JP2013514156A5 - - Google Patents
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- JP2013514156A5 JP2013514156A5 JP2012544798A JP2012544798A JP2013514156A5 JP 2013514156 A5 JP2013514156 A5 JP 2013514156A5 JP 2012544798 A JP2012544798 A JP 2012544798A JP 2012544798 A JP2012544798 A JP 2012544798A JP 2013514156 A5 JP2013514156 A5 JP 2013514156A5
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Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28651909P | 2009-12-15 | 2009-12-15 | |
US61/286,519 | 2009-12-15 | ||
US38561310P | 2010-09-23 | 2010-09-23 | |
US61/385,613 | 2010-09-23 | ||
PCT/US2010/060586 WO2011084528A1 (fr) | 2009-12-15 | 2010-12-15 | Système et méthode permettant de fournir un guidage anatomique en temps réel au cours d'un acte diagnostique ou thérapeutique |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013514156A JP2013514156A (ja) | 2013-04-25 |
JP2013514156A5 true JP2013514156A5 (fr) | 2015-07-02 |
JP6275382B2 JP6275382B2 (ja) | 2018-02-07 |
Family
ID=44152058
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012544798A Expired - Fee Related JP6275382B2 (ja) | 2009-12-15 | 2010-12-15 | 診断又は治療処置においてリアルタイム解剖学的指針を提供するシステム及び方法 |
Country Status (7)
Country | Link |
---|---|
US (2) | US20110152692A1 (fr) |
EP (1) | EP2512337B1 (fr) |
JP (1) | JP6275382B2 (fr) |
CN (2) | CN104757936B (fr) |
AU (1) | AU2010339972B2 (fr) |
CA (1) | CA2784576C (fr) |
WO (1) | WO2011084528A1 (fr) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE336717T1 (de) | 2001-05-17 | 2006-09-15 | Xenogen Corp | Verfahren und vorrichtung zur feststellung von zieltiefe, helligkeit und grösse in einer körperregion |
WO2009020680A2 (fr) * | 2007-05-04 | 2009-02-12 | Stanford University | Imagerie moléculaire d'êtres vivants utilisant la spectroscopie raman et des nanoparticules raman étiquetées |
WO2010004365A1 (fr) | 2008-07-10 | 2010-01-14 | Ecole Polytechnique Federale De Lausanne (Epfl) | Imagerie optique cohérente fonctionnelle |
CN104757936B (zh) | 2009-12-15 | 2018-02-23 | 爱默蕾大学 | 用于在诊断或治疗程序中提供实时解剖学指导的系统和方法 |
JP5380348B2 (ja) * | 2010-03-31 | 2014-01-08 | 富士フイルム株式会社 | 内視鏡観察を支援するシステムおよび方法、並びに、装置およびプログラム |
US9833145B2 (en) | 2010-08-11 | 2017-12-05 | Snu R&Db Foundation | Method for simultaneously detecting fluorescence and raman signals for multiple fluorescence and raman signal targets, and medical imaging device for simultaneously detecting multiple targets using the method |
KR101207695B1 (ko) * | 2010-08-11 | 2012-12-03 | 서울대학교산학협력단 | 형광 및 라만 신호 표적에 대한 형광 및 라만 신호 동시검출방법 및 이를 이용한 표적 동시검출용 의학영상장치 |
WO2012065163A2 (fr) | 2010-11-12 | 2012-05-18 | Emory University | Systèmes et procédés additionnels fournissant une assistance anatomique en temps réel lors d'une procédure diagnostique ou thérapeutique |
JP5385350B2 (ja) * | 2011-08-16 | 2014-01-08 | 富士フイルム株式会社 | 画像表示方法および装置 |
WO2013032839A2 (fr) * | 2011-09-02 | 2013-03-07 | The Board Of Trustees Of The Leland Stanford Junior University | Dispositifs d'imagerie raman et procédés d'imagerie moléculaire |
