JP2013515744A5 - - Google Patents
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- JP2013515744A5 JP2013515744A5 JP2012546241A JP2012546241A JP2013515744A5 JP 2013515744 A5 JP2013515744 A5 JP 2013515744A5 JP 2012546241 A JP2012546241 A JP 2012546241A JP 2012546241 A JP2012546241 A JP 2012546241A JP 2013515744 A5 JP2013515744 A5 JP 2013515744A5
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- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- complex
- complex according
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052747 lanthanoid Inorganic materials 0.000 claims description 4
- 150000002602 lanthanoids Chemical class 0.000 claims description 4
- 229910052768 actinide Inorganic materials 0.000 claims description 3
- 150000001255 actinides Chemical class 0.000 claims description 3
- 229910021645 metal ion Inorganic materials 0.000 claims description 3
- 125000004404 heteroalkyl group Chemical group 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000003118 aryl group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- 125000001072 heteroaryl group Chemical group 0.000 claims 10
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 239000001301 oxygen Substances 0.000 claims 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000013522 chelant Substances 0.000 claims 4
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 4
- 230000008685 targeting Effects 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 229910052757 nitrogen Chemical group 0.000 claims 3
- 239000002738 chelating agent Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091034117 Oligonucleotide Proteins 0.000 claims 1
- 229910052776 Thorium Inorganic materials 0.000 claims 1
- 229910052770 Uranium Inorganic materials 0.000 claims 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 1
- 229910052767 actinium Inorganic materials 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000000524 functional group Chemical group 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229910052705 radium Inorganic materials 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 229910052726 zirconium Inorganic materials 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000013078 crystal Substances 0.000 description 3
- 0 *c(c(*)c1*)c(*)c(*)*1O* Chemical compound *c(c(*)c1*)c(*)c(*)*1O* 0.000 description 1
- CUJRVFIICFDLGR-UHFFFAOYSA-N acetylacetonate Chemical compound CC(=O)[CH-]C(C)=O CUJRVFIICFDLGR-UHFFFAOYSA-N 0.000 description 1
- 150000004696 coordination complex Chemical class 0.000 description 1
- 229910021644 lanthanide ion Inorganic materials 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29015509P | 2009-12-24 | 2009-12-24 | |
| US61/290,155 | 2009-12-24 | ||
| PCT/US2010/062048 WO2011079291A1 (en) | 2009-12-24 | 2010-12-23 | Radiopharmaceutical complexes |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017041620A Division JP2017119705A (ja) | 2009-12-24 | 2017-03-06 | 放射性医薬品錯体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013515744A JP2013515744A (ja) | 2013-05-09 |
| JP2013515744A5 true JP2013515744A5 (enExample) | 2014-02-13 |
Family
ID=44196160
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012546241A Pending JP2013515744A (ja) | 2009-12-24 | 2010-12-23 | 放射性医薬品錯体 |
| JP2017041620A Pending JP2017119705A (ja) | 2009-12-24 | 2017-03-06 | 放射性医薬品錯体 |
| JP2018222522A Pending JP2019052164A (ja) | 2009-12-24 | 2018-11-28 | 放射性医薬品錯体 |
| JP2020158380A Pending JP2021006542A (ja) | 2009-12-24 | 2020-09-23 | 放射性医薬品錯体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017041620A Pending JP2017119705A (ja) | 2009-12-24 | 2017-03-06 | 放射性医薬品錯体 |
| JP2018222522A Pending JP2019052164A (ja) | 2009-12-24 | 2018-11-28 | 放射性医薬品錯体 |
| JP2020158380A Pending JP2021006542A (ja) | 2009-12-24 | 2020-09-23 | 放射性医薬品錯体 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20110189088A1 (enExample) |
| EP (2) | EP2516407A4 (enExample) |
| JP (4) | JP2013515744A (enExample) |
| AU (1) | AU2010336403B2 (enExample) |
| WO (1) | WO2011079291A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2659251C (en) | 2006-07-10 | 2016-06-14 | The Regents Of The University Of California | Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides |
| WO2011025790A1 (en) | 2009-08-24 | 2011-03-03 | Lumiphore, Inc. | Macrocyclic hopo chelators |
| GB201002508D0 (en) * | 2010-02-12 | 2010-03-31 | Algeta As | Product |
| GB201208309D0 (en) * | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
| EP2920157B1 (en) * | 2012-11-16 | 2019-09-11 | Lumiphore, Inc. | Di-macrocycles |
| US11453652B2 (en) | 2013-03-15 | 2022-09-27 | Lumiphore, Inc. | Di-macrocycles |
| EP3129350B1 (en) * | 2014-04-09 | 2021-10-27 | Lumiphore, Inc. | Macrocycles |
| AU2015369722A1 (en) | 2014-12-22 | 2017-08-03 | Lumiphore, Inc. | Functionalized linear ligands and complexes thereof |
| JP2019517547A (ja) * | 2016-06-10 | 2019-06-24 | バイエル・ファルマ・アクティエンゲゼルシャフト | 放射性医薬品錯体 |
