JP2013530719A5 - - Google Patents

Info

Publication number

JP2013530719A5

JP2013530719A5 JP2013520127A JP2013520127A JP2013530719A5 JP 2013530719 A5 JP2013530719 A5 JP 2013530719A5 JP 2013520127 A JP2013520127 A JP 2013520127A JP 2013520127 A JP2013520127 A JP 2013520127A JP 2013530719 A5 JP2013530719 A5 JP 2013530719A5

Authority

JP

Japan

Prior art keywords

galactosyl

enzyme

amino acid

acid sequence

donor

Prior art date

2011-07-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 125000002519 galactosyl group Chemical group C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)* 0.000 claims 19
• 238000000034 method Methods 0.000 claims 14
• 102000004190 Enzymes Human genes 0.000 claims 10
• 108090000790 Enzymes Proteins 0.000 claims 10
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 239000000203 mixture Substances 0.000 claims 9
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 6
• 235000021255 galacto-oligosaccharides Nutrition 0.000 claims 4
• 150000003271 galactooligosaccharides Chemical class 0.000 claims 4
• 102000005936 beta-Galactosidase Human genes 0.000 claims 2
• 108010005774 beta-Galactosidase Proteins 0.000 claims 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
• 238000003556 assay Methods 0.000 claims 1
• 238000013375 chromatographic separation Methods 0.000 claims 1
• 125000003147 glycosyl group Chemical group 0.000 claims 1
• VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 claims 1
• 229960003451 lactitol Drugs 0.000 claims 1
• 235000010448 lactitol Nutrition 0.000 claims 1
• 239000000832 lactitol Substances 0.000 claims 1
• 239000008101 lactose Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000001728 nano-filtration Methods 0.000 claims 1
• 150000005846 sugar alcohols Chemical class 0.000 claims 1