WO2013057697A1 (fr) | 2011-10-19 | 2013-04-25 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Cartes d'imagerie par résonance magnétique permettant d'analyser un tissu |
JP5977440B2 (ja) | 2012-04-27 | 2016-08-24 | アイマゴ ソシエテ アノニムAimago S.A. | 光コヒーレントイメージング医療デバイス |
US10101571B2 (en) | 2012-07-10 | 2018-10-16 | Novadaq Technologies ULC | Perfusion assessment multi-modality optical medical device |
CA2882388C (fr) | 2012-08-31 | 2020-10-20 | Sloan-Kettering Institute For Cancer Research | Particules, procedes et leurs utilisations |
US9824440B2 (en) * | 2012-11-20 | 2017-11-21 | Vanderbilt University | Methods and systems for three-dimensional real-time intraoperative surgical margin evaluation of tumor tissues |
CA2894719C (fr) | 2012-12-19 | 2019-10-22 | Sloan-Kettering Institute For Cancer Research | Particules multimodales, procedes et utilisations associees |
JP6635791B2 (ja) * | 2013-02-20 | 2020-01-29 | スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ | 広視野ラマン撮像装置および関連方法 |
WO2014168734A1 (fr) | 2013-03-15 | 2014-10-16 | Cedars-Sinai Medical Center | Systèmes de spectroscopie de fluorescence induite par laser résolu dans le temps et leurs utilisations |
JP6335433B2 (ja) * | 2013-03-28 | 2018-05-30 | 株式会社日立ハイテクサイエンス | Icp発光分光分析装置 |
JP6526627B2 (ja) | 2013-04-24 | 2019-06-05 | テル ハショメール メディカル リサーチ インフラストラクチャー アンド サービシズ リミテッド | 組織解析用の磁気共鳴マップ |
US10441177B2 (en) | 2013-07-23 | 2019-10-15 | Bae Systems Information And Electronic Systems Integration Inc. | High definition thermal imaging for medical applications |
WO2016069086A1 (fr) * | 2014-10-30 | 2016-05-06 | Bae Systems Information & Electronic Systems Integration Inc. | Imagerie thermique haute définition pour applications médicales |
WO2015069657A1 (fr) * | 2013-11-05 | 2015-05-14 | Emory University | Systèmes et procédés avancés destinés à assurer un guidage anatomique en temps réel au cours d'un acte diagnostique ou thérapeutique |
CA2935690A1 (fr) * | 2013-12-31 | 2015-07-09 | Memorial Sloan Kettering Cancer Center | Systemes, procedes, et appareil pour l'imagerie multicanal de sources fluorescentes en temps reel |
WO2015126466A1 (fr) * | 2014-02-21 | 2015-08-27 | The University Of Akron | Système d'imagerie et d'affichage permettant de guider des interventions médicales |
US10912947B2 (en) | 2014-03-04 | 2021-02-09 | Memorial Sloan Kettering Cancer Center | Systems and methods for treatment of disease via application of mechanical force by controlled rotation of nanoparticles inside cells |
US10688202B2 (en) | 2014-07-28 | 2020-06-23 | Memorial Sloan-Kettering Cancer Center | Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes |
EP3182917A1 (fr) * | 2014-08-20 | 2017-06-28 | Memorial Sloan Kettering Cancer Center | Systèmes et procédés d'ablation/résection déclenchés par un rapporteur raman |
JP6319448B2 (ja) * | 2014-09-08 | 2018-05-09 | 株式会社島津製作所 | イメージング装置 |
