JP2013525266A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013525266A5 JP2013525266A5 JP2012554464A JP2012554464A JP2013525266A5 JP 2013525266 A5 JP2013525266 A5 JP 2013525266A5 JP 2012554464 A JP2012554464 A JP 2012554464A JP 2012554464 A JP2012554464 A JP 2012554464A JP 2013525266 A5 JP2013525266 A5 JP 2013525266A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- fragment
- seq
- synuclein
- nos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012634 fragment Substances 0.000 claims 24
- 208000015122 neurodegenerative disease Diseases 0.000 claims 9
- 102000003802 alpha-Synuclein Human genes 0.000 claims 8
- 108090000185 alpha-Synuclein Proteins 0.000 claims 8
- 208000018737 Parkinson disease Diseases 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 201000002832 Lewy body dementia Diseases 0.000 claims 4
- 206010067889 Dementia with Lewy bodies Diseases 0.000 claims 3
- 230000003902 lesion Effects 0.000 claims 3
- 208000001089 Multiple system atrophy Diseases 0.000 claims 2
- 210000004558 lewy body Anatomy 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 claims 1
- 208000009829 Lewy Body Disease Diseases 0.000 claims 1
- 208000028017 Psychotic disease Diseases 0.000 claims 1
- 102000003799 beta-Synuclein Human genes 0.000 claims 1
- 108090000182 beta-Synuclein Proteins 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30863810P | 2010-02-26 | 2010-02-26 | |
| US61/308,638 | 2010-02-26 | ||
| US40626010P | 2010-10-25 | 2010-10-25 | |
| US61/406,260 | 2010-10-25 | ||
| PCT/IB2011/050826 WO2011104696A1 (en) | 2010-02-26 | 2011-02-25 | Protofibril-binding antibodies and their use in therapeutic and diagnostic methods for parkinson's disease, dementia with lewy bodies and other alpha-synucleinopathies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525266A JP2013525266A (ja) | 2013-06-20 |
| JP2013525266A5 true JP2013525266A5 (OSRAM) | 2014-05-15 |
| JP5894939B2 JP5894939B2 (ja) | 2016-03-30 |
Family
ID=44227520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012554464A Active JP5894939B2 (ja) | 2010-02-26 | 2011-02-25 | プロトフィブリル結合抗体ならびにパーキンソン病、レビー小体型認知症および他のα−シヌクレイノパチーの治療および診断方法におけるこれらの使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8632776B2 (OSRAM) |
| EP (1) | EP2539366B1 (OSRAM) |
| JP (1) | JP5894939B2 (OSRAM) |
| CN (3) | CN102869680B (OSRAM) |
| AU (1) | AU2011219414B2 (OSRAM) |
| CA (1) | CA2789963C (OSRAM) |
| CY (1) | CY1120014T1 (OSRAM) |
| DK (1) | DK2539366T3 (OSRAM) |
| ES (1) | ES2661925T3 (OSRAM) |
| HR (1) | HRP20180230T8 (OSRAM) |
| HU (1) | HUE038313T2 (OSRAM) |
| LT (1) | LT2539366T (OSRAM) |
| NO (1) | NO2539366T3 (OSRAM) |
| PL (1) | PL2539366T3 (OSRAM) |
| PT (1) | PT2539366T (OSRAM) |
| RS (1) | RS57029B1 (OSRAM) |
| RU (1) | RU2555526C2 (OSRAM) |
| SI (1) | SI2539366T1 (OSRAM) |
| SM (1) | SMT201800044T1 (OSRAM) |
| WO (1) | WO2011104696A1 (OSRAM) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2282758T (lt) | 2008-04-29 | 2019-03-12 | Bioarctic Ab | Antikūnai ir vakcinos, skirti su alfa sinukleinu susijusių sutrikimų gydymo ir diagnostiniams metodams |
| CN102869680B (zh) | 2010-02-26 | 2016-10-05 | 生命北极神经科学公司 | 原细纤维结合抗体及其在帕金森氏症、路易体痴呆和其他α-共核蛋白病的治疗和诊断方法中的应用 |
| US10989718B2 (en) * | 2014-09-11 | 2021-04-27 | Amprion, Inc. | Detection of misfolded alpha synuclein protein |
