JP2013518032A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013518032A5 JP2013518032A5 JP2012533416A JP2012533416A JP2013518032A5 JP 2013518032 A5 JP2013518032 A5 JP 2013518032A5 JP 2012533416 A JP2012533416 A JP 2012533416A JP 2012533416 A JP2012533416 A JP 2012533416A JP 2013518032 A5 JP2013518032 A5 JP 2013518032A5
- Authority
- JP
- Japan
- Prior art keywords
- substituent
- hydrocarbon group
- formula
- anticancer agent
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims 24
- 239000002246 antineoplastic agent Substances 0.000 claims 17
- 239000003795 chemical substances by application Substances 0.000 claims 17
- 125000001931 aliphatic group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 8
- 208000033808 peripheral neuropathy Diseases 0.000 claims 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 7
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 6
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000000651 prodrug Substances 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 229930012538 Paclitaxel Natural products 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 229960001592 paclitaxel Drugs 0.000 claims 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 4
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 3
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 3
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 3
- 229960001467 bortezomib Drugs 0.000 claims 3
- 229960004562 carboplatin Drugs 0.000 claims 3
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 3
- 229960004316 cisplatin Drugs 0.000 claims 3
- 229960003668 docetaxel Drugs 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229960004528 vincristine Drugs 0.000 claims 3
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 3
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 3
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims 2
- 229940123237 Taxane Drugs 0.000 claims 2
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 2
- 229940122803 Vinca alkaloid Drugs 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- KOBUOXDVUDRKJX-UHFFFAOYSA-N ethyl 6-[(2-chloro-4-fluorophenyl)methylsulfonyl]cyclohexene-1-carboxylate Chemical compound CCOC(=O)C1=CCCCC1S(=O)(=O)CC1=CC=C(F)C=C1Cl KOBUOXDVUDRKJX-UHFFFAOYSA-N 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 2
- 229960001756 oxaliplatin Drugs 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- 229960003048 vinblastine Drugs 0.000 claims 2
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 2
- 206010040021 Sensory abnormalities Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- LRJFAKQFYIWRQN-CYBMUJFWSA-N ethyl (3s)-3-[(2-chloro-4-fluorophenyl)sulfamoyl]-3,6-dihydro-2h-pyran-4-carboxylate Chemical compound CCOC(=O)C1=CCOC[C@H]1S(=O)(=O)NC1=CC=C(F)C=C1Cl LRJFAKQFYIWRQN-CYBMUJFWSA-N 0.000 claims 1
- LEEIJTHMHDMWLJ-CQSZACIVSA-N ethyl (6r)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate Chemical compound CCOC(=O)C1=CCCC[C@H]1S(=O)(=O)NC1=CC=C(F)C=C1Cl LEEIJTHMHDMWLJ-CQSZACIVSA-N 0.000 claims 1
- 229960002870 gabapentin Drugs 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 231100000862 numbness Toxicity 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 claims 1
- 229960001233 pregabalin Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2012533416A JP6131046B2 (ja) | 2010-01-27 | 2011-01-26 | 抗癌剤により誘発される末梢神経障害を抑制する化合物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010015935 | 2010-01-27 | ||
| JP2010015935 | 2010-01-27 | ||
| JP2012533416A JP6131046B2 (ja) | 2010-01-27 | 2011-01-26 | 抗癌剤により誘発される末梢神経障害を抑制する化合物 |
