JP2013529919A5 - - Google Patents
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- JP2013529919A5 JP2013529919A5 JP2013515559A JP2013515559A JP2013529919A5 JP 2013529919 A5 JP2013529919 A5 JP 2013529919A5 JP 2013515559 A JP2013515559 A JP 2013515559A JP 2013515559 A JP2013515559 A JP 2013515559A JP 2013529919 A5 JP2013529919 A5 JP 2013529919A5
- Authority
- JP
- Japan
- Prior art keywords
- skin substitute
- cells
- tsc2
- skin
- tsc1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 210000004027 cell Anatomy 0.000 claims description 29
- 101000795659 Homo sapiens Tuberin Proteins 0.000 claims description 25
- 102100031638 Tuberin Human genes 0.000 claims description 22
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 210000002950 fibroblast Anatomy 0.000 claims description 5
- 210000003780 hair follicle Anatomy 0.000 claims description 5
- 230000007547 defect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 210000001061 forehead Anatomy 0.000 claims description 2
- 210000003491 skin Anatomy 0.000 claims 37
- 210000002919 epithelial cell Anatomy 0.000 claims 7
- 239000011159 matrix material Substances 0.000 claims 7
- 102100027909 Folliculin Human genes 0.000 claims 5
- 101001060703 Homo sapiens Folliculin Proteins 0.000 claims 5
- 210000002510 keratinocyte Anatomy 0.000 claims 5
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- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
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- 239000004055 small Interfering RNA Substances 0.000 claims 4
- 206010027145 Melanocytic naevus Diseases 0.000 claims 3
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- 230000002500 effect on skin Effects 0.000 claims 3
- 210000003953 foreskin Anatomy 0.000 claims 3
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- 102000010400 1-phosphatidylinositol-3-kinase activity proteins Human genes 0.000 claims 1
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- 201000009030 Carcinoma Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000012422 Collagen Type I Human genes 0.000 claims 1
- 108010022452 Collagen Type I Proteins 0.000 claims 1
- 208000012609 Cowden disease Diseases 0.000 claims 1
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- 108010086291 Deubiquitinating Enzyme CYLD Proteins 0.000 claims 1
- 102000007443 Deubiquitinating Enzyme CYLD Human genes 0.000 claims 1
- 102100022466 Eukaryotic translation initiation factor 4E-binding protein 1 Human genes 0.000 claims 1
- 108050000946 Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 claims 1
- 102000001267 GSK3 Human genes 0.000 claims 1
- 108060006662 GSK3 Proteins 0.000 claims 1
- 102100031561 Hamartin Human genes 0.000 claims 1
- 101000795643 Homo sapiens Hamartin Proteins 0.000 claims 1
- 101000582631 Homo sapiens Menin Proteins 0.000 claims 1
- 101000690268 Homo sapiens Proline-rich AKT1 substrate 1 Proteins 0.000 claims 1
- 102000046985 LST8 Homolog mTOR Associated Human genes 0.000 claims 1
- 102000008135 Mechanistic Target of Rapamycin Complex 1 Human genes 0.000 claims 1
- 108010035196 Mechanistic Target of Rapamycin Complex 1 Proteins 0.000 claims 1
- 102000009308 Mechanistic Target of Rapamycin Complex 2 Human genes 0.000 claims 1
- 108010034057 Mechanistic Target of Rapamycin Complex 2 Proteins 0.000 claims 1
- 102100030550 Menin Human genes 0.000 claims 1
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- 101100388114 Mus musculus Deptor gene Proteins 0.000 claims 1
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- 108091007960 PI3Ks Proteins 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 102100024184 Polymerase delta-interacting protein 3 Human genes 0.000 claims 1
- 101710142722 Polymerase delta-interacting protein 3 Proteins 0.000 claims 1
- 102100024091 Proline-rich AKT1 substrate 1 Human genes 0.000 claims 1
- 101150020518 RHEB gene Proteins 0.000 claims 1
- 101150071831 RPS6KA1 gene Proteins 0.000 claims 1
- 102000046951 Ras Homolog Enriched in Brain Human genes 0.000 claims 1
- 108700019578 Ras Homolog Enriched in Brain Proteins 0.000 claims 1
- 108010029031 Regulatory-Associated Protein of mTOR Proteins 0.000 claims 1