| DK2663579T3 (en) | 2011-01-14 | 2017-07-31 | Univ California | THERAPEUTIC ANTIBODIES AGAINST ROR-1 PROTEIN AND PROCEDURES FOR USE THEREOF |
| PT2804878T (pt) * | 2012-01-20 | 2018-11-29 | Genzyme Corp | Anticorpos anti-cxcr3 |
| US9534044B2 (en) * | 2013-02-28 | 2017-01-03 | United Arab Emirates University | Alpha-synuclein antibodies and uses thereof |
| SI3071597T1 (sl) | 2013-11-21 | 2020-11-30 | F. Hoffmann-La Roche Ag | Anti alfa-sinukleinska protitelesa in postopki uporabe |
| PE20170768A1 (es) * | 2014-07-10 | 2017-07-04 | Eisai Randd Man Co Ltd | Anticuerpos de union a protofibrillas ab mejorados |
| CN107074938A (zh) | 2014-10-16 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 抗‑α‑突触核蛋白抗体和使用方法 |
| WO2016137947A1 (en) | 2015-02-24 | 2016-09-01 | Rpeptide, Llc | Anti-amyloid-beta antibodies |
| EP3091087A1 (en) | 2015-05-08 | 2016-11-09 | Fundació Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol | Method for in vitro diagnosis of synucleinopathies using alpha-synuclein gene transcripts |
| GB201512203D0 (en) | 2015-07-13 | 2015-08-19 | Lundbeck & Co As H | Agents,uses and methods |
| CA2991856A1 (en) | 2015-07-21 | 2017-01-26 | Bioarctic Neuroscience Ab | Method for treatment of traumatic brain injury targeting aggregated peptides |
| EP3374379A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | N-TERMINAL EPITOPES IN AMYLOID BETA AND CONFORMATION-SELECTIVE ANTIBODIES |
| EP3374381A4 (en) | 2015-11-09 | 2019-05-15 | The University Of British Columbia | EPITOPES IN THE AMYLOID-BETA MEDIUM REGION AND CONFORMITY-SELECTIVE ANTIBODIES THEREOF |
| WO2017079835A1 (en) | 2015-11-09 | 2017-05-18 | The University Of British Columbia | Amyloid beta epitopes and antibodies thereto |
| TWI805127B (zh) | 2016-03-04 | 2023-06-11 | 美商Ｊｎ生物科學有限責任公司 | 針對tigit之抗體 |
| TW202309093A (zh) * | 2016-06-02 | 2023-03-01 | 英商梅迪繆思有限公司 | 針對α-突觸核蛋白之抗體及其用途 |
| WO2018011353A1 (en) * | 2016-07-14 | 2018-01-18 | Bioarctic Ab | Brain delivery protein |
| CN109476729A (zh) | 2016-07-18 | 2019-03-15 | 英属哥伦比亚大学 | 淀粉样蛋白β的抗体 |
| US20180125920A1 (en) | 2016-11-09 | 2018-05-10 | The University Of British Columbia | Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions |
| RU2019114679A (ru) | 2016-11-15 | 2020-12-17 | Х. Лундбекк А/С | Средства, пути применения и способы лечения синуклеопатии |
| CN110072888B (zh) | 2016-12-16 | 2023-07-18 | H.隆德贝克有限公司 | 药剂、用途和方法 |
| US10364286B2 (en) | 2016-12-22 | 2019-07-30 | H. Lundbeck A/S | Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation |
| EA039807B1 (ru) * | 2017-01-06 | 2022-03-16 | ЭйБиЭл БИО ИНК. | Антитело к -синуклеину и его применение |
| CA3049110A1 (en) * | 2017-01-06 | 2018-07-12 | Abl Bio Inc. | Anti-.alpha.-syn antibody and use thereof |
| EP3583124A1 (en) * | 2017-02-17 | 2019-12-25 | Bristol-Myers Squibb Company | Antibodies to alpha-synuclein and uses thereof |
| AU2018255489B2 (en) * | 2017-04-21 | 2024-06-13 | Implicit Bioscience Limited | CD 14 antagonist antibodies for treating neurodegenerative diseases |
| IL270361B2 (en) * | 2017-05-01 | 2025-04-01 | Univ Pennsylvania | Monoclonal antibodies against alpha-synuclein fibrils |
| TW201901153A (zh) | 2017-05-16 | 2019-01-01 | 美商安培恩股份有限公司 | 折疊錯誤之ｔａｕ蛋白的檢測及檢測折疊錯誤之ｔａｕ蛋白的套組 |
| US12286469B2 (en) | 2017-07-18 | 2025-04-29 | The University Of British Columbia | Humanized antibodies binding to amyloid-beta (A-beta) |