US11553844B2 (en) * | 2014-10-14 | 2023-01-17 | East Carolina University | Methods, systems and computer program products for calculating MetaKG signals for regions having multiple sets of optical characteristics |
US10792492B2 (en) | 2014-10-14 | 2020-10-06 | East Carolina University | Methods, systems and computer program products for determining physiologic status parameters using signals derived from multispectral blood flow and perfusion imaging |
CA2963861C (fr) * | 2014-10-14 | 2023-10-03 | East Carolina University | Procedes, systemes et produits-programmes informatique pour visualiser des structures anatomiques, un debit sanguin et une physiologie de perfusion a l'aide de techniques d'imager ie |
JP2018501839A (ja) * | 2014-11-27 | 2018-01-25 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | 患者の画像を生成するイメージングデバイス及び方法 |
CN104523230B (zh) * | 2014-12-29 | 2016-07-13 | 华中科技大学 | 一种静脉穿刺针头位置定位的装置 |
EP3250104B1 (fr) * | 2015-01-28 | 2019-03-06 | Brainlab AG | Procédé d'identification de point lumineux |
US10169862B2 (en) | 2015-05-07 | 2019-01-01 | Novadaq Technologies ULC | Methods and systems for laser speckle imaging of tissue using a color image sensor |
US10071141B2 (en) | 2015-05-08 | 2018-09-11 | Spectral Platforms, Inc. | Albumin-based non-covalent complexes and methods of use thereof |
CA2988519A1 (fr) * | 2015-06-10 | 2016-12-15 | Boston Scientific Scimed, Inc. | Detection de substance corporelle par evaluation de reponse photoluminescente a un rayonnement d'excitation |
US10919089B2 (en) | 2015-07-01 | 2021-02-16 | Memorial Sloan Kettering Cancer Center | Anisotropic particles, methods and uses thereof |
JP2017018483A (ja) * | 2015-07-14 | 2017-01-26 | オリンパス株式会社 | 医療用プローブ |
US10656089B2 (en) * | 2016-04-01 | 2020-05-19 | Black Light Surgical, Inc. | Systems, devices, and methods for time-resolved fluorescent spectroscopy |
US20170354357A1 (en) * | 2016-06-11 | 2017-12-14 | Boston Scientific Scimed Inc. | Systems, methods, and devices for monitoring tissue ablation using tissue autofluorescence |
CN211433450U (zh) * | 2016-07-27 | 2020-09-08 | 阿莱恩技术有限公司 | 透照适配器套筒设备和透照适配器 |
US10507087B2 (en) | 2016-07-27 | 2019-12-17 | Align Technology, Inc. | Methods and apparatuses for forming a three-dimensional volumetric model of a subject's teeth |
KR101855395B1 (ko) * | 2016-09-26 | 2018-05-09 | 부경대학교 산학협력단 | 근적외선을 이용한 폐종양 스크리닝 방법 |
CN106840395B (zh) * | 2017-01-16 | 2021-01-15 | 中国人民解放军国防科学技术大学 | 用于主动高光谱成像的近红外超连续谱照明系统 |
MX2019009040A (es) | 2017-01-30 | 2019-11-11 | Medibeacon Inc | Metodo para monitoreo no invasivo de agente trazador fluorescente con correcciones de reflejo difuso. |
JP6708143B2 (ja) * | 2017-02-07 | 2020-06-10 | 株式会社島津製作所 | 時間強度曲線測定装置 |
WO2018175346A1 (fr) * | 2017-03-20 | 2018-09-27 | Spectral Platforms, Inc. | Procédés de spectroscopie pour détecter et caractériser des micro-organismes |
JPWO2018216658A1 (ja) * | 2017-05-23 | 2020-03-26 | 国立研究開発法人産業技術総合研究所 | 撮像装置、撮像システム、及び撮像方法 |
CN108937849A (zh) * | 2017-05-29 | 2018-12-07 | 王虎 | 一种用于肿瘤纳米靶向探针荧光成像及手术导航指示系统 |
CN107569213A (zh) * | 2017-09-04 | 2018-01-12 | 上海市第十人民医院 | 一种可见光与近红外双波段成像的医用辅助检查设备 |
