JP2013519717A5 - - Google Patents
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- Publication number
- JP2013519717A5 JP2013519717A5 JP2012553390A JP2012553390A JP2013519717A5 JP 2013519717 A5 JP2013519717 A5 JP 2013519717A5 JP 2012553390 A JP2012553390 A JP 2012553390A JP 2012553390 A JP2012553390 A JP 2012553390A JP 2013519717 A5 JP2013519717 A5 JP 2013519717A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- variant
- composition
- bir01i
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims description 68
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 55
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims 21
- 210000001744 T-lymphocyte Anatomy 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 2
- 239000004475 Arginine Substances 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 101000614700 Rattus norvegicus ATP-sensitive inward rectifier potassium channel 10 Proteins 0.000 claims 1
- 101000614706 Rattus norvegicus Inward rectifier potassium channel 4 Proteins 0.000 claims 1
- 206010048908 Seasonal allergy Diseases 0.000 claims 1
- 230000021736 acetylation Effects 0.000 claims 1
- 238000006640 acetylation reaction Methods 0.000 claims 1
- 230000009435 amidation Effects 0.000 claims 1
- 238000007112 amidation reaction Methods 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000013595 glycosylation Effects 0.000 claims 1
- 238000006206 glycosylation reaction Methods 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000026731 phosphorylation Effects 0.000 claims 1
- 238000006366 phosphorylation reaction Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 239000013566 allergen Substances 0.000 description 30
- 235000018185 Betula X alpestris Nutrition 0.000 description 4
- 235000018212 Betula X uliginosa Nutrition 0.000 description 4
- 239000000428 dust Substances 0.000 description 3
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 2
- 241000223600 Alternaria Species 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000223218 Fusarium Species 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 241000441510 Hormodendrum Species 0.000 description 2
- 102100037611 Lysophospholipase Human genes 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 102000007079 Peptide Fragments Human genes 0.000 description 2
- 108010033276 Peptide Fragments Proteins 0.000 description 2
- 108010058864 Phospholipases A2 Proteins 0.000 description 2
- 244000305267 Quercus macrolepis Species 0.000 description 2
- 239000003659 bee venom Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000013568 food allergen Substances 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000208140 Acer Species 0.000 description 1
- 241000186361 Actinobacteria <class> Species 0.000 description 1
- 244000036975 Ambrosia artemisiifolia Species 0.000 description 1
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 description 1
- 240000002470 Amphicarpaea bracteata Species 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 241000228212 Aspergillus Species 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 241001164374 Calyx Species 0.000 description 1
- 241000723418 Carya Species 0.000 description 1
- 244000068645 Carya illinoensis Species 0.000 description 1
- 235000009025 Carya illinoensis Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 108010068370 Glutens Proteins 0.000 description 1
- 241000235395 Mucor Species 0.000 description 1
- 241000187654 Nocardia Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 244000134552 Plantago ovata Species 0.000 description 1
- 235000003421 Plantago ovata Nutrition 0.000 description 1
- 241000209504 Poaceae Species 0.000 description 1
- 241000219000 Populus Species 0.000 description 1
- 239000009223 Psyllium Substances 0.000 description 1
- 244000137827 Rumex acetosa Species 0.000 description 1
- 235000005291 Rumex acetosa Nutrition 0.000 description 1
- 241000779819 Syncarpia glomulifera Species 0.000 description 1
- 244000204900 Talipariti tiliaceum Species 0.000 description 1
- 239000004098 Tetracycline Substances 0.000 description 1
