JP2013518615A5 - - Google Patents
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- Publication number
- JP2013518615A5 JP2013518615A5 JP2012551368A JP2012551368A JP2013518615A5 JP 2013518615 A5 JP2013518615 A5 JP 2013518615A5 JP 2012551368 A JP2012551368 A JP 2012551368A JP 2012551368 A JP2012551368 A JP 2012551368A JP 2013518615 A5 JP2013518615 A5 JP 2013518615A5
- Authority
- JP
- Japan
- Prior art keywords
- nitrogen dioxide
- reservoir
- air
- container
- nitric oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 16
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 claims 15
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims 15
- 239000007789 gas Substances 0.000 claims 12
- 239000003963 antioxidant agent Substances 0.000 claims 7
- 230000003078 antioxidant effect Effects 0.000 claims 7
- 235000006708 antioxidants Nutrition 0.000 claims 7
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229910001882 dioxygen Inorganic materials 0.000 claims 5
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 239000011149 active material Substances 0.000 claims 4
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims 4
- 239000004094 surface-active agent Substances 0.000 claims 4
- 230000001225 therapeutic effect Effects 0.000 claims 4
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 3
- 239000007864 aqueous solution Substances 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 3
- 239000003085 diluting agent Substances 0.000 claims 3
- 239000001301 oxygen Substances 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 2
- 229940087168 alpha tocopherol Drugs 0.000 claims 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims 2
- 235000010323 ascorbic acid Nutrition 0.000 claims 2
- 239000011668 ascorbic acid Substances 0.000 claims 2
- 229960005070 ascorbic acid Drugs 0.000 claims 2
- WFPZPJSADLPSON-UHFFFAOYSA-N dinitrogen tetraoxide Chemical compound [O-][N+](=O)[N+]([O-])=O WFPZPJSADLPSON-UHFFFAOYSA-N 0.000 claims 2
- 235000010382 gamma-tocopherol Nutrition 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000000741 silica gel Substances 0.000 claims 2
- 229910002027 silica gel Inorganic materials 0.000 claims 2
- 229960000984 tocofersolan Drugs 0.000 claims 2
- 235000004835 α-tocopherol Nutrition 0.000 claims 2
- 239000002076 α-tocopherol Substances 0.000 claims 2
- 239000002478 γ-tocopherol Substances 0.000 claims 2
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30042510P | 2010-02-01 | 2010-02-01 | |
| US61/300,425 | 2010-02-01 | ||
| PCT/US2011/023172 WO2011094684A1 (en) | 2010-02-01 | 2011-01-31 | Nitric oxide delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518615A JP2013518615A (ja) | 2013-05-23 |
| JP2013518615A5 true JP2013518615A5 (https=) | 2014-03-27 |
| JP5965845B2 JP5965845B2 (ja) | 2016-08-10 |
Family
ID=44319849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551368A Expired - Fee Related JP5965845B2 (ja) | 2010-02-01 | 2011-01-31 | 一酸化窒素送達システム |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110240019A1 (https=) |
| EP (1) | EP2531249B1 (https=) |
| JP (1) | JP5965845B2 (https=) |
| AU (1) | AU2011210543B2 (https=) |
| CA (1) | CA2788582C (https=) |
| ES (1) | ES2873089T3 (https=) |
| WO (1) | WO2011094684A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005277397B2 (en) | 2004-08-18 | 2011-08-25 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| CA2713049C (en) | 2008-01-28 | 2017-02-28 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| EP2445508B1 (en) | 2009-06-22 | 2018-11-14 | VERO Biotech LLC | Nitric oxide therapies |
