JP2013527778A - 分解速度の調節可能なポリ(l−ラクチド)ステントの作製方法 - Google Patents
分解速度の調節可能なポリ(l−ラクチド)ステントの作製方法 Download PDFInfo
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Abstract
【選択図】図2
Description
本発明は、生体吸収性ポリマー医療器具、特に、ステントによる血管の治療方法に関する。
本発明は、身体の管腔内に留置するように構成された、半径方向に拡大可能な体内人工装具に関する。「体内人工装具」は、体内に配置される人工器具に相当する。「管腔」とは、血管などの筒状器官の空洞を指す。ステントは、そのような体内人工装具の一例である。ステントは、一般に円筒状の器具であり、血管又は尿管及び胆管などの他の解剖学的管腔の一区域を開放状態に維持し、時には拡大するように機能する。ステントは、血管内の粥状硬化性狭窄の治療に使用されることが多い。「狭窄」とは、体内の通路又は開口を狭く又は圧縮することを指す。そのような治療では、ステントは、体内の血管を補強及び脈管系の血管形成術に伴う再狭窄を予防する。「再狭窄」とは、血管又は明らかに成功した治療(バルーン血管形成術、ステント留置法、又は弁形成術による)後の心臓弁の狭窄の再発を指す。
冠動脈は、一般に、酸素を含んだ血液を心筋に供給するために大動脈から枝分かれしている動脈を指す。末梢動脈は、一般に、心臓及び脳の外部の血管を指す。
ステップ2 クロロホルムを蒸発させて、25重量%LLAを含むPLLAとLLAの均一な混合物を形成する。
ステップ3 25重量%LLA混合物を390gのPLLAと押出機でブレンドし、0.5重量%LLAを含むPLLAを得る。
ステップ2 その溶液を1kgのPLLAペレットに吹付け、撹拌する。
ステップ3 ペレットを真空オーブンに入れて、溶媒を除去する。
ステップ4 ペレットを押出機に入れ、0.5重量%のLLAを含むチューブを形成する。
Claims (21)
- LLAモノマーの重合反応によって、LLAモノマー含有率が4重量%超のPLLAポリマー材料を作製するステップと、
前記PLLAポリマー材料を処理して、前記LLAモノマー含有率を2重量%以下まで削減するステップと、
処理した前記PLLAポリマー材料からポリマー製ステント本体を作製するステップと
を含む、ステントの製作方法。 - 前記重合反応によって前記PLLAポリマー材料を作製するステップが、
160℃未満の反応温度で前記重合反応を第1の期間実行するサブステップ、続いて
180〜200℃の間の温度で前記重合反応を実行して、4重量%超の前記LLAモノマー含有率を有する前記PLLAポリマー材料を得るサブステップ
を含む、請求項1に記載の方法。 - 前記重合反応の温度を調整して、4重量%超の前記モノマー含有率を得る、請求項1に記載の方法。
- 処理する前記ステップが、前記モノマー含有率を削減する溶媒を使用して、合成された前記PLLAを処理するサブステップを含む、請求項1に記載の方法。
- 処理する前記ステップが、前記PLLAポリマー材料を曝露することによって、前記材料からLLAモノマーを抽出する、液体溶媒抽出プロセスを含む、請求項1に記載の方法。
- 処理する前記ステップが、超臨界CO2抽出法及び真空/高温抽出法から成る群から選択される、請求項1に記載の方法。
- 処理された前記PLLA材料が0.01〜2重量%のLLAモノマー含有率を有する、請求項1に記載の方法。
- 処理された前記PLLA材料が0.01〜1重量%のLLAモノマー含有率を有する、請求項1に記載の方法。
- 処理された前記PLLA材料が0.01〜0.5重量%のLLAモノマー含有率を有する、請求項1に記載の方法。
- 処理された前記PLLA材料が0.01〜2重量%のLLAモノマー含有率を有する、請求項1に記載の方法。
- 4重量%超のLLAモノマー含有率を有するPLLAポリマー材料を得るステップと、
前記PLLAポリマーを処理して、前記モノマー含有率を2重量%以下まで削減するステップと、
処理した前記PLLAからポリマー製ステント本体を作製するステップと
を含む、ステントの製作方法。 - 処理する前記ステップが、前記モノマー含有率を削減する溶媒を使用して、合成された前記PLLAを処理するサブステップを含む、請求項11に記載の方法。
- 処理する前記ステップが、前記PLLAポリマー材料を曝露することによって、前記材料からLLAモノマーを抽出する、液体溶媒抽出プロセスを含む、請求項11に記載の方法。
- 処理する前記ステップが、超臨界CO2抽出法及び真空/高温抽出法から成る群から選択される、請求項11に記載の方法。
- 処理された前記PLLA材料が、0.01〜2重量%のLLAモノマー含有率を有する、請求項11に記載の方法。
- LLAモノマーの重合反応によって、LLAモノマー含有率が0.5重量%未満のPLLAポリマー材料を作製するステップと、
前記PLLAポリマー材料の反応温度を高めて、前記PLLAの0.5未満〜2重量%の間の目標LLAモノマー含有率まで前記モノマー含有率を増加させる、解重合を引き起こすステップと、
増加した前記モノマー含有率を有する前記PLLAポリマー材料からステント本体を作製するステップと
を含む、ステントの製作方法。 - 前記温度を目標温度まで高め、反応時間を調整して、前記目標モノマー含有率を得る、請求項16に記載の方法。
- 前記反応温度を、120〜140℃の範囲内の温度から180℃を超える範囲内の温度まで高める、請求項16に記載の方法。
- LLAモノマーからPLLAへの重合反応の反応温度を、120〜180℃の間で選択するステップと、
前記重合反応によるPLLAポリマー材料に対する目標LLAモノマー含有率を、0.5〜2重量%の間で選択するステップと、
異なる反応時間の間、前記重合反応を実行して、前記目標LLAモノマー含有率を有するPLLAポリマー材料が得られる目標反応時間を求めるステップと、
前記目標反応時間の間、前記目標反応温度での前記重合反応によって、前記目標LLAモノマー含有率を有する前記PLLAポリマー材料を作製するステップと、
前記目標LLAモノマーを有する前記PLLAポリマー材料から、ステントを作製するステップと
を含む、ステントの作製方法。 - LLAモノマーのPLLAへの重合反応の反応時間を、1〜100時間の間で選択するステップと、
前記重合反応によるPLLAポリマー材料の目標モノマー含有率を、0.5〜2重量%の間で選択するステップと、
120〜180℃の間の異なる反応温度に対して前記重合反応を実行して、前記目標LLAモノマー含有率が得られる目標反応温度を求めるステップと、
前記目標反応時間の間の前記目標反応温度での前記重合反応によって、前記目標LLAモノマー含有率を有する前記PLLAポリマー材料を作製するステップと、