| PCT/JP2011/052077 WO2011093512A1 (en) | 2010-01-27 | 2011-01-26 | Compounds for suppressing a peripheral nerve disorder induced by an anti - cancer agent |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016056186A Division JP2016175903A (ja) | 2010-01-27 | 2016-03-18 | 抗癌剤により誘発される末梢神経障害を抑制する化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013518032A JP2013518032A (ja) | 2013-05-20 |
| JP2013518032A5 true JP2013518032A5 (https=) | 2014-02-13 |
| JP6131046B2 JP6131046B2 (ja) | 2017-05-17 |
Family
ID=43770309
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012533416A Active JP6131046B2 (ja) | 2010-01-27 | 2011-01-26 | 抗癌剤により誘発される末梢神経障害を抑制する化合物 |
| JP2016056186A Pending JP2016175903A (ja) | 2010-01-27 | 2016-03-18 | 抗癌剤により誘発される末梢神経障害を抑制する化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016056186A Pending JP2016175903A (ja) | 2010-01-27 | 2016-03-18 | 抗癌剤により誘発される末梢神経障害を抑制する化合物 |
Country Status (41)
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104254521B (zh) * | 2012-04-27 | 2016-05-04 | 日本脏器制药株式会社 | 反式-2-癸烯酸衍生物及含有其的药物 |
| WO2015095404A2 (en) * | 2013-12-17 | 2015-06-25 | Genentech, Inc. | Methods of treating cancers using pd-1 axis binding antagonists and taxanes |
| TW201704206A (zh) | 2015-05-08 | 2017-02-01 | 武田藥品工業股份有限公司 | 環狀化合物 |
| JP6896650B2 (ja) | 2015-06-17 | 2021-06-30 | ジェネンテック， インコーポレイテッド | Ｐｄ−１軸結合アンタゴニスト及びタキサンを使用した局所進行性または転移性乳癌の治療方法 |
| JP7029400B2 (ja) * | 2016-09-09 | 2022-03-03 | 武田薬品工業株式会社 | 環状化合物 |
| US11957758B2 (en) * | 2017-09-07 | 2024-04-16 | Shenzhen Salubris Pharmaceuticals Co. Ltd. | Pharmaceutical composition of docetaxel conjugate and preparation method |
| US12589085B2 (en) | 2019-07-22 | 2026-03-31 | Guangzhou Insighter Biotechnology Co., Ltd. | Use of diaminoguanidine derivative and feed composition thereof in preparation of veterinary drug |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5804374A (en) | 1980-12-05 | 1998-09-08 | Massachusetts Insti. Technology | Nuclear factors associates with transcriptional regulation |
| WO1987004170A1 (en) | 1986-01-09 | 1987-07-16 | Massachusetts Institute Of Technology | Nuclear factors associated with transcriptional regulation |
| US6410516B1 (en) | 1986-01-09 | 2002-06-25 | President & Fellows Of Harvard College | Nuclear factors associated with transcriptional regulation |
| US4769372A (en) | 1986-06-18 | 1988-09-06 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
| US4785000A (en) | 1986-06-18 | 1988-11-15 | The Rockefeller University | Method of treating patients suffering from chronic pain or chronic cough |
| WO1988005083A1 (en) | 1986-12-24 | 1988-07-14 | Whitehead Institute For Biomedical Research | Method of inducible gene expression |
| WO1989007614A1 (en) | 1988-02-12 | 1989-08-24 | Massachusetts Institute Of Technology | Nuclear factors associated with transcriptional regulation |
| CA1341606C (en) | 1988-03-01 | 2010-06-08 | Whitehead Institute For Biomedical Research | Activation of nf-kb precursor |
| US5506231A (en) | 1989-03-31 | 1996-04-09 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5334618A (en) | 1991-04-04 | 1994-08-02 | The Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| WO1990011761A1 (en) | 1989-03-31 | 1990-10-18 | The Children's Medical Center Corporation | Treatment of aids dementia, myelopathy and blindness |
| US5158883A (en) | 1989-09-13 | 1992-10-27 | Cornell Research Foundation, Inc. | Method of using aminoarginine to block nitric oxide formation in vitro |
| US5059712A (en) | 1989-09-13 | 1991-10-22 | Cornell Research Foundation, Inc. | Isolating aminoarginine and use to block nitric oxide formation in body |