- 102100040969 Regulatory-associated protein of mTOR Human genes 0.000 claims 1
- 102000002278 Ribosomal Proteins Human genes 0.000 claims 1
- 108010000605 Ribosomal Proteins Proteins 0.000 claims 1
- 102100024908 Ribosomal protein S6 kinase beta-1 Human genes 0.000 claims 1
- 101710108924 Ribosomal protein S6 kinase beta-1 Proteins 0.000 claims 1
- 102000008078 Sterol Regulatory Element Binding Protein 1 Human genes 0.000 claims 1
- 108010074436 Sterol Regulatory Element Binding Protein 1 Proteins 0.000 claims 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
- 101710115678 Target of rapamycin complex subunit LST8 Proteins 0.000 claims 1
- 208000026911 Tuberous sclerosis complex Diseases 0.000 claims 1
- 101150045355 akt1 gene Proteins 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
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- 238000009472 formulation Methods 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
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- 239000007972 injectable composition Substances 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims 1
- 208000007538 neurilemmoma Diseases 0.000 claims 1
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- 206010039667 schwannoma Diseases 0.000 claims 1
- 210000001732 sebaceous gland Anatomy 0.000 claims 1
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- 210000002107 sheath cell Anatomy 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 210000004243 sweat Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 208000009999 tuberous sclerosis Diseases 0.000 claims 1
- 108020004414 DNA Proteins 0.000 description 3
- 238000001976 enzyme digestion Methods 0.000 description 3
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- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 108020004485 Nonsense Codon Proteins 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 108020005038 Terminator Codon Proteins 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
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- 238000001531 micro-dissection Methods 0.000 description 1
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- 102000054765 polymorphisms of proteins Human genes 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34425810P | 2010-06-18 | 2010-06-18 | |
| US61/344,258 | 2010-06-18 | ||
| PCT/US2011/040937 WO2011160055A2 (en) | 2010-06-18 | 2011-06-17 | Hair follicle neogenesis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016253496A Division JP6449220B2 (ja) | 2010-06-18 | 2016-12-27 | 毛包新生 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013529919A JP2013529919A (ja) | 2013-07-25 |
| JP2013529919A5 true JP2013529919A5 (https=) | 2014-07-03 |
| JP6071875B2 JP6071875B2 (ja) | 2017-02-08 |
Family
ID=45348909
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013515559A Expired - Fee Related JP6071875B2 (ja) | 2010-06-18 | 2011-06-17 | 毛包新生 |
| JP2016253496A Expired - Fee Related JP6449220B2 (ja) | 2010-06-18 | 2016-12-27 | 毛包新生 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016253496A Expired - Fee Related JP6449220B2 (ja) | 2010-06-18 | 2016-12-27 | 毛包新生 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130209427A1 (https=) |
| EP (1) | EP2582791B8 (https=) |
| JP (2) | JP6071875B2 (https=) |
| AU (1) | AU2011268139B2 (https=) |
| CA (1) | CA2802880C (https=) |
| ES (1) | ES2667532T3 (https=) |
| WO (1) | WO2011160055A2 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| US20140072613A1 (en) * | 2012-09-10 | 2014-03-13 | Cynthia Lander | Compositions and Methods for Treating Cutaneous Scarring |
| US9655930B2 (en) | 2012-10-01 | 2017-05-23 | Aderans Research Institute, Inc. | Compositions and methods for producing reconstituted skin |
| JP6469655B2 (ja) * | 2013-05-03 | 2019-02-13 | ザ ヘンリー エム． ジャクソン ファウンデーション フォー ザ アドヴァンスメント オブ ミリタリー メディシン インコーポレイテッド | 代用皮膚および毛包新生の方法 |
| US9545302B2 (en) | 2013-11-20 | 2017-01-17 | Dermagenesis Llc | Skin printing and auto-grafting |
| US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
