JP2013520681A - 質量スペクトル分析を用いた、治療薬投与のための癌患者のセレクション - Google Patents
質量スペクトル分析を用いた、治療薬投与のための癌患者のセレクション Download PDFInfo
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| JP2014505257A (ja) * | 2011-01-28 | 2014-02-27 | バイオデシックス・インコーポレイテッド | ホルモン療法および組み合わせ療法のための転移性乳癌患者の選択の予測試験 |
| JP2014514579A (ja) * | 2011-04-29 | 2014-06-19 | セルジーン コーポレイション | セレブロンを予測因子として使用する癌及び炎症性疾患の治療方法 |
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| WO2013180818A2 (en) | 2012-05-29 | 2013-12-05 | Biodesix, Inc. | Deep-maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof |
| SG11201408652SA (en) | 2012-06-26 | 2015-01-29 | Biodesix Inc | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| WO2014007859A1 (en) * | 2012-07-05 | 2014-01-09 | Biodesix, Inc. | Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents |
| US9211314B2 (en) | 2014-04-04 | 2015-12-15 | Biodesix, Inc. | Treatment selection for lung cancer patients using mass spectrum of blood-based sample |
| WO2015157109A1 (en) * | 2014-04-08 | 2015-10-15 | Biodesix, Inc. | Egfr and hgf inhibitor therapy for lung cancer |
| WO2016054031A1 (en) * | 2014-10-02 | 2016-04-07 | Biodesix, Inc. | Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample |
| US11594403B1 (en) | 2014-12-03 | 2023-02-28 | Biodesix Inc. | Predictive test for prognosis of myelodysplastic syndrome patients using mass spectrometry of blood-based sample |
| US10037874B2 (en) | 2014-12-03 | 2018-07-31 | Biodesix, Inc. | Early detection of hepatocellular carcinoma in high risk populations using MALDI-TOF mass spectrometry |
| US11152197B2 (en) * | 2015-06-24 | 2021-10-19 | City University Of Hong Kong | Method of determining cell cycle stage distribution of cells |
| CN112710723B (zh) * | 2015-07-13 | 2024-11-12 | 佰欧迪塞克斯公司 | 受益于pd-1抗体药物的肺癌患者的预测性测试和分类器开发方法 |
| US11710539B2 (en) | 2016-02-01 | 2023-07-25 | Biodesix, Inc. | Predictive test for melanoma patient benefit from interleukin-2 (IL2) therapy |
| CN106596824A (zh) * | 2016-12-30 | 2017-04-26 | 广州中大南沙科技创新产业园有限公司 | 一种lc‑ms/ms法检测血浆中沙利度胺的方法 |
| CN110383069A (zh) | 2017-01-05 | 2019-10-25 | 佰欧迪塞克斯公司 | 用于鉴定总体不良预后亚组中持久受益于免疫疗法的癌症患者的方法 |
| CN109212042B (zh) * | 2017-06-30 | 2022-03-04 | 齐鲁制药有限公司 | 一种采用液质联用法测定盐酸培唑帕尼基因毒性杂质的分析方法 |
| KR102633621B1 (ko) | 2017-09-01 | 2024-02-05 | 벤 바이오사이언시스 코포레이션 | 진단 및 치료 모니터링용 바이오마커로서의 당펩티드의 식별 및 용도 |
| EP3724885A2 (en) | 2017-12-15 | 2020-10-21 | Iovance Biotherapeutics, Inc. | Systems and methods for determining the beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof and beneficial administration of tumor infiltrating lymphocytes, and methods of use thereof |
| WO2019190732A1 (en) * | 2018-03-29 | 2019-10-03 | Biodesix, Inc. | Apparatus and method for identification of primary immune resistance in cancer patients |
| WO2020019095A1 (es) * | 2018-07-26 | 2020-01-30 | Universidad Católica Del Maule | Proteína rage (receptor de productos finales de glicacíon avanzada) como biomarcador de sensibilidad tumoral y evaluacion de terapia radiologica y radiomimética |
