JP2013529600A5 - - Google Patents

Info

Publication number

JP2013529600A5

JP2013529600A5 JP2013514392A JP2013514392A JP2013529600A5 JP 2013529600 A5 JP2013529600 A5 JP 2013529600A5 JP 2013514392 A JP2013514392 A JP 2013514392A JP 2013514392 A JP2013514392 A JP 2013514392A JP 2013529600 A5 JP2013529600 A5 JP 2013529600A5

Authority

JP

Japan

Prior art keywords

gly

asp

ala

pharmaceutical composition

peptide derivative

Prior art date

2011-06-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 108090000765 processed proteins & peptides Proteins 0.000 claims description 34
• 108090000190 Thrombin Proteins 0.000 claims description 22
• 229960004072 thrombin Drugs 0.000 claims description 22
• 229920001184 polypeptide Polymers 0.000 claims description 12
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 12
• 239000012634 fragment Substances 0.000 claims description 10
• 210000004899 c-terminal region Anatomy 0.000 claims description 6
• 239000000539 dimer Substances 0.000 claims description 4
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
• 150000001408 amides Chemical group 0.000 claims description 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 125000000539 amino acid group Chemical group 0.000 claims 6
• 208000014674 injury Diseases 0.000 claims 4
• 230000005855 radiation Effects 0.000 claims 4
• 230000008733 trauma Effects 0.000 claims 3
• 108091036078 conserved sequence Proteins 0.000 claims 2
• 230000006378 damage Effects 0.000 claims 2
• DVUFTQLHHHJEMK-IMJSIDKUSA-N Asp-Ala Chemical group OC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O DVUFTQLHHHJEMK-IMJSIDKUSA-N 0.000 claims 1
• 108090000371 Esterases Proteins 0.000 claims 1
• IEHDJWSAXBGJIP-RYUDHWBXSA-N Phe-Val Chemical compound CC(C)[C@@H](C([O-])=O)NC(=O)[C@@H]([NH3+])CC1=CC=CC=C1 IEHDJWSAXBGJIP-RYUDHWBXSA-N 0.000 claims 1
• 208000028990 Skin injury Diseases 0.000 claims 1
• 208000027418 Wounds and injury Diseases 0.000 claims 1
• 108010086780 arginyl-glycyl-aspartyl-alanine Proteins 0.000 claims 1
• 230000006931 brain damage Effects 0.000 claims 1
• 231100000874 brain damage Toxicity 0.000 claims 1
• 208000029028 brain injury Diseases 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 231100000636 lethal dose Toxicity 0.000 claims 1
• 230000008816 organ damage Effects 0.000 claims 1
• 108010084572 phenylalanyl-valine Proteins 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 108020002447 serine esterase Proteins 0.000 claims 1
• 102000005428 serine esterase Human genes 0.000 claims 1
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
• 230000037380 skin damage Effects 0.000 claims 1
• 230000009885 systemic effect Effects 0.000 claims 1
• 210000001835 viscera Anatomy 0.000 claims 1
• 150000001413 amino acids Chemical group 0.000 description 10
• 235000001014 amino acid Nutrition 0.000 description 5
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
• 238000003776 cleavage reaction Methods 0.000 description 4
• 230000007017 scission Effects 0.000 description 4
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
• 235000004279 alanine Nutrition 0.000 description 3
• 238000000034 method Methods 0.000 description 3
• MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
• 239000004471 Glycine Substances 0.000 description 2
• 235000018417 cysteine Nutrition 0.000 description 2
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
• 150000003857 carboxamides Chemical class 0.000 description 1
• 238000006467 substitution reaction Methods 0.000 description 1