| US11629331B2 (en) * | 2017-07-19 | 2023-04-18 | Seoul National University R & Db Foundation | Method of differentiation of human induced pluripotent stem cell to dermal papilla precursor cell and use thereof |
| CN108525021B (zh) * | 2018-04-17 | 2021-05-18 | 山西医科大学 | 基于3d打印的含血管及毛囊结构组织工程皮肤及其制备方法 |
| JP2021526556A (ja) | 2018-05-30 | 2021-10-07 | ダイレクト バイオロジクス エルエルシー | 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞（ｍｓｃ）の調製物を含む助剤、ならびにその使用方法 |
| CN109321513B (zh) * | 2018-09-30 | 2021-05-04 | 洛阳师范学院 | 一种具有生理功能的组织工程皮肤构建方法 |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| KR20210121039A (ko) * | 2018-12-26 | 2021-10-07 | 다이렉트 바이오로직스 엘엘씨 | 피부 및 모발 장애를 치료하기 위한 방법 및 조성물 |
| BR112021015549A2 (pt) | 2019-02-07 | 2021-10-26 | Direct Biologics Llc | Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes |
| CA3146433A1 (en) | 2019-07-18 | 2021-01-21 | Direct Biologics Llc | Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use |
| WO2021038289A1 (en) * | 2019-08-23 | 2021-03-04 | Orbsen Therapeutics Limited | Compositions for monocyte and macrophage polarization and methods of use |
| US12590310B2 (en) | 2020-04-22 | 2026-03-31 | Direct Biologics, Llc | Methods and compositions for treating inflammatory conditions associated with infectious disease |
| US20230272401A1 (en) * | 2020-06-11 | 2023-08-31 | Genetic Intelligence, Inc | Compositions for flcn gene modulation and methods thereof |
| US20240240143A1 (en) * | 2021-05-27 | 2024-07-18 | The University Of Hong Kong | Bioengineered dermal papilla and hair follicles and related products, methods and applications |
| US20240350436A1 (en) * | 2021-07-14 | 2024-10-24 | The Regents Of The University Of Michigan | Methods for hair growth |
| EP4403568A4 (en) * | 2021-09-17 | 2025-07-23 | Acro Biomedical Company Ltd | USE OF COLLAGEN PARTICLES TO PROMOTE HAIR FOLLICLE FORMATION OR ANGIOGENESIS |
| CN114195458B (zh) * | 2021-12-27 | 2023-02-07 | 东莞市优鼎新材料科技有限公司 | 微球改性材料及其制备方法、填缝剂及其制备方法 |
| US12502407B2 (en) | 2024-04-25 | 2025-12-23 | Direct Biologics, Llc | Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles |
| WO2026063864A1 (en) * | 2024-09-23 | 2026-03-26 | Medeze Treasury Pte. Ltd. | The method of hair transplant using dermal papilla and dermal sheath obtained from hair follicle |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI924773L (fi) * | 1990-04-24 | 1992-10-21 | Mark Eisenberg | Kompositionssubstituter av levande hud |
| SE9701162D0 (sv) * | 1997-03-27 | 1997-03-27 | Karolinska Innovations Ab | New use II |
| EP2295540A1 (en) * | 1998-11-19 | 2011-03-16 | Organogenesis, Inc. | Bioengineered tissue constructs and methods for producing and using them |
| WO2001074164A1 (en) * | 2000-03-31 | 2001-10-11 | The General Hospital Corporation | Methods of modulating hair growth |
| DE60126815T2 (de) * | 2000-12-08 | 2007-11-15 | Xgene Corp., San Carlos | Herstellung von geschichteten und nach zelltyp geordneten geweben in vitro |
| WO2003055990A2 (en) * | 2001-12-21 | 2003-07-10 | Pharmagap Inc. | Method for culturing and expansion of mammalian undifferentiated epidermal keratinocytes exhibiting stem cell characteristics |
| US7597885B2 (en) * | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
| GB0505202D0 (en) * | 2005-03-14 | 2005-04-20 | Intercytex Ltd | Skin equivalent culture |
| JP2007274949A (ja) * | 2006-04-05 | 2007-10-25 | Shiseido Co Ltd | 毛乳頭細胞培養方法 |
| US20090143418A1 (en) * | 2007-11-30 | 2009-06-04 | The Regents Of The University Of Michigan | Compositions and Methods for Preventing and Treating Hair Growth Cycle-Related Conditions |
-
2011
- 2011-06-17 CA CA2802880A patent/CA2802880C/en active Active
- 2011-06-17 US US13/704,431 patent/US20130209427A1/en not_active Abandoned
- 2011-06-17 WO PCT/US2011/040937 patent/WO2011160055A2/en not_active Ceased
- 2011-06-17 EP EP11796538.4A patent/EP2582791B8/en active Active
- 2011-06-17 JP JP2013515559A patent/JP6071875B2/ja not_active Expired - Fee Related
- 2011-06-17 AU AU2011268139A patent/AU2011268139B2/en active Active
- 2011-06-17 ES ES11796538.4T patent/ES2667532T3/es active Active
-
2016
- 2016-12-27 JP JP2016253496A patent/JP6449220B2/ja not_active Expired - Fee Related
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