JP2013514386A5 - - Google Patents
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- Publication number
- JP2013514386A5 JP2013514386A5 JP2012544825A JP2012544825A JP2013514386A5 JP 2013514386 A5 JP2013514386 A5 JP 2013514386A5 JP 2012544825 A JP2012544825 A JP 2012544825A JP 2012544825 A JP2012544825 A JP 2012544825A JP 2013514386 A5 JP2013514386 A5 JP 2013514386A5
- Authority
- JP
- Japan
- Prior art keywords
- viscosity modifier
- tablet
- strong film
- tablet according
- natural
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 7
- 229960001410 hydromorphone Drugs 0.000 claims description 7
- 239000004034 viscosity adjusting agent Substances 0.000 claims 20
- 239000003826 tablet Substances 0.000 claims 19
- 238000000034 method Methods 0.000 claims 16
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 7
- 239000011248 coating agent Substances 0.000 claims 5
- 238000000576 coating method Methods 0.000 claims 5
- 239000008187 granular material Substances 0.000 claims 5
- 239000000758 substrate Substances 0.000 claims 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical group CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 4
- 241001312219 Amorphophallus konjac Species 0.000 claims 4
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- 239000001856 Ethyl cellulose Substances 0.000 claims 4
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 4
- 108010010803 Gelatin Proteins 0.000 claims 4
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 4
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 4
- 229920002752 Konjac Polymers 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- 229920001800 Shellac Polymers 0.000 claims 4
- 229920002125 Sokalan® Polymers 0.000 claims 4
- 229920002472 Starch Polymers 0.000 claims 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 4
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 4
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 4
- 229940105329 carboxymethylcellulose Drugs 0.000 claims 4
- 235000010418 carrageenan Nutrition 0.000 claims 4
- 239000000679 carrageenan Substances 0.000 claims 4
- 229920001525 carrageenan Polymers 0.000 claims 4
- 229940113118 carrageenan Drugs 0.000 claims 4
- 229920002678 cellulose Polymers 0.000 claims 4
- 239000001913 cellulose Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 235000019325 ethyl cellulose Nutrition 0.000 claims 4
- 229920001249 ethyl cellulose Polymers 0.000 claims 4
- 235000013312 flour Nutrition 0.000 claims 4
- 229920000159 gelatin Polymers 0.000 claims 4
- 239000008273 gelatin Substances 0.000 claims 4
- 235000019322 gelatine Nutrition 0.000 claims 4
- 235000011852 gelatine desserts Nutrition 0.000 claims 4
- 229920000591 gum Polymers 0.000 claims 4
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 4
- 239000000252 konjac Substances 0.000 claims 4
- 235000010485 konjac Nutrition 0.000 claims 4
- 239000000113 methacrylic resin Substances 0.000 claims 4
- 229920000609 methyl cellulose Polymers 0.000 claims 4
- 239000001923 methylcellulose Substances 0.000 claims 4
- 235000010981 methylcellulose Nutrition 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000001814 pectin Substances 0.000 claims 4
- 235000010987 pectin Nutrition 0.000 claims 4
- 229920001277 pectin Polymers 0.000 claims 4
- 239000004584 polyacrylic acid Substances 0.000 claims 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 4
- 239000011347 resin Substances 0.000 claims 4
- 229920005989 resin Polymers 0.000 claims 4
- 239000004208 shellac Substances 0.000 claims 4
- 229940113147 shellac Drugs 0.000 claims 4
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims 4
- 235000013874 shellac Nutrition 0.000 claims 4
- 235000010413 sodium alginate Nutrition 0.000 claims 4
- 239000000661 sodium alginate Substances 0.000 claims 4
- 229940005550 sodium alginate Drugs 0.000 claims 4
- 239000008107 starch Substances 0.000 claims 4
- 235000019698 starch Nutrition 0.000 claims 4
- 239000002966 varnish Substances 0.000 claims 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 4
- 229920002554 vinyl polymer Polymers 0.000 claims 4
- 239000000230 xanthan gum Substances 0.000 claims 4
- 235000010493 xanthan gum Nutrition 0.000 claims 4
- 229920001285 xanthan gum Polymers 0.000 claims 4
- 229940082509 xanthan gum Drugs 0.000 claims 4
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 4
- 239000007931 coated granule Substances 0.000 claims 3
- 239000002552 dosage form Substances 0.000 claims 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 3
- 239000004927 clay Substances 0.000 claims 2
- 239000003607 modifier Substances 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 150000003839 salts Chemical group 0.000 claims 2
- 239000007939 sustained release tablet Substances 0.000 claims 2