前記目標モノマー含有率を有する前記PLLAポリマー材料からステントを作製するステップと
を含む、ステントの作製方法。 - 前記目標LLAモノマー含有率が0.5〜2%の間である、請求項20に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/751,773 | 2010-03-31 | ||
US12/751,773 US8889823B2 (en) | 2009-07-21 | 2010-03-31 | Method to make poly(L-lactide) stent with tunable degradation rate |
PCT/US2011/025074 WO2011123194A1 (en) | 2010-03-31 | 2011-02-16 | Method to make poly(l-lactide) stent with tunable degradation rate |
Publications (3)
Publication Number | Publication Date |
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JP2013527778A true JP2013527778A (ja) | 2013-07-04 |
JP2013527778A5 JP2013527778A5 (ja) | 2014-03-20 |
JP5850042B2 JP5850042B2 (ja) | 2016-02-03 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014517751A (ja) * | 2011-05-10 | 2014-07-24 | アボット カルディオバスキュラー システムズ インコーポレーテッド | 生体吸収性ポリ(l−ラクチド)スキャフォールドの分解プロファイルの管理 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8370120B2 (en) * | 2010-04-30 | 2013-02-05 | Abbott Cardiovascular Systems Inc. | Polymeric stents and method of manufacturing same |
US8709070B2 (en) | 2011-05-10 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Bioabsorbable scaffold with particles providing delayed acceleration of degradation |
US8545546B2 (en) * | 2011-05-13 | 2013-10-01 | Abbott Cardiovascular Systems Inc. | Bioabsorbable scaffolds made from composites |
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US10143572B2 (en) | 2013-09-04 | 2018-12-04 | Abbott Cardiovascular Systems Inc. | Assessment of a drug eluting bioresorbable vascular scaffold |
WO2015157281A1 (en) | 2014-04-08 | 2015-10-15 | Boston Scientific Scimed, Inc. | Partially coated stents |
US20150328373A1 (en) | 2014-05-19 | 2015-11-19 | Abbott Cardiovascular Systems Inc. | Additives To Increase Degradation Rate Of A Biodegradable Scaffolding And Methods Of Forming Same |
US10518003B2 (en) * | 2014-07-07 | 2019-12-31 | Meril Life Sciences Pvt. Ltd. | Method to manufacture thin strut stent from bioabsorbable polymer with high fatigue and radial strength |
US9730819B2 (en) * | 2014-08-15 | 2017-08-15 | Elixir Medical Corporation | Biodegradable endoprostheses and methods of their fabrication |
US20160374838A1 (en) * | 2015-06-29 | 2016-12-29 | Abbott Cardiovascular Systems Inc. | Drug-eluting coatings on poly(dl-lactide)-based scaffolds |
AU2016361380B2 (en) | 2015-11-26 | 2021-04-08 | Japan Medical Device Technology Co., Ltd. | Bioabsorbable stent |
CN115337466A (zh) * | 2022-08-23 | 2022-11-15 | 苏州健雄职业技术学院 | 一种调节降解环境酸碱性的植入材料及其制备方法 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04166165A (ja) * | 1990-10-30 | 1992-06-12 | Shimadzu Corp | 骨固定用材料 |
JPH04229208A (ja) * | 1990-05-10 | 1992-08-18 | Boehringer Ingelheim Kg | 射出成形法等に使用可能な、溶媒及び残存モノマー不含ポリマーの製造方法 |
JPH04283227A (ja) * | 1991-03-11 | 1992-10-08 | Mitsui Toatsu Chem Inc | 加水分解性樹脂組成物 |
JPH0889567A (ja) * | 1982-11-08 | 1996-04-09 | Johnson & Johnson Professional Inc | 骨固定用器具 |