- 241000159243 Toxicodendron radicans Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 241001106462 Ulmus Species 0.000 description 1
- 235000009108 Urtica dioica Nutrition 0.000 description 1
- 241000218215 Urticaceae Species 0.000 description 1
- 235000005072 Vigna sesquipedalis Nutrition 0.000 description 1
- 244000090207 Vigna sesquipedalis Species 0.000 description 1
- 235000003484 annual ragweed Nutrition 0.000 description 1
- 239000003319 ant venom Substances 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 235000006263 bur ragweed Nutrition 0.000 description 1
- -1 but not limited to Substances 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 235000003488 common ragweed Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 235000013365 dairy product Nutrition 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 210000003746 feather Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000021312 gluten Nutrition 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000021278 navy bean Nutrition 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 235000014571 nuts Nutrition 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
- 239000001739 pinus spp. Substances 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- 235000009736 ragweed Nutrition 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 235000015170 shellfish Nutrition 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 229960002180 tetracycline Drugs 0.000 description 1
- 229930101283 tetracycline Natural products 0.000 description 1
- 235000019364 tetracycline Nutrition 0.000 description 1
- 150000003522 tetracyclines Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 229950002929 trinitrophenol Drugs 0.000 description 1
- 229940036248 turpentine Drugs 0.000 description 1
- 239000002578 wasp venom Substances 0.000 description 1
- 210000002268 wool Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1002559.1A GB201002559D0 (en) | 2010-02-15 | 2010-02-15 | Birch peptides for vaccine |
| GB1002559.1 | 2010-02-15 | ||
| PCT/GB2011/000206 WO2011098778A2 (en) | 2010-02-15 | 2011-02-15 | Peptides for vaccines against birch allergy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016042511A Division JP2016166194A (ja) | 2010-02-15 | 2016-03-04 | カバノキアレルギーに対するワクチン用ペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013519717A JP2013519717A (ja) | 2013-05-30 |
| JP2013519717A5 true JP2013519717A5 (enExample) | 2014-04-03 |
| JP5926198B2 JP5926198B2 (ja) | 2016-05-25 |
Family
ID=42110757
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012553390A Expired - Fee Related JP5926198B2 (ja) | 2010-02-15 | 2011-02-15 | カバノキアレルギーに対するワクチン用ペプチド |
| JP2016042511A Pending JP2016166194A (ja) | 2010-02-15 | 2016-03-04 | カバノキアレルギーに対するワクチン用ペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016042511A Pending JP2016166194A (ja) | 2010-02-15 | 2016-03-04 | カバノキアレルギーに対するワクチン用ペプチド |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US9017689B2 (enExample) |
| EP (2) | EP3056213A1 (enExample) |
| JP (2) | JP5926198B2 (enExample) |
| KR (1) | KR20120120965A (enExample) |
| CN (1) | CN102762225B (enExample) |
| AU (1) | AU2011214104B2 (enExample) |
| CA (2) | CA3139588A1 (enExample) |
| DK (1) | DK2536429T3 (enExample) |
| EA (1) | EA201290792A1 (enExample) |
| ES (1) | ES2573651T3 (enExample) |
| GB (2) | GB201002559D0 (enExample) |
| HR (1) | HRP20160481T1 (enExample) |
| HU (1) | HUE029138T2 (enExample) |
| IL (1) | IL221196A0 (enExample) |
| MX (1) | MX2012009431A (enExample) |
| NZ (1) | NZ602380A (enExample) |
| PL (1) | PL2536429T3 (enExample) |
| SG (1) | SG183198A1 (enExample) |
| SI (1) | SI2536429T1 (enExample) |
| WO (1) | WO2011098778A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201002559D0 (en) * | 2010-02-15 | 2010-03-31 | Circassia Ltd | Birch peptides for vaccine |
| JP2015509487A (ja) * | 2012-02-07 | 2015-03-30 | ラ ホーヤ インスティテュート フォー アレルギー アンド イムノロジーＬａ Ｊｏｌｌａ Ｉｎｓｔｉｔｕｔｅ Ｆｏｒ Ａｌｌｅｒｇｙ Ａｎｄ Ｉｍｍｕｎｏｌｏｇｙ | アレルゲンタンパク質由来のエピトープ並びに免疫応答モジュレーションのための方法及び使用 |
| GB201209862D0 (en) | 2012-06-01 | 2012-07-18 | Circassia Ltd | Cladosporium peptides |
| GB201211586D0 (en) * | 2012-06-29 | 2012-08-15 | Circassia Ltd | Japanese cedar peptides for preventing or treating allergy |
