JP2013512199A5 - - Google Patents
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- Publication number
- JP2013512199A5 JP2013512199A5 JP2012540278A JP2012540278A JP2013512199A5 JP 2013512199 A5 JP2013512199 A5 JP 2013512199A5 JP 2012540278 A JP2012540278 A JP 2012540278A JP 2012540278 A JP2012540278 A JP 2012540278A JP 2013512199 A5 JP2013512199 A5 JP 2013512199A5
- Authority
- JP
- Japan
- Prior art keywords
- azilsartanamine
- salt according
- salt
- formula
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims 7
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical group NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 3
- 239000005485 Azilsartan Substances 0.000 claims 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical group CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims 2
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical group CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 claims 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical group C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical group 0.000 claims 2
- KGSXMPPBFPAXLY-UHFFFAOYSA-N azilsartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NOC(=O)N1 KGSXMPPBFPAXLY-UHFFFAOYSA-N 0.000 claims 2
- 229960002731 azilsartan Drugs 0.000 claims 2
- 229960001231 choline Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical group CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 claims 2
- GRWKNBPOGBTZMN-UHFFFAOYSA-N 2-benzyl-3-phenylpropane-1,2-diamine Chemical group C=1C=CC=CC=1CC(N)(CN)CC1=CC=CC=C1 GRWKNBPOGBTZMN-UHFFFAOYSA-N 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- -1 amine salt Chemical class 0.000 claims 1
- 239000002220 antihypertensive agent Substances 0.000 claims 1
- 229940127088 antihypertensive drug Drugs 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical group CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 229960003194 meglumine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N mono-methylamine Natural products NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 125000001453 quaternary ammonium group Chemical group 0.000 claims 1
- 150000003248 quinolines Chemical group 0.000 claims 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims 1
- 229960000281 trometamol Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910246554.9 | 2009-11-30 | ||
| CN200910246554 | 2009-11-30 | ||
| PCT/CN2010/079222 WO2011063764A1 (zh) | 2009-11-30 | 2010-11-29 | 阿齐沙坦有机胺盐及其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013512199A JP2013512199A (ja) | 2013-04-11 |
| JP2013512199A5 true JP2013512199A5 (cg-RX-API-DMAC7.html) | 2014-12-25 |
Family
ID=44065877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012540278A Pending JP2013512199A (ja) | 2009-11-30 | 2010-11-29 | アジルサルタン有機アミン塩、その製造方法及び使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20120238606A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2508522A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2013512199A (cg-RX-API-DMAC7.html) |
| CN (1) | CN102548988B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2010324249B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112012012484A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2782224A1 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2012005776A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2554947C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011063764A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201202683B (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102603723B (zh) * | 2011-01-20 | 2014-10-08 | 江苏豪森医药集团有限公司 | 阿齐沙坦有机胺盐及其制备方法和用途 |
| CN103930419B (zh) | 2011-09-30 | 2016-06-01 | 广东东阳光药业有限公司 | 阿齐沙坦的晶型及其制备方法 |
| JP2017036215A (ja) * | 2013-12-27 | 2017-02-16 | トーアエイヨー株式会社 | アンジオテンシンｉｉ受容体拮抗物質の塩 |
| CN105037341B (zh) * | 2014-04-04 | 2019-12-03 | 江苏豪森药业集团有限公司 | 阿齐沙坦醇铵晶型及其制备方法 |
| CN105503848A (zh) * | 2014-10-13 | 2016-04-20 | 江苏豪森药业集团有限公司 | 阿齐沙坦有机胺盐复合物及其制备方法和用途 |
| CZ2014702A3 (cs) | 2014-10-15 | 2016-04-27 | Zentiva, K.S. | Způsob přípravy vysoce čistého azilsartanu |
| KR102220011B1 (ko) * | 2020-05-15 | 2021-02-25 | 대봉엘에스 주식회사 | 친환경 용매를 이용한 아질사탄의 제조방법 및 이에 관한 핵심 중간체 화합물 |
| KR102862852B1 (ko) * | 2022-09-19 | 2025-09-22 | 대봉엘에스 주식회사 | 안지오텐신 ⅱ 길항제로서의 아질사르탄 디시클로헥실아민 및 이를 유효성분으로 하는 심혈관질환 치료 또는 예방용 약학적 조성물 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA924666B (en) * | 1991-06-27 | 1993-12-24 | Takeda Chemical Industries Ltd | Heterocyclic compounds, their production and use |
| TW251288B (cg-RX-API-DMAC7.html) * | 1991-06-27 | 1995-07-11 | Takeda Dharm Industry Co Ltd | |
| AU2002336267B2 (en) * | 2001-03-08 | 2006-10-05 | Merck & Co., Inc. | Antihypertensive agent and cholesterol absorption inhibitor combination therapy |
| JP4484427B2 (ja) * | 2001-12-03 | 2010-06-16 | 武田薬品工業株式会社 | インスリン抵抗性改善剤 |
| US20050032854A1 (en) * | 2001-12-03 | 2005-02-10 | Kiminori Kawahara | Insulin resistance improving agents |
| WO2006038722A1 (en) * | 2004-10-07 | 2006-04-13 | Takeda Pharmaceutical Company Limited | Agent for prophylaxis or treatment of metabolic syndrome |
| CN101035524A (zh) * | 2004-10-07 | 2007-09-12 | 武田药品工业株式会社 | 预防或治疗代谢综合征的药剂 |
| US20090239882A1 (en) * | 2004-12-17 | 2009-09-24 | Astrazeneca Ab | Thiazolopyramidine Compounds for the Modulation of Chemokine Receptor Activity |
-
2010
- 2010-11-29 US US13/512,652 patent/US20120238606A1/en not_active Abandoned
- 2010-11-29 CA CA2782224A patent/CA2782224A1/en not_active Abandoned
- 2010-11-29 MX MX2012005776A patent/MX2012005776A/es not_active Application Discontinuation
- 2010-11-29 CN CN2010800449716A patent/CN102548988B/zh not_active Expired - Fee Related
- 2010-11-29 RU RU2012124332/04A patent/RU2554947C2/ru active
- 2010-11-29 JP JP2012540278A patent/JP2013512199A/ja active Pending
- 2010-11-29 WO PCT/CN2010/079222 patent/WO2011063764A1/zh not_active Ceased
- 2010-11-29 AU AU2010324249A patent/AU2010324249B2/en not_active Ceased
- 2010-11-29 EP EP10832671.1A patent/EP2508522A4/en not_active Withdrawn
- 2010-11-29 BR BR112012012484A patent/BR112012012484A2/pt not_active IP Right Cessation
-
2012
- 2012-04-13 ZA ZA2012/02683A patent/ZA201202683B/en unknown