JP2013527778A5 - - Google Patents
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- JP2013527778A5 JP2013527778A5 JP2013502575A JP2013502575A JP2013527778A5 JP 2013527778 A5 JP2013527778 A5 JP 2013527778A5 JP 2013502575 A JP2013502575 A JP 2013502575A JP 2013502575 A JP2013502575 A JP 2013502575A JP 2013527778 A5 JP2013527778 A5 JP 2013527778A5
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- JP
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- Prior art keywords
- monomer content
- plla
- lla
- temperature
- polymer material
- Prior art date
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- 239000000178 monomer Substances 0.000 claims 15
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 claims 14
- 229920001432 poly(L-lactide) Polymers 0.000 claims 14
- 239000002861 polymer material Substances 0.000 claims 9
- 238000006116 polymerization reaction Methods 0.000 claims 6
- 238000006243 chemical reaction Methods 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 238000000605 extraction Methods 0.000 claims 2
- 239000000284 extract Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000035484 reaction time Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
Claims (11)
- ＬＬＡモノマーの重合反応によって、ＬＬＡモノマー含有率が４重量％超のＰＬＬＡポリマー材料を作製するステップと、
前記ＰＬＬＡポリマー材料を処理して、前記ＬＬＡモノマー含有率を０．０１〜２重量％に削減するステップと、
処理した前記ＰＬＬＡポリマー材料からポリマー製ステント本体を作製するステップと
を含み、
前記重合反応によって前記ＰＬＬＡポリマー材料を作製するステップが、
１６０℃未満の反応温度で前記重合反応を第１の期間実行するサブステップ、続いて
１８０〜２００℃の間の温度で前記重合反応を実行して、４重量％超の前記ＬＬＡモノマー含有率を有する前記ＰＬＬＡポリマー材料を得るサブステップ
を含む、ステントの製作方法。 - 前記重合反応の温度を調整して、４重量％超の前記モノマー含有率を得る、請求項１に記載の方法。
- 処理する前記ステップが、前記モノマー含有率を削減する溶媒を使用して、合成された前記ＰＬＬＡを処理するサブステップを含む、請求項１に記載の方法。
- 処理する前記ステップが、前記ＰＬＬＡポリマー材料を曝露することによって、前記材料からＬＬＡモノマーを抽出する、液体溶媒抽出プロセスを含む、請求項１に記載の方法。
- 処理する前記ステップが、超臨界ＣＯ２抽出法及び真空／高温抽出法から成る群から選択される、請求項１に記載の方法。
- 処理された前記ＰＬＬＡ材料が０．０１〜１重量％のＬＬＡモノマー含有率を有する、請求項１に記載の方法。
- 処理された前記ＰＬＬＡ材料が０．０１〜０．５重量％のＬＬＡモノマー含有率を有する、請求項１に記載の方法。
- ＬＬＡモノマーの重合反応によって、ＬＬＡモノマー含有率が０．５重量％未満のＰＬＬＡポリマー材料を作製するステップと、
前記ＰＬＬＡポリマー材料の反応温度を高めて、前記ＰＬＬＡの０．０１〜２重量％の目標ＬＬＡモノマー含有率まで前記モノマー含有率を増加させる、解重合を引き起こすステップと、
増加した前記モノマー含有率を有する前記ＰＬＬＡポリマー材料からステント本体を作製するステップと
を含む、ステントの製作方法。 - 前記温度を目標温度まで高め、反応時間を調整して、前記目標モノマー含有率を得る、請求項８に記載の方法。
- 前記反応温度を、１２０〜１４０℃の範囲内の温度から１８０℃を超える範囲内の温度まで高める、請求項８に記載の方法。
- 前記ＰＬＬＡの０．０５〜１重量％の目標ＬＬＡモノマー含有率まで前記モノマー含有率を増加させる、請求項８に記載の方法。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/751,773 | 2010-03-31 | ||
| US12/751,773 US8889823B2 (en) | 2009-07-21 | 2010-03-31 | Method to make poly(L-lactide) stent with tunable degradation rate |
| PCT/US2011/025074 WO2011123194A1 (en) | 2010-03-31 | 2011-02-16 | Method to make poly(l-lactide) stent with tunable degradation rate |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013527778A JP2013527778A (ja) | 2013-07-04 |
| JP2013527778A5 true JP2013527778A5 (ja) | 2014-03-20 |
| JP5850042B2 JP5850042B2 (ja) | 2016-02-03 |
Family
ID=43983510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013502575A Expired - Fee Related JP5850042B2 (ja) | 2010-03-31 | 2011-02-16 | 分解速度の調節可能なポリ（ｌ−ラクチド）ステントの作製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (4) | US8889823B2 (ja) |
| EP (1) | EP2552504B1 (ja) |
| JP (1) | JP5850042B2 (ja) |
| CN (1) | CN102892442B (ja) |
| ES (1) | ES2559207T3 (ja) |
| WO (1) | WO2011123194A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8370120B2 (en) * | 2010-04-30 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Polymeric stents and method of manufacturing same |
| US8834776B2 (en) * | 2011-05-10 | 2014-09-16 | Abbott Cardiovascular Systems Inc. | Control of degradation profile of bioabsorbable poly(l-lactide) scaffold |
