JP2013527847A5 - - Google Patents
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- Publication number
- JP2013527847A5 JP2013527847A5 JP2013508120A JP2013508120A JP2013527847A5 JP 2013527847 A5 JP2013527847 A5 JP 2013527847A5 JP 2013508120 A JP2013508120 A JP 2013508120A JP 2013508120 A JP2013508120 A JP 2013508120A JP 2013527847 A5 JP2013527847 A5 JP 2013527847A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- independently
- membered heterocyclic
- atom
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052760 oxygen Inorganic materials 0.000 claims 28
- 229910052717 sulfur Inorganic materials 0.000 claims 28
- 125000005842 heteroatoms Chemical group 0.000 claims 27
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 22
- 125000004433 nitrogen atoms Chemical group N* 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 21
- 150000002367 halogens Chemical class 0.000 claims 21
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 16
- 125000004043 oxo group Chemical group O=* 0.000 claims 15
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- -1 tetrahydropyrimidinyl Chemical group 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 6
- 125000002837 carbocyclic group Chemical group 0.000 claims 5
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052757 nitrogen Chemical group 0.000 claims 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N oxygen Chemical group O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 4
- 239000001301 oxygen Substances 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 4
- 239000011593 sulfur Chemical group 0.000 claims 4
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 3
- 125000004504 1,2,4-oxadiazolyl group Chemical group 0.000 claims 3
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims 3
- 125000004506 1,2,5-oxadiazolyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 125000005051 dihydropyrazinyl group Chemical group N1(CC=NC=C1)* 0.000 claims 3
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 claims 3
- 125000005053 dihydropyrimidinyl group Chemical group N1(CN=CC=C1)* 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000002971 oxazolyl group Chemical group 0.000 claims 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000002098 pyridazinyl group Chemical group 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000011780 sodium chloride Substances 0.000 claims 3
- 125000003831 tetrazolyl group Chemical group 0.000 claims 3
- 125000000335 thiazolyl group Chemical group 0.000 claims 3
- 230000004913 activation Effects 0.000 claims 2
- 125000004429 atoms Chemical group 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000001404 mediated Effects 0.000 claims 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 1
- 102100014184 ADRB3 Human genes 0.000 claims 1
- 101700073744 ADRB3 Proteins 0.000 claims 1
- 206010020853 Hypertonic bladder Diseases 0.000 claims 1
- 206010027566 Micturition urgency Diseases 0.000 claims 1
- 208000009722 Overactive Urinary Bladder Diseases 0.000 claims 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 102000016959 beta-3 Adrenergic Receptors Human genes 0.000 claims 1
- 108010014502 beta-3 Adrenergic Receptors Proteins 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 0 C(*Cc1c2)c1ccc2C1=Cc2ccccc2*1 Chemical compound C(*Cc1c2)c1ccc2C1=Cc2ccccc2*1 0.000 description 2
- YXTKDOFTHKWCKQ-UHFFFAOYSA-N C(C1)CN2C1=NC=CC2 Chemical compound C(C1)CN2C1=NC=CC2 YXTKDOFTHKWCKQ-UHFFFAOYSA-N 0.000 description 1
- ZWETXQBHVRWLPW-UHFFFAOYSA-N C(C1)C[n]2c1ncc2 Chemical compound C(C1)C[n]2c1ncc2 ZWETXQBHVRWLPW-UHFFFAOYSA-N 0.000 description 1
- BRXYDRIZVHRXCQ-UHFFFAOYSA-N C(C1)C[n]2c1nnc2 Chemical compound C(C1)C[n]2c1nnc2 BRXYDRIZVHRXCQ-UHFFFAOYSA-N 0.000 description 1
- QCCKBDNIBZPFCH-UHFFFAOYSA-N C(C1)Cc2c1nc[s]2 Chemical compound C(C1)Cc2c1nc[s]2 QCCKBDNIBZPFCH-UHFFFAOYSA-N 0.000 description 1
- RMFVVPBBEDMZQI-UHFFFAOYSA-N C(CC1)Cc2c1[s]cn2 Chemical compound C(CC1)Cc2c1[s]cn2 RMFVVPBBEDMZQI-UHFFFAOYSA-N 0.000 description 1
