CO6630107A2 - Formas de dosificación sólidas orales con dosis muy bajas para hrt - Google Patents
Formas de dosificación sólidas orales con dosis muy bajas para hrtInfo
- Publication number
- CO6630107A2 CO6630107A2 CO12180903A CO12180903A CO6630107A2 CO 6630107 A2 CO6630107 A2 CO 6630107A2 CO 12180903 A CO12180903 A CO 12180903A CO 12180903 A CO12180903 A CO 12180903A CO 6630107 A2 CO6630107 A2 CO 6630107A2
- Authority
- CO
- Colombia
- Prior art keywords
- hrt
- low doses
- dosage form
- dosage forms
- oral dosage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Una forma de dosificación con una dosis muy baja para la terapia de reemplazo de hormonas (HRT), más particularmente una forma de dosificación sólida oral que comprende aproximadamente 0,5 mg de estradiol (que se abrevie E2) y aproximadamente 0,25 mg de drospirenona (que se abrevia DRSP), así como al menos un excipiente farmacéuticamente aceptable. A pesar de las dosis muy bajas de E2 y de DRSP, sorprendentemente se ha descubierto que una proporción elevada de las mujeres que sufren calores moderados a severos de hecho responden a este tratamiento. Por consiguiente, la forma de dosificación de la invención puede usarse como HRT de mantenimiento o puede usarse cuando ye se ha iniciado la HRT.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10160072 | 2010-04-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6630107A2 true CO6630107A2 (es) | 2013-03-01 |
Family
ID=44260074
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO12180903A CO6630107A2 (es) | 2010-04-15 | 2012-10-12 | Formas de dosificación sólidas orales con dosis muy bajas para hrt |
Country Status (18)
Country | Link |
---|---|
US (3) | US20130137664A1 (es) |
EP (1) | EP2558063B1 (es) |
JP (1) | JP5820465B2 (es) |
KR (2) | KR20180018827A (es) |
CN (1) | CN102985070A (es) |
AR (1) | AR080912A1 (es) |
AU (1) | AU2011240102B2 (es) |
BR (1) | BR112012026115B1 (es) |
CA (1) | CA2795801C (es) |
CO (1) | CO6630107A2 (es) |
CR (1) | CR20120523A (es) |
EA (1) | EA026095B1 (es) |
GT (1) | GT201200281A (es) |
IL (1) | IL222353A0 (es) |
MX (1) | MX356702B (es) |
TW (1) | TWI519300B (es) |
UY (1) | UY33343A (es) |
WO (1) | WO2011128336A1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
ES2885523T3 (es) | 2011-11-23 | 2021-12-14 | Therapeuticsmd Inc | Formulaciones y terapias de reposición hormonal de combinación naturales |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
ME03728B (me) | 2015-06-18 | 2021-01-20 | Estetra Sprl | Orodisperzibilna dozna jedinica koja sadrži komponentu estetrola |
RS61777B1 (sr) | 2015-06-18 | 2021-06-30 | Estetra Sprl | Oralno-disperzibilna tableta koja sadrži estetrol |
MY195019A (en) | 2015-06-18 | 2023-01-03 | Estetra Sprl | Orodispersible dosage unit containing an estetrol component |
SI3310345T1 (sl) | 2015-06-18 | 2021-05-31 | Estetra Sprl | Orodisperzibilna tableta, ki vsebuje estetrol |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
KR20220144885A (ko) | 2016-08-05 | 2022-10-27 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4826831A (en) | 1983-08-05 | 1989-05-02 | Pre Jay Holdings Limited | Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens |
US4590569A (en) | 1983-10-14 | 1986-05-20 | Navigation Sciences Inc. | Navigation system including an integrated electronic chart display |
DE4426709A1 (de) | 1994-07-20 | 1996-01-25 | Schering Ag | Steroidale Sexualhormone enthaltende feste Arzneiformen |
EP1380301B1 (en) * | 1999-08-31 | 2009-01-14 | Bayer Schering Pharma Aktiengesellschaft | Pharmaceutical combination of ethinylestradiol and dropirenone for use as a contraceptive |
US20020132801A1 (en) * | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
DE60113809T2 (de) * | 2000-01-18 | 2006-06-22 | Schering Ag | Pharmazeutische kombination aus mikronisiertem drospirenon und einen estrogen für die hormonersatztherapie |
EP1216713A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
EP1216712A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Cyclodextrin-drospirenone inclusion complexes |
EP1406634A1 (en) | 2001-07-13 | 2004-04-14 | Schering Aktiengesellschaft | Combination of drospirenone and an estrogen sulphamate for hrt |