| JPH06500554A (ja) | 1990-08-23 | 1994-01-20 | ザ・チルドレンズ・メディカル・センター・コーポレイション | エイズ性痴呆、脊髄障害、末梢神経障害、および視覚喪失の治療 |
| US5455279A (en) | 1991-04-19 | 1995-10-03 | The Children's Medical Center Corporation | Regimen method of mediating neuronal damage using nitroglycerine |
| WO1992017168A1 (en) | 1991-04-04 | 1992-10-15 | The Children's Medical Center Corporation | Method of preventing nmda receptor-mediated neuronal damage |
| US5614560A (en) | 1991-04-04 | 1997-03-25 | Children's Medical Center Corporation | Method of preventing NMDA receptor-mediated neuronal damage |
| DE69229598T2 (de) | 1991-04-19 | 1999-11-04 | Children's Medical Center Corp., Boston | Verfahren zur vorbeugung nmda-rezeptorkomplex-vermittelter neuronaler schäden |
| US6071876A (en) | 1991-04-19 | 2000-06-06 | Children's Medical Center Corporation | Method of preventing NMDA receptor complex-mediated neuronal damage |
| KR19990022369A (ko) * | 1995-06-07 | 1999-03-25 | 스테판 이반스-프레크 | 어뎁터 단백질/티로신 카이나제 상호작용을 방해하는 조성물과그 방법 |
| US20020086368A1 (en) | 1997-10-17 | 2002-07-04 | Genentech Inc | Human toll homologues |
| US20020052019A1 (en) | 1997-11-13 | 2002-05-02 | Genentech Inc | Human toll homologue |
| US20030032090A1 (en) | 1997-05-07 | 2003-02-13 | Schering Corporation, A New Jersey Corporation | Human receptor proteins; related reagents and methods |
| ES2298905T3 (es) | 1997-10-17 | 2008-05-16 | Genentech, Inc. | Homologos de tipo toll humanos. |
| WO1999027101A1 (en) | 1997-11-25 | 1999-06-03 | Princeton University | Method for preparing adenovirus vectors, vectors so prepared, and uses thereof |
| WO1999026657A1 (en) | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| US20040072138A1 (en) | 1997-11-25 | 2004-04-15 | Medical University Of South Carolina | Attenuation of ischemia/reperfusion injury |
| US20080275104A1 (en) | 1997-11-25 | 2008-11-06 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
| CN100432049C (zh) | 1998-03-09 | 2008-11-12 | 武田药品工业株式会社 | 环烯衍生物、其制造方法和用途 |
| US7078540B1 (en) | 1999-08-06 | 2006-07-18 | Takeda Pharmaceutical Company Limited | Substituted aromatic-ring compounds, process for producing the same, and use |
| SE9903930D0 (sv) * | 1999-10-29 | 1999-10-29 | Astra Pharma Inc | Novel compounds and a novel process for their preparation |
| US7105572B2 (en) | 2000-02-04 | 2006-09-12 | Takeda Pharmaceutical Company Limited | Stable emulsion compositions |
| NZ522327A (en) | 2000-05-25 | 2004-09-24 | Schering Corp | Mammalian DNAX Toll-like receptor protein, DTLR 10, antibodies and medicaments made therefrom and use in treating immunological disorders |
| AU2001278705A1 (en) | 2000-08-10 | 2002-02-25 | Takeda Chemical Industries Ltd. | Pharmaceutical composition |
| EP1334966B1 (en) | 2000-10-18 | 2011-05-04 | Takeda Pharmaceutical Company Limited | Process for preparation of optically active sulfonamides and intermediates for their synthesis |
| EP1339271B1 (en) | 2000-11-30 | 2011-07-27 | Tokuyama Corporation | Substrate and production method therefor |
| CA2431206C (en) | 2000-12-08 | 2009-09-01 | Takeda Chemical Industries, Ltd. | Combination drugs containing anti-sepsis cycloalkene compound |
| EP1420783A4 (en) | 2001-08-03 | 2009-09-30 | Takeda Pharmaceutical | STABLE EMULSION COMPOSITION |
| EP1495756A4 (en) | 2002-04-08 | 2009-10-28 | Takeda Pharmaceutical | THERAPEUTIC AGENT FOR SEVERE SEPTIC STATE PREVENTION |
| US8710095B2 (en) | 2002-04-30 | 2014-04-29 | Bionumerik Pharmaceuticals, Inc. | Drugs for prophylaxis or mitigation of taxane-induced neurotoxicity |