WO2001067990A1 (fr) * | 2000-03-13 | 2001-09-20 | Keiji Igaki | Tige en fil pour stents intravasculaires et stents intravasculaires ainsi conçus |
JP2009501559A (ja) * | 2005-07-15 | 2009-01-22 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 再吸収性ポリエーテルエステル及び医療用インプラントを製造するためのその使用 |
WO2010010685A1 (ja) * | 2008-07-24 | 2010-01-28 | 東洋紡績株式会社 | 脂肪族ポリエステル樹脂及びその製造方法 |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04282337A (ja) | 1991-03-08 | 1992-10-07 | Fuji Photo Film Co Ltd | 2−アリールオキシ−1−クロルプロパンの製造方法 |
US5357034A (en) * | 1992-09-08 | 1994-10-18 | Camelot Technologies Inc. | Lactide polymerization |
US5338822A (en) | 1992-10-02 | 1994-08-16 | Cargill, Incorporated | Melt-stable lactide polymer composition and process for manufacture thereof |
US5747637A (en) * | 1995-09-07 | 1998-05-05 | Mitsui Toatsu Chemicals, Inc. | Bioabsorbable polymer and process for preparing the same |
US6174330B1 (en) | 1997-08-01 | 2001-01-16 | Schneider (Usa) Inc | Bioabsorbable marker having radiopaque constituents |
US5824059A (en) | 1997-08-05 | 1998-10-20 | Wijay; Bandula | Flexible stent |
US6206883B1 (en) | 1999-03-05 | 2001-03-27 | Stryker Technologies Corporation | Bioabsorbable materials and medical devices made therefrom |
KR100354828B1 (ko) | 2001-03-12 | 2002-10-05 | 주식회사 씨엠리서치 | 생분해성 폴리에스테르의 제조방법 및 그에 의해 제조된생분해성 폴리에스테르 |
US20030069629A1 (en) | 2001-06-01 | 2003-04-10 | Jadhav Balkrishna S. | Bioresorbable medical devices |
GB0116341D0 (en) | 2001-07-04 | 2001-08-29 | Smith & Nephew | Biodegradable polymer systems |
US8747879B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
US20060041102A1 (en) | 2004-08-23 | 2006-02-23 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same |
US8778375B2 (en) * | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
US7291166B2 (en) | 2005-05-18 | 2007-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
US20070179276A1 (en) | 2006-01-31 | 2007-08-02 | Purac Biochem Bv | Method for the purification of resorbable polymers from residual monomers |
US8486135B2 (en) | 2006-06-01 | 2013-07-16 | Abbott Cardiovascular Systems Inc. | Implantable medical devices fabricated from branched polymers |
EP3009477B1 (en) * | 2006-07-20 | 2024-01-24 | Orbusneich Medical Pte. Ltd | Bioabsorbable polymeric composition for a medical device |
JP5150074B2 (ja) * | 2006-09-06 | 2013-02-20 | 帝人株式会社 | ポリ乳酸およびその製造方法 |
JP5647788B2 (ja) * | 2006-10-11 | 2015-01-07 | トルマー セラピューティクス, インコーポレイテッド. | 超臨界流体抽出による低バースト特性の生分解性ポリエステルの調製 |
DE602007008125D1 (de) | 2006-10-31 | 2010-09-09 | Surmodics Pharmaceuticals Inc | Kugelförmige polymer-teilchen |
US8182890B2 (en) | 2007-01-19 | 2012-05-22 | Elixir Medical Corporation | Biodegradable endoprostheses and methods for their fabrication |
US9248219B2 (en) | 2007-09-14 | 2016-02-02 | Boston Scientific Scimed, Inc. | Medical devices having bioerodable layers for the release of therapeutic agents |
US8303650B2 (en) | 2008-01-10 | 2012-11-06 | Telesis Research, Llc | Biodegradable self-expanding drug-eluting prosthesis |