| WO2018044812A2 (en) | 2016-08-29 | 2018-03-08 | Fred Hutchinson Cancer Research Center | Chelating platform for delivery of radionuclides |
| JP2020506163A (ja) * | 2017-01-12 | 2020-02-27 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | クリプテート誘導体、及び発光ランタニド錯体としてのそれらの使用 |
| WO2019246311A1 (en) * | 2018-06-19 | 2019-12-26 | Lumiphore, Inc. | Macrocycle conjugates |
| EP4424686A1 (en) * | 2018-10-22 | 2024-09-04 | The General Hospital Corporation | Complexes and ligands |
| JP2024060110A (ja) * | 2021-02-19 | 2024-05-02 | 住友化学株式会社 | 放射性金属錯体及びその製造方法 |
| JP2024045789A (ja) * | 2021-02-19 | 2024-04-03 | 住友化学株式会社 | 化合物及び金属錯体 |
| AU2022262350B2 (en) | 2021-04-20 | 2026-05-07 | Terrapower Isotopes, Llc | Titania based generators for ac-225 generation |
| CN117180277A (zh) * | 2023-08-04 | 2023-12-08 | 中国辐射防护研究院 | 一种核素标记的靶向探针及其制备方法和应用 |
Family Cites Families (48)
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| BE561256A (enExample) * | 1956-10-02 | |||
| US4309305A (en) | 1978-07-24 | 1982-01-05 | The United States As Represented By The United States Department Of Energy | In vitro removal of actinide (IV) ions |
| US4543213A (en) | 1978-07-24 | 1985-09-24 | The United States Of America As Represented By The United States Department Of Energy | Process for preparing 2,3-dihydroxybenzoic acid amides of tetraazaalkanes and cycloalkanes |
| US4181654A (en) * | 1978-07-24 | 1980-01-01 | The United States Of America As Represented By The United States Department Of Energy | 2,3-Dihydroxybenzoic acid amides of tetraazaalkanes and tetaaza cycloalkanes |
| US4442305A (en) | 1981-08-24 | 1984-04-10 | The United States Of America As Represented By The United States Department Of Energy | Polycatecholamide chelating agents |
| US4748184A (en) * | 1982-07-26 | 1988-05-31 | E. I. Du Pont De Nemours And Company | Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility |
| GB8325494D0 (en) * | 1983-09-23 | 1983-10-26 | Hider R C | Pharmaceutical compositions |
| US5010191A (en) | 1985-08-19 | 1991-04-23 | The Regents Of The University Of California | Imaging agents for in vivo magnetic resonance and scintigraphic imaging |
| US4698431A (en) | 1985-11-12 | 1987-10-06 | The United States Of America As Represented By The United States Department Of Energy | Hydroxypyridonate chelating agents |
| US4855225A (en) * | 1986-02-07 | 1989-08-08 | Applied Biosystems, Inc. | Method of detecting electrophoretically separated oligonucleotides |
| US4868103A (en) * | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| US5047519A (en) * | 1986-07-02 | 1991-09-10 | E. I. Du Pont De Nemours And Company | Alkynylamino-nucleotides |
| US4978614A (en) * | 1988-10-26 | 1990-12-18 | Tropix, Inc. | Method of detecting a substance using enzymatically-induced decomposition of dioxetanes |
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| JP2831073B2 (ja) * | 1988-06-24 | 1998-12-02 | ザ ダウ ケミカル カンパニー | 大環状二官能キレート剤、その錯体及びそれらの抗体接合体 |
| US5049280A (en) | 1989-03-29 | 1991-09-17 | The Regents Of The University Of California | 2,3-dihydroxyterephthalamides as highly effective metal ion sequestering compounds |
| WO1993008839A1 (en) * | 1991-11-08 | 1993-05-13 | Curators Of The University Of Missouri | Multifunctional ligands for potential use in the design of therapeutic or diagnostic radiopharmaceutical imaging agents |
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| CA2659251C (en) * | 2006-07-10 | 2016-06-14 | The Regents Of The University Of California | Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides |
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| WO2010051544A2 (en) * | 2008-10-31 | 2010-05-06 | Lumiphore, Inc. | Rapid homogeneous diagnostic testing platform based on lanthanide fluorescent resonance energy transfer |
| WO2010129962A2 (en) * | 2009-05-08 | 2010-11-11 | The Regents Of The University Of California | Combination treatment of hydroxypyridonate actinide/lanthanide decorporation agents |
| WO2011025790A1 (en) * | 2009-08-24 | 2011-03-03 | Lumiphore, Inc. | Macrocyclic hopo chelators |
| US20120190012A1 (en) * | 2010-04-06 | 2012-07-26 | Lumiphore, Inc. | Compositions and methods for dna sequencing |
-
2010
- 2010-12-23 EP EP20100840184 patent/EP2516407A4/en not_active Ceased
- 2010-12-23 AU AU2010336403A patent/AU2010336403B2/en active Active
- 2010-12-23 WO PCT/US2010/062048 patent/WO2011079291A1/en not_active Ceased
- 2010-12-23 JP JP2012546241A patent/JP2013515744A/ja active Pending
- 2010-12-23 US US12/977,957 patent/US20110189088A1/en not_active Abandoned
- 2010-12-23 EP EP17186299.8A patent/EP3263562A1/en not_active Withdrawn
-
2017
- 2017-03-06 JP JP2017041620A patent/JP2017119705A/ja active Pending
-
2018
- 2018-11-28 JP JP2018222522A patent/JP2019052164A/ja active Pending
-
2019
- 2019-01-07 US US16/241,507 patent/US20200024234A1/en not_active Abandoned
-
2020
- 2020-09-23 JP JP2020158380A patent/JP2021006542A/ja active Pending
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