JP2013520681A5 - - Google Patents
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- JP2013520681A5 JP2013520681A5 JP2012555001A JP2012555001A JP2013520681A5 JP 2013520681 A5 JP2013520681 A5 JP 2013520681A5 JP 2012555001 A JP2012555001 A JP 2012555001A JP 2012555001 A JP2012555001 A JP 2012555001A JP 2013520681 A5 JP2013520681 A5 JP 2013520681A5
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- JP
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- Prior art keywords
- patient
- mass spectrum
- treatment
- combination
- predetermined
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 24
- 238000000034 method Methods 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 17
- 238000001819 mass spectrum Methods 0.000 claims 16
- 229940124597 therapeutic agent Drugs 0.000 claims 16
- 238000011282 treatment Methods 0.000 claims 16
- 201000011510 cancer Diseases 0.000 claims 14
- 239000008280 blood Substances 0.000 claims 10
- 210000004369 blood Anatomy 0.000 claims 10
- 229940111134 coxibs Drugs 0.000 claims 10
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 10
- 238000001228 spectrum Methods 0.000 claims 8
- 238000007635 classification algorithm Methods 0.000 claims 7
- 102000003923 Protein Kinase C Human genes 0.000 claims 6
- 108090000315 Protein Kinase C Proteins 0.000 claims 6
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 6
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 6
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 6
- 229940121647 egfr inhibitor Drugs 0.000 claims 4
- 102000043136 MAP kinase family Human genes 0.000 claims 3
- 108091054455 MAP kinase family Proteins 0.000 claims 3
- 102000005962 receptors Human genes 0.000 claims 3
- 108020003175 receptors Proteins 0.000 claims 3
- FAWLNURBQMTKEB-URDPEVQOSA-N 213546-53-3 Chemical compound N([C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(O)=O)C(C)C)C(C)C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(C)C FAWLNURBQMTKEB-URDPEVQOSA-N 0.000 claims 2
- 108091007960 PI3Ks Proteins 0.000 claims 2
- 102000038030 PI3Ks Human genes 0.000 claims 2
- 229960000590 celecoxib Drugs 0.000 claims 2
- RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 claims 2
- 230000017128 negative regulation of NF-kappaB transcription factor activity Effects 0.000 claims 2
- 230000037361 pathway Effects 0.000 claims 2
- 229960000371 rofecoxib Drugs 0.000 claims 2
- RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 claims 2
- 230000008685 targeting Effects 0.000 claims 2
- 238000011144 upstream manufacturing Methods 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 229940124638 COX inhibitor Drugs 0.000 claims 1
- 102000001301 EGF receptor Human genes 0.000 claims 1
- 108060006698 EGF receptor Proteins 0.000 claims 1
- 239000000556 agonist Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 230000018883 protein targeting Effects 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33893810P | 2010-02-24 | 2010-02-24 | |
| US61/338,938 | 2010-02-24 | ||
| PCT/US2011/000323 WO2011106084A1 (en) | 2010-02-24 | 2011-02-22 | Cancer patient selection for administration of therapeutic agents using mass spectral analysis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015121648A Division JP2015222257A (ja) | 2010-02-24 | 2015-06-17 | 質量スペクトル分析を用いた、治療薬投与のための癌患者のセレクション |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013520681A JP2013520681A (ja) | 2013-06-06 |
| JP2013520681A5 true JP2013520681A5 (enExample) | 2014-05-08 |
Family
ID=44477214
