JP2013515015A5 - - Google Patents
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- Publication number
- JP2013515015A5 JP2013515015A5 JP2012545030A JP2012545030A JP2013515015A5 JP 2013515015 A5 JP2013515015 A5 JP 2013515015A5 JP 2012545030 A JP2012545030 A JP 2012545030A JP 2012545030 A JP2012545030 A JP 2012545030A JP 2013515015 A5 JP2013515015 A5 JP 2013515015A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- polypeptide
- immunogenic
- pharmaceutically acceptable
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 44
- 229920001184 polypeptide Polymers 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 27
- 102000004196 processed proteins & peptides Human genes 0.000 claims 27
- 230000002163 immunogen Effects 0.000 claims 24
- 239000000546 pharmaceutical excipient Substances 0.000 claims 18
- 101710183389 Pneumolysin Proteins 0.000 claims 13
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 10
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 10
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 101100420868 Anuroctonus phaiodactylus phtx gene Proteins 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000000839 emulsion Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical group Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 claims 2
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 230000005847 immunogenicity Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 239000002736 nonionic surfactant Substances 0.000 claims 2
- 229920002704 polyhistidine Polymers 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 235000000346 sugar Nutrition 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000031729 Bacteremia Diseases 0.000 claims 1
- 206010010741 Conjunctivitis Diseases 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical group OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 239000007995 HEPES buffer Substances 0.000 claims 1
- 201000009906 Meningitis Diseases 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 206010033078 Otitis media Diseases 0.000 claims 1
- 208000035109 Pneumococcal Infections Diseases 0.000 claims 1
- 206010035664 Pneumonia Diseases 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- 150000005215 alkyl ethers Chemical class 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000003125 aqueous solvent Substances 0.000 claims 1
- 239000000872 buffer Substances 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003599 detergent Substances 0.000 claims 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000002831 pharmacologic agent Substances 0.000 claims 1
- 229920001308 poly(aminoacid) Polymers 0.000 claims 1
- -1 polyoxyethylene Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 229940031439 squalene Drugs 0.000 claims 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 239000005720 sucrose Substances 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 150000008163 sugars Chemical class 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28923609P | 2009-12-22 | 2009-12-22 | |
| US61/289,236 | 2009-12-22 | ||
| US32566010P | 2010-04-19 | 2010-04-19 | |
| US61/325,660 | 2010-04-19 | ||
| PCT/CA2010/001977 WO2011075823A1 (en) | 2009-12-22 | 2010-12-20 | Immunogenic compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015254259A Division JP2016104776A (ja) | 2009-12-22 | 2015-12-25 | 免疫原性組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013515015A JP2013515015A (ja) | 2013-05-02 |
| JP2013515015A5 true JP2013515015A5 (cg-RX-API-DMAC10.html) | 2015-01-29 |
| JP5894083B2 JP5894083B2 (ja) | 2016-03-23 |
Family
ID=44194860
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012545030A Expired - Fee Related JP5894083B2 (ja) | 2009-12-22 | 2010-12-20 | 免疫原性組成物 |
| JP2015254259A Pending JP2016104776A (ja) | 2009-12-22 | 2015-12-25 | 免疫原性組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015254259A Pending JP2016104776A (ja) | 2009-12-22 | 2015-12-25 | 免疫原性組成物 |