| CA2819854A1 (en) | 2010-12-03 | 2012-06-07 | Geno Llc | Nitric oxide treatments |
| AU2013257484B2 (en) * | 2011-01-06 | 2017-09-28 | Mallinckrodt Hospital Products IP Limited | Nitric oxide delivery device |
| DK2661300T3 (en) | 2011-01-06 | 2018-01-15 | Ino Therapeutics Llc | Gas supply device and system |
| EP3391891A3 (en) * | 2011-06-10 | 2019-01-02 | VERO Biotech LLC | Pressurized vessel of nitric oxide (no) |
| US20150272988A1 (en) | 2012-03-07 | 2015-10-01 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| MX368858B (es) * | 2012-03-15 | 2019-10-18 | Mallinckrodt Hospital Products Ip Ltd | Metodos para administrar altas concentraciones de oxido nitrico. |
| US9423051B2 (en) * | 2012-08-17 | 2016-08-23 | The Coca-Cola Company | Dispensing carbonated beverages from a closed package |
| JP2016500550A (ja) * | 2012-11-05 | 2016-01-14 | ゲノ エルエルシー | 一酸化窒素を含むガスを混合する方法 |
| WO2014136111A2 (en) | 2013-03-07 | 2014-09-12 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| WO2014160373A1 (en) * | 2013-03-13 | 2014-10-02 | Ino Therapeutics Llc | Devices and methods for monitoring oxygenation during treatment with delivery of nitric oxide |
| JP6072611B2 (ja) * | 2013-05-28 | 2017-02-01 | 住友精化株式会社 | 二酸化窒素の変換方法および二酸化窒素変換装置 |
| US10525226B2 (en) * | 2014-05-14 | 2020-01-07 | Mallinckrodt Hospital Products IP Limited | Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| CA2987046A1 (en) * | 2015-05-25 | 2016-12-01 | Geno Llc | Nitric oxide treatment system and method |
| EP4512819A3 (en) * | 2015-08-12 | 2025-08-06 | The General Hospital Corporation | Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders |
| MX2018004020A (es) | 2015-10-01 | 2018-09-11 | Mallinckrodt Hospital Products Ip Ltd | Dispositivo y método para la dispersión de no de concentración alta con gas de terapia de inhalación. |
| JP2019506259A (ja) * | 2015-12-11 | 2019-03-07 | ベロ バイオテック エルエルシー | 線維症に対処するために一酸化窒素を含むガスを投与するための方法及び装置 |
| WO2018157175A1 (en) | 2017-02-27 | 2018-08-30 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| BR112019016708B1 (pt) | 2017-02-27 | 2024-01-30 | Third Pole, Inc | Sistemas de geração de óxido nítrico |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| JP7263261B2 (ja) * | 2017-06-08 | 2023-04-24 | ケース ウエスタン リザーブ ユニバーシティ | 制御された濃度で送達を行うための気化システム |
| US11754538B1 (en) * | 2018-07-18 | 2023-09-12 | Vero Biotech Inc. | Method and apparatus for automatic calibration |
| US11672938B1 (en) * | 2018-07-18 | 2023-06-13 | Vero Biotech LLC | Start-up protocols for nitric oxide delivery device |
| US12544403B2 (en) | 2019-01-10 | 2026-02-10 | The General Hospital Corporation | Methods to treat mitochondrial-associated dysfunctions or diseases |
| CN114269685A (zh) | 2019-05-15 | 2022-04-01 | 第三极股份有限公司 | 用于一氧化氮生成的电极 |
| WO2020232414A1 (en) | 2019-05-15 | 2020-11-19 | Third Pole, Inc. | Architectures for production of nitric oxide |
| EP3969416A4 (en) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE |
| EP4069069A4 (en) | 2020-01-11 | 2024-07-03 | Third Pole, Inc. | SYSTEMS AND METHODS FOR NITROGEN OXIDE PRODUCTION WITH HUMIDITY CONTROL |
| US12059531B2 (en) * | 2020-06-07 | 2024-08-13 | Alti Llc | Nitric oxide generation, delivery, and monitoring system |
| EP4167920A4 (en) | 2020-06-18 | 2024-06-12 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| EP4405019A4 (en) | 2021-09-23 | 2025-07-16 | Third Pole Inc | SYSTEMS AND METHODS FOR PROVIDING NITRIC OXIDE |
| WO2023201363A2 (en) | 2022-04-14 | 2023-10-19 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