| CN119139478A (zh) * | 2024-10-11 | 2024-12-17 | 首都医科大学附属北京胸科医院 | 一种治疗anxa6+egfr突变的肺腺癌的组合物 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008057305A2 (en) * | 2006-10-27 | 2008-05-15 | George Mason Intellectual Properties, Inc. | Assay for metastatic colorectal cancer |
| JP2009532673A (ja) * | 2006-03-31 | 2009-09-10 | バイオデシックス・インコーポレイテッド | 疾患を有する患者に薬物が有効かどうかを決定するための方法およびシステム |
| JP2011513728A (ja) * | 2009-01-20 | 2011-04-28 | バイオデシックス・インコーポレイテッド | Ｅｇｆｒ経路を標的化する薬物による治療のための頭頸部癌患者の選択 |
| JP2012507033A (ja) * | 2009-01-20 | 2012-03-22 | バイオデシックス・インコーポレイテッド | Ｅｇｆｒ経路を標的にする薬物による治療のための結腸直腸癌患者の選択 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4802102A (en) * | 1987-07-15 | 1989-01-31 | Hewlett-Packard Company | Baseline correction for chromatography |
| US5291426A (en) * | 1991-02-27 | 1994-03-01 | The Perkin-Elmer Corporation | Method of correcting spectral data for background |
| ES2070739B1 (es) * | 1993-04-30 | 1997-06-01 | Alcatel Standard Electrica | Dispositivo de conversion de interfaces. |
| US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
| US6017693A (en) * | 1994-03-14 | 2000-01-25 | University Of Washington | Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry |
| US5672869A (en) * | 1996-04-03 | 1997-09-30 | Eastman Kodak Company | Noise and background reduction method for component detection in chromatography/spectrometry |
| US6253162B1 (en) * | 1999-04-07 | 2001-06-26 | Battelle Memorial Institute | Method of identifying features in indexed data |
| IL153189A0 (en) * | 2000-06-19 | 2003-06-24 | Correlogic Systems Inc | Heuristic method of classification |
| CA2414610A1 (en) * | 2000-07-13 | 2002-01-24 | Medi-Physics, Inc. | Diagnostic procedures using 129xe spectroscopy characteristic chemical shift to detect pathology in vivo |
| SG144731A1 (en) * | 2000-07-18 | 2008-08-28 | Correlogic Systems Inc | A process for discriminating between biological states based on hidden patterns from biological data |
| AU2002241535B2 (en) * | 2000-11-16 | 2006-05-18 | Ciphergen Biosystems, Inc. | Method for analyzing mass spectra |
| US20020119490A1 (en) * | 2000-12-26 | 2002-08-29 | Aebersold Ruedi H. | Methods for rapid and quantitative proteome analysis |
| US20020115056A1 (en) * | 2000-12-26 | 2002-08-22 | Goodlett David R. | Rapid and quantitative proteome analysis and related methods |
| US6829539B2 (en) * | 2001-04-13 | 2004-12-07 | The Institute For Systems Biology | Methods for quantification and de novo polypeptide sequencing by mass spectrometry |
| US6849121B1 (en) * | 2001-04-24 | 2005-02-01 | The United States Of America As Represented By The Secretary Of The Air Force | Growth of uniform crystals |
| US7314717B2 (en) * | 2001-04-30 | 2008-01-01 | Nanogen Inc. | Biopolymer marker indicative of disease state having a molecular weight of 1562 daltons |
| US7113896B2 (en) * | 2001-05-11 | 2006-09-26 | Zhen Zhang | System and methods for processing biological expression data |