CN109864747B (zh) * | 2017-12-05 | 2023-08-25 | 心脏起搏器股份公司 | 多模式分析物传感器光电子接口 |
KR101903423B1 (ko) * | 2018-02-20 | 2018-10-04 | 한국광기술원 | 광진단 및 광치료를 위한 하이브리드 이미징 시스템 |
CN108309247A (zh) * | 2018-03-06 | 2018-07-24 | 南京生命源医药实业有限公司 | 肿瘤定位系统 |
CN108209878A (zh) * | 2018-03-06 | 2018-06-29 | 南京生命源医药实业有限公司 | 可视化系统及方法 |
CN109276230A (zh) * | 2018-08-15 | 2019-01-29 | 华中科技大学鄂州工业技术研究院 | 一种短波红外肿瘤成像系统及方法 |
CN109363768A (zh) * | 2018-10-10 | 2019-02-22 | 南京诺源医疗器械有限公司 | 785nm波长光源近红外荧光造影手术引导系统 |
WO2020075247A1 (fr) * | 2018-10-10 | 2020-04-16 | オリンパス株式会社 | Dispositif de traitement d'image, système d'observation et procédé d'observation |
USD908161S1 (en) | 2019-01-15 | 2021-01-19 | Moleculight, Inc. | Handheld imaging device |
JP2022523642A (ja) * | 2019-01-17 | 2022-04-26 | エス・ビィ・アイ・アラファーマ・カナダ・インコーポレイテッド | 腫瘍の視覚化および除去のためのデバイス、システムおよび方法 |
USD908881S1 (en) | 2019-01-17 | 2021-01-26 | Sbi Alapharma Canada, Inc. | Handheld endoscopic imaging device |
USD910182S1 (en) | 2019-01-17 | 2021-02-09 | Sbi Alapharma Canada, Inc. | Handheld multi-modal imaging device |
WO2020154351A1 (fr) * | 2019-01-25 | 2020-07-30 | Intuitive Surgical Operations, Inc. | Systèmes et procédés de vision médicale augmentée |
US11819193B2 (en) | 2019-02-26 | 2023-11-21 | Ai Biomed Corp. | Tissue detection system and methods for use thereof |
CA3132350A1 (fr) * | 2019-04-08 | 2020-10-15 | Stephen Tully | Systemes et procedes d'imagerie medicale |
CN109998494A (zh) * | 2019-05-10 | 2019-07-12 | 苏州工业职业技术学院 | 一种小动物活体全身高分辨多光谱光学成像系统 |
CN114599263A (zh) | 2019-08-21 | 2022-06-07 | 艾科缇弗外科公司 | 用于医疗成像的系统和方法 |
CN110464309B (zh) * | 2019-08-27 | 2021-12-17 | 深圳大学 | 一种跨尺度的荧光内窥成像系统 |
CN111166470B (zh) * | 2019-10-15 | 2021-06-18 | 东北大学 | 一种深度可分辨的目标探测及消融系统 |
CN111166478B (zh) * | 2019-12-30 | 2021-04-27 | 吉林大学第一医院 | 近红外二区肿瘤一级淋巴结手术导航系统及其搭建方法 |
CN112067586B (zh) * | 2020-06-24 | 2021-08-03 | 江南大学 | 一种基于荧光淬灭拉曼增强的前列腺特异性抗原双信号光谱分析方法 |
WO2023273014A1 (fr) * | 2021-06-29 | 2023-01-05 | 南京微纳科技研究院有限公司 | Dispositif d'imagerie médicale |
CN114569903A (zh) * | 2022-01-20 | 2022-06-03 | 重庆医科大学 | 一种脉冲超声协同药物体外无创治疗仪及其操作方法 |
WO2023150222A1 (fr) * | 2022-02-02 | 2023-08-10 | Vergent Bioscience, Inc. | Procédés de localisation de tissu cancéreux à l'aide d'un agent d'imagerie moléculaire fluorescent pour le diagnostic ou le traitement |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5261410A (en) * | 1991-02-07 | 1993-11-16 | Alfano Robert R | Method for determining if a tissue is a malignant tumor tissue, a benign tumor tissue, or a normal or benign tissue using Raman spectroscopy |
DE4304571A1 (de) | 1993-02-16 | 1994-08-18 | Mdc Med Diagnostic Computing | Verfahren zur Planung und Kontrolle eines chirurgischen Eingriffs |
WO1994024631A1 (fr) | 1993-04-20 | 1994-10-27 | General Electric Company | Systeme video interactif et d'infographie permettant d'ameliorer la visualisation de structures corporelles pendant une intervention chirurgicale |
JPH09497A (ja) * | 1995-06-19 | 1997-01-07 | Fuji Photo Film Co Ltd | 蛍光画像診断装置 |