| US11098108B2 (en) | 2017-08-02 | 2021-08-24 | Stressmarq Biosciences Inc. | Antibody binding active alpha-synuclein |
| US11155608B2 (en) | 2017-08-23 | 2021-10-26 | The Trustees Of The University Of Pennsylvania | Monoclonal antibodies against pathological alpha-synuclein, and methods using same |
| RU2657763C1 (ru) * | 2017-09-12 | 2018-06-15 | федеральное государственное бюджетное образовательное учреждение высшего образования "Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова" Министерства здравоохранения Российской Федерации | Способ диагностики болезни паркинсона |
| JP7173618B2 (ja) * | 2017-11-17 | 2022-11-16 | エービーエル バイオ インコーポレイテッド | アルファ－シヌクレインに対する抗体およびその用途 |
| CN116731173A (zh) | 2017-12-14 | 2023-09-12 | Abl生物公司 | 抗a-syn/igf1r的双特异性抗体及其用途 |
| GB201720970D0 (en) * | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Antibodies |
| GB201720975D0 (en) * | 2017-12-15 | 2018-01-31 | Ucb Biopharma Sprl | Anti-alpha synuclein antibodies |
| AU2018392605B2 (en) | 2017-12-19 | 2025-06-12 | Chase Therapeutics Corporation | Methods for developing pharmaceuticals for treating neurodegenerative conditions |
| EP3729088B1 (en) * | 2017-12-21 | 2021-10-20 | H. Lundbeck A/S | Diagnosis and treatment of alpha-synucleinopathies |
| CN109957546A (zh) * | 2017-12-25 | 2019-07-02 | 深圳宾德生物技术有限公司 | 一种靶向cd317的嵌合抗原受体t细胞及其制备方法和应用 |
| CN109957547A (zh) * | 2017-12-25 | 2019-07-02 | 深圳宾德生物技术有限公司 | 一种靶向cd317的嵌合抗原受体t细胞及其制备方法和应用 |
| US20210093670A1 (en) * | 2018-04-04 | 2021-04-01 | University Of Florida Research Foundation, Inc. | Materials and methods for the treatment of lewy body disorders |
| US20200017596A1 (en) * | 2018-05-10 | 2020-01-16 | Abvision, Inc. | Monoclonal antibodies activating cd40 and uses thereof |
| WO2020009482A1 (ko) * | 2018-07-03 | 2020-01-09 | 에이비엘바이오 주식회사 | 항 알파-시누클레인 항체 및 그 용도 |
| IL280315B2 (en) | 2018-07-24 | 2024-06-01 | Eisai R&D Man Co Ltd | Methods for treating and preventing Alzheimer's disease |
| BR112021006123A2 (pt) * | 2018-10-19 | 2021-07-20 | Janssen Vaccines & Prevention B.V. | anticorpos anti-sinucleína |
| US20210340252A1 (en) * | 2018-12-12 | 2021-11-04 | WuXi Biologics Ireland Limited | Anti-tim-3 antibodies and uses thereof |
| RU2703430C1 (ru) * | 2018-12-13 | 2019-10-16 | Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр глазных болезней имени Гельмгольца" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ГБ им. Гельмгольца" Минздрава России) | Способ прогнозирования развития нейродегенеративных заболеваний, в основе патогенеза которых лежит гамма-синуклеинопатия |
| TWI734279B (zh) * | 2018-12-14 | 2021-07-21 | 美商美國禮來大藥廠 | 抗α-突觸核蛋白抗體及其用途 |
| EP3946266A4 (en) * | 2019-03-28 | 2023-07-12 | The Chinese University Of Hong Kong | SUMO PEPTIDES FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
| JP7480180B2 (ja) | 2019-04-30 | 2024-05-09 | チェイス セラピューティクス コーポレイション | アルファ－シヌクレインアッセイ |
| US20220291240A1 (en) * | 2019-08-27 | 2022-09-15 | The Johns Hopkins University | Biomarkers for neurodegenerative disorders |
| US20230349906A1 (en) | 2019-12-31 | 2023-11-02 | Chase Therapeutics Corporation | Kinases as biomarkers for neurodegenerative conditions |
| CN111171152B (zh) * | 2020-01-15 | 2023-04-18 | 吉林医药学院 | Pcsk9抗体及其制备方法和应用 |