| US6675106B1 (en) * | 2001-06-01 | 2004-01-06 | Sandia Corporation | Method of multivariate spectral analysis |
| US7112408B2 (en) * | 2001-06-08 | 2006-09-26 | The Brigham And Women's Hospital, Inc. | Detection of ovarian cancer based upon alpha-haptoglobin levels |
| WO2003006951A2 (en) * | 2001-07-13 | 2003-01-23 | Syngenta Participations Ag | System and method of determining proteomic differences |
| US7016884B2 (en) * | 2002-06-27 | 2006-03-21 | Microsoft Corporation | Probability estimate for K-nearest neighbor |
| WO2004019003A2 (en) * | 2002-08-23 | 2004-03-04 | Efeckta Technologies Corporation | Image processing of mass spectrometry data for using at multiple resolutions |
| US20040147428A1 (en) * | 2002-11-15 | 2004-07-29 | Pluenneke John D. | Methods of treatment using an inhibitor of epidermal growth factor receptor |
| US6906320B2 (en) * | 2003-04-02 | 2005-06-14 | Merck & Co., Inc. | Mass spectrometry data analysis techniques |
| JP2007506442A (ja) * | 2003-05-30 | 2007-03-22 | ゲノミック ヘルス， インコーポレイテッド | Ｅｇｆｒ阻害薬への応答に関する遺伝子発現マーカー |
| US20050267689A1 (en) * | 2003-07-07 | 2005-12-01 | Maxim Tsypin | Method to automatically identify peak and monoisotopic peaks in mass spectral data for biomolecular applications |
| US20050048547A1 (en) * | 2003-07-17 | 2005-03-03 | Hongyu Zhao | Classification of disease states using mass spectrometry data |
| SG145705A1 (en) * | 2003-08-01 | 2008-09-29 | Correlogic Systems Inc | Multiple high-resolution serum proteomic features for ovarian cancer detection |
| EP1709442A4 (en) * | 2003-12-11 | 2010-01-20 | Correlogic Systems Inc | METHOD FOR DIAGNOSING BIOLOGICAL CONDITIONS BY USING A CENTRALIZED ADAPTIVE MODEL AND SAMPLE PREPARATION |
| ES2244326B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
| JP2008501654A (ja) * | 2004-06-03 | 2008-01-24 | エフ．ホフマン−ラ ロシュ アーゲー | シスプラチンとｅｇｆｒ阻害剤を用いた治療 |
| US20060029574A1 (en) * | 2004-08-06 | 2006-02-09 | Board Of Regents, The University Of Texas System | Biomarkers for diagnosis, prognosis, monitoring, and treatment decisions for drug resistance and sensitivity |
| SI1948180T1 (sl) * | 2005-11-11 | 2013-06-28 | Boehringer Ingelheim International Gmbh | Kombinacijsko zdravljenje raka, ki obsega EGFR/HER2 inhibitorje |
| US7858389B2 (en) * | 2006-03-31 | 2010-12-28 | Biodesix, Inc. | Selection of non-small-cell lung cancer patients for treatment with monoclonal antibody drugs targeting EGFR pathway |
| US7906342B2 (en) * | 2006-03-31 | 2011-03-15 | Biodesix, Inc. | Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples |
| CN101201355A (zh) * | 2006-12-15 | 2008-06-18 | 许洋 | 免疫组质谱检测个体化肿瘤生物标志及疗效试剂盒和方法 |
| ES2412432T3 (es) * | 2007-02-27 | 2013-07-11 | Nuclea Biomarkers Llc | Método para predecir la respuesta de pacientes de nsclc al tratamiento mediante un inhibidor de egfr-tk |
| CN101329346A (zh) * | 2007-06-18 | 2008-12-24 | 许洋 | 检测乳腺癌特征蛋白的优化质谱模型及其制备方法和应用 |
| WO2009036123A1 (en) * | 2007-09-11 | 2009-03-19 | Cancer Prevention And Cure, Ltd. | Method of identifying biomarkers in human serum indicative of pathologies of human lung tissues |