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims 1
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 claims 1
- 229960002900 methylcellulose Drugs 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 208000002193 Pain Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 208000025940 Back injury Diseases 0.000 description 1
- 208000000094 Chronic Pain Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000955 prescription drug Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28751509P | 2009-12-17 | 2009-12-17 | |
| US61/287,515 | 2009-12-17 | ||
| PCT/US2010/060755 WO2011084593A2 (en) | 2009-12-17 | 2010-12-16 | Abuse-resistant formulations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013514386A JP2013514386A (ja) | 2013-04-25 |
| JP2013514386A5 true JP2013514386A5 (enExample) | 2014-02-13 |
| JP5894717B2 JP5894717B2 (ja) | 2016-03-30 |
Family
ID=43618139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012544825A Expired - Fee Related JP5894717B2 (ja) | 2009-12-17 | 2010-12-16 | 乱用抑止性製剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20120225122A1 (enExample) |
| EP (1) | EP2512456A2 (enExample) |
| JP (1) | JP5894717B2 (enExample) |
| CN (1) | CN102665694A (enExample) |
| AU (1) | AU2010339882B2 (enExample) |
| CA (1) | CA2784407A1 (enExample) |
| IL (1) | IL219961A (enExample) |
| MX (1) | MX348361B (enExample) |
| NZ (1) | NZ600640A (enExample) |
| WO (1) | WO2011084593A2 (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8784336B2 (en) | 2005-08-24 | 2014-07-22 | C. R. Bard, Inc. | Stylet apparatuses and methods of manufacture |
| US7794407B2 (en) | 2006-10-23 | 2010-09-14 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
| US8388546B2 (en) | 2006-10-23 | 2013-03-05 | Bard Access Systems, Inc. | Method of locating the tip of a central venous catheter |
| EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| US8849382B2 (en) | 2007-11-26 | 2014-09-30 | C. R. Bard, Inc. | Apparatus and display methods relating to intravascular placement of a catheter |
| US9521961B2 (en) | 2007-11-26 | 2016-12-20 | C. R. Bard, Inc. | Systems and methods for guiding a medical instrument |
| US10449330B2 (en) | 2007-11-26 | 2019-10-22 | C. R. Bard, Inc. | Magnetic element-equipped needle assemblies |
| US10751509B2 (en) | 2007-11-26 | 2020-08-25 | C. R. Bard, Inc. | Iconic representations for guidance of an indwelling medical device |
| EP2992825B1 (en) | 2007-11-26 | 2017-11-01 | C.R. Bard Inc. | Integrated system for intravascular placement of a catheter |
| US9649048B2 (en) | 2007-11-26 | 2017-05-16 | C. R. Bard, Inc. | Systems and methods for breaching a sterile field for intravascular placement of a catheter |
| US8781555B2 (en) | 2007-11-26 | 2014-07-15 | C. R. Bard, Inc. | System for placement of a catheter including a signal-generating stylet |
| US10524691B2 (en) | 2007-11-26 | 2020-01-07 | C. R. Bard, Inc. | Needle assembly including an aligned magnetic element |
| US8478382B2 (en) | 2008-02-11 | 2013-07-02 | C. R. Bard, Inc. | Systems and methods for positioning a catheter |
| US9901714B2 (en) | 2008-08-22 | 2018-02-27 | C. R. Bard, Inc. | Catheter assembly including ECG sensor and magnetic assemblies |
| US8437833B2 (en) | 2008-10-07 | 2013-05-07 | Bard Access Systems, Inc. | Percutaneous magnetic gastrostomy |
| EP2393484A1 (en) | 2009-02-06 | 2011-12-14 | Egalet Ltd. | Immediate release composition resistant to abuse by intake of alcohol |
| US9532724B2 (en) | 2009-06-12 | 2017-01-03 | Bard Access Systems, Inc. | Apparatus and method for catheter navigation using endovascular energy mapping |
| US9445734B2 (en) | 2009-06-12 | 2016-09-20 | Bard Access Systems, Inc. | Devices and methods for endovascular electrography |
| WO2010144922A1 (en) | 2009-06-12 | 2010-12-16 | Romedex International Srl | Catheter tip positioning method |
| EP2445487A2 (en) | 2009-06-24 | 2012-05-02 | Egalet Ltd. | Controlled release formulations |
| EP2482719A4 (en) | 2009-09-29 | 2016-03-09 | Bard Inc C R | STYLETS FOR USE WITH APPARATUS FOR INTRAVASCULAR PLACEMENT OF A CATHETER |
| WO2011044421A1 (en) | 2009-10-08 | 2011-04-14 | C. R. Bard, Inc. | Spacers for use with an ultrasound probe |
| US10639008B2 (en) | 2009-10-08 | 2020-05-05 | C. R. Bard, Inc. | Support and cover structures for an ultrasound probe head |
| BR112012019354B1 (pt) | 2010-02-02 | 2021-09-08 | C.R.Bard, Inc | Método para localização de um dispositivo médico implantável |
| WO2011150376A1 (en) | 2010-05-28 | 2011-12-01 | C.R. Bard, Inc. | Apparatus for use with needle insertion guidance system |
| CA2800810C (en) | 2010-05-28 | 2019-11-05 | C.R. Bard, Inc. | Insertion guidance system for needles and medical components |
| WO2012024577A2 (en) | 2010-08-20 | 2012-02-23 | C.R. Bard, Inc. | Reconfirmation of ecg-assisted catheter tip placement |
