JP5965845B2 - 一酸化窒素送達システム - Google Patents
一酸化窒素送達システム Download PDFInfo
- Publication number
- JP5965845B2 JP5965845B2 JP2012551368A JP2012551368A JP5965845B2 JP 5965845 B2 JP5965845 B2 JP 5965845B2 JP 2012551368 A JP2012551368 A JP 2012551368A JP 2012551368 A JP2012551368 A JP 2012551368A JP 5965845 B2 JP5965845 B2 JP 5965845B2
- Authority
- JP
- Japan
- Prior art keywords
- reservoir
- gas
- nitrogen dioxide
- tube
- oxygen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims description 268
- 239000007789 gas Substances 0.000 claims description 80
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 38
- 229910052760 oxygen Inorganic materials 0.000 claims description 38
- 239000001301 oxygen Substances 0.000 claims description 38
- JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 claims description 34
- MGWGWNFMUOTEHG-UHFFFAOYSA-N 4-(3,5-dimethylphenyl)-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CC(C=2N=C(N)SC=2)=C1 MGWGWNFMUOTEHG-UHFFFAOYSA-N 0.000 claims description 33
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- 239000003963 antioxidant agent Substances 0.000 claims description 18
- 230000003078 antioxidant effect Effects 0.000 claims description 18
- 235000006708 antioxidants Nutrition 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 18
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 17
- 229910001882 dioxygen Inorganic materials 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 12
- 239000011149 active material Substances 0.000 claims description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical class [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 10
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 10
- 230000001225 therapeutic effect Effects 0.000 claims description 10
- 235000010323 ascorbic acid Nutrition 0.000 claims description 9
- 239000011668 ascorbic acid Substances 0.000 claims description 9
- 229960005070 ascorbic acid Drugs 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- WFPZPJSADLPSON-UHFFFAOYSA-N dinitrogen tetraoxide Chemical compound [O-][N+](=O)[N+]([O-])=O WFPZPJSADLPSON-UHFFFAOYSA-N 0.000 claims description 8
- 229920006395 saturated elastomer Polymers 0.000 claims description 8
- 239000004094 surface-active agent Substances 0.000 claims description 8
- 241000124008 Mammalia Species 0.000 claims description 7
- 229940087168 alpha tocopherol Drugs 0.000 claims description 6
- 235000010382 gamma-tocopherol Nutrition 0.000 claims description 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 6
- 239000000741 silica gel Substances 0.000 claims description 6
- 229910002027 silica gel Inorganic materials 0.000 claims description 6
- 229960000984 tocofersolan Drugs 0.000 claims description 6
- 235000004835 α-tocopherol Nutrition 0.000 claims description 6
- 239000002076 α-tocopherol Substances 0.000 claims description 6
- 239000002478 γ-tocopherol Substances 0.000 claims description 6
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 claims description 6
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 5
- 239000003085 diluting agent Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 229910052757 nitrogen Inorganic materials 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 2
- 229910001873 dinitrogen Inorganic materials 0.000 claims description 2
- 239000013543 active substance Substances 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 description 9
- 210000004072 lung Anatomy 0.000 description 9
- 230000029058 respiratory gaseous exchange Effects 0.000 description 6
- 230000004044 response Effects 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 230000007954 hypoxia Effects 0.000 description 5
- 230000003434 inspiratory effect Effects 0.000 description 5
- 230000002685 pulmonary effect Effects 0.000 description 5
