JP2013525262A5 - - Google Patents
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- Publication number
- JP2013525262A5 JP2013525262A5 JP2012547392A JP2012547392A JP2013525262A5 JP 2013525262 A5 JP2013525262 A5 JP 2013525262A5 JP 2012547392 A JP2012547392 A JP 2012547392A JP 2012547392 A JP2012547392 A JP 2012547392A JP 2013525262 A5 JP2013525262 A5 JP 2013525262A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- salt
- optionally substituted
- group
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 5
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 208000002249 Diabetes Complications Diseases 0.000 claims 2
- 206010012655 Diabetic complications Diseases 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- 208000031226 Hyperlipidaemia Diseases 0.000 claims 2
- 206010020772 Hypertension Diseases 0.000 claims 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 208000008589 Obesity Diseases 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- MGNZXYYWBUKAII-UHFFFAOYSA-N cyclohexa-1,3-diene Chemical group C1CC=CC=C1 MGNZXYYWBUKAII-UHFFFAOYSA-N 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims 2
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 2
- 235000020824 obesity Nutrition 0.000 claims 2
- 230000000069 prophylactic effect Effects 0.000 claims 2
- 208000001076 sarcopenia Diseases 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- QWENRTYMTSOGBR-UHFFFAOYSA-N 1H-1,2,3-Triazole Chemical compound C=1C=NNN=1 QWENRTYMTSOGBR-UHFFFAOYSA-N 0.000 claims 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical compound C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 claims 1
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 229940121373 acetyl-coa carboxylase inhibitor Drugs 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- AFSPJJIONSZSCB-AWEZNQCLSA-N n-[(2s)-1-[1-[5-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C1=NC2=CC(OCC3CC3)=CC=C2O1 AFSPJJIONSZSCB-AWEZNQCLSA-N 0.000 claims 1
- NQFDYRVHKCXJQP-HNNXBMFYSA-N n-[(2s)-1-[1-[6-(2-cyclopropylethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCCC1CC1 NQFDYRVHKCXJQP-HNNXBMFYSA-N 0.000 claims 1
- ZTQJADDEMCINFS-AWEZNQCLSA-N n-[(2s)-1-[1-[6-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]oxypropan-2-yl]acetamide Chemical compound C1CC(OC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCC1CC1 ZTQJADDEMCINFS-AWEZNQCLSA-N 0.000 claims 1
- MFVUXRRTNVGQNW-HNNXBMFYSA-N n-[(2s)-4-[1-[6-(cyclopropylmethoxy)-1,3-benzoxazol-2-yl]piperidin-4-yl]butan-2-yl]acetamide Chemical compound C1CC(CC[C@H](C)NC(C)=O)CCN1C(OC1=C2)=NC1=CC=C2OCC1CC1 MFVUXRRTNVGQNW-HNNXBMFYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012547392A JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010102718 | 2010-04-27 | ||
| JP2010102718 | 2010-04-27 | ||
| PCT/JP2011/060616 WO2011136385A1 (en) | 2010-04-27 | 2011-04-26 | Bicyclic compound derivatives and their use as acc inhibitors. |
| JP2012547392A JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013525262A JP2013525262A (ja) | 2013-06-20 |