| US20150088644A1 (en) | 2013-09-23 | 2015-03-26 | Facebook, Inc., a Delaware corporation | Predicting User Interactions With Objects Associated With Advertisements On An Online System |
| CN106699584B (zh) * | 2016-12-30 | 2018-06-26 | 南京农业大学 | 一种利用花粉作为天然催化剂制备的γ-氨基丁酸及其制备方法和应用 |
| NZ759513A (en) | 2017-06-01 | 2022-01-28 | Regeneron Pharma | Human antibodies to bet v 1 and methods of use thereof |
| CN110175468B (zh) * | 2019-05-05 | 2020-12-01 | 浙江工业大学 | 一种保留分布特征的姓名脱敏方法 |
| CN115633666B (zh) * | 2021-07-19 | 2025-11-18 | 四川大学华西医院 | 人源化双致敏动物模型和系统性过敏动物模型的构建方法及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| WO1994001560A1 (en) | 1991-07-12 | 1994-01-20 | Immulogic Pharmaceutical Corporation | Allergenic proteins and peptides from japanese cedar pollen |
| US5968526A (en) | 1994-04-14 | 1999-10-19 | Immulogic Pharamaceutical Corporation | T cell epitopes of the major allergens from Dermatophagoides (house dust mite) |
| WO1999034826A1 (en) | 1998-01-09 | 1999-07-15 | Circassia Limited | Methods and compositions for desensitisation |
| FR2788698B1 (fr) | 1999-01-27 | 2001-03-30 | Commissariat Energie Atomique | Peptides et proteines aptes a desensibiliser les sujets allergiques au venin d'abeille et compositions les contenant |
| ES2316632T3 (es) | 2001-12-05 | 2009-04-16 | Circassia Limited | Metodos y sistemas inmunoterapeuticos. |
| PT1403280E (pt) | 2002-09-27 | 2005-11-30 | Biomay Prod & Handel | Vacinas hipoalergenicas baseadas no alergenio ph1 p 7 de polen de capim timoteo |
| US7923209B2 (en) | 2003-03-14 | 2011-04-12 | Anergis, S.A. | Allergen peptide fragments and use thereof |
| ES2425486T3 (es) | 2007-05-09 | 2013-10-15 | Circassia Limited | Análisis de pronóstico para determinar la respuesta de células T a antígenos HLA y uso del mismo en el campo del trasplante de tejidos |
| GB0710529D0 (en) | 2007-06-01 | 2007-07-11 | Circassia Ltd | Vaccine |
| SI2083856T1 (sl) * | 2007-08-15 | 2011-02-28 | Circassia Ltd | Peptidi za desenzibilizacijo proti alergijam |
| US8821887B2 (en) | 2008-08-15 | 2014-09-02 | Circassia Limited | T-cell antigen peptide from allergen for stimulation of IL-10 production |
| GB201002559D0 (en) * | 2010-02-15 | 2010-03-31 | Circassia Ltd | Birch peptides for vaccine |
-
2010
- 2010-02-15 GB GBGB1002559.1A patent/GB201002559D0/en not_active Ceased
-
2011
- 2011-02-15 CA CA3139588A patent/CA3139588A1/en active Pending
- 2011-02-15 CA CA2789353A patent/CA2789353A1/en not_active Abandoned
- 2011-02-15 SI SI201130818A patent/SI2536429T1/sl unknown
- 2011-02-15 GB GB1102657.2A patent/GB2481475B/en not_active Expired - Fee Related
- 2011-02-15 HR HRP20160481TT patent/HRP20160481T1/hr unknown
- 2011-02-15 EP EP15200538.5A patent/EP3056213A1/en not_active Withdrawn
- 2011-02-15 SG SG2012058228A patent/SG183198A1/en unknown
- 2011-02-15 KR KR1020127024247A patent/KR20120120965A/ko not_active Ceased
- 2011-02-15 EA EA201290792A patent/EA201290792A1/ru unknown
- 2011-02-15 NZ NZ602380A patent/NZ602380A/en not_active IP Right Cessation
- 2011-02-15 WO PCT/GB2011/000206 patent/WO2011098778A2/en not_active Ceased
- 2011-02-15 HU HUE11730036A patent/HUE029138T2/hu unknown
- 2011-02-15 CN CN201180009545.3A patent/CN102762225B/zh not_active Expired - Fee Related
- 2011-02-15 JP JP2012553390A patent/JP5926198B2/ja not_active Expired - Fee Related
- 2011-02-15 PL PL11730036.8T patent/PL2536429T3/pl unknown
- 2011-02-15 MX MX2012009431A patent/MX2012009431A/es active IP Right Grant
- 2011-02-15 ES ES11730036.8T patent/ES2573651T3/es active Active
- 2011-02-15 EP EP11730036.8A patent/EP2536429B1/en not_active Not-in-force
- 2011-02-15 AU AU2011214104A patent/AU2011214104B2/en not_active Ceased
- 2011-02-15 US US13/578,888 patent/US9017689B2/en active Active
- 2011-02-15 DK DK11730036.8T patent/DK2536429T3/en active
-
2012
- 2012-07-31 IL IL221196A patent/IL221196A0/en unknown
-
2015
- 2015-03-31 US US14/674,370 patent/US20150196635A1/en not_active Abandoned
-
2016
- 2016-03-04 JP JP2016042511A patent/JP2016166194A/ja active Pending
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