| NL2025332B1 (en) | 2020-04-10 | 2021-10-26 | Syngle Therapeutics B V | Novel alpha-synuclein binding antibodies, or antigen binding portions thereof. |
| AU2021284273A1 (en) | 2020-06-02 | 2022-12-15 | Arcus Biosciences, Inc. | Antibodies to TIGIT |
| CN115803341A (zh) | 2020-06-26 | 2023-03-14 | 生命北极公司 | 结合α-突触核蛋白原纤维的抗体 |
| US20230365665A1 (en) | 2020-09-17 | 2023-11-16 | Qatar Foundation For Education, Science And Community Development | ANTIBODY COMPOSITIONS TARGETING NON-PHOSPHORYLATED a-SYNUCLEIN AGGREGATES |
| JP2024525559A (ja) | 2021-07-09 | 2024-07-12 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | アルツハイマー病治療用バイオマーカー |
| MX2024002567A (es) | 2021-08-30 | 2024-03-20 | Eisai R&D Man Co Ltd | Formulaciones subcutaneas de anticuerpo anti protofibrillas de beta-amiloide (abeta) y metodos de uso de las mismas. |
| AU2022439338A1 (en) | 2022-02-02 | 2024-08-15 | Eisai R&D Management Co., Ltd. | Methods of treatment using p-tau181 level |
| CN117430686B (zh) * | 2022-07-22 | 2025-07-01 | 深圳市安群生物工程有限公司 | α-突触核蛋白抗原表位肽及测定唾液中SNCA试剂盒和在帕金森病诊断中的应用 |
| CN116589567B (zh) * | 2022-11-30 | 2024-03-19 | 西南大学 | 马铃薯x病毒单克隆抗体pvx-2及其应用 |
| WO2025245381A1 (en) | 2024-05-23 | 2025-11-27 | The Trustrees Of Dartmouth College | Methods and compositions for enhancing the persistence of car expressing tregs in the cns and other tissues |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1316055A (zh) | 1998-07-03 | 2001-10-03 | 基因创新有限公司 | 神经变性的鉴别诊断 |
| UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
| EP1309341A2 (en) | 2000-07-07 | 2003-05-14 | Lars Lannfelt | Prevention and treatment of alzheimer's disease |
| US20060018918A1 (en) | 2000-12-27 | 2006-01-26 | Board Of Regents, The University Of Texas System | Production of stabilized conformational isomers of disease associated proteins |
| US20080014194A1 (en) | 2003-10-31 | 2008-01-17 | Elan Pharmaceuticals, Inc. | Prevention and Treatment of Synucleinopathic and Amyloidogenic Disease |
| TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
| US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| US7358331B2 (en) | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
| WO2005047331A2 (en) * | 2003-11-07 | 2005-05-26 | Immunex Corporation | Antibodies that bind interleukin-4 receptor |
| US7674599B2 (en) | 2003-11-08 | 2010-03-09 | Elan Pharmaceuticals, Inc. | Methods of using antibodies to detect alpha-synuclein in fluid samples |
| US20050203010A1 (en) | 2003-11-14 | 2005-09-15 | Atgen Co., Ltd. | Novel peptides conferring environmental stress resistance and fusion proteins including said peptides |
| SE0401601D0 (sv) | 2004-06-21 | 2004-06-21 | Bioarctic Neuroscience Ab | Protofibril specific antibodies and uses thereof |
| CA2641219A1 (en) | 2006-01-31 | 2007-08-09 | Elan Pharmaceuticals, Inc. | Alpha-synuclein kinase |
| RS51723B2 (sr) | 2006-03-23 | 2018-03-30 | Bioarctic Neuroscience Ab | Poboljšana antitela selektivna za protofibrile i njihova primena |
| US8147833B2 (en) | 2007-02-23 | 2012-04-03 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
| CN101161245B (zh) * | 2007-11-29 | 2011-11-09 | 首都医科大学宣武医院 | 二苯乙烯苷及其衍生物抑制突触核蛋白过度表达的用途 |
| LT2282758T (lt) | 2008-04-29 | 2019-03-12 | Bioarctic Ab | Antikūnai ir vakcinos, skirti su alfa sinukleinu susijusių sutrikimų gydymo ir diagnostiniams metodams |
