JP2013516496A5 - - Google Patents

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Publication number
JP2013516496A5
JP2013516496A5 JP2012548234A JP2012548234A JP2013516496A5 JP 2013516496 A5 JP2013516496 A5 JP 2013516496A5 JP 2012548234 A JP2012548234 A JP 2012548234A JP 2012548234 A JP2012548234 A JP 2012548234A JP 2013516496 A5 JP2013516496 A5 JP 2013516496A5
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JP
Japan
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compound
substituted
phenyl
nch
alkyl
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JP2012548234A
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English (en)
Japanese (ja)
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JP5840143B2 (ja
JP2013516496A (ja
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Priority claimed from PCT/US2011/020881 external-priority patent/WO2011085389A1/en
Publication of JP2013516496A publication Critical patent/JP2013516496A/ja
Publication of JP2013516496A5 publication Critical patent/JP2013516496A5/ja
Application granted granted Critical
Publication of JP5840143B2 publication Critical patent/JP5840143B2/ja
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JP2012548234A 2010-01-11 2011-01-11 ニコチン性アセチルコリン受容体モジュレーター Active JP5840143B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29404410P 2010-01-11 2010-01-11
US61/294,044 2010-01-11
PCT/US2011/020881 WO2011085389A1 (en) 2010-01-11 2011-01-11 Nicotinic acetylcholine receptor modulators

Publications (3)

Publication Number Publication Date
JP2013516496A JP2013516496A (ja) 2013-05-13
JP2013516496A5 true JP2013516496A5 (OSRAM) 2014-02-27
JP5840143B2 JP5840143B2 (ja) 2016-01-06

Family

ID=44258996

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012548234A Active JP5840143B2 (ja) 2010-01-11 2011-01-11 ニコチン性アセチルコリン受容体モジュレーター

Country Status (9)

Country Link
US (4) US9062042B2 (OSRAM)
EP (1) EP2523562B1 (OSRAM)
JP (1) JP5840143B2 (OSRAM)
CN (1) CN102905527B (OSRAM)
CA (1) CA2787063C (OSRAM)
IL (1) IL220839B (OSRAM)
MX (1) MX2012008082A (OSRAM)
RU (1) RU2560729C2 (OSRAM)
WO (1) WO2011085389A1 (OSRAM)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2560729C2 (ru) 2010-01-11 2015-08-20 АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи Модуляторы никотиновых ацетилхолиновых рецепторов
CN110804051B (zh) * 2019-10-17 2020-10-20 杭州励德生物科技有限公司 一种格拉司琼中间体的制备方法

