JP2013523861A5 - - Google Patents
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- Publication number
- JP2013523861A5 JP2013523861A5 JP2013504243A JP2013504243A JP2013523861A5 JP 2013523861 A5 JP2013523861 A5 JP 2013523861A5 JP 2013504243 A JP2013504243 A JP 2013504243A JP 2013504243 A JP2013504243 A JP 2013504243A JP 2013523861 A5 JP2013523861 A5 JP 2013523861A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- form according
- estradiol
- packaging unit
- women
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002552 dosage form Substances 0.000 claims 14
- 238000004806 packaging method and process Methods 0.000 claims 7
- 208000024891 symptom Diseases 0.000 claims 5
- 230000001457 vasomotor Effects 0.000 claims 5
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 4
- 229960005309 estradiol Drugs 0.000 claims 4
- 229930182833 estradiol Natural products 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 201000000736 Amenorrhea Diseases 0.000 claims 2
- 206010001928 Amenorrhoea Diseases 0.000 claims 2
- 231100000540 amenorrhea Toxicity 0.000 claims 2
- 230000000740 bleeding effect Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000007909 solid dosage form Substances 0.000 claims 2
- ZVVGLAMWAQMPDR-WVEWYJOQSA-N (8r,9s,13s,14s,17s)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol;hydrate Chemical compound O.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1.OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 ZVVGLAMWAQMPDR-WVEWYJOQSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000033830 Hot Flashes Diseases 0.000 claims 1
- 206010060800 Hot flush Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- METQSPRSQINEEU-UHFFFAOYSA-N dihydrospirorenone Natural products CC12CCC(C3(CCC(=O)C=C3C3CC33)C)C3C1C1CC1C21CCC(=O)O1 METQSPRSQINEEU-UHFFFAOYSA-N 0.000 claims 1
- METQSPRSQINEEU-HXCATZOESA-N drospirenone Chemical compound C([C@]12[C@H]3C[C@H]3[C@H]3[C@H]4[C@@H]([C@]5(CCC(=O)C=C5[C@@H]5C[C@@H]54)C)CC[C@@]31C)CC(=O)O2 METQSPRSQINEEU-HXCATZOESA-N 0.000 claims 1
- 229960004845 drospirenone Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229960003851 estradiol hemihydrate Drugs 0.000 claims 1
- 230000001788 irregular Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10160069.0 | 2010-04-15 | ||
| EP10160069 | 2010-04-15 | ||
| PCT/EP2011/055717 WO2011128337A2 (en) | 2010-04-15 | 2011-04-12 | Low-dosed solid oral dosage forms for hrt |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523861A JP2013523861A (ja) | 2013-06-17 |
| JP2013523861A5 true JP2013523861A5 (https=) | 2014-05-29 |
| JP5852639B2 JP5852639B2 (ja) | 2016-02-03 |
Family
ID=44625782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013504243A Expired - Fee Related JP5852639B2 (ja) | 2010-04-15 | 2011-04-12 | Ｈｒｔのための低用量固体経口投与形態 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20130140210A1 (https=) |
| EP (1) | EP2558076B1 (https=) |
| JP (1) | JP5852639B2 (https=) |
| CN (2) | CN102985076A (https=) |
| CA (1) | CA2796139A1 (https=) |
| ES (1) | ES2533584T3 (https=) |
| WO (1) | WO2011128337A2 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025132539A1 (en) | 2023-12-19 | 2025-06-26 | Qbdc Gmbh | Predicting the quality of a bioprocess and product |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4426709A1 (de) | 1994-07-20 | 1996-01-25 | Schering Ag | Steroidale Sexualhormone enthaltende feste Arzneiformen |
| DE19651000A1 (de) * | 1996-12-01 | 1998-06-04 | Schering Ag | Oxyiminopregnancarbolactone |
| US5891868A (en) * | 1997-11-21 | 1999-04-06 | Kaiser Foundation Health Plan, Inc. | Methods for treating postmenopausal women using ultra-low doses of estrogen |
| US6787531B1 (en) * | 1999-08-31 | 2004-09-07 | Schering Ag | Pharmaceutical composition for use as a contraceptive |
| KR100913910B1 (ko) | 2000-01-18 | 2009-08-26 | 바이엘 쉐링 파마 악티엔게젤샤프트 | 호르몬 보충 요법용 드로스피렌온 |
| US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| DE60113142T2 (de) * | 2000-10-30 | 2006-07-06 | University Of Zurich | Verwendung von gnrh-analogue zur behandlung der harninkontinenz |
| EP1216713A1 (en) * | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
| EP1216712A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Cyclodextrin-drospirenone inclusion complexes |
| JP2004521951A (ja) * | 2001-07-13 | 2004-07-22 | シエーリング アクチエンゲゼルシャフト | Ｈｒｔのためのドロスピレノン及びエストロゲンスルファメートの組み合わせ |
| GT200500315A (es) | 2004-11-02 | 2006-06-06 | Formas de dosificacion oral solidas que contienen una dosis baja de estradiol | |
| US8022053B2 (en) * | 2004-11-02 | 2011-09-20 | Bayer Schering Pharma Aktiengesellschaft | Oral solid dosage forms containing a low dose of estradiol |
| US8475838B2 (en) | 2005-06-03 | 2013-07-02 | Sandoz Ag | Rapidly-dissolving pharmaceutical composition for inhibiting ovulation |
| US20080066739A1 (en) * | 2006-09-20 | 2008-03-20 | Lemahieu Edward | Methods and systems of delivering medication via inhalation |
| US20090023693A1 (en) * | 2007-04-05 | 2009-01-22 | Vladimir Hanes | New drospirenone/17beta-estradiol regimen, pharmaceutical combination product and kit for performing this regimen |
| WO2009138224A1 (en) | 2008-05-14 | 2009-11-19 | Helm Ag | Pharmaceutical composition comprising drospirenone |
-
2011
- 2011-04-12 EP EP11713829.7A patent/EP2558076B1/en not_active Not-in-force
- 2011-04-12 CA CA2796139A patent/CA2796139A1/en not_active Abandoned
- 2011-04-12 CN CN2011800283857A patent/CN102985076A/zh active Pending
- 2011-04-12 JP JP2013504243A patent/JP5852639B2/ja not_active Expired - Fee Related
- 2011-04-12 CN CN201610391347.2A patent/CN106038574A/zh active Pending
- 2011-04-12 US US13/641,431 patent/US20130140210A1/en not_active Abandoned
- 2011-04-12 WO PCT/EP2011/055717 patent/WO2011128337A2/en not_active Ceased
- 2011-04-12 ES ES11713829.7T patent/ES2533584T3/es active Active
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