| KR102831194B1 (ko) * | 2022-12-22 | 2025-07-09 | 성균관대학교산학협력단 | 관류 mri 획득 방법 및 시스템 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3521865A (en) * | 1968-05-20 | 1970-07-28 | Du Pont | Generation of accurately known vapor concentrations by permeation |
| US3856204A (en) * | 1973-03-12 | 1974-12-24 | Ecology Board Inc | Gas emitting device |
| US4399942A (en) * | 1981-11-09 | 1983-08-23 | Gc Industries | Gas emitting device |
| US5324478A (en) * | 1987-08-14 | 1994-06-28 | American Air Liquide | Gas generating apparatus |
| US5653885A (en) * | 1990-07-13 | 1997-08-05 | Isco, Inc. | Apparatus and method for supercritical fluid extraction |
| US5156334A (en) * | 1990-08-15 | 1992-10-20 | Kimbell Charles L | Gas permeation system |
| US5396882A (en) * | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| DE59409834D1 (de) * | 1993-04-17 | 2001-09-27 | Messer Griesheim Austria Ges M | Gerät zur kontrollierten Zudosierung von NO zur Atemluft von Patienten |
| GB9320978D0 (en) * | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
| US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
| JP3142716B2 (ja) * | 1994-04-28 | 2001-03-07 | 裕一 石部 | 呼吸器への一酸化窒素の供給装置 |
| DE19612289A1 (de) * | 1996-03-28 | 1997-10-02 | Messer Griesheim Gmbh | Verfahren und Vorrichtung zur Minderung von Risiken bei der inhalativen NO-Therapie |
| US5692495A (en) * | 1996-04-02 | 1997-12-02 | The Boc Group, Inc. | Method and apparatus for the production of nitric oxide gas mixture |
| US5743251A (en) * | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
| US6564656B1 (en) * | 1998-05-19 | 2003-05-20 | Markes International Limited | Sampling device |
| US6089229A (en) * | 1998-05-26 | 2000-07-18 | Datex-Ohmeda, Inc. | High concentration no pulse delivery device |
| US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| MY136453A (en) * | 2000-04-27 | 2008-10-31 | Philip Morris Usa Inc | "improved method and apparatus for generating an aerosol" |
| ES2473591T3 (es) * | 2001-07-31 | 2014-07-07 | Philip Morris Products S.A. | Método y aparato para generar líquidos volatilizados |
| US6681769B2 (en) * | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
| US20080029093A1 (en) * | 2004-05-11 | 2008-02-07 | Alex Stenzler | Intermittent Dosing Of Nitric Oxide Gas |
| AU2005277397B2 (en) * | 2004-08-18 | 2011-08-25 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US20070181126A1 (en) * | 2006-02-08 | 2007-08-09 | Tolmie Craig R | Method and apparatus for ventilating a patient with a breathing gas mixture formed from nitric oxide, air, and oxygen |
| EP2131903B1 (en) * | 2007-03-23 | 2018-01-24 | Geno LLC | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| CA2713049C (en) * | 2008-01-28 | 2017-02-28 | Geno Llc | Conversion of nitrogen dioxide (no2) to nitric oxide (no) |
| WO2010011928A1 (en) * | 2008-07-24 | 2010-01-28 | Geno Llc | Methods for diagnosing and treating a heart condition in a patient |
| CA2781295C (en) | 2009-11-20 | 2018-02-13 | Geno Llc | Nitric oxide delivery system |
-
2011
- 2011-01-31 JP JP2012551368A patent/JP5965845B2/ja not_active Expired - Fee Related
- 2011-01-31 WO PCT/US2011/023172 patent/WO2011094684A1/en not_active Ceased
- 2011-01-31 ES ES11737816T patent/ES2873089T3/es active Active
- 2011-01-31 CA CA2788582A patent/CA2788582C/en active Active
- 2011-01-31 AU AU2011210543A patent/AU2011210543B2/en active Active
- 2011-01-31 US US13/017,768 patent/US20110240019A1/en not_active Abandoned
- 2011-01-31 EP EP11737816.6A patent/EP2531249B1/en active Active
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