JP2013523860A5 - - Google Patents

Info

Publication number

JP2013523860A5

JP2013523860A5 JP2013504242A JP2013504242A JP2013523860A5 JP 2013523860 A5 JP2013523860 A5 JP 2013523860A5 JP 2013504242 A JP2013504242 A JP 2013504242A JP 2013504242 A JP2013504242 A JP 2013504242A JP 2013523860 A5 JP2013523860 A5 JP 2013523860A5

Authority

JP

Japan

Prior art keywords

administration

packaging unit

dosage formulation

preparation according

estradiol

Prior art date

2011-04-12

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 208000024891 symptom Diseases 0.000 claims description 6
• 230000001457 vasomotor Effects 0.000 claims description 6
• METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims description 4
• 208000033830 Hot Flashes Diseases 0.000 claims description 2
• 206010060800 Hot flush Diseases 0.000 claims description 2
• 238000002360 preparation method Methods 0.000 claims 9
• 238000009472 formulation Methods 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 7
• 238000004806 packaging method and process Methods 0.000 claims 6
• VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 4
• 229960005309 estradiol Drugs 0.000 claims 4
• 229930182833 estradiol Natural products 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 3
• 201000000736 Amenorrhea Diseases 0.000 claims 2
• 206010001928 Amenorrhoea Diseases 0.000 claims 2
• 231100000540 amenorrhea Toxicity 0.000 claims 2
• 230000000740 bleeding effect Effects 0.000 claims 2
• 230000001788 irregular Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• ZVVGLAMWAQMPDR-WVEWYJOQSA-N (8r,9s,13s,14s,17s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol;hydrate Chemical compound O.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 ZVVGLAMWAQMPDR-WVEWYJOQSA-N 0.000 claims 1
• METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims 1
• 229960004845 drospirenone Drugs 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• 229960003851 estradiol hemihydrate Drugs 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 101000605827 Homo sapiens Pinin Proteins 0.000 description 3
• 102100038374 Pinin Human genes 0.000 description 3
• METQSPRSQINEEU-OLKMEILKSA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3C3C4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-OLKMEILKSA-N 0.000 description 3
• 229940068196 placebo Drugs 0.000 description 2
• 239000000902 placebo Substances 0.000 description 2