| JP2013525262A5 true JP2013525262A5 (OSRAM) | 2014-04-17 |
| JP5693611B2 JP5693611B2 (ja) | 2015-04-01 |
Family
ID=44120718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012547392A Expired - Fee Related JP5693611B2 (ja) | 2010-04-27 | 2011-04-26 | 二環性化合物 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8703758B2 (OSRAM) |
| EP (1) | EP2563765B1 (OSRAM) |
| JP (1) | JP5693611B2 (OSRAM) |
| KR (1) | KR20130094211A (OSRAM) |
| CN (1) | CN103025716B (OSRAM) |
| AR (1) | AR080969A1 (OSRAM) |
| AU (1) | AU2011246004A1 (OSRAM) |
| BR (1) | BR112012027648A2 (OSRAM) |
| CA (1) | CA2797767A1 (OSRAM) |
| CO (1) | CO6640253A2 (OSRAM) |
| CR (1) | CR20120598A (OSRAM) |
| EA (1) | EA021698B1 (OSRAM) |
| EC (1) | ECSP12012311A (OSRAM) |
| ES (1) | ES2546130T3 (OSRAM) |
| GE (1) | GEP20146178B (OSRAM) |
| MA (1) | MA34245B1 (OSRAM) |
| NZ (1) | NZ603777A (OSRAM) |
| PH (1) | PH12012502347A1 (OSRAM) |
| SG (1) | SG185759A1 (OSRAM) |
| TW (1) | TW201206911A (OSRAM) |
| UA (1) | UA108102C2 (OSRAM) |
| UY (1) | UY33354A (OSRAM) |
| WO (1) | WO2011136385A1 (OSRAM) |
| ZA (1) | ZA201208895B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20140001965A (ko) | 2010-11-30 | 2014-01-07 | 다케다 야쿠힌 고교 가부시키가이샤 | 바이시클릭 화합물 |
| CN103998432A (zh) * | 2011-10-24 | 2014-08-20 | 武田药品工业株式会社 | 双环化合物 |
| US8530460B2 (en) | 2011-12-19 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
| US8530461B2 (en) | 2011-12-29 | 2013-09-10 | Boehringer Ingelheim International Gmbh | Azetidine derivatives |
| US8623860B2 (en) * | 2011-12-30 | 2014-01-07 | Boehringer Ingelheim International Gmbh | Azetidine derivatives, pharmaceutical compositions and uses thereof |
| WO2015036892A1 (en) | 2013-09-12 | 2015-03-19 | Pfizer Inc. | Use of acetyl-coa carboxylase inhibitors for treating acne vulgaris |
| JP6050291B2 (ja) * | 2014-08-07 | 2016-12-21 | 長谷川香料株式会社 | ソラノンの製造方法およびその合成中間体 |
| JP2016079168A (ja) * | 2014-10-17 | 2016-05-16 | 塩野義製薬株式会社 | ９員縮合環誘導体 |
| CN106636402B (zh) * | 2016-12-22 | 2020-09-15 | 中南大学湘雅医院 | 一种判断鼻咽癌放疗敏感性的分子标志物及应用 |
| JP7361584B2 (ja) * | 2018-12-19 | 2023-10-16 | 高砂香料工業株式会社 | アミドの還元によるアミンの製造方法 |
| EP4434520A4 (en) * | 2021-11-19 | 2025-10-29 | Shionogi & Co | PHARMACEUTICAL PRODUCT FOR THE TREATMENT OF HEART DISEASE OR SKELETAL MUSCLE DISEASE |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6944296A (en) | 1995-09-13 | 1997-04-01 | Takeda Chemical Industries Ltd. | Benzoxazepine compounds, their production and use as lipid lowering agents |
| EP1177181B1 (en) | 1999-05-05 | 2009-01-28 | Aventis Pharma Limited | Substituted bicyclic compounds |
| AR035016A1 (es) | 1999-08-25 | 2004-04-14 | Takeda Chemical Industries Ltd | Composicion de azol promotor de produccion/secrecion de neurotrofina, compuesto prodroga del mismo, composicion farmaceutica que lo comprende y uso del mismo para preparar esta ultima. |
| EP1285651B1 (en) | 2000-04-28 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Melanin concentrating hormone antagonists |