| US20040259790A1 (en) | 2003-01-30 | 2004-12-23 | Bali Pulendran | Methods for identifying and administering agents that bias the immune response via dendritic cells |
| US7485432B2 (en) | 2003-02-27 | 2009-02-03 | 3M Innovative Properties Company | Selective modulation of TLR-mediated biological activity |
| US20040191833A1 (en) | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Selective activation of cellular activities mediated through a common toll-like receptor |
| EP1664342A4 (en) | 2003-09-17 | 2007-12-26 | 3M Innovative Properties Co | SELECTIVE MODULATION OF TLR GENE EXPRESSION |
| WO2005084180A2 (en) | 2003-12-19 | 2005-09-15 | University Of Cincinnati | Polyamides and polyamide complexes for delivery of oligonucleotide decoys |
| TWI462745B (zh) | 2005-04-28 | 2014-12-01 | Takeda Pharmaceutical | 安定的乳化組成物 |
| AU2006253356B2 (en) | 2005-06-03 | 2011-12-01 | Ono Pharmaceutical Co., Ltd. | Agent for regeneration and/or protection of nerves |
| US7618982B2 (en) | 2005-12-19 | 2009-11-17 | Nerviano Medical Sciences S.R.L. | Heteroarylpyrrolopyridinones active as kinase inhibitors |
| WO2007091790A1 (en) | 2006-02-07 | 2007-08-16 | Korea Institute Of Radiological & Medical Sciences | A composition for treating damage of central or peripheral nerve system |
| US7985538B2 (en) | 2006-02-23 | 2011-07-26 | Yale University | Drug resistance and methods of reversing |
| US7943588B2 (en) | 2006-03-28 | 2011-05-17 | Trustees Of Dartmouth College | Method for preventing or treating neuropathic pain |
| JP4962982B2 (ja) | 2006-03-30 | 2012-06-27 | 国立大学法人広島大学 | スクリーニング方法 |
| WO2007123186A1 (ja) * | 2006-04-20 | 2007-11-01 | Takeda Pharmaceutical Company Limited | 医薬 |
| EP2018855A1 (en) | 2006-05-15 | 2009-01-28 | Takeda Pharmaceutical Company Limited | Pharmaceutical agent |
| JPWO2008004673A1 (ja) | 2006-07-07 | 2009-12-10 | 武田薬品工業株式会社 | シクロアルケン誘導体、その製造法および用途 |
| EP1882687A1 (en) * | 2006-07-27 | 2008-01-30 | Amorepacific Corporation | Heterocyclic compounds useful as vanilloid receptor antagonists and pharmaceutical compositions containing the same |
| WO2008112887A1 (en) | 2007-03-13 | 2008-09-18 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
| US8399421B2 (en) | 2007-03-30 | 2013-03-19 | The Board Of Regents Of The University Of Texas System | Treatment for neuropathic pain due to spinal cord injury |
| US20100239523A1 (en) | 2007-10-30 | 2010-09-23 | The Regents Of The University Of Colorado | Tlr modulators and methods for using the same |
| WO2009145814A2 (en) | 2008-03-10 | 2009-12-03 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyridines useful as inhibitors of protein kinases |
| JP5238381B2 (ja) | 2008-07-07 | 2013-07-17 | スタンレー電気株式会社 | 照明用車両用灯具 |
| JP5675821B2 (ja) | 2009-09-23 | 2015-02-25 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレート | Ｔｏｌｌ様受容体モジュレーター及びその使用 |
-
2011
- 2011-01-26 UY UY0001033203A patent/UY33203A/es not_active Application Discontinuation
- 2011-01-26 KR KR1020127021846A patent/KR20120118044A/ko not_active Abandoned
- 2011-01-26 PT PT117050476T patent/PT2528598E/pt unknown
- 2011-01-26 TW TW100102774A patent/TWI481401B/zh not_active IP Right Cessation
- 2011-01-26 ME MEP-2016-31A patent/ME02364B/me unknown
- 2011-01-26 SG SG2012051967A patent/SG182522A1/en unknown
- 2011-01-26 CA CA2788150A patent/CA2788150C/en not_active Expired - Fee Related
- 2011-01-26 UA UAA201210137A patent/UA109540C2/uk unknown
- 2011-01-26 EP EP11705047.6A patent/EP2528598B1/en active Active
- 2011-01-26 HR HRP20160165TT patent/HRP20160165T1/hr unknown
- 2011-01-26 SG SG10201503402XA patent/SG10201503402XA/en unknown
- 2011-01-26 EA EA201290697A patent/EA201290697A1/ru unknown
