JP2013529919A5 - - Google Patents
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- JP2013529919A5 JP2013529919A5 JP2013515559A JP2013515559A JP2013529919A5 JP 2013529919 A5 JP2013529919 A5 JP 2013529919A5 JP 2013515559 A JP2013515559 A JP 2013515559A JP 2013515559 A JP2013515559 A JP 2013515559A JP 2013529919 A5 JP2013529919 A5 JP 2013529919A5
- Authority
- JP
- Japan
- Prior art keywords
- skin substitute
- cells
- tsc2
- skin
- tsc1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims description 29
- 101000795659 Homo sapiens Tuberin Proteins 0.000 claims description 25
- 102100031638 Tuberin Human genes 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 210000002950 fibroblast Anatomy 0.000 claims description 5
- 210000003780 hair follicle Anatomy 0.000 claims description 5
- 230000007547 defect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 210000001061 forehead Anatomy 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims 37
- 210000002919 epithelial cell Anatomy 0.000 claims 7
- 239000011159 matrix material Substances 0.000 claims 7
- 102100027909 Folliculin Human genes 0.000 claims 5
- 101001060703 Homo sapiens Folliculin Proteins 0.000 claims 5
- 210000002510 keratinocyte Anatomy 0.000 claims 5
- 230000003278 mimic effect Effects 0.000 claims 5
- 108091030071 RNAI Proteins 0.000 claims 4
- 108091027967 Small hairpin RNA Proteins 0.000 claims 4
- 108020004459 Small interfering RNA Proteins 0.000 claims 4
- 230000009368 gene silencing by RNA Effects 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 230000002829 reductive effect Effects 0.000 claims 4
- 230000001105 regulatory effect Effects 0.000 claims 4
- 239000004055 small Interfering RNA Substances 0.000 claims 4
- 206010027145 Melanocytic naevus Diseases 0.000 claims 3
- 208000007256 Nevus Diseases 0.000 claims 3
- 230000002500 effect on skin Effects 0.000 claims 3
- 210000003953 foreskin Anatomy 0.000 claims 3
- 208000003200 Adenoma Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010016629 fibroma Diseases 0.000 claims 2
- 210000004209 hair Anatomy 0.000 claims 2
- 239000004005 microsphere Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
- 101150107888 AKT2 gene Proteins 0.000 claims 1
- 206010001233 Adenoma benign Diseases 0.000 claims 1
- 101150051155 Akt3 gene Proteins 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 201000007651 Brooke-Spiegler syndrome Diseases 0.000 claims 1
- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 208000012609 Cowden disease Diseases 0.000 claims 1
- 201000002847 Cowden syndrome Diseases 0.000 claims 1
- 108010086291 Deubiquitinating Enzyme CYLD Proteins 0.000 claims 1
- 102000007443 Deubiquitinating Enzyme CYLD Human genes 0.000 claims 1
- 102100022466 Eukaryotic translation initiation factor 4E-binding protein 1 Human genes 0.000 claims 1
- 108050000946 Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 claims 1
- 102000001267 GSK3 Human genes 0.000 claims 1
- 108060006662 GSK3 Proteins 0.000 claims 1
- 102100031561 Hamartin Human genes 0.000 claims 1
- 101000795643 Homo sapiens Hamartin Proteins 0.000 claims 1
- 101000582631 Homo sapiens Menin Proteins 0.000 claims 1
- 101000690268 Homo sapiens Proline-rich AKT1 substrate 1 Proteins 0.000 claims 1
- 102000046985 LST8 Homolog mTOR Associated Human genes 0.000 claims 1
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 claims 1
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 claims 1
- 102000009308 Mechanistic Target of Rapamycin Complex 2 Human genes 0.000 claims 1
- 108010034057 Mechanistic Target of Rapamycin Complex 2 Proteins 0.000 claims 1
- 102100030550 Menin Human genes 0.000 claims 1
- 208000008770 Multiple Hamartoma Syndrome Diseases 0.000 claims 1
- 101100388114 Mus musculus Deptor gene Proteins 0.000 claims 1
- 101100087591 Mus musculus Rictor gene Proteins 0.000 claims 1
- 208000009905 Neurofibromatoses Diseases 0.000 claims 1
- 102000007530 Neurofibromin 1 Human genes 0.000 claims 1
- 108010085793 Neurofibromin 1 Proteins 0.000 claims 1
- 108091007960 PI3Ks Proteins 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 102100024184 Polymerase delta-interacting protein 3 Human genes 0.000 claims 1
- 101710142722 Polymerase delta-interacting protein 3 Proteins 0.000 claims 1
- 102100024091 Proline-rich AKT1 substrate 1 Human genes 0.000 claims 1