JP3568280B2 (ja) | 1995-07-12 | 2004-09-22 | 富士写真フイルム株式会社 | 外科手術支援システム |
US6008889A (en) * | 1997-04-16 | 1999-12-28 | Zeng; Haishan | Spectrometer system for diagnosis of skin disease |
JPH114898A (ja) * | 1997-06-18 | 1999-01-12 | Hamamatsu Photonics Kk | 生体診断治療装置 |
US6422994B1 (en) | 1997-09-24 | 2002-07-23 | Olympus Optical Co., Ltd. | Fluorescent diagnostic system and method providing color discrimination enhancement |
JPH11104059A (ja) * | 1997-10-02 | 1999-04-20 | Olympus Optical Co Ltd | 蛍光観察装置 |
US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
JP2000206047A (ja) * | 1999-01-08 | 2000-07-28 | Fuji Photo Film Co Ltd | スペクトル測定装置 |
US6167297A (en) * | 1999-05-05 | 2000-12-26 | Benaron; David A. | Detecting, localizing, and targeting internal sites in vivo using optical contrast agents |
AU5908000A (en) | 1999-07-02 | 2001-01-22 | Hypermed Imaging, Inc. | Imaging apparatus with means for fusing thermal and hyperspectral images |
JP4849755B2 (ja) | 1999-07-02 | 2012-01-11 | ハイパースペクトラル・イメージング・インコーポレイテツド | イメージング装置および試料分析方法 |
US6317616B1 (en) | 1999-09-15 | 2001-11-13 | Neil David Glossop | Method and system to facilitate image guided surgery |
JP2001299676A (ja) * | 2000-04-25 | 2001-10-30 | Fuji Photo Film Co Ltd | センチネルリンパ節検出方法および検出システム |
AU2001259435A1 (en) | 2000-05-03 | 2001-11-12 | Stephen T Flock | Optical imaging of subsurface anatomical structures and biomolecules |
US6748259B1 (en) | 2000-06-15 | 2004-06-08 | Spectros Corporation | Optical imaging of induced signals in vivo under ambient light conditions |
US6826424B1 (en) | 2000-12-19 | 2004-11-30 | Haishan Zeng | Methods and apparatus for fluorescence and reflectance imaging and spectroscopy and for contemporaneous measurements of electromagnetic radiation with multiple measuring devices |
US7596404B2 (en) | 2001-06-28 | 2009-09-29 | Chemimage Corporation | Method of chemical imaging to determine tissue margins during surgery |
ES2406697T3 (es) | 2002-03-12 | 2013-06-07 | Beth Israel Deaconess Medical Center | Sistema de obtención de imágenes médicas |
US20040073120A1 (en) | 2002-04-05 | 2004-04-15 | Massachusetts Institute Of Technology | Systems and methods for spectroscopy of biological tissue |
US7257437B2 (en) * | 2002-07-05 | 2007-08-14 | The Regents Of The University Of California | Autofluorescence detection and imaging of bladder cancer realized through a cystoscope |
US8285015B2 (en) * | 2002-07-05 | 2012-10-09 | Lawrence Livermore Natioonal Security, LLC | Simultaneous acquisition of differing image types |
JP2004089533A (ja) * | 2002-09-02 | 2004-03-25 | Toshiba Corp | 蛍光物質集積性腫瘍の境界識別装置 |
US7583380B2 (en) | 2003-03-11 | 2009-09-01 | Koninklijke Philips Electronics N.V. | Spectroscopic analysis apparatus and method with excitation system and focus monitoring system |
JP2004294099A (ja) * | 2003-03-25 | 2004-10-21 | Institute Of Physical & Chemical Research | ラマンプローブ及びそれを用いたラマン散乱計測装置 |