Family Cites Families (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198447A (en) * 1986-11-21 1993-03-30 Glaxo Group Limited Medicaments
US5200413A (en) * 1987-01-05 1993-04-06 Beecham Group P.L.C. Indolyl carboxamides useful treating migraine, cluster headache, trigeminal neuralgia or emesis
US4835162A (en) * 1987-02-12 1989-05-30 Abood Leo G Agonists and antagonists to nicotine as smoking deterents
DE3852145T2 (de) * 1987-02-18 1995-04-06 Beecham Group Plc Indolderivate, Verfahren zu deren Herstellung und pharmazeutische Präparate, die diese enthalten.
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
US5223511A (en) * 1987-09-23 1993-06-29 Boehringer Ingelheim Italia S.P.A. Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists
EP0315390B1 (en) * 1987-11-04 1994-07-20 Beecham Group Plc Novel 4-oxobenzotriazines and 4-oxoquinazolines
GB2236751B (en) * 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
US5446050A (en) * 1989-11-17 1995-08-29 Pfizer Inc. Azabicyclo amides and esters as 5-HT3 receptor antagonists
JP3122671B2 (ja) * 1990-05-23 2001-01-09 協和醗酵工業株式会社 複素環式化合物
JP3087763B2 (ja) * 1990-11-30 2000-09-11 三井化学株式会社 新規な複素環式化合物およびそれを含有する医薬組成物
US5491148A (en) * 1991-04-26 1996-02-13 Syntex (U.S.A.) Inc. Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists
PH30413A (en) * 1992-03-26 1997-05-09 Boehringer Ingelheim Italia Crystalline forms of endo-2,3-dihydro-n-(8-methyl)-8-azabicyclo-(3,2,1)oct-3-yl)-2-oxo-1h-benzimidazole-1-carboxamides
US5280028A (en) * 1992-06-24 1994-01-18 G. D. Searle & Co. Benzimidazole compounds
AU701227B2 (en) * 1993-09-10 1999-01-21 Cytomed, Inc Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
US5399562A (en) * 1994-02-04 1995-03-21 G. D. Searle & Co. Indolones useful as serotonergic agents
US6117889A (en) * 1994-04-01 2000-09-12 University Of Virginia 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents
GB9410441D0 (en) * 1994-05-25 1994-07-13 Erba Carlo Spa Azabicycloakyl derivatives of imidazo (1,5-a) indol-3-one and process for their preparation
JPH11505547A (ja) * 1996-03-13 1999-05-21 エール ユニバーシティ ナルトレキソン及び関連化合物を用いる禁煙処置
DK0984966T3 (da) * 1997-05-30 2003-05-05 Neurosearch As 9-azabicyclo[3.3.1]non-2-en derivater, som er cholinerge ligander på nikotin-ACh receptorer
CA2289574C (en) * 1997-05-30 2007-04-24 Neurosearch A/S 8-azabicyclo(3,2,1)oct-2-ene and octane derivatives as cholinergic ligands at nicotinic ach receptors
AU744539B2 (en) * 1997-10-27 2002-02-28 Neurosearch A/S Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
AU2349999A (en) * 1998-01-29 1999-08-16 Sepracor, Inc. Pharmacological uses of pure (+) -bupropion
IT1303123B1 (it) * 1998-10-13 2000-10-30 Rotta Research Lab Derivati basici di benz(e)isoindol-1-oni e pirrolo(3,4-c)chinolin-1-oni ad attivita' 5ht3 antagonista, loro preparazione ed
NZ510287A (en) 1998-11-27 2003-05-30 Neurosearch As 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives useful as cholinergic ligands at the nicotinic acetyl choline receptor
FR2788982B1 (fr) 1999-02-02 2002-08-02 Synthelabo Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique
DE10045112A1 (de) 2000-09-11 2002-03-21 Merck Patent Gmbh Verwendung von Indolderivaten zur Behandlung von Erkrankungen des zentralen Nervensystems
BR0209129A (pt) 2001-04-18 2005-12-20 Euro Celtique Sa Compostos, composições farmacêuticas, métodos para tratamento de dores, métodos para modulação de uma resposta farmacológica e usos de compostos
AR036041A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
US7199147B2 (en) * 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
AR036040A1 (es) * 2001-06-12 2004-08-04 Upjohn Co Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
US7642278B2 (en) * 2001-07-03 2010-01-05 Novartis Vaccines And Diagnostics, Inc. Indazole benzimidazole compounds
EP1425286B1 (en) * 2001-09-12 2007-02-28 Pharmacia & Upjohn Company LLC Substituted 7-aza-[2.2.1]bicycloheptanes for the treatment of diseases
EP1432707B1 (en) * 2001-10-02 2012-03-28 Pharmacia & Upjohn Company LLC Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
US6951849B2 (en) * 2001-10-02 2005-10-04 Acadia Pharmaceuticals Inc. Benzimidazolidinone derivatives as muscarinic agents
US6849620B2 (en) * 2001-10-26 2005-02-01 Pfizer Inc N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
MXPA04004464A (es) * 2001-11-08 2004-08-11 Upjohn Co Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades.
US6951868B2 (en) * 2001-11-09 2005-10-04 Pfizer Inc. Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease
JP2005522456A (ja) * 2002-02-15 2005-07-28 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー Cns関連障害治療のためのアザビシクロ置換ベンゾイルアミドおよびチオアミド
BR0307782A (pt) * 2002-02-19 2005-01-04 Upjohn Co Compostos azabiciclo para o tratamento de doença
US6858613B2 (en) * 2002-02-19 2005-02-22 Pfizer Inc. Fused bicyclic-N-bridged-heteroaromatic carboxamides for the treatment of disease
US7176198B2 (en) 2002-08-01 2007-02-13 Pfizer Inc. 1H-pyrazole and 1H-pyrrole-azabicyclic compounds for the treatment of disease
CA2503786A1 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases
AU2003283648A1 (en) 2002-12-06 2004-06-30 Pharmacia & Upjohn Company Llc Compounds as radioligands for the diagnosis of disease
EP1678172B1 (en) * 2003-10-15 2009-12-09 Targacept, Inc. Azabicyclic compounds for relieving pain and treating central nervous system disorders
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
DE602004010299T2 (de) * 2003-12-22 2008-09-18 Memory Pharmaceuticals Corp. Indole, 1h-indazole, 1,2-benzisoxazole und 1,2-benzisothiazole und deren herstellung und anwendungen
JP2007534692A (ja) * 2004-04-22 2007-11-29 メモリー・ファーマシューティカルズ・コーポレイション インドール、1h−インダゾール、1,2−ベンズイソキサゾール、1,2−ベンゾイソチアゾール、ならびにその調製および使用
JP2007538011A (ja) 2004-05-07 2007-12-27 メモリー・ファーマシューティカルズ・コーポレイション 1h−インダゾール、ベンゾチアゾール、1,2−ベンゾイソキサゾール、1,2−ベンゾイソチアゾール、およびクロモン、ならびにそれらの調製および使用
US20090131430A1 (en) 2004-11-23 2009-05-21 Palle Venkata P Pyrido'2,3-dipyrimidines as anti-inflammatory agents
TW200745101A (en) * 2005-09-30 2007-12-16 Organon Nv 9-Azabicyclo[3.3.1]nonane derivatives
US7868017B2 (en) * 2005-09-30 2011-01-11 N.V. Organon 9-azabicyclo[3.3.1]nonane derivatives
NZ567127A (en) * 2005-10-06 2010-04-30 Nippon Soda Co Bridged cyclic amine compound and pest control agent
CN101528225B (zh) * 2006-08-07 2013-07-17 阿尔巴尼分子研究公司 作为5ht3调节剂的2-氨基苯并噁唑羧酰胺
GB0719644D0 (en) * 2007-10-05 2007-11-14 Cancer Rec Tech Ltd Therapeutic compounds and their use
WO2009058120A1 (en) * 2007-11-02 2009-05-07 Sri International Nicotinic acetylcholine receptor modulators
US8697722B2 (en) * 2007-11-02 2014-04-15 Sri International Nicotinic acetylcholine receptor modulators
US7902222B2 (en) 2007-11-21 2011-03-08 Abbott Laboratories Biaryl substituted azabicyclic alkane derivatives
HRP20150341T1 (hr) 2008-11-14 2015-05-08 Bayer Intellectual Property Gmbh Heterocikliäśki supstituirani spojevi arila kao inhibitori hif
RU2011143740A (ru) 2009-03-30 2013-05-10 Астеллас Фарма Инк. Соединение пиримидина
RU2560729C2 (ru) 2010-01-11 2015-08-20 АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи Модуляторы никотиновых ацетилхолиновых рецепторов

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