ATE524732T1 - Wirkstoffresistenz gegen pflanzenalkaloide basieren auf dem myd88-status in einer zelle und verfahren zum hemmen der signalgebung durch den tlr-4:myd88-signalweg - Google Patents
Wirkstoffresistenz gegen pflanzenalkaloide basieren auf dem myd88-status in einer zelle und verfahren zum hemmen der signalgebung durch den tlr-4:myd88-signalwegInfo
- Publication number
- ATE524732T1 ATE524732T1 AT07751467T AT07751467T ATE524732T1 AT E524732 T1 ATE524732 T1 AT E524732T1 AT 07751467 T AT07751467 T AT 07751467T AT 07751467 T AT07751467 T AT 07751467T AT E524732 T1 ATE524732 T1 AT E524732T1
- Authority
- AT
- Austria
- Prior art keywords
- myd88
- plant alkaloids
- signaling
- tlr
- status
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57449—Specifically defined cancers of ovaries
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/44—Multiple drug resistance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Oncology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77630406P | 2006-02-23 | 2006-02-23 | |
US78816806P | 2006-03-31 | 2006-03-31 | |
PCT/US2007/004707 WO2007100650A2 (en) | 2006-02-23 | 2007-02-23 | Drug resistance to plant alkaloids based upon myd88 status in a cell and methods of inhibiting signaling through the tlr-4:myd88 pathway |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE524732T1 true ATE524732T1 (de) | 2011-09-15 |
Family
ID=38349578
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07751467T ATE524732T1 (de) | 2006-02-23 | 2007-02-23 | Wirkstoffresistenz gegen pflanzenalkaloide basieren auf dem myd88-status in einer zelle und verfahren zum hemmen der signalgebung durch den tlr-4:myd88-signalweg |
Country Status (4)
Country | Link |
---|---|
US (1) | US7985538B2 (de) |
EP (1) | EP1996935B1 (de) |
AT (1) | ATE524732T1 (de) |
WO (1) | WO2007100650A2 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0606096D0 (en) * | 2006-03-27 | 2006-05-03 | Cbmm Sa | Screening method |
EP2316032A1 (de) | 2008-08-20 | 2011-05-04 | INSERM - Institut National de la Santé et de la Recherche Médicale | Verfahren zur vorhersage des ansprechens auf eine antikrebsbehandlung mit einem agonisten von tlr7 oder einem agonisten von tlr8 |
WO2010135671A1 (en) * | 2009-05-22 | 2010-11-25 | The Usa, As Represented By The Secretary, Dpt Of Health And Human Services | Akt phosphorylation at ser473 as an indicator for taxane-based chemotherapy |
SG182522A1 (en) | 2010-01-27 | 2012-08-30 | Takeda Pharmaceutical | Compounds for suppressing a peripheral nerve disorder induced by an anti - cancer agent |
US20190077874A1 (en) * | 2017-09-13 | 2019-03-14 | National Tuberous Sclerosis Association, Inc. | Methods and compositions for the treatment of tuberous sclerosis |
CN111643677B (zh) * | 2020-05-26 | 2023-06-27 | 四川省肿瘤医院 | 一种包封TLR4/MyD88信号通路拮抗剂的纳米脂质体及其制备方法和应用 |
CN115715802A (zh) * | 2022-09-09 | 2023-02-28 | 上海市普陀区中心医院 | MyD88抑制剂在制备治疗乳腺癌和逆转乳腺癌紫杉醇耐药的药物中的应用 |
CN117418013A (zh) * | 2023-12-19 | 2024-01-19 | 四川省肿瘤医院 | 用于检测卵巢癌细胞MyD88基因5'URR CpG岛甲基化水平的引物、方法及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005054814A1 (en) | 2003-11-26 | 2005-06-16 | Yale University | Apoptosis-based evaluation of chemosensitivity in cancer patients |
US20090169472A1 (en) | 2005-10-12 | 2009-07-02 | Cancer Research Technology Ltd. | Methods and compositions for treating immune disorders |
-
2007
- 2007-02-23 AT AT07751467T patent/ATE524732T1/de not_active IP Right Cessation
- 2007-02-23 EP EP07751467A patent/EP1996935B1/de not_active Not-in-force
- 2007-02-23 WO PCT/US2007/004707 patent/WO2007100650A2/en active Application Filing
- 2007-02-23 US US12/224,244 patent/US7985538B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US7985538B2 (en) | 2011-07-26 |
EP1996935B1 (de) | 2011-09-14 |
WO2007100650A2 (en) | 2007-09-07 |
WO2007100650A3 (en) | 2008-04-03 |
EP1996935A2 (de) | 2008-12-03 |
US20090220427A1 (en) | 2009-09-03 |
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