- 208000002815 pulmonary hypertension Diseases 0.000 description 5
- 210000004204 blood vessel Anatomy 0.000 description 4
- 239000003638 chemical reducing agent Substances 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000001154 acute effect Effects 0.000 description 3
- 230000004872 arterial blood pressure Effects 0.000 description 3
- 230000001684 chronic effect Effects 0.000 description 3
- 208000035475 disorder Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 208000018875 hypoxemia Diseases 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000004962 physiological condition Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- GQPLMRYTRLFLPF-UHFFFAOYSA-N Nitrous Oxide Chemical compound [O-][N+]#N GQPLMRYTRLFLPF-UHFFFAOYSA-N 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 2
- 208000010378 Pulmonary Embolism Diseases 0.000 description 2
- 241001116459 Sequoia Species 0.000 description 2
- 241000282887 Suidae Species 0.000 description 2
- 238000001949 anaesthesia Methods 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 208000006673 asthma Diseases 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000916 dilatatory effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 230000006698 induction Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001404 mediated effect Effects 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 230000036581 peripheral resistance Effects 0.000 description 2
- 239000010453 quartz Substances 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000011664 signaling Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 238000002627 tracheal intubation Methods 0.000 description 2
- 208000010444 Acidosis Diseases 0.000 description 1
- 206010001029 Acute pulmonary oedema Diseases 0.000 description 1
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 1
- 208000003241 Fat Embolism Diseases 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 208000034388 Mountain sickness acute Diseases 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 description 1
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 1
- 241000277284 Salvelinus fontinalis Species 0.000 description 1
- 206010040047 Sepsis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 230000007950 acidosis Effects 0.000 description 1
- 208000026545 acidosis disease Diseases 0.000 description 1
- 208000018315 acute mountain sickness Diseases 0.000 description 1
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 1
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 description 1
- 238000007675 cardiac surgery Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000007257 malfunction Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002464 muscle smooth vascular Anatomy 0.000 description 1
- XKLJHFLUAHKGGU-UHFFFAOYSA-N nitrous amide Chemical compound ON=N XKLJHFLUAHKGGU-UHFFFAOYSA-N 0.000 description 1
- 239000001272 nitrous oxide Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 201000008312 primary pulmonary hypertension Diseases 0.000 description 1
- 229940048914 protamine Drugs 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000008695 pulmonary vasoconstriction Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000002020 sage Nutrition 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 231100000925 very toxic Toxicity 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/021—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes operated by electrical means
- A61M16/022—Control means therefor
- A61M16/024—Control means therefor including calculation means, e.g. using a processor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/1005—Preparation of respiratory gases or vapours with O2 features or with parameter measurement
- A61M2016/102—Measuring a parameter of the content of the delivered gas
