JP2013530233A5 - - Google Patents
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- Publication number
- JP2013530233A5 JP2013530233A5 JP2013518561A JP2013518561A JP2013530233A5 JP 2013530233 A5 JP2013530233 A5 JP 2013530233A5 JP 2013518561 A JP2013518561 A JP 2013518561A JP 2013518561 A JP2013518561 A JP 2013518561A JP 2013530233 A5 JP2013530233 A5 JP 2013530233A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- amino acid
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- 150000003839 salts Chemical class 0.000 claims 19
- 229940024606 amino acid Drugs 0.000 claims 10
- 235000001014 amino acid Nutrition 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 10
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 210000004003 subcutaneous fat Anatomy 0.000 claims 4
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 claims 4
- REQCSZJUXVVNII-UHFFFAOYSA-N n-(3-methylbutyl)octanamide Chemical compound CCCCCCCC(=O)NCCC(C)C REQCSZJUXVVNII-UHFFFAOYSA-N 0.000 claims 3
- 238000007920 subcutaneous administration Methods 0.000 claims 3
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 claims 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 2
- 208000035484 Cellulite Diseases 0.000 claims 2
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010049752 Peau d'orange Diseases 0.000 claims 2
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 2
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 238000009825 accumulation Methods 0.000 claims 2
- 210000001789 adipocyte Anatomy 0.000 claims 2
- 229960003556 aminophylline Drugs 0.000 claims 2
- FQPFAHBPWDRTLU-UHFFFAOYSA-N aminophylline Chemical compound NCCN.O=C1N(C)C(=O)N(C)C2=C1NC=N2.O=C1N(C)C(=O)N(C)C2=C1NC=N2 FQPFAHBPWDRTLU-UHFFFAOYSA-N 0.000 claims 2
- 229960001948 caffeine Drugs 0.000 claims 2
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 229960004203 carnitine Drugs 0.000 claims 2
- 230000036232 cellulite Effects 0.000 claims 2
- 235000014113 dietary fatty acids Nutrition 0.000 claims 2
- 229930195729 fatty acid Natural products 0.000 claims 2
- 239000000194 fatty acid Substances 0.000 claims 2
- 229940039009 isoproterenol Drugs 0.000 claims 2
- 206010033675 panniculitis Diseases 0.000 claims 2
- 229940016667 resveratrol Drugs 0.000 claims 2
- 235000021283 resveratrol Nutrition 0.000 claims 2
- 210000004304 subcutaneous tissue Anatomy 0.000 claims 2
- 229960000278 theophylline Drugs 0.000 claims 2
- NJIYXAMLJYXSKJ-UHFFFAOYSA-N 4-methyl-2-(octanoylamino)pentanoic acid Chemical compound CCCCCCCC(=O)NC(C(O)=O)CC(C)C NJIYXAMLJYXSKJ-UHFFFAOYSA-N 0.000 claims 1
- 206010020880 Hypertrophy Diseases 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 206010024612 Lipoma Diseases 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000011759 adipose tissue development Effects 0.000 claims 1
- 239000000443 aerosol Substances 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 125000001924 fatty-acyl group Chemical group 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 229960000310 isoleucine Drugs 0.000 claims 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 1
- 230000037356 lipid metabolism Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 210000000229 preadipocyte Anatomy 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36117910P | 2010-07-02 | 2010-07-02 | |