- 2011-01-26 US US13/574,848 patent/US20130046000A1/en not_active Abandoned
- 2011-01-26 MY MYPI2012003414A patent/MY163936A/en unknown
- 2011-01-26 PL PL11705047T patent/PL2528598T3/pl unknown
- 2011-01-26 MX MX2012008514A patent/MX2012008514A/es not_active Application Discontinuation
- 2011-01-26 RS RS20160076A patent/RS54591B1/sr unknown
- 2011-01-26 CN CN201510072433.2A patent/CN104744321A/zh active Pending
- 2011-01-26 SI SI201130755T patent/SI2528598T1/sl unknown
- 2011-01-26 AU AU2011211294A patent/AU2011211294B2/en not_active Ceased
- 2011-01-26 BR BR112012018434A patent/BR112012018434A2/pt not_active IP Right Cessation
- 2011-01-26 DK DK11705047.6T patent/DK2528598T3/en active
- 2011-01-26 NZ NZ601635A patent/NZ601635A/xx not_active IP Right Cessation
- 2011-01-26 HU HUE11705047A patent/HUE027310T2/en unknown
- 2011-01-26 JP JP2012533416A patent/JP6131046B2/ja active Active
- 2011-01-26 PE PE2012001062A patent/PE20121694A1/es not_active Application Discontinuation
- 2011-01-26 ES ES11705047.6T patent/ES2560215T3/es active Active
- 2011-01-26 GE GEAP201112845A patent/GEP20166441B/en unknown
- 2011-01-26 AR ARP110100247A patent/AR080024A1/es unknown
- 2011-01-26 MA MA35162A patent/MA34014B1/fr unknown
- 2011-01-26 CN CN201180015681.3A patent/CN102821763B/zh not_active Expired - Fee Related
- 2011-01-26 WO PCT/JP2011/052077 patent/WO2011093512A1/en not_active Ceased
- 2011-01-26 PH PH1/2012/501538A patent/PH12012501538A1/en unknown
-
2012
- 2012-07-17 TN TNP2012000364A patent/TN2012000364A1/en unknown
- 2012-07-23 IL IL221066A patent/IL221066A/en not_active IP Right Cessation
- 2012-07-25 DO DO2012000209A patent/DOP2012000209A/es unknown
- 2012-07-26 CL CL2012002079A patent/CL2012002079A1/es unknown
- 2012-07-27 ZA ZA2012/05681A patent/ZA201205681B/en unknown
- 2012-08-07 CR CR20120412A patent/CR20120412A/es unknown
- 2012-08-17 CO CO12140288A patent/CO6592110A2/es not_active Application Discontinuation
- 2012-08-27 EC ECSP12012126 patent/ECSP12012126A/es unknown
-
2013
- 2013-08-20 US US13/971,159 patent/US8901171B2/en not_active Expired - Fee Related
-
2014
- 2014-10-28 US US14/525,576 patent/US20150051256A1/en not_active Abandoned
-
2015
- 2015-04-02 US US14/676,947 patent/US20150203464A1/en not_active Abandoned
-
2016
- 2016-02-19 US US15/047,965 patent/US20160166526A1/en not_active Abandoned
- 2016-03-04 CY CY20161100189T patent/CY1117268T1/el unknown
- 2016-03-18 JP JP2016056186A patent/JP2016175903A/ja active Pending
- 2016-04-12 SM SM201600103T patent/SMT201600103B/xx unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013518032A5 (https=) | ||
| JP2016503797A5 (https=) | ||
| JP2013533253A5 (https=) | ||
| JP2013537203A5 (https=) | ||
| JP2012508252A5 (https=) | ||
| IN2014DN07283A (https=) | ||
| JP2015524457A5 (https=) | ||
| JP2014524441A5 (https=) | ||
| JP2019513770A5 (https=) | ||
| CA2569850A1 (en) | 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2h-pyrido [2,3-d] pyrimidine derivatives and related compounds for the treatment of cancer | |
| JP2017511321A5 (https=) | ||
| JP2010511721A5 (https=) | ||
| JP2012515776A5 (https=) | ||
| JP2009514881A5 (https=) | ||
| JP2011037841A5 (https=) | ||
| JP2013505946A5 (https=) | ||
| JP2014500295A5 (https=) | ||
| JP2015501833A5 (https=) | ||
| AR065845A1 (es) | Quinolonas y tetrahidroquinolinas y compuestos relacionados con actividad inhibidoria de nos | |
| JP2013508288A5 (https=) | ||
| JP2015504081A5 (https=) | ||
| RU2012155118A (ru) | Способы лечения биполярного расстройства | |
| JP2012533601A5 (https=) | ||
| JP2014511366A5 (https=) | ||
| JP2007500734A5 (https=) |