DE112004001398T5 (de) | 2003-07-29 | 2006-06-29 | Pentax Corp. | Gerät zur inneren Behandlung eines Patienten und System zur inneren Behandlung eines Patienten |
US7182166B2 (en) | 2004-03-23 | 2007-02-27 | Deka Products Limited Partnership | Footrest tuck mechanism |
US20060184040A1 (en) * | 2004-12-09 | 2006-08-17 | Keller Kurtis P | Apparatus, system and method for optically analyzing a substrate |
JP2006180926A (ja) * | 2004-12-24 | 2006-07-13 | Mitaka Koki Co Ltd | 医療用表示装置 |
US7283241B2 (en) * | 2005-01-31 | 2007-10-16 | Chemimage Corp. | Method and apparatus for a microscope image selector |
EP1951104A1 (fr) | 2005-07-25 | 2008-08-06 | Massachusetts Institute of Technology | Spectroscopie multimodale |
WO2007081874A2 (fr) * | 2006-01-05 | 2007-07-19 | Chemimage Corporation | Systeme et methode de classification de cellules et traitement pharmaceutique de ces cellules par spectroscopie raman |
US20080058629A1 (en) * | 2006-08-21 | 2008-03-06 | University Of Washington | Optical fiber scope with both non-resonant illumination and resonant collection/imaging for multiple modes of operation |
US7680522B2 (en) * | 2006-09-29 | 2010-03-16 | Nellcor Puritan Bennett Llc | Method and apparatus for detecting misapplied sensors |
US20090024018A1 (en) | 2007-08-07 | 2009-01-22 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anatomical imaging system |
WO2009028136A1 (fr) * | 2007-08-29 | 2009-03-05 | Panasonic Corporation | Dispositif d'observation de la fluorescence |
JP2009125411A (ja) * | 2007-11-27 | 2009-06-11 | Fujinon Corp | 内視鏡画像処理方法および装置ならびにこれを用いた内視鏡システム |
US20090236541A1 (en) * | 2008-03-24 | 2009-09-24 | General Electric Company | System and Methods for Optical Imaging |
US9020581B2 (en) * | 2008-12-05 | 2015-04-28 | Vanderbilt University | Spatially offset Raman spectroscopy of layered soft tissues and applications of same |
US9155471B2 (en) | 2009-05-27 | 2015-10-13 | Lumicell, Inc'. | Methods and systems for spatially identifying abnormal cells |
CN104757936B (zh) | 2009-12-15 | 2018-02-23 | 爱默蕾大学 | 用于在诊断或治疗程序中提供实时解剖学指导的系统和方法 |
WO2012065163A2 (fr) | 2010-11-12 | 2012-05-18 | Emory University | Systèmes et procédés additionnels fournissant une assistance anatomique en temps réel lors d'une procédure diagnostique ou thérapeutique |
-
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- 2010-12-15 CA CA2784576A patent/CA2784576C/fr not_active Expired - Fee Related
- 2010-12-15 JP JP2012544798A patent/JP6275382B2/ja not_active Expired - Fee Related
- 2010-12-15 US US12/969,396 patent/US20110152692A1/en not_active Abandoned
- 2010-12-15 WO PCT/US2010/060586 patent/WO2011084528A1/fr active Application Filing
- 2010-12-15 AU AU2010339972A patent/AU2010339972B2/en not_active Ceased
- 2010-12-15 CN CN201080063264.1A patent/CN102770071B/zh not_active Expired - Fee Related
- 2010-12-15 EP EP10842563.8A patent/EP2512337B1/fr active Active
-
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- 2013-11-21 US US14/086,334 patent/US9451882B2/en active Active
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