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012555001A Withdrawn JP2013520681A (ja) | 2010-02-24 | 2011-02-22 | 質量スペクトル分析を用いた、治療薬投与のための癌患者のセレクション |
| JP2015121648A Withdrawn JP2015222257A (ja) | 2010-02-24 | 2015-06-17 | 質量スペクトル分析を用いた、治療薬投与のための癌患者のセレクション |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015121648A Withdrawn JP2015222257A (ja) | 2010-02-24 | 2015-06-17 | 質量スペクトル分析を用いた、治療薬投与のための癌患者のセレクション |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20110208433A1 (enExample) |
| EP (1) | EP2539704A4 (enExample) |
| JP (2) | JP2013520681A (enExample) |
| KR (1) | KR101556726B1 (enExample) |
| CN (1) | CN102770760A (enExample) |
| AU (2) | AU2011219069C1 (enExample) |
| CA (1) | CA2790928A1 (enExample) |
| TW (1) | TW201142292A (enExample) |
| WO (1) | WO2011106084A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012102829A1 (en) * | 2011-01-28 | 2012-08-02 | Biodesix, Inc. | Predictive test for selection of metastatic breast cancer patients for hormonal and combination therapy |
| EP3096142A3 (en) * | 2011-04-29 | 2017-03-08 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| WO2013180818A2 (en) | 2012-05-29 | 2013-12-05 | Biodesix, Inc. | Deep-maldi tof mass spectrometry of complex biological samples, e.g., serum, and uses thereof |
| SG11201408652SA (en) | 2012-06-26 | 2015-01-29 | Biodesix Inc | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| US8718996B2 (en) | 2012-07-05 | 2014-05-06 | Biodesix, Inc. | Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents |
| US9211314B2 (en) | 2014-04-04 | 2015-12-15 | Biodesix, Inc. | Treatment selection for lung cancer patients using mass spectrum of blood-based sample |
| US20150285817A1 (en) * | 2014-04-08 | 2015-10-08 | Biodesix, Inc. | Method for treating and identifying lung cancer patients likely to benefit from EGFR inhibitor and a monoclonal antibody HGF inhibitor combination therapy |
| US9779204B2 (en) | 2014-10-02 | 2017-10-03 | Biodesix, Inc. | Predictive test for aggressiveness or indolence of prostate cancer from mass spectrometry of blood-based sample |
| US11594403B1 (en) | 2014-12-03 | 2023-02-28 | Biodesix Inc. | Predictive test for prognosis of myelodysplastic syndrome patients using mass spectrometry of blood-based sample |
| TW201621315A (zh) | 2014-12-03 | 2016-06-16 | 拜歐迪希克斯公司 | 使用ｍａｌｄｉ－ｔｏｆ質譜分析以早期偵測高風險群中之肝細胞癌 |
| US11152197B2 (en) * | 2015-06-24 | 2021-10-19 | City University Of Hong Kong | Method of determining cell cycle stage distribution of cells |
| US10007766B2 (en) | 2015-07-13 | 2018-06-26 | Biodesix, Inc. | Predictive test for melanoma patient benefit from antibody drug blocking ligand activation of the T-cell programmed cell death 1 (PD-1) checkpoint protein and classifier development methods |
| US11710539B2 (en) | 2016-02-01 | 2023-07-25 | Biodesix, Inc. | Predictive test for melanoma patient benefit from interleukin-2 (IL2) therapy |
| CN106596824A (zh) * | 2016-12-30 | 2017-04-26 | 广州中大南沙科技创新产业园有限公司 | 一种lc‑ms/ms法检测血浆中沙利度胺的方法 |
| CN110383069A (zh) | 2017-01-05 | 2019-10-25 | 佰欧迪塞克斯公司 | 用于鉴定总体不良预后亚组中持久受益于免疫疗法的癌症患者的方法 |
| CN109212042B (zh) * | 2017-06-30 | 2022-03-04 | 齐鲁制药有限公司 | 一种采用液质联用法测定盐酸培唑帕尼基因毒性杂质的分析方法 |
| AU2018324195B2 (en) | 2017-09-01 | 2024-12-12 | Venn Biosciences Corporation | Identification and use of glycopeptides as biomarkers for diagnosis and treatment monitoring |
| JP7565795B2 (ja) | 2017-12-15 | 2024-10-11 | アイオバンス バイオセラピューティクス，インコーポレイテッド | 腫瘍浸潤リンパ球の有益な投与を決定するシステム及び方法並びにその使用方法、並びに腫瘍浸潤リンパ球の有益な投与及びその使用方法 |
| US12094587B2 (en) * | 2018-03-29 | 2024-09-17 | Biodesix, Inc. | Apparatus and method for identification of primary immune resistance in cancer patients |