- A61M2016/1035—Measuring a parameter of the content of the delivered gas the anaesthetic agent concentration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0266—Nitrogen (N)
- A61M2202/0275—Nitric oxide [NO]
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30042510P | 2010-02-01 | 2010-02-01 | |
| US61/300,425 | 2010-02-01 | ||
| PCT/US2011/023172 WO2011094684A1 (en) | 2010-02-01 | 2011-01-31 | Nitric oxide delivery system |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518615A JP2013518615A (ja) | 2013-05-23 |
| JP2013518615A5 JP2013518615A5 (https=) | 2014-03-27 |
| JP5965845B2 true JP5965845B2 (ja) | 2016-08-10 |
Family
ID=44319849
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012551368A Expired - Fee Related JP5965845B2 (ja) | 2010-02-01 | 2011-01-31 | 一酸化窒素送達システム |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110240019A1 (https=) |
| EP (1) | EP2531249B1 (https=) |
| JP (1) | JP5965845B2 (https=) |
| AU (1) | AU2011210543B2 (https=) |
| CA (1) | CA2788582C (https=) |
| ES (1) | ES2873089T3 (https=) |
| WO (1) | WO2011094684A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005277397B2 (en) | 2004-08-18 | 2011-08-25 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7914743B2 (en) | 2008-01-28 | 2011-03-29 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US8607785B2 (en) | 2008-08-21 | 2013-12-17 | Geno Llc | Systems and devices for generating nitric oxide |
| JP5878866B2 (ja) | 2009-06-22 | 2016-03-08 | ゲノ エルエルシー | 一酸化窒素治療 |
| AU2011336358B2 (en) | 2010-12-03 | 2016-09-29 | VERO Biotech LLC. | Nitric oxide treatments |
| MX2013007931A (es) | 2011-01-06 | 2013-09-26 | Ino Therapeutics Llc | Dispositivo y sistema de entrega de gas. |
| AU2013257484B2 (en) * | 2011-01-06 | 2017-09-28 | Mallinckrodt Hospital Products IP Limited | Nitric oxide delivery device |
| WO2012170843A1 (en) * | 2011-06-10 | 2012-12-13 | Geno Llc | Pressurized vessel of nitric oxide (no) |
| US20150174158A1 (en) | 2012-03-07 | 2015-06-25 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| WO2013138654A1 (en) * | 2012-03-15 | 2013-09-19 | Ino Therapeutics Llc | Methods of administering high concentrations of nitric oxide |
| US9423051B2 (en) * | 2012-08-17 | 2016-08-23 | The Coca-Cola Company | Dispensing carbonated beverages from a closed package |
| CA2890202A1 (en) * | 2012-11-05 | 2014-05-08 | Geno Llc | Method of mixing gases including nitric oxide |
| WO2014136111A2 (en) | 2013-03-07 | 2014-09-12 | Advanced Inhalation Therapies (Ait) Ltd. | Inhalation of nitric oxide for treating respiratory diseases |
| JP6654558B2 (ja) * | 2013-03-13 | 2020-02-26 | マリンクロット ホスピタル プロダクツ アイピー リミテッド | 一酸化窒素の送達による治療の最中に酸素化を監視する装置および方法 |
| JP6072611B2 (ja) * | 2013-05-28 | 2017-02-01 | 住友精化株式会社 | 二酸化窒素の変換方法および二酸化窒素変換装置 |
| US10525226B2 (en) * | 2014-05-14 | 2020-01-07 | Mallinckrodt Hospital Products IP Limited | Systems and methods for indicating lifetime of an NO2-to-NO reactor cartridge used to deliver NO for inhalation therapy to a patient |
| EP3302277A4 (en) * | 2015-05-25 | 2019-01-02 | VERO Biotech LLC | Nitric oxide treatment system and method |
| EP4512819A3 (en) * | 2015-08-12 | 2025-08-06 | The General Hospital Corporation | Compositions and methods that promote hypoxia or the hypoxia response for treatment and prevention of mitochondrial dysfunction and oxidative stress disorders |
| MX2018004020A (es) | 2015-10-01 | 2018-09-11 | Mallinckrodt Hospital Products Ip Ltd | Dispositivo y método para la dispersión de no de concentración alta con gas de terapia de inhalación. |
| EP3386574A4 (en) * | 2015-12-11 | 2019-07-17 | Vero Biotech LLC | METHOD AND APPARATUS FOR GAS ADMINISTRATION COMPRISING NITRIC OXIDE FOR TREATING FIBROSIS |
| RU2717525C1 (ru) | 2017-02-27 | 2020-03-23 | Сёрд Поул, Инк. | Системы и способы получения оксида азота |