| WO2012058461A1 (en) | 2010-10-29 | 2012-05-03 | C.R.Bard, Inc. | Bioimpedance-assisted placement of a medical device |
| CA2835890A1 (en) | 2011-07-06 | 2013-01-10 | C.R. Bard, Inc. | Needle length determination and calibration for insertion guidance system |
| USD699359S1 (en) | 2011-08-09 | 2014-02-11 | C. R. Bard, Inc. | Ultrasound probe head |
| US9211107B2 (en) | 2011-11-07 | 2015-12-15 | C. R. Bard, Inc. | Ruggedized ultrasound hydrogel insert |
| US20150086626A1 (en) * | 2012-04-17 | 2015-03-26 | Mylan, Inc | Stable dosage forms of skeletal muscle relaxants with extended release coating |
| EP2861153A4 (en) | 2012-06-15 | 2016-10-19 | Bard Inc C R | APPARATUS AND METHODS FOR DETECTION OF A REMOVABLE CAP ON AN ULTRASONIC PROBE |
| EP2893928B1 (en) | 2012-09-03 | 2018-10-24 | Daiichi Sankyo Company, Limited | Hydromorphone hydrochloride-containing oral sustained-release pharmaceutical composition |
| CA2817728A1 (en) * | 2013-05-31 | 2014-11-30 | Pharmascience Inc. | Abuse deterrent immediate release formulation |
| AU2014306759B2 (en) | 2013-08-12 | 2018-04-26 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| ES2811323T3 (es) | 2014-02-06 | 2021-03-11 | Bard Inc C R | Sistemas para el guiado y la colocación de un dispositivo intravascular |
| ES2809458T3 (es) | 2014-07-17 | 2021-03-04 | Pharmaceutical Manufacturing Res Services Inc | Forma de dosificación llena de líquido, disuasoria del abuso y de liberación inmediata |
| US9132096B1 (en) | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
| WO2016064873A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| US10973584B2 (en) | 2015-01-19 | 2021-04-13 | Bard Access Systems, Inc. | Device and method for vascular access |
| WO2016210325A1 (en) | 2015-06-26 | 2016-12-29 | C.R. Bard, Inc. | Connector interface for ecg-based catheter positioning system |
| US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| US11000207B2 (en) | 2016-01-29 | 2021-05-11 | C. R. Bard, Inc. | Multiple coil system for tracking a medical device |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| EP3852622B1 (en) | 2018-10-16 | 2025-04-02 | Bard Access Systems, Inc. | Safety-equipped connection systems and methods thereof for establishing electrical connections |
| WO2020112699A1 (en) | 2018-11-26 | 2020-06-04 | The Procter & Gamble Company | Solid pharmaceutical preparation containing lipoic acid and use thereof |
| EP4062973A4 (en) | 2019-11-20 | 2023-11-29 | Shionogi & Co., Ltd | 6,7-unsaturated-7-carbamoyl morphinan derivative-containing solid formulation |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8626098D0 (en) * | 1986-10-31 | 1986-12-03 | Euro Celtique Sa | Controlled release hydromorphone composition |
| US5223264A (en) | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| IL110014A (en) * | 1993-07-01 | 1999-11-30 | Euro Celtique Sa | Solid controlled-release oral dosage forms of opioid analgesics |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| PE20001396A1 (es) * | 1999-01-18 | 2000-12-23 | Gruenenthal Chemie | Formulaciones medicamentosas retardadas que contienen una combinacion de un opioide o una sal fisiologicamente tolerables del mismo, un o-agonista |
| US20030068375A1 (en) * | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| CA2572491A1 (en) * | 2004-07-01 | 2006-01-12 | Gruenenthal Gmbh | Oral dosage form safeguarded against abuse |
| US20080069891A1 (en) * | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
| US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
| DK2200593T5 (en) * | 2007-09-13 | 2016-12-12 | Cima Labs Inc | Hog-resistant pharmaceutical formulation |
| ATE455538T1 (de) * | 2007-11-09 | 2010-02-15 | Acino Pharma Ag | Retardtabletten mit hydromorphon |
| CA2798702A1 (en) * | 2010-05-11 | 2011-11-17 | Cima Labs Inc. | Alcoholresistant metoprolol-containing extended-release oral dosage forms |
-
2010
- 2010-12-16 EP EP10801741A patent/EP2512456A2/en not_active Withdrawn
- 2010-12-16 CA CA2784407A patent/CA2784407A1/en not_active Abandoned
- 2010-12-16 JP JP2012544825A patent/JP5894717B2/ja not_active Expired - Fee Related
- 2010-12-16 CN CN2010800576355A patent/CN102665694A/zh active Pending
- 2010-12-16 AU AU2010339882A patent/AU2010339882B2/en not_active Ceased
- 2010-12-16 WO PCT/US2010/060755 patent/WO2011084593A2/en not_active Ceased
- 2010-12-16 NZ NZ600640A patent/NZ600640A/en not_active IP Right Cessation
- 2010-12-16 MX MX2012006829A patent/MX348361B/es active IP Right Grant
-
2012
- 2012-05-14 US US13/470,963 patent/US20120225122A1/en not_active Abandoned
- 2012-05-23 IL IL219961A patent/IL219961A/en not_active IP Right Cessation
-
2014
- 2014-06-05 US US14/296,572 patent/US9474721B2/en not_active Expired - Fee Related
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