US8252215B2 (en) * | 2008-03-31 | 2012-08-28 | Abbott Cardiovascular Systems Inc. | Method for fabricating a stent with nucleating agent |
US9492587B2 (en) | 2009-04-13 | 2016-11-15 | Abbott Cardiovascular Systems Inc. | Stent made from an ultra high molecular weight bioabsorbable polymer with high fatigue and fracture resistance |
US9889238B2 (en) | 2009-07-21 | 2018-02-13 | Abbott Cardiovascular Systems Inc. | Biodegradable stent with adjustable degradation rate |
US8834776B2 (en) | 2011-05-10 | 2014-09-16 | Abbott Cardiovascular Systems Inc. | Control of degradation profile of bioabsorbable poly(l-lactide) scaffold |
-
2010
- 2010-03-31 US US12/751,773 patent/US8889823B2/en active Active
-
2011
- 2011-02-16 ES ES11707253.8T patent/ES2559207T3/es active Active
- 2011-02-16 EP EP11707253.8A patent/EP2552504B1/en not_active Not-in-force
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-
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-
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-
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- 2017-05-17 US US15/597,962 patent/US9844612B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0889567A (ja) * | 1982-11-08 | 1996-04-09 | Johnson & Johnson Professional Inc | 骨固定用器具 |
JPH04229208A (ja) * | 1990-05-10 | 1992-08-18 | Boehringer Ingelheim Kg | 射出成形法等に使用可能な、溶媒及び残存モノマー不含ポリマーの製造方法 |
JPH04166165A (ja) * | 1990-10-30 | 1992-06-12 | Shimadzu Corp | 骨固定用材料 |
JPH04283227A (ja) * | 1991-03-11 | 1992-10-08 | Mitsui Toatsu Chem Inc | 加水分解性樹脂組成物 |
WO2001067990A1 (fr) * | 2000-03-13 | 2001-09-20 | Keiji Igaki | Tige en fil pour stents intravasculaires et stents intravasculaires ainsi conçus |
JP2009501559A (ja) * | 2005-07-15 | 2009-01-22 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 再吸収性ポリエーテルエステル及び医療用インプラントを製造するためのその使用 |
WO2010010685A1 (ja) * | 2008-07-24 | 2010-01-28 | 東洋紡績株式会社 | 脂肪族ポリエステル樹脂及びその製造方法 |
Non-Patent Citations (4)
Title |
---|
JPN6015003080; Polymer Degradation and Stability Vol.59,No.1-3, 1998, p129-135 * |
JPN6015003081; Journal of Biomedical Materials Research. Part B, Vol.74,No.2, 2005, p792-799 * |
JPN6015003082; BJU International Vol.92,No.8, 2003, p843-850 * |
JPN6015003083; 高分子 Vol.57,No.5, 2008, p358-361 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014517751A (ja) * | 2011-05-10 | 2014-07-24 | アボット カルディオバスキュラー システムズ インコーポレーテッド | 生体吸収性ポリ(l−ラクチド)スキャフォールドの分解プロファイルの管理 |
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US8889823B2 (en) | 2014-11-18 |
CN102892442B (zh) | 2015-06-10 |
WO2011123194A1 (en) | 2011-10-06 |
US20160101222A1 (en) | 2016-04-14 |
US9844612B2 (en) | 2017-12-19 |
CN102892442A (zh) | 2013-01-23 |
US20150057744A1 (en) | 2015-02-26 |
EP2552504A1 (en) | 2013-02-06 |
EP2552504B1 (en) | 2015-10-14 |
US9248218B2 (en) | 2016-02-02 |
US20110021717A1 (en) | 2011-01-27 |
US9687594B2 (en) | 2017-06-27 |
JP5850042B2 (ja) | 2016-02-03 |
ES2559207T3 (es) | 2016-02-11 |
US20170252493A1 (en) | 2017-09-07 |
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