Country Status (12)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011075822A1 (en) | 2009-12-22 | 2011-06-30 | Sanofi Pasteur Limited | Immunogenic compositions and related methods |
| AU2011336366B2 (en) * | 2010-12-03 | 2016-05-12 | Sanofi Pasteur Limited | Composition for immunization against Streptococcus pneumoniae |
| KR20140033127A (ko) | 2011-05-17 | 2014-03-17 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 스트렙토코쿠스 뉴모니애에 대한 백신 |
| WO2014060385A1 (en) * | 2012-10-17 | 2014-04-24 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| GB201218660D0 (en) | 2012-10-17 | 2012-11-28 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| CA2894903A1 (en) * | 2012-12-14 | 2014-06-19 | Sanofi Pasteur, Ltd. | Methods for assessing immunogenicity |
| CA2941826A1 (en) * | 2014-03-10 | 2015-09-17 | Sanofi Pasteur Limited | Immunogenic compositions |
| KR101688960B1 (ko) * | 2014-06-11 | 2016-12-23 | 전남대학교산학협력단 | 스쿠티카충 백신 조성물 |
| CN107206066A (zh) * | 2015-01-27 | 2017-09-26 | 3M创新有限公司 | 用于微针疫苗贴剂的含明矾的涂层制剂 |
| US11173197B2 (en) | 2015-07-07 | 2021-11-16 | Bluewillow Biologics, Inc. | Methods and compositions for nanoemulsion vaccine formulations |
| EP3736574A1 (en) * | 2019-05-07 | 2020-11-11 | Atlas Antibodies AB | A formulation comprising an isotope labeled fusion polypeptide |
| WO2023034932A1 (en) * | 2021-09-02 | 2023-03-09 | Vaxcyte, Inc. | Stabilization of adjuvanted vaccine compositions and their use |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3237842B2 (ja) * | 1988-12-16 | 2001-12-10 | オランダ国 | ニューモリシンミュータント及びそれから製造されたニューモコッカルワクチン |
| US6800744B1 (en) * | 1997-07-02 | 2004-10-05 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics |
| CA2355364C (en) * | 1998-12-21 | 2014-03-18 | Medimmune, Inc. | Streptococcus pneumoniae proteins and immunogenic fragments for vaccines |
| GB0022742D0 (en) * | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| GB0213622D0 (en) * | 2002-06-13 | 2002-07-24 | Glaxosmithkline Biolog Sa | Vaccine Corporation |
| GB0410220D0 (en) * | 2004-05-07 | 2004-06-09 | Kirkham Lea Ann | Mutant pneumolysin proteins |
| DK1861120T3 (en) * | 2005-03-23 | 2016-07-25 | Glaxosmithkline Biologicals Sa | Use of an influenza virus and an oil-in-water emulsion adjuvant to induce CD 4 T cell and / or enhanced B memory cell response |
| TWI457133B (zh) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | 新穎組合物 |
| US20110002962A1 (en) | 2006-08-17 | 2011-01-06 | The Uab Research Foundation | Immunogenic PcpA Polypeptides and Uses Thereof |
| CA2694466A1 (en) | 2007-07-23 | 2009-01-29 | Sanofi Pasteur Limited | Immunogenic polypeptides and monoclonal antibodies |
| CN101952728B (zh) * | 2008-02-01 | 2016-05-11 | 圣诺菲·帕斯图尔有限公司 | 用于诊断肺炎链球菌的试验 |
| CN106008679A (zh) * | 2008-12-24 | 2016-10-12 | 荷兰王国卫生福利和运动部国家公共卫生和环境研究所 | 修饰的肺炎链球菌溶血素(ply)多肽 |
-
2010
- 2010-12-20 KR KR1020127019061A patent/KR20120107121A/ko not_active Abandoned
- 2010-12-20 JP JP2012545030A patent/JP5894083B2/ja not_active Expired - Fee Related
- 2010-12-20 WO PCT/CA2010/001977 patent/WO2011075823A1/en not_active Ceased
- 2010-12-20 US US13/515,093 patent/US20130183350A1/en not_active Abandoned
- 2010-12-20 CA CA2783955A patent/CA2783955A1/en not_active Abandoned
- 2010-12-20 CN CN201080064532.1A patent/CN102802664B/zh not_active Expired - Fee Related
- 2010-12-20 BR BR112012018343A patent/BR112012018343A2/pt not_active IP Right Cessation
- 2010-12-20 EP EP10838456.1A patent/EP2515938A4/en not_active Withdrawn
- 2010-12-20 AU AU2010335970A patent/AU2010335970B2/en not_active Ceased
- 2010-12-22 AR ARP100104897A patent/AR079712A1/es unknown
-
2012
- 2012-06-21 ZA ZA2012/04628A patent/ZA201204628B/en unknown
- 2012-06-21 IL IL220576A patent/IL220576B/en not_active IP Right Cessation
-
2015
- 2015-11-15 IL IL242592A patent/IL242592A/en not_active IP Right Cessation
- 2015-12-25 JP JP2015254259A patent/JP2016104776A/ja active Pending
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