| US61/361,179 | 2010-07-02 | ||
| PCT/US2011/042123 WO2012003176A1 (en) | 2010-07-02 | 2011-06-28 | N-acyl amino acid derivatives for treating skin conditions such as cellulite |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013530233A JP2013530233A (ja) | 2013-07-25 |
| JP2013530233A5 true JP2013530233A5 (enExample) | 2014-07-10 |
| JP6043283B2 JP6043283B2 (ja) | 2016-12-14 |
Family
ID=44326260
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013518561A Expired - Fee Related JP6043283B2 (ja) | 2010-07-02 | 2011-06-28 | セルライト等の皮膚状態を治療するためのｎ−アシルアミノ酸誘導体 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9511042B2 (enExample) |
| EP (1) | EP2588101B1 (enExample) |
| JP (1) | JP6043283B2 (enExample) |
| KR (1) | KR101639196B1 (enExample) |
| CN (1) | CN103079553B (enExample) |
| AR (1) | AR082277A1 (enExample) |
| AU (1) | AU2011271466B2 (enExample) |
| BR (1) | BR112013000045A2 (enExample) |
| CA (1) | CA2800301C (enExample) |
| DK (1) | DK2588101T3 (enExample) |
| ES (1) | ES2528012T3 (enExample) |
| MX (1) | MX362721B (enExample) |
| MY (1) | MY156618A (enExample) |
| NZ (1) | NZ605804A (enExample) |
| PH (1) | PH12012502423B1 (enExample) |
| PL (1) | PL2588101T3 (enExample) |
| RU (1) | RU2590977C2 (enExample) |
| SG (1) | SG186234A1 (enExample) |
| SI (1) | SI2588101T1 (enExample) |
| TW (1) | TWI539945B (enExample) |
| WO (1) | WO2012003176A1 (enExample) |
| ZA (1) | ZA201209603B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201701476PA (en) | 2014-08-28 | 2017-03-30 | Caliway Biopharmaceuticals Co Ltd | Composition for reducing local fat and body weight, and pharmaceuticals and use thereof |
| US10226503B2 (en) | 2014-08-28 | 2019-03-12 | Caliway Biopharmaceuticals Co., Ltd. | Plant extract composition for reducing topical fat and promoting weight loss as well as applications thereof |
| HRP20251142T1 (hr) | 2015-08-28 | 2025-11-21 | Caliway Biopharmaceuticals Co., Ltd. | Farmaceutski pripravak koji se koristi za smanjenje lokaliziranih masnoća i uporaba farmaceutskog pripravka |
| US11318110B2 (en) | 2015-08-28 | 2022-05-03 | Caliway Biopharmaceuticals Co., Ltd. | Pharmaceutical composition for reducing local fat and uses thereof |
| US11202743B2 (en) | 2016-07-27 | 2021-12-21 | Conopco, Inc. | Personal care compositions comprising fatty acid amide derivatives |
| WO2019071093A1 (en) * | 2017-10-05 | 2019-04-11 | North Carolina State University | ALKAMIDE COMPOUNDS AND USES THEREOF |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU85643A1 (fr) | 1984-11-16 | 1986-06-04 | Oreal | Composition cosmetique thermo-amincissante a base d'extraits vegetaux oleosolubles |
| US5510531A (en) | 1989-04-10 | 1996-04-23 | Suntory Limited | Proteinase inhibitor |
| JP2701932B2 (ja) * | 1989-04-10 | 1998-01-21 | サントリー株式会社 | タンパク質分解酵素阻害剤 |
| DK255889D0 (da) | 1989-05-25 | 1989-05-25 | Novo Nordisk As | Fremgangsmaade til fremstilling af organiske forbindelser |
| DE69225631T2 (de) * | 1991-02-19 | 1998-12-17 | Cci Corp., Gifu | Acylaminosäure-Verbindungen und Verfahren zu ihrer Herstellung |
| JPH08337515A (ja) * | 1995-04-11 | 1996-12-24 | Kashima Sekiyu Kk | 化粧料 |
| FR2789085B1 (fr) * | 1999-01-29 | 2003-06-20 | Arkopharma Laboratoires | Procede d'obtention d'une huile enrichie en acides gras hydroxyoctadecadienoiques (hode), ou de ses esters a partir d'un melange huileux contenant de l'acide linoleique, ou ses esters |