| CN101836991B (zh) * | 2009-03-19 | 2013-05-22 | 鼎泓国际投资（香港）有限公司 | 含有索拉非尼、cMet抑制剂与EGFR酪氨酸激酶抑制剂的药物组合物及其应用 |
| WO2014007859A1 (en) * | 2012-07-05 | 2014-01-09 | Biodesix, Inc. | Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents |
-
2011
- 2011-02-22 AU AU2011219069A patent/AU2011219069C1/en not_active Ceased
- 2011-02-22 US US12/932,295 patent/US20110208433A1/en not_active Abandoned
- 2011-02-22 KR KR1020127024976A patent/KR101556726B1/ko not_active Expired - Fee Related
- 2011-02-22 CN CN2011800110326A patent/CN102770760A/zh active Pending
- 2011-02-22 WO PCT/US2011/000323 patent/WO2011106084A1/en not_active Ceased
- 2011-02-22 JP JP2012555001A patent/JP2013520681A/ja not_active Withdrawn
- 2011-02-22 EP EP11747809.9A patent/EP2539704A4/en not_active Withdrawn
- 2011-02-22 CA CA2790928A patent/CA2790928A1/en not_active Abandoned
- 2011-02-24 TW TW100106286A patent/TW201142292A/zh unknown
-
2014
- 2014-05-19 AU AU2014202716A patent/AU2014202716B2/en not_active Expired - Fee Related
- 2014-06-04 US US14/295,783 patent/US20140284468A1/en not_active Abandoned
-
2015
- 2015-06-17 JP JP2015121648A patent/JP2015222257A/ja not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009532673A (ja) * | 2006-03-31 | 2009-09-10 | バイオデシックス・インコーポレイテッド | 疾患を有する患者に薬物が有効かどうかを決定するための方法およびシステム |
| WO2008057305A2 (en) * | 2006-10-27 | 2008-05-15 | George Mason Intellectual Properties, Inc. | Assay for metastatic colorectal cancer |
| JP2011513728A (ja) * | 2009-01-20 | 2011-04-28 | バイオデシックス・インコーポレイテッド | Ｅｇｆｒ経路を標的化する薬物による治療のための頭頸部癌患者の選択 |
| JP2012507033A (ja) * | 2009-01-20 | 2012-03-22 | バイオデシックス・インコーポレイテッド | Ｅｇｆｒ経路を標的にする薬物による治療のための結腸直腸癌患者の選択 |
Non-Patent Citations (1)
| Title |
|---|
| JPN5013003688; ＴＡＧＵＣＨＩ Ｆ ｅｔ ａｌ．: 'Ｍａｓｓ Ｓｐｅｃｔｒｏｍｅｔｒｙ ｔｏ Ｃｌａｓｓｉｆｙ Ｎｏｎ-Ｓｍａｌｌ-Ｃｅｌｌ Ｌｕｎｇ Ｃａｎｃｅｒ Ｐａｔｉｅｎｔｓ ｆｏｒ Ｃｌｉｎｉｃａｌ Ｏｕｔｃｏｍｅ Ａｆｔｅｒ Ｔｒｅａｔｍｅ' Ｊ． Ｎａｔｌ． Ｃａｎｃｅｒ Ｉｎｓｔ． Ｖｏｌ．９９， Ｉｓｓｕｅ １１, 20070606, ｐｐ．８３８-８４６ * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014505257A (ja) * | 2011-01-28 | 2014-02-27 | バイオデシックス・インコーポレイテッド | ホルモン療法および組み合わせ療法のための転移性乳癌患者の選択の予測試験 |
| JP2014514579A (ja) * | 2011-04-29 | 2014-06-19 | セルジーン コーポレイション | セレブロンを予測因子として使用する癌及び炎症性疾患の治療方法 |
| JP2017037081A (ja) * | 2011-04-29 | 2017-02-16 | セルジーン コーポレイション | セレブロンを予測因子として使用する癌及び炎症性疾患の治療方法 |
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| AU2011219069A1 (en) | 2012-09-13 |
| US20140284468A1 (en) | 2014-09-25 |
| KR101556726B1 (ko) | 2015-10-02 |
| EP2539704A4 (en) | 2015-12-02 |
| EP2539704A1 (en) | 2013-01-02 |
| US20110208433A1 (en) | 2011-08-25 |
| CA2790928A1 (en) | 2011-09-01 |
| JP2015222257A (ja) | 2015-12-10 |
| AU2014202716B2 (en) | 2016-02-25 |
| AU2011219069C1 (en) | 2014-07-17 |
| WO2011106084A1 (en) | 2011-09-01 |
| AU2014202716A1 (en) | 2014-06-12 |
| CN102770760A (zh) | 2012-11-07 |
| TW201142292A (en) | 2011-12-01 |
| KR20130004309A (ko) | 2013-01-09 |
| AU2011219069B2 (en) | 2014-02-20 |
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