| PL2448968T3 (pl) | 2009-06-29 | 2021-09-13 | Bioarctic Ab | Antybiotyki selektywne względem n-końcowych skróconych protofibryli/oligomerów amyloidu beta |
| CN102869680B (zh) | 2010-02-26 | 2016-10-05 | 生命北极神经科学公司 | 原细纤维结合抗体及其在帕金森氏症、路易体痴呆和其他α-共核蛋白病的治疗和诊断方法中的应用 |
-
2011
- 2011-02-25 CN CN201180011363.XA patent/CN102869680B/zh active Active
- 2011-02-25 RU RU2012140954/10A patent/RU2555526C2/ru active
- 2011-02-25 EP EP11713058.3A patent/EP2539366B1/en active Active
- 2011-02-25 CN CN201610801424.7A patent/CN106397588B/zh active Active
- 2011-02-25 JP JP2012554464A patent/JP5894939B2/ja active Active
- 2011-02-25 PT PT117130583T patent/PT2539366T/pt unknown
- 2011-02-25 SM SM20180044T patent/SMT201800044T1/it unknown
- 2011-02-25 HU HUE11713058A patent/HUE038313T2/hu unknown
- 2011-02-25 AU AU2011219414A patent/AU2011219414B2/en active Active
- 2011-02-25 RS RS20180129A patent/RS57029B1/sr unknown
- 2011-02-25 CA CA2789963A patent/CA2789963C/en active Active
- 2011-02-25 LT LTEP11713058.3T patent/LT2539366T/lt unknown
- 2011-02-25 WO PCT/IB2011/050826 patent/WO2011104696A1/en not_active Ceased
- 2011-02-25 DK DK11713058.3T patent/DK2539366T3/en active
- 2011-02-25 HR HRP20180230TT patent/HRP20180230T8/hr unknown
- 2011-02-25 US US13/578,710 patent/US8632776B2/en active Active
- 2011-02-25 CN CN201910950804.0A patent/CN110655573B/zh active Active
- 2011-02-25 PL PL11713058T patent/PL2539366T3/pl unknown
- 2011-02-25 ES ES11713058.3T patent/ES2661925T3/es active Active
- 2011-02-25 SI SI201131419T patent/SI2539366T1/en unknown
- 2011-02-25 NO NO11713058A patent/NO2539366T3/no unknown
-
2013
- 2013-08-01 US US13/957,239 patent/US8859501B2/en active Active
-
2014
- 2014-08-28 US US14/472,036 patent/US8968734B2/en active Active
-
2015
- 2015-02-02 US US14/611,690 patent/US9084832B2/en active Active
-
2018
- 2018-02-05 CY CY20181100140T patent/CY1120014T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013525266A5 (OSRAM) | ||
| HRP20180230T1 (hr) | Protutijela koja se vežu na protofibrile i njihova upotreba u terapijskim i dijagnostičkim postupcima kod parkinsonove bolesti, demencije s lewyjevim tijelima i drugih alfa-sinukleinopatija | |
| JP2016511254A5 (OSRAM) | ||
| JP2021501744A5 (OSRAM) | ||
| JP2013519364A5 (OSRAM) | ||
| JP2016503065A5 (OSRAM) | ||
| AR112816A2 (es) | Compuestos que inhiben el enlace de la proteína smac al inhibidor de proteínas de apoptosis (iap) | |
| JP2010522141A5 (OSRAM) | ||
| JP2015514110A5 (OSRAM) | ||
| JP2010506596A5 (OSRAM) | ||
| RU2015143886A (ru) | Антитела к тау и способы применения | |
| HRP20131066T1 (hr) | Sp35 antitijela i njihova upotreba | |
| CY1112374T1 (el) | Επιλεκτικα του υποτυπου νικοτινικου υποδοχεα της ακετυλχολινης αμιδια διαζαδικυκλοαλκανιων | |
| RU2571204C3 (ru) | Специфические связывающие агенты против в7-н1 | |
| JP2017532048A5 (OSRAM) | ||
| JP2016502515A5 (OSRAM) | ||
| CY1118319T1 (el) | Αλατα και πολυμορφα της 8-φθορο-2-{4-[(μεθυλαμινο)μεθυλο]φαινυλο}-1,3,4,5-τετραϋδρο-6η-αζεπινο[5,4,3-cd]ινδολο-6-ονης | |
| JP2011528561A5 (OSRAM) | ||
| JP2013542194A5 (OSRAM) | ||
| UA102867C2 (uk) | Антитіла до cxcr4 та їх застосування у лікуванні раку | |
| JP2011173884A5 (OSRAM) | ||
| JP2011528901A5 (OSRAM) | ||
| JP2017515792A5 (OSRAM) | ||
| JP2014508748A5 (OSRAM) | ||
| NO20084650L (no) | Modifiserte humaniserte anti-interleukin-18 antistoffer |