| US10328228B2 (en) | 2017-02-27 | 2019-06-25 | Third Pole, Inc. | Systems and methods for ambulatory generation of nitric oxide |
| MX2020010523A (es) | 2017-02-27 | 2021-02-09 | Third Pole Inc | Sistemas y metodos para generar oxido nitrico. |
| JP7263261B2 (ja) * | 2017-06-08 | 2023-04-24 | ケース ウエスタン リザーブ ユニバーシティ | 制御された濃度で送達を行うための気化システム |
| US11672938B1 (en) | 2018-07-18 | 2023-06-13 | Vero Biotech LLC | Start-up protocols for nitric oxide delivery device |
| US11754538B1 (en) * | 2018-07-18 | 2023-09-12 | Vero Biotech Inc. | Method and apparatus for automatic calibration |
| WO2020146758A1 (en) | 2019-01-10 | 2020-07-16 | The General Hospital Corporation | Methods to treat mitochondrial-associated dysfunctions or diseases |
| EP3969016A4 (en) | 2019-05-15 | 2023-08-16 | Third Pole, Inc. | ARCHITECTURES FOR THE PRODUCTION OF NITROUS OXIDE |
| EP3969416A4 (en) | 2019-05-15 | 2023-11-01 | Third Pole, Inc. | SYSTEMS AND DEVICES FOR GENERATING NITROGEN OXIDE |
| JP2022533628A (ja) | 2019-05-15 | 2022-07-25 | サード ポール，インコーポレイテッド | 一酸化窒素生成用電極 |
| US11691879B2 (en) | 2020-01-11 | 2023-07-04 | Third Pole, Inc. | Systems and methods for nitric oxide generation with humidity control |
| US12059531B2 (en) * | 2020-06-07 | 2024-08-13 | Alti Llc | Nitric oxide generation, delivery, and monitoring system |
| US20210395905A1 (en) | 2020-06-18 | 2021-12-23 | Third Pole, Inc. | Systems and methods for preventing and treating infections with nitric oxide |
| WO2022082072A1 (en) | 2020-10-16 | 2022-04-21 | Third Pole, Inc. | Nitric oxide generation process controls |
| US11975139B2 (en) | 2021-09-23 | 2024-05-07 | Third Pole, Inc. | Systems and methods for delivering nitric oxide |
| US12569628B2 (en) | 2022-04-14 | 2026-03-10 | Third Pole, Inc. | Delivery of medicinal gas in a liquid medium |
| KR102831194B1 (ko) * | 2022-12-22 | 2025-07-09 | 성균관대학교산학협력단 | 관류 mri 획득 방법 및 시스템 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3521865A (en) * | 1968-05-20 | 1970-07-28 | Du Pont | Generation of accurately known vapor concentrations by permeation |
| US3856204A (en) * | 1973-03-12 | 1974-12-24 | Ecology Board Inc | Gas emitting device |
| US4399942A (en) * | 1981-11-09 | 1983-08-23 | Gc Industries | Gas emitting device |
| US5324478A (en) * | 1987-08-14 | 1994-06-28 | American Air Liquide | Gas generating apparatus |
| US5653885A (en) * | 1990-07-13 | 1997-08-05 | Isco, Inc. | Apparatus and method for supercritical fluid extraction |
| US5156334A (en) * | 1990-08-15 | 1992-10-20 | Kimbell Charles L | Gas permeation system |
| US5396882A (en) * | 1992-03-11 | 1995-03-14 | The General Hospital Corporation | Generation of nitric oxide from air for medical uses |
| DE59409834D1 (de) * | 1993-04-17 | 2001-09-27 | Messer Griesheim Austria Ges M | Gerät zur kontrollierten Zudosierung von NO zur Atemluft von Patienten |
| GB9320978D0 (en) * | 1993-10-12 | 1993-12-01 | Higenbottam Timohy W | Nitric oxide treatment |
| US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
| JP3142716B2 (ja) * | 1994-04-28 | 2001-03-07 | 裕一 石部 | 呼吸器への一酸化窒素の供給装置 |
| DE19612289A1 (de) * | 1996-03-28 | 1997-10-02 | Messer Griesheim Gmbh | Verfahren und Vorrichtung zur Minderung von Risiken bei der inhalativen NO-Therapie |
| US5692495A (en) * | 1996-04-02 | 1997-12-02 | The Boc Group, Inc. | Method and apparatus for the production of nitric oxide gas mixture |
| US5743251A (en) * | 1996-05-15 | 1998-04-28 | Philip Morris Incorporated | Aerosol and a method and apparatus for generating an aerosol |
| US6564656B1 (en) * | 1998-05-19 | 2003-05-20 | Markes International Limited | Sampling device |
| US6089229A (en) * | 1998-05-26 | 2000-07-18 | Datex-Ohmeda, Inc. | High concentration no pulse delivery device |
| US7516742B2 (en) * | 1999-11-24 | 2009-04-14 | Cardinal Health 207, Inc. | Method and apparatus for delivery of inhaled nitric oxide to spontaneous-breathing and mechanically-ventilated patients with intermittent dosing |