NZ548754A (en) * | 2002-04-26 | 2008-06-30 | Schering Aktiengellschaft | Treatment of hypertension in women receiving hormone replacement therapy |
AU2002368326A1 (en) | 2002-11-05 | 2004-06-07 | Schering Aktiengesellschaft | Hormone replacement therapy with drospirenone |
AU2004275469B2 (en) | 2003-09-29 | 2010-07-15 | Novo Nordisk Health Care Ag | HRT formulations |
WO2005030176A1 (en) | 2003-09-29 | 2005-04-07 | Novo Nordisk Femcare Ag | Improved stability of progestogen formulations |
DE602004017045D1 (de) | 2003-11-14 | 2008-11-20 | Warner Chilcott Co Inc | Graduierte östrogen-kontrazeptiva |
UY29185A1 (es) * | 2004-11-02 | 2006-05-31 | Schering Ag | Formas de dosificación oral sólidas que contienen una dosis baja de estradiol |
UY29527A1 (es) | 2005-05-13 | 2006-12-29 | Schering Ag | Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato. |
US8475838B2 (en) | 2005-06-03 | 2013-07-02 | Sandoz Ag | Rapidly-dissolving pharmaceutical composition for inhibiting ovulation |
CN101489563A (zh) * | 2006-07-06 | 2009-07-22 | 拜耳先灵医药股份有限公司 | 用于避孕和预防先天性畸形风险的药物制剂 |
BRPI0810049A2 (pt) | 2007-04-05 | 2015-05-05 | Bayer Schering Pharma Ag | Regime de drospirenona/17beta-estradiol, produto de combinação farmacêutica e kit para realizar esse regime |
US20090045024A1 (en) | 2007-08-13 | 2009-02-19 | Means Industries, Inc. | Overrunning Radial Coupling Assembly Having Dual Bearing Support |
WO2009112232A2 (en) * | 2008-03-10 | 2009-09-17 | Vladimir Hanes | New drospirenone/17beta-estradiol regimen, pharmaceutical combination product and kit for performing this regimen |
WO2009138224A1 (en) | 2008-05-14 | 2009-11-19 | Helm Ag | Pharmaceutical composition comprising drospirenone |
-
2011
- 2011-04-12 EA EA201201403A patent/EA026095B1/ru not_active IP Right Cessation
- 2011-04-12 US US13/641,419 patent/US20130137664A1/en not_active Abandoned
- 2011-04-12 BR BR112012026115A patent/BR112012026115B1/pt active IP Right Grant
- 2011-04-12 AU AU2011240102A patent/AU2011240102B2/en not_active Ceased
- 2011-04-12 KR KR1020187003598A patent/KR20180018827A/ko not_active Application Discontinuation
- 2011-04-12 JP JP2013504242A patent/JP5820465B2/ja active Active
- 2011-04-12 MX MX2012012026A patent/MX356702B/es active IP Right Grant
- 2011-04-12 KR KR1020127029796A patent/KR20130097073A/ko active Application Filing
- 2011-04-12 WO PCT/EP2011/055716 patent/WO2011128336A1/en active Application Filing
- 2011-04-12 EP EP11714967.4A patent/EP2558063B1/en active Active
- 2011-04-12 CN CN2011800282252A patent/CN102985070A/zh active Pending
- 2011-04-12 CA CA2795801A patent/CA2795801C/en active Active
- 2011-04-14 TW TW100113034A patent/TWI519300B/zh not_active IP Right Cessation
- 2011-04-15 AR ARP110101302A patent/AR080912A1/es unknown
- 2011-04-15 UY UY0001033343A patent/UY33343A/es not_active Application Discontinuation
- 2011-04-15 US US13/087,701 patent/US8906890B2/en active Active
-
2012
- 2012-10-11 IL IL222353A patent/IL222353A0/en unknown
- 2012-10-12 CO CO12180903A patent/CO6630107A2/es not_active Application Discontinuation
- 2012-10-15 GT GT201200281A patent/GT201200281A/es unknown
- 2012-10-16 CR CR20120523A patent/CR20120523A/es unknown
-
2014
- 2014-12-08 US US14/564,076 patent/US9592245B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
AU2011240102B2 (en) | 2015-07-23 |
GT201200281A (es) | 2014-11-26 |
MX2012012026A (es) | 2013-01-22 |
CA2795801A1 (en) | 2011-10-20 |
US20110275601A1 (en) | 2011-11-10 |
CN102985070A (zh) | 2013-03-20 |
EA201201403A1 (ru) | 2013-04-30 |
US8906890B2 (en) | 2014-12-09 |
JP5820465B2 (ja) | 2015-11-24 |
AU2011240102A1 (en) | 2012-11-01 |
EP2558063B1 (en) | 2021-09-29 |
JP2013523860A (ja) | 2013-06-17 |
EA026095B1 (ru) | 2017-03-31 |
MX356702B (es) | 2018-06-11 |
EP2558063A1 (en) | 2013-02-20 |
US9592245B2 (en) | 2017-03-14 |
UY33343A (es) | 2011-12-01 |
AR080912A1 (es) | 2012-05-16 |
BR112012026115A2 (pt) | 2016-06-28 |
TW201204368A (en) | 2012-02-01 |
KR20130097073A (ko) | 2013-09-02 |
IL222353A0 (en) | 2012-12-31 |
US20150094287A1 (en) | 2015-04-02 |
CA2795801C (en) | 2018-05-29 |
WO2011128336A1 (en) | 2011-10-20 |
BR112012026115B1 (pt) | 2019-12-24 |
US20130137664A1 (en) | 2013-05-30 |
CR20120523A (es) | 2013-01-09 |
TWI519300B (zh) | 2016-02-01 |
KR20180018827A (ko) | 2018-02-21 |
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