- LQKUERRPRLVSLZ-UHFFFAOYSA-N C1C[n]2nccc2C1 Chemical compound C1C[n]2nccc2C1 LQKUERRPRLVSLZ-UHFFFAOYSA-N 0.000 description 1
- LFHLEABTNIQIQO-UHFFFAOYSA-N C1N=Cc2ccccc12 Chemical compound C1N=Cc2ccccc12 LFHLEABTNIQIQO-UHFFFAOYSA-N 0.000 description 1
- KLXLVXOOWGCLAG-UHFFFAOYSA-N C1NC=Nc2c1cc[s]2 Chemical compound C1NC=Nc2c1cc[s]2 KLXLVXOOWGCLAG-UHFFFAOYSA-N 0.000 description 1
- HCKWIDXZRSTLMG-UHFFFAOYSA-N C1NC=Nc2c1cn[nH]2 Chemical compound C1NC=Nc2c1cn[nH]2 HCKWIDXZRSTLMG-UHFFFAOYSA-N 0.000 description 1
- MXMZCLLIUQEKSN-UHFFFAOYSA-N C1Nc2ccccc2N1 Chemical compound C1Nc2ccccc2N1 MXMZCLLIUQEKSN-UHFFFAOYSA-N 0.000 description 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N c1c[nH]c2ccccc12 Chemical compound c1c[nH]c2ccccc12 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 description 1
- BAXOFTOLAUCFNW-UHFFFAOYSA-N c1n[nH]c2ccccc12 Chemical compound c1n[nH]c2ccccc12 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 description 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N c1nc2ccccc2[nH]1 Chemical compound c1nc2ccccc2[nH]1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33001310P | 2010-04-30 | 2010-04-30 | |
US61/330,013 | 2010-04-30 | ||
PCT/US2011/033741 WO2011137054A1 (en) | 2010-04-30 | 2011-04-25 | Novel beta 3 adrenergic receptor agonists |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013527847A JP2013527847A (ja) | 2013-07-04 |
JP2013527847A5 true JP2013527847A5 (US07981874-20110719-C00313.png) | 2014-06-19 |
JP5812500B2 JP5812500B2 (ja) | 2015-11-17 |
Family
ID=44861881
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013508120A Expired - Fee Related JP5812500B2 (ja) | 2010-04-30 | 2011-04-25 | 新規なβ3アドレナリン作動性受容体アゴニスト |
Country Status (6)
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9907767B2 (en) | 2010-08-03 | 2018-03-06 | Velicept Therapeutics, Inc. | Pharmaceutical compositions and the treatment of overactive bladder |
EP2600859A1 (en) | 2010-08-03 | 2013-06-12 | Altherx Inc. | Combinations of beta - 3 adrenergic receptor agonists and muscarinic receptor antagonists for treating overactive bladder |
US9522129B2 (en) | 2010-08-03 | 2016-12-20 | Velicept Therapeutics, Inc. | Pharmaceutical Combination |
JP6088535B2 (ja) | 2011-10-27 | 2017-03-08 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | ベータ3アゴニストおよび中間体を製造するプロセス |
WO2013062881A1 (en) | 2011-10-27 | 2013-05-02 | Merck Sharp & Dohme Corp. | Process for making beta 3 agonists and intermediates |
PT2968269T (pt) * | 2013-03-15 | 2019-10-08 | Merck Sharp & Dohme | Processo para preparação de beta 3 agonistas e intermediários |
MX2017007054A (es) | 2014-12-03 | 2018-05-02 | Velicept Therapeutics Inc | Composiciones y métodos para usar solabegron de liberación modificada para sintomas del tracto urinario inferior. |
IL310527A (en) | 2015-10-23 | 2024-03-01 | B3Ar Therapeutics Inc | Zwitterion solvegron and its uses |
CN108250194A (zh) * | 2018-02-12 | 2018-07-06 | 李化绪 | 一种二氟苯并噻唑类化合物及其在降血脂药物中的应用 |
WO2023056029A1 (en) * | 2021-10-01 | 2023-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Beta3-adrenergic agonists for treatment of disorders of hair growth |
Family Cites Families (40)
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DD106643A1 (US07981874-20110719-C00313.png) | 1973-07-12 | 1974-06-20 | ||
JPS5980664A (ja) | 1982-09-30 | 1984-05-10 | Fujisawa Pharmaceut Co Ltd | α−アリ−ル−α−ピリジル脂肪酸誘導体およびその製法 |
US5382600A (en) | 1988-01-22 | 1995-01-17 | Pharmacia Aktiebolag | 3,3-diphenylpropylamines and pharmaceutical compositions thereof |
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-
2011
- 2011-04-25 AU AU2011245499A patent/AU2011245499B2/en not_active Ceased
- 2011-04-25 US US13/643,361 patent/US8748433B2/en active Active
- 2011-04-25 JP JP2013508120A patent/JP5812500B2/ja not_active Expired - Fee Related
- 2011-04-25 CA CA2796877A patent/CA2796877A1/en active Pending
- 2011-04-25 EP EP11775471.3A patent/EP2563123B1/en active Active
- 2011-04-25 WO PCT/US2011/033741 patent/WO2011137054A1/en active Application Filing