| MY136453A (en) * | 2000-04-27 | 2008-10-31 | Philip Morris Usa Inc | "improved method and apparatus for generating an aerosol" |
| TWI239251B (en) * | 2001-07-31 | 2005-09-11 | Chrysalis Tech Inc | Method and apparatus for generating a volatilized liquid |
| US6681769B2 (en) * | 2001-12-06 | 2004-01-27 | Crysalis Technologies Incorporated | Aerosol generator having a multiple path heater arrangement and method of use thereof |
| AU2005244078A1 (en) * | 2004-05-11 | 2005-11-24 | Pulmonox Technologies Corporation | Intermittent dosing of nitric oxide gas |
| AU2005277397B2 (en) * | 2004-08-18 | 2011-08-25 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7618594B2 (en) * | 2004-08-18 | 2009-11-17 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US20070181126A1 (en) * | 2006-02-08 | 2007-08-09 | Tolmie Craig R | Method and apparatus for ventilating a patient with a breathing gas mixture formed from nitric oxide, air, and oxygen |
| AU2008232413B2 (en) * | 2007-03-23 | 2013-09-19 | VERO Biotech LLC. | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| US7914743B2 (en) * | 2008-01-28 | 2011-03-29 | Geno Llc | Conversion of nitrogen dioxide (NO2) to nitric oxide (NO) |
| EP2306814B1 (en) * | 2008-07-24 | 2013-11-27 | Geno LLC | Methods for diagnosing and treating a heart condition in a patient |
| WO2011063335A1 (en) | 2009-11-20 | 2011-05-26 | Geno Llc | Nitric oxide delivery system |
-
2011
- 2011-01-31 AU AU2011210543A patent/AU2011210543B2/en active Active
- 2011-01-31 JP JP2012551368A patent/JP5965845B2/ja not_active Expired - Fee Related
- 2011-01-31 WO PCT/US2011/023172 patent/WO2011094684A1/en not_active Ceased
- 2011-01-31 ES ES11737816T patent/ES2873089T3/es active Active
- 2011-01-31 US US13/017,768 patent/US20110240019A1/en not_active Abandoned
- 2011-01-31 EP EP11737816.6A patent/EP2531249B1/en active Active
- 2011-01-31 CA CA2788582A patent/CA2788582C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2531249A4 (en) | 2014-08-27 |
| WO2011094684A1 (en) | 2011-08-04 |
| AU2011210543B2 (en) | 2016-02-25 |
| ES2873089T3 (es) | 2021-11-03 |
| US20110240019A1 (en) | 2011-10-06 |
| JP2013518615A (ja) | 2013-05-23 |
| EP2531249B1 (en) | 2021-03-24 |
| CA2788582A1 (en) | 2011-08-04 |
| EP2531249A1 (en) | 2012-12-12 |
| CA2788582C (en) | 2020-01-07 |
| AU2011210543A1 (en) | 2012-08-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5965845B2 (ja) | 一酸化窒素送達システム | |
| US12383692B2 (en) | Systems and methods for synthesis of nitric oxide | |
| US20220016379A1 (en) | Delivery of high concentration nitric oxide | |
| AU2013337351B2 (en) | Method of mixing gases including nitric oxide | |
| US10682486B1 (en) | Single treatment disposable nitric oxide delivery | |
| HK40041930A (en) | Systems and methods for synthesis of nitric oxide | |
| HK40041930B (en) | Systems and methods for synthesis of nitric oxide |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140130 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20140130 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20141031 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20141104 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20150130 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150501 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20150707 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20151001 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160105 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20160607 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160704 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 5965845 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| LAPS | Cancellation because of no payment of annual fees |