JP2013514788A5 - - Google Patents

Info

Publication number

JP2013514788A5

JP2013514788A5 JP2012545018A JP2012545018A JP2013514788A5 JP 2013514788 A5 JP2013514788 A5 JP 2013514788A5 JP 2012545018 A JP2012545018 A JP 2012545018A JP 2012545018 A JP2012545018 A JP 2012545018A JP 2013514788 A5 JP2013514788 A5 JP 2013514788A5

Authority

JP

Japan

Prior art keywords

protein

residues

kabat numbering

numbering system

compound

Prior art date

2010-12-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 235000018102 proteins Nutrition 0.000 claims 50
• 102000004169 proteins and genes Human genes 0.000 claims 50
• 108090000623 proteins and genes Proteins 0.000 claims 50
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 26
• NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 17
• 150000001875 compounds Chemical class 0.000 claims 16
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 238000000034 method Methods 0.000 claims 9
• 239000000203 mixture Substances 0.000 claims 7
• 108090000765 processed proteins & peptides Proteins 0.000 claims 5
• 239000002202 Polyethylene glycol Substances 0.000 claims 4
• 102000039446 nucleic acids Human genes 0.000 claims 4
• 108020004707 nucleic acids Proteins 0.000 claims 4
• 150000007523 nucleic acids Chemical class 0.000 claims 4
• 229920001223 polyethylene glycol Polymers 0.000 claims 4
• 229920001184 polypeptide Polymers 0.000 claims 4
• 102000004196 processed proteins & peptides Human genes 0.000 claims 4
• 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
• 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 3
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims 2
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims 2
• 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
• 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
• 238000003745 diagnosis Methods 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 229920000642 polymer Polymers 0.000 claims 2
• 238000004393 prognosis Methods 0.000 claims 2
• 229940126062 Compound A Drugs 0.000 claims 1
• 108090000288 Glycoproteins Proteins 0.000 claims 1
• 102000003886 Glycoproteins Human genes 0.000 claims 1
• NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
• 101500025419 Homo sapiens Epidermal growth factor Proteins 0.000 claims 1
• 101000998953 Homo sapiens Immunoglobulin heavy variable 1-2 Proteins 0.000 claims 1
• 101001008255 Homo sapiens Immunoglobulin kappa variable 1D-8 Proteins 0.000 claims 1
• 101001047628 Homo sapiens Immunoglobulin kappa variable 2-29 Proteins 0.000 claims 1
• 101001008321 Homo sapiens Immunoglobulin kappa variable 2D-26 Proteins 0.000 claims 1
• 101001047619 Homo sapiens Immunoglobulin kappa variable 3-20 Proteins 0.000 claims 1
• 101001008263 Homo sapiens Immunoglobulin kappa variable 3D-15 Proteins 0.000 claims 1
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102100036887 Immunoglobulin heavy variable 1-2 Human genes 0.000 claims 1
• 102100022949 Immunoglobulin kappa variable 2-29 Human genes 0.000 claims 1
• 102100034256 Mucin-1 Human genes 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 1
• 239000004473 Threonine Substances 0.000 claims 1
• 239000000084 colloidal system Substances 0.000 claims 1
• 238000012258 culturing Methods 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000002405 diagnostic procedure Methods 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 229940116978 human epidermal growth factor Drugs 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 230000004807 localization Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• GVUGOAYIVIDWIO-UFWWTJHBSA-N nepidermin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C(C)C)C(C)C)C1=CC=C(O)C=C1 GVUGOAYIVIDWIO-UFWWTJHBSA-N 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 101150047061 tag-72 gene Proteins 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1