| WO2020019095A1 (es) * | 2018-07-26 | 2020-01-30 | Universidad Católica Del Maule | Proteína rage (receptor de productos finales de glicacíon avanzada) como biomarcador de sensibilidad tumoral y evaluacion de terapia radiologica y radiomimética |
| CN119139478A (zh) * | 2024-10-11 | 2024-12-17 | 首都医科大学附属北京胸科医院 | 一种治疗anxa6+egfr突变的肺腺癌的组合物 |
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| US20030108545A1 (en) * | 1994-02-10 | 2003-06-12 | Patricia Rockwell | Combination methods of inhibiting tumor growth with a vascular endothelial growth factor receptor antagonist |
| US5538897A (en) * | 1994-03-14 | 1996-07-23 | University Of Washington | Use of mass spectrometry fragmentation patterns of peptides to identify amino acid sequences in databases |
| US5672869A (en) * | 1996-04-03 | 1997-09-30 | Eastman Kodak Company | Noise and background reduction method for component detection in chromatography/spectrometry |
| US6253162B1 (en) * | 1999-04-07 | 2001-06-26 | Battelle Memorial Institute | Method of identifying features in indexed data |
| ATE406627T1 (de) * | 2000-06-19 | 2008-09-15 | Correlogic Systems Inc | Heuristisches klassifikationsverfahren |
| US6696040B2 (en) * | 2000-07-13 | 2004-02-24 | Medi-Physics, Inc. | Diagnostic procedures using 129Xe spectroscopy characteristic chemical shift to detect pathology in vivo |
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| RU2006146612A (ru) * | 2004-06-03 | 2008-07-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Лечение цисплатином и ингибитором рецептора эпидермального фактора роста (egfr) |
| US20060029574A1 (en) * | 2004-08-06 | 2006-02-09 | Board Of Regents, The University Of Texas System | Biomarkers for diagnosis, prognosis, monitoring, and treatment decisions for drug resistance and sensitivity |
| PL1948180T3 (pl) * | 2005-11-11 | 2013-09-30 | Boehringer Ingelheim Int | Terapia skojarzona raka polegająca na podawaniu inhibitorów EGFR/HER2 |
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| US20080206777A1 (en) * | 2007-02-27 | 2008-08-28 | Nuclea Biomarkers, Llc | Gene and protein expression profiles associated with the therapeutic efficacy of EGFR-TK inhibitors |
| CN101329346A (zh) * | 2007-06-18 | 2008-12-24 | 许洋 | 检测乳腺癌特征蛋白的优化质谱模型及其制备方法和应用 |
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| CN101836991B (zh) * | 2009-03-19 | 2013-05-22 | 鼎泓国际投资（香港）有限公司 | 含有索拉非尼、cMet抑制剂与EGFR酪氨酸激酶抑制剂的药物组合物及其应用 |
| US8718996B2 (en) * | 2012-07-05 | 2014-05-06 | Biodesix, Inc. | Method for predicting whether a cancer patient will not benefit from platinum-based chemotherapy agents |
-
2011
- 2011-02-22 WO PCT/US2011/000323 patent/WO2011106084A1/en not_active Ceased
- 2011-02-22 EP EP11747809.9A patent/EP2539704A4/en not_active Withdrawn
- 2011-02-22 US US12/932,295 patent/US20110208433A1/en not_active Abandoned
- 2011-02-22 CN CN2011800110326A patent/CN102770760A/zh active Pending
- 2011-02-22 AU AU2011219069A patent/AU2011219069C1/en not_active Ceased
- 2011-02-22 JP JP2012555001A patent/JP2013520681A/ja not_active Withdrawn
- 2011-02-22 CA CA2790928A patent/CA2790928A1/en not_active Abandoned
- 2011-02-22 KR KR1020127024976A patent/KR101556726B1/ko not_active Expired - Fee Related
- 2011-02-24 TW TW100106286A patent/TW201142292A/zh unknown
-
2014
- 2014-05-19 AU AU2014202716A patent/AU2014202716B2/en not_active Expired - Fee Related
- 2014-06-04 US US14/295,783 patent/US20140284468A1/en not_active Abandoned
-
2015
- 2015-06-17 JP JP2015121648A patent/JP2015222257A/ja not_active Withdrawn
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