| US8709070B2 (en) | 2011-05-10 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Bioabsorbable scaffold with particles providing delayed acceleration of degradation |
| US8545546B2 (en) * | 2011-05-13 | 2013-10-01 | Abbott Cardiovascular Systems Inc. | Bioabsorbable scaffolds made from composites |
| US9205456B2 (en) | 2012-07-24 | 2015-12-08 | Abbott Cardiovascular Systems Inc. | Modifying polymer properties with penetrants in the fabrication of bioresorbable scaffolds |
| US10143572B2 (en) | 2013-09-04 | 2018-12-04 | Abbott Cardiovascular Systems Inc. | Assessment of a drug eluting bioresorbable vascular scaffold |
| WO2015157281A1 (en) | 2014-04-08 | 2015-10-15 | Boston Scientific Scimed, Inc. | Partially coated stents |
| US20150328373A1 (en) | 2014-05-19 | 2015-11-19 | Abbott Cardiovascular Systems Inc. | Additives To Increase Degradation Rate Of A Biodegradable Scaffolding And Methods Of Forming Same |
| US10518003B2 (en) * | 2014-07-07 | 2019-12-31 | Meril Life Sciences Pvt. Ltd. | Method to manufacture thin strut stent from bioabsorbable polymer with high fatigue and radial strength |
| US9730819B2 (en) * | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
| US20160374838A1 (en) * | 2015-06-29 | 2016-12-29 | Abbott Cardiovascular Systems Inc. | Drug-eluting coatings on poly(dl-lactide)-based scaffolds |
| AU2016361380B2 (en) | 2015-11-26 | 2021-04-08 | Japan Medical Device Technology Co., Ltd. | Bioabsorbable stent |
| CN115337466A (zh) * | 2022-08-23 | 2022-11-15 | 苏州健雄职业技术学院 | 一种调节降解环境酸碱性的植入材料及其制备方法 |
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| DE4014974A1 (de) * | 1990-05-10 | 1991-11-14 | Boehringer Ingelheim Kg | Verfahren zur herstellung von loesungsmittel- und restmonomerenfreien in spritzgiess-, extrusions- und schmelzspinnverfahren einsetzbaren polymeren |
| JPH04166165A (ja) * | 1990-10-30 | 1992-06-12 | Shimadzu Corp | 骨固定用材料 |
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| KR100354828B1 (ko) | 2001-03-12 | 2002-10-05 | 주식회사 씨엠리서치 | 생분해성 폴리에스테르의 제조방법 및 그에 의해 제조된생분해성 폴리에스테르 |
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| JP5647788B2 (ja) * | 2006-10-11 | 2015-01-07 | トルマー セラピューティクス， インコーポレイテッド． | 超臨界流体抽出による低バースト特性の生分解性ポリエステルの調製 |
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| US8182890B2 (en) | 2007-01-19 | 2012-05-22 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
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| WO2010010685A1 (ja) * | 2008-07-24 | 2010-01-28 | 東洋紡績株式会社 | 脂肪族ポリエステル樹脂及びその製造方法 |
| US9492587B2 (en) | 2009-04-13 | 2016-11-15 | Abbott Cardiovascular Systems Inc. | Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance |
| US9889238B2 (en) | 2009-07-21 | 2018-02-13 | Abbott Cardiovascular Systems Inc. | Biodegradable stent with adjustable degradation rate |
| US8834776B2 (en) | 2011-05-10 | 2014-09-16 | Abbott Cardiovascular Systems Inc. | Control of degradation profile of bioabsorbable poly(l-lactide) scaffold |
-
2010
- 2010-03-31 US US12/751,773 patent/US8889823B2/en active Active
-
2011
- 2011-02-16 ES ES11707253.8T patent/ES2559207T3/es active Active
- 2011-02-16 EP EP11707253.8A patent/EP2552504B1/en not_active Not-in-force
- 2011-02-16 JP JP2013502575A patent/JP5850042B2/ja not_active Expired - Fee Related
- 2011-02-16 CN CN201180017582.9A patent/CN102892442B/zh active Active
- 2011-02-16 WO PCT/US2011/025074 patent/WO2011123194A1/en active Application Filing
-
2014
- 2014-10-31 US US14/530,595 patent/US9248218B2/en active Active
-
2015
- 2015-12-16 US US14/970,890 patent/US9687594B2/en active Active
-
2017
- 2017-05-17 US US15/597,962 patent/US9844612B2/en active Active
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