JP2013517282A - 受容体チロシンキナーゼ（ｒｔｋ）のインヒビターおよびその使用方法 - Google Patents

受容体チロシンキナーゼ（ｒｔｋ）のインヒビターおよびその使用方法 Download PDF

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Publication number
JP2013517282A
JP2013517282A JP2012549070A JP2012549070A JP2013517282A JP 2013517282 A JP2013517282 A JP 2013517282A JP 2012549070 A JP2012549070 A JP 2012549070A JP 2012549070 A JP2012549070 A JP 2012549070A JP 2013517282 A JP2013517282 A JP 2013517282A
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JP
Japan
Prior art keywords
rtk
antibody
moiety
binds
fgfr1
Prior art date
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Withdrawn
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JP2012549070A
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English (en)
Japanese (ja)
Inventor
ジェ ヒョン ベ，
イリット ラックス，
ジョセフ シュレシンジャー，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
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Yale University
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Publication date
Application filed by Yale University filed Critical Yale University
Publication of JP2013517282A publication Critical patent/JP2013517282A/ja
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
JP2012549070A 2010-01-14 2011-01-13 受容体チロシンキナーゼ（ｒｔｋ）のインヒビターおよびその使用方法 Withdrawn JP2013517282A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33595010P 2010-01-14 2010-01-14
US61/335,950 2010-01-14
PCT/US2011/021109 WO2011088196A2 (en) 2010-01-14 2011-01-13 Inhibitors of receptor tyrosine kinases (rtk) and methods of use thereof

Publications (1)

Publication Number Publication Date
JP2013517282A true JP2013517282A (ja) 2013-05-16

Family

ID=44304965

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012549070A Withdrawn JP2013517282A (ja) 2010-01-14 2011-01-13 受容体チロシンキナーゼ（ｒｔｋ）のインヒビターおよびその使用方法

Country Status (14)

Country Link
US (1) US20120328599A1 (enExample)
EP (1) EP2523679A4 (enExample)
JP (1) JP2013517282A (enExample)
KR (1) KR20120130758A (enExample)
CN (1) CN102762221A (enExample)
AU (1) AU2011205297A1 (enExample)
BR (1) BR112012016992A2 (enExample)
CA (1) CA2786276A1 (enExample)
IL (1) IL220206A0 (enExample)
IN (1) IN2012DN05017A (enExample)
MX (1) MX2012008222A (enExample)
RU (1) RU2012134637A (enExample)
SG (1) SG181850A1 (enExample)
WO (1) WO2011088196A2 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008262384B9 (en) 2007-06-05 2014-11-27 Yale University Inhibitors of receptor tyrosine kinases and methods of use thereof
EP2668210B1 (en) 2011-01-26 2020-06-17 Celldex Therapeutics, Inc. Anti-kit antibodies and uses thereof
NZ731881A (en) 2012-07-25 2022-07-29 Celldex Therapeutics Inc Anti-kit antibodies and uses thereof
WO2014111744A1 (en) 2013-01-16 2014-07-24 INSERM (Institut National de la Santé et de la Recherche Médicale) A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders
WO2014201034A2 (en) * 2013-06-10 2014-12-18 Ansun Biopharma, Inc. Treatment for polyomavirus infection
SI3027651T1 (sl) 2013-08-01 2019-05-31 Five Prime Therapeutics, Inc. Afukozilirana protitelesa proti fgfr2iiib
HUE039268T2 (hu) 2013-10-18 2018-12-28 Eisai R&D Man Co Ltd Pirimidin FGFR4 inhibitorok
US10239943B2 (en) 2014-05-23 2019-03-26 Celldex Therapeutics, Inc. Treatment of eosinophil or mast cell related disorders
JP6431622B2 (ja) 2015-04-14 2018-11-28 エーザイ・アール・アンド・ディー・マネジメント株式会社 結晶性ｆｇｆｒ４阻害剤化合物およびその使用
IL291926B2 (en) 2015-11-23 2024-06-01 Five Prime Therapeutics Inc FGFR2 inhibitors alone or in combination with immunostimulating agents in cancer treatment
EP3454898B1 (en) 2016-05-10 2021-11-10 Eisai R&D Management Co., Ltd. Drug combinations for reducing cell viability and/or cell proliferation
CN106085984B (zh) * 2016-06-02 2019-07-19 天津科技大学 一种新型磷脂酶d及其制备磷脂酸、磷脂酰丝氨酸的方法
CN109715658B (zh) 2016-07-07 2023-09-12 辉瑞大药厂 可溶性成纤维细胞生长因子受体3(sfgfr3)多肽及其用途
KR20250010107A (ko) 2017-05-16 2025-01-20 파이브 프라임 테라퓨틱스, 인크. 암 치료에서 화학요법제와 병용되는 항-fgfr2 항체
CA3189470A1 (en) 2020-08-21 2022-02-24 Yves SABBAGH Fgfr3 antibodies and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8426396B2 (en) * 2008-01-08 2013-04-23 Shriners Hospitals For Children Treatment for achondroplasia

Also Published As

Publication number Publication date
IN2012DN05017A (enExample) 2015-10-02
EP2523679A2 (en) 2012-11-21
MX2012008222A (es) 2012-08-17
KR20120130758A (ko) 2012-12-03
RU2012134637A (ru) 2014-02-20
US20120328599A1 (en) 2012-12-27
BR112012016992A2 (pt) 2019-09-24
AU2011205297A1 (en) 2012-06-28
CN102762221A (zh) 2012-10-31
SG181850A1 (en) 2012-08-30
CA2786276A1 (en) 2011-07-21
WO2011088196A3 (en) 2011-11-17
IL220206A0 (en) 2012-07-31
WO2011088196A2 (en) 2011-07-21
EP2523679A4 (en) 2013-07-24

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