- 101150020518 RHEB gene Proteins 0.000 claims 1
- 101150071831 RPS6KA1 gene Proteins 0.000 claims 1
- 102000046951 Ras Homolog Enriched in Brain Human genes 0.000 claims 1
- 108700019578 Ras Homolog Enriched in Brain Proteins 0.000 claims 1
- 108010029031 Regulatory-Associated Protein of mTOR Proteins 0.000 claims 1
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 claims 1
- 102000002278 Ribosomal Proteins Human genes 0.000 claims 1
- 108010000605 Ribosomal Proteins Proteins 0.000 claims 1
- 102100024908 Ribosomal protein S6 kinase beta-1 Human genes 0.000 claims 1
- 101710108924 Ribosomal protein S6 kinase beta-1 Proteins 0.000 claims 1
- 102000008078 Sterol Regulatory Element Binding Protein 1 Human genes 0.000 claims 1
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 101710115678 Target of rapamycin complex subunit LST8 Proteins 0.000 claims 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims 1
- 101150045355 akt1 gene Proteins 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 210000000804 eccrine gland Anatomy 0.000 claims 1
- 230000002124 endocrine Effects 0.000 claims 1
- 208000010932 epithelial neoplasm Diseases 0.000 claims 1
- 239000013604 expression vector Substances 0.000 claims 1
- 230000003325 follicular Effects 0.000 claims 1
- 201000004260 follicular adenoma Diseases 0.000 claims 1
- 208000030878 follicular thyroid adenoma Diseases 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000007972 injectable composition Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
- 201000004931 neurofibromatosis Diseases 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 230000036961 partial effect Effects 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 206010039667 schwannoma Diseases 0.000 claims 1
- 210000001732 sebaceous gland Anatomy 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 210000002107 sheath cell Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000009999 tuberous sclerosis Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 description 3
- 238000001976 enzyme digestion Methods 0.000 description 3
- 230000000762 glandular Effects 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 108091092878 Microsatellite Proteins 0.000 description 2
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- 108091008146 restriction endonucleases Proteins 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 238000012163 sequencing technique Methods 0.000 description 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 108020004485 Nonsense Codon Proteins 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 238000001531 micro-dissection Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000037434 nonsense mutation Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 210000004287 null lymphocyte Anatomy 0.000 description 1
- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34425810P | 2010-06-18 | 2010-06-18 | |
| US61/344,258 | 2010-06-18 | ||
| PCT/US2011/040937 WO2011160055A2 (en) | 2010-06-18 | 2011-06-17 | Hair follicle neogenesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016253496A Division JP6449220B2 (ja) | 2010-06-18 | 2016-12-27 | 毛包新生 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529919A JP2013529919A (ja) | 2013-07-25 |
| JP2013529919A5 true JP2013529919A5 (https=) | 2014-07-03 |
| JP6071875B2 JP6071875B2 (ja) | 2017-02-08 |
Family
ID=45348909
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515559A Expired - Fee Related JP6071875B2 (ja) | 2010-06-18 | 2011-06-17 | 毛包新生 |
| JP2016253496A Expired - Fee Related JP6449220B2 (ja) | 2010-06-18 | 2016-12-27 | 毛包新生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016253496A Expired - Fee Related JP6449220B2 (ja) | 2010-06-18 | 2016-12-27 | 毛包新生 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130209427A1 (https=) |
| EP (1) | EP2582791B8 (https=) |
| JP (2) | JP6071875B2 (https=) |
| AU (1) | AU2011268139B2 (https=) |
| CA (1) | CA2802880C (https=) |
| ES (1) | ES2667532T3 (https=) |
| WO (1) | WO2011160055A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| US20140072613A1 (en) * | 2012-09-10 | 2014-03-13 | Cynthia Lander | Compositions and Methods for Treating Cutaneous Scarring |
| US9655930B2 (en) | 2012-10-01 | 2017-05-23 | Aderans Research Institute, Inc. | Compositions and methods for producing reconstituted skin |