| US6492326B1 (en) | 1999-04-19 | 2002-12-10 | The Procter & Gamble Company | Skin care compositions containing combination of skin care actives |
| EA006556B1 (ru) | 2001-03-27 | 2006-02-24 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Способы, соединения и композиции для борьбы с ожирением и регулирования метаболизма жирных кислот |
| AU2002320407A1 (en) * | 2001-07-10 | 2003-01-29 | Trustees Of Boston University | Modified-fat nutritional products useful for preventing or treating obesity |
| ITMI20030210A1 (it) * | 2003-02-07 | 2004-08-08 | Res & Innovation Soc Coop A R L | Composti endocannabinoido-simili e loro impiego |
| JP2005194252A (ja) * | 2004-01-09 | 2005-07-21 | Shiseido Co Ltd | 脂肪蓄積抑制用組成物 |
| WO2006029818A2 (en) | 2004-09-16 | 2006-03-23 | Dsm Ip Assets B.V. | Cosmetic compositions containing an hydroxamic acid compound optionally in combination with a retinoid |
| JP4527655B2 (ja) * | 2004-11-30 | 2010-08-18 | ライオン株式会社 | フォーマー容器入り洗浄剤組成物 |
| JP2008105945A (ja) | 2005-02-07 | 2008-05-08 | Ajinomoto Co Inc | アディポネクチンの分泌促進又は誘導作用を有するアシルアミド化合物 |
| JP2007153845A (ja) * | 2005-12-07 | 2007-06-21 | Yamaha Motor Co Ltd | 脂肪蓄積抑制剤 |
| JP5105297B2 (ja) * | 2006-05-25 | 2012-12-26 | 味の素株式会社 | Ｐｐａｒ活性調節剤 |
| DE102006060439A1 (de) * | 2006-12-19 | 2008-06-26 | Henkel Kgaa | Verbesserung der Hautverträglichkeit von hyperämisierenden Wirkstoffen |
| US20080200704A1 (en) | 2007-02-20 | 2008-08-21 | Multi Formulations Ltd. | Preparation of amino acid-fatty acid amides |
-
2011
- 2011-06-28 US US13/703,292 patent/US9511042B2/en active Active
- 2011-06-28 PL PL11731209T patent/PL2588101T3/pl unknown
- 2011-06-28 MX MX2012014751A patent/MX362721B/es active IP Right Grant
- 2011-06-28 CN CN201180032994.XA patent/CN103079553B/zh not_active Expired - Fee Related
- 2011-06-28 KR KR1020137001965A patent/KR101639196B1/ko not_active Expired - Fee Related
- 2011-06-28 RU RU2013104424/15A patent/RU2590977C2/ru not_active IP Right Cessation
- 2011-06-28 MY MYPI2012005292A patent/MY156618A/en unknown
- 2011-06-28 JP JP2013518561A patent/JP6043283B2/ja not_active Expired - Fee Related
- 2011-06-28 EP EP11731209.0A patent/EP2588101B1/en active Active
- 2011-06-28 DK DK11731209.0T patent/DK2588101T3/en active
- 2011-06-28 PH PH1/2012/502423A patent/PH12012502423B1/en unknown
- 2011-06-28 CA CA2800301A patent/CA2800301C/en not_active Expired - Fee Related
- 2011-06-28 WO PCT/US2011/042123 patent/WO2012003176A1/en not_active Ceased
- 2011-06-28 SI SI201130336T patent/SI2588101T1/sl unknown
- 2011-06-28 ES ES11731209.0T patent/ES2528012T3/es active Active
- 2011-06-28 SG SG2012090346A patent/SG186234A1/en unknown
- 2011-06-28 AU AU2011271466A patent/AU2011271466B2/en not_active Ceased
- 2011-06-28 BR BR112013000045A patent/BR112013000045A2/pt not_active Application Discontinuation
- 2011-06-29 TW TW100122944A patent/TWI539945B/zh not_active IP Right Cessation
- 2011-06-30 AR ARP110102319A patent/AR082277A1/es not_active Application Discontinuation
- 2011-07-22 NZ NZ605804A patent/NZ605804A/en not_active IP Right Cessation
-
2012
- 2012-12-18 ZA ZA2012/09603A patent/ZA201209603B/en unknown
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