRINOLYSE INHIBITOR (TAFI) AND METHOD FOR THE USE THEREOF |
| AU2009347614A1 (en) * | 2009-06-12 | 2012-01-19 | Paion Deutschland Gmbh | Treatment of coagulopathy with hyperfibrinolysis |
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2010
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- 2010-12-15 CN CN201080068202XA patent/CN103037893A/zh active Pending
- 2010-12-15 WO PCT/EP2010/007632 patent/WO2011157283A1/en not_active Ceased
- 2010-12-15 AU AU2010355558A patent/AU2010355558A1/en not_active Abandoned
- 2010-12-15 JP JP2013514555A patent/JP2013531651A/ja active Pending
- 2010-12-15 BR BR112012031920A patent/BR112012031920A2/pt not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993025675A1 (en) * | 1992-06-10 | 1993-12-23 | Schering Aktiengesellschaft | Mutants of the epidermal growth factor domains of human thrombomodulin |
| JP2010512411A (ja) * | 2006-12-12 | 2010-04-22 | イーライ リリー アンド カンパニー | 可溶性トロンボモジュリン変異体を用いる急性腎不全の治療 |
Non-Patent Citations (1)
| Title |
|---|
| JPN5013007762; ＷＡＮＧ Ｗ: 'ＥＬＥＭＥＮＴＳ ＯＦ ＴＨＥ ＰＲＩＭＡＲＹ ＳＴＲＵＣＴＵＲＥ ＯＦ ＴＨＲＯＭＢＯＭＯＤＵＬＩＮ ＲＥＱＵＩＲＥＤ 以下備考' ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖ２７５ Ｎ３０, 20000728, Ｐ２２９４２-２２９４７ * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011157283A1 (en) | 2011-12-22 |
| CN103037893A (zh) | 2013-04-10 |
| BR112012031920A2 (pt) | 2017-05-16 |
| AU2010355558A1 (en) | 2013-01-24 |
| CA2802072A1 (en) | 2011-12-22 |
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