| CA2408913A1 (en) | 2000-05-16 | 2001-11-22 | Takeda Chemical Industries, Ltd. | Melanin-concentrating hormone antagonist |
| AU2001269531A1 (en) | 2000-07-17 | 2002-01-30 | Takeda Chemical Industries Ltd. | Sulfone derivatives, process for their production and use thereof |
| EP1478437B1 (en) * | 2002-02-27 | 2005-08-31 | Pfizer Products Inc. | Acc inhibitors |
| AU2003242252A1 (en) | 2002-06-07 | 2003-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Bicyclic pyrimidine derivatives |
| MXPA05004505A (es) | 2002-11-01 | 2005-07-26 | Takeda Pharmaceutical | Agente para prevenir o tratar la neuropatia. |
| CA2505322A1 (en) | 2002-11-08 | 2004-05-21 | Takeda Pharmaceutical Company Limited | Receptor function regulator |
| US20070004736A1 (en) | 2002-11-22 | 2007-01-04 | Keiji Kubo | Imidazole derivative, process for producing the same, and use |
| US7820837B2 (en) | 2003-05-30 | 2010-10-26 | Takeda Pharmaceutical Company Limited | Condensed ring compound |
| WO2005030740A1 (ja) | 2003-09-30 | 2005-04-07 | Takeda Pharmaceutical Company Limited | チアゾリン誘導体およびその用途 |
| JP4769082B2 (ja) | 2003-12-17 | 2011-09-07 | 武田薬品工業株式会社 | ウレア誘導体、その製造法及び用途 |
| RU2006126978A (ru) | 2003-12-25 | 2008-01-27 | Такеда Фармасьютикал Компани Лимитед (Jp) | Производные 3-(4-бензилоксифенил)пропановой кислоты |
| WO2005063725A1 (ja) | 2003-12-26 | 2005-07-14 | Takeda Pharmaceutical Company Limited | フェニルプロパン酸誘導体 |
| JP4875978B2 (ja) | 2004-03-15 | 2012-02-15 | 武田薬品工業株式会社 | アミノフェニルプロパン酸誘導体 |
| EP1731505B1 (en) | 2004-03-30 | 2015-01-14 | Takeda Pharmaceutical Company Limited | Alkoxyphenylpropanoic acid derivatives |
| JPWO2005108370A1 (ja) * | 2004-04-16 | 2008-03-21 | 味の素株式会社 | ベンゼン化合物 |
| TWI396686B (zh) | 2004-05-21 | 2013-05-21 | Takeda Pharmaceutical | 環狀醯胺衍生物、以及其製品和用法 |
| EP2308839B1 (en) | 2005-04-20 | 2017-03-01 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| GB0511851D0 (en) * | 2005-06-11 | 2005-07-20 | Astrazeneca Ab | Chemical compounds |
| EP1911738A4 (en) | 2005-07-29 | 2009-12-16 | Takeda Pharmaceutical | COMPOUND OF PHENOXYALKANOIC ACID |
| JP5084503B2 (ja) | 2005-07-29 | 2012-11-28 | 武田薬品工業株式会社 | シクロプロパンカルボン酸化合物 |
| JP4094660B1 (ja) | 2005-08-10 | 2008-06-04 | 武田薬品工業株式会社 | 糖尿病治療剤 |
| JP2007063225A (ja) | 2005-09-01 | 2007-03-15 | Takeda Chem Ind Ltd | イミダゾピリジン化合物 |
| EP1966221A1 (en) * | 2005-12-22 | 2008-09-10 | AstraZeneca AB | Pyrimido- [4, 5-]-oxazines for use as dgat inhibitors |
| CA2641673A1 (en) * | 2006-02-15 | 2007-08-23 | Abbott Laboratories | Novel acetyl-coa carboxylase (acc) inhibitors and their use in diabetes, obesity and metabolic syndrome |
| EP2431367A3 (en) | 2006-06-27 | 2012-07-04 | Takeda Pharmaceutical Company Limited | Fused cyclic compounds as GPR40 receptor modulators |
| EP2298772A1 (en) | 2006-10-18 | 2011-03-23 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compounds |
| CN101573357B (zh) | 2006-10-19 | 2013-01-23 | 武田药品工业株式会社 | 吲哚化合物 |
| JP2008179621A (ja) * | 2006-12-28 | 2008-08-07 | Taisho Pharmaceutical Co Ltd | 含窒素飽和複素環化合物 |