| EP2991692B1 (en) * | 2013-05-03 | 2019-08-21 | The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. | Skin substitutes and methods for hair follicle neogenesis |
| US9545302B2 (en) | 2013-11-20 | 2017-01-17 | Dermagenesis Llc | Skin printing and auto-grafting |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| KR102122039B1 (ko) * | 2017-07-19 | 2020-06-11 | 서울대학교산학협력단 | 인간 유래 만능줄기세포에서 모유두전구세포로의 분화방법 및 이의 용도 |
| CN108525021B (zh) * | 2018-04-17 | 2021-05-18 | 山西医科大学 | 基于3d打印的含血管及毛囊结构组织工程皮肤及其制备方法 |
| EP3801028A4 (en) | 2018-05-30 | 2022-04-13 | Direct Biologics LLC | A growth factor and extracellular vesicle frozen or powdered additive comprising a mesenchymal stem cell (msc) preparation and methods of use |
| CN109321513B (zh) * | 2018-09-30 | 2021-05-04 | 洛阳师范学院 | 一种具有生理功能的组织工程皮肤构建方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US20220079990A1 (en) * | 2018-12-26 | 2022-03-17 | Direct Biologics Llc | Methods and compositions for treating skin and hair disorders |
| US12569517B2 (en) | 2019-02-07 | 2026-03-10 | Direct Biologics, Llc | Method for treating osteoarthritis with mesenchymal stem cell exosomes |
| US12213995B2 (en) | 2019-07-18 | 2025-02-04 | Direct Biologics, Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| EP4556072A3 (en) * | 2019-08-23 | 2025-06-11 | Orbsen Therapeutics Limited | Compositions for monocyte and macrophage polarization and methods of use |
| KR20230004709A (ko) | 2020-04-22 | 2023-01-06 | 다이렉트 바이오로직스 엘엘씨 | 감염성 질환과 연관된 염증성 병태를 치료하기 위한 방법 및 조성물 |
| EP4165185A4 (en) * | 2020-06-11 | 2025-09-10 | Genetic Intelligence Inc New York Ny | FLCN GENE MODULATION COMPOSITIONS AND RELATED METHODS |
| WO2022247930A1 (en) * | 2021-05-27 | 2022-12-01 | The University Of Hong Kong | Bioengineered dermal papilla and hair follicles and related products, methods and applications |
| WO2023287986A1 (en) * | 2021-07-14 | 2023-01-19 | The Regents Of The University Of Michigan | Methods for hair growth |
| WO2023039833A1 (zh) * | 2021-09-17 | 2023-03-23 | 谢达仁 | 胶原蛋白颗粒于促进毛囊生成或血管生成的用途 |
| CN114195458B (zh) * | 2021-12-27 | 2023-02-07 | 东莞市优鼎新材料科技有限公司 | 微球改性材料及其制备方法、填缝剂及其制备方法 |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| WO2026063864A1 (en) * | 2024-09-23 | 2026-03-26 | Medeze Treasury Pte. Ltd. | The method of hair transplant using dermal papilla and dermal sheath obtained from hair follicle |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2135191C1 (ru) * | 1990-04-24 | 1999-08-27 | Ортек Интернэшнл, Инк. | Композиционный эквивалент живой кожи, способ его получения, тест-набор |
| SE9701162D0 (sv) * | 1997-03-27 | 1997-03-27 | Karolinska Innovations Ab | New use II |
| EP2295540A1 (en) * | 1998-11-19 | 2011-03-16 | Organogenesis, Inc. | Bioengineered tissue constructs and methods for producing and using them |
| ATE369144T1 (de) * | 2000-03-31 | 2007-08-15 | Gen Hospital Corp | Verfahren zur steigerung des haarwuchses durch wnt polypeptid |
| ATE354640T1 (de) * | 2000-12-08 | 2007-03-15 | Xgene Corp | Herstellung von geschichteten und nach zelltyp geordneten geweben in vitro |
| US20050019310A1 (en) * | 2001-12-21 | 2005-01-27 | Isaacs Richard John | Method for culturing and expansion of mammalian undifferentiated epidermal kerainocytes exhibiting stem cell characteristics |
| US7597885B2 (en) * | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
| GB0505202D0 (en) * | 2005-03-14 | 2005-04-20 | Intercytex Ltd | Skin equivalent culture |
| JP2007274949A (ja) * | 2006-04-05 | 2007-10-25 | Shiseido Co Ltd | 毛乳頭細胞培養方法 |
| US20090143418A1 (en) * | 2007-11-30 | 2009-06-04 | The Regents Of The University Of Michigan | Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions |
-
2011
- 2011-06-17 EP EP11796538.4A patent/EP2582791B8/en active Active
- 2011-06-17 AU AU2011268139A patent/AU2011268139B2/en active Active
- 2011-06-17 ES ES11796538.4T patent/ES2667532T3/es active Active
- 2011-06-17 US US13/704,431 patent/US20130209427A1/en not_active Abandoned
- 2011-06-17 WO PCT/US2011/040937 patent/WO2011160055A2/en not_active Ceased
- 2011-06-17 CA CA2802880A patent/CA2802880C/en active Active
- 2011-06-17 JP JP2013515559A patent/JP6071875B2/ja not_active Expired - Fee Related
-
2016
- 2016-12-27 JP JP2016253496A patent/JP6449220B2/ja not_active Expired - Fee Related
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