| JPWO2008090944A1 (ja) | 2007-01-25 | 2010-05-20 | 武田薬品工業株式会社 | スピロ環化合物 |
| JPWO2008093639A1 (ja) | 2007-01-29 | 2010-05-20 | 武田薬品工業株式会社 | ピラゾール化合物 |
| BRPI0807014A2 (pt) | 2007-02-09 | 2014-04-22 | Takeda Pharmaceutical | Composto, pró-droga, agente farmacêutico, métodos para melhorar a resistência a insulina em um mamífero, método para a profilaxia ou o tratamento de diabetes em um mamífero, e, uso de um composto. |
| EP2149550A4 (en) | 2007-04-27 | 2010-08-11 | Takeda Pharmaceutical | NITROGENIC FIVE-GLOSS HETEROCYCLIC COMPOUND |
| WO2008156757A1 (en) | 2007-06-19 | 2008-12-24 | Takeda Pharmaceutical Company Limited | Indazole compounds for activating glucokinase |
| JP5613656B2 (ja) | 2008-03-26 | 2014-10-29 | グローバル、アライアンス、フォア、ティービー、ドラッグ、ディベロップメント | 置換されたフェニルオキサゾリジノンと共有結合した二環式ニトロイミダゾール |
| CA2730606A1 (en) | 2008-07-16 | 2010-01-21 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| US8501804B2 (en) | 2008-10-27 | 2013-08-06 | Takeda Pharmaceutical Company Limited | Bicyclic compound |
| JP2010102718A (ja) | 2009-11-27 | 2010-05-06 | Toshiba Corp | 情報処理装置 |
| KR20140001965A (ko) | 2010-11-30 | 2014-01-07 | 다케다 야쿠힌 고교 가부시키가이샤 | 바이시클릭 화합물 |
| WO2012108478A1 (ja) | 2011-02-09 | 2012-08-16 | 武田薬品工業株式会社 | 単環化合物 |
-
2011
- 2011-04-26 UA UAA201213528A patent/UA108102C2/ru unknown
- 2011-04-26 CA CA2797767A patent/CA2797767A1/en not_active Abandoned
- 2011-04-26 ES ES11722184.6T patent/ES2546130T3/es active Active
- 2011-04-26 JP JP2012547392A patent/JP5693611B2/ja not_active Expired - Fee Related
- 2011-04-26 AR ARP110101434A patent/AR080969A1/es unknown
- 2011-04-26 WO PCT/JP2011/060616 patent/WO2011136385A1/en not_active Ceased
- 2011-04-26 UY UY0001033354A patent/UY33354A/es not_active Application Discontinuation
- 2011-04-26 BR BR112012027648A patent/BR112012027648A2/pt not_active IP Right Cessation
- 2011-04-26 GE GEAP201112904A patent/GEP20146178B/en unknown
- 2011-04-26 EP EP11722184.6A patent/EP2563765B1/en active Active
- 2011-04-26 US US13/094,015 patent/US8703758B2/en not_active Expired - Fee Related
- 2011-04-26 KR KR1020127030925A patent/KR20130094211A/ko not_active Withdrawn
- 2011-04-26 EA EA201291115A patent/EA021698B1/ru not_active IP Right Cessation
- 2011-04-26 AU AU2011246004A patent/AU2011246004A1/en not_active Abandoned
- 2011-04-26 SG SG2012086880A patent/SG185759A1/en unknown
- 2011-04-26 TW TW100114410A patent/TW201206911A/zh unknown
- 2011-04-26 MA MA35387A patent/MA34245B1/fr unknown
- 2011-04-26 PH PH1/2012/502347A patent/PH12012502347A1/en unknown
- 2011-04-26 CN CN201180031899.8A patent/CN103025716B/zh not_active Expired - Fee Related
- 2011-04-26 NZ NZ603777A patent/NZ603777A/xx not_active IP Right Cessation
-
2012
- 2012-11-26 CR CR20120598A patent/CR20120598A/es not_active Application Discontinuation
- 2012-11-26 ZA ZA2012/08895A patent/ZA201208895B/en unknown
- 2012-11-27 CO CO12214563A patent/CO6640253A2/es active IP Right Grant
- 2012-11-27 EC ECSP12012311 patent/ECSP12012311A/es unknown
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