JP2013510861A - 外耳炎の迅速な治療のための方法および組成物 - Google Patents

外耳炎の迅速な治療のための方法および組成物 Download PDF

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JP2013510861A
JP2013510861A JP2012538954A JP2012538954A JP2013510861A JP 2013510861 A JP2013510861 A JP 2013510861A JP 2012538954 A JP2012538954 A JP 2012538954A JP 2012538954 A JP2012538954 A JP 2012538954A JP 2013510861 A JP2013510861 A JP 2013510861A
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composition
antibiotics
lipid
antibiotic
otitis externa
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JP2013510861A5 (enExample
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ウィリアム アール. キャンベル
ネイル イー. ポールセン
ローランド エイチ. ジョンソン
ダグラス アイ. ヘプラー
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バイエル ビー. ブイ.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012538954A 2009-11-11 2010-11-10 外耳炎の迅速な治療のための方法および組成物 Pending JP2013510861A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26030909P 2009-11-11 2009-11-11
US61/260,309 2009-11-11
PCT/US2010/056255 WO2011060083A1 (en) 2009-11-11 2010-11-10 Methods and compositions for rapid treatment of otitis externa

Related Child Applications (1)

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JP2015222609A Division JP6138891B2 (ja) 2009-11-11 2015-11-13 外耳炎の迅速な治療のための方法および組成物

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JP2013510861A true JP2013510861A (ja) 2013-03-28
JP2013510861A5 JP2013510861A5 (enExample) 2013-08-22

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JP2012538954A Pending JP2013510861A (ja) 2009-11-11 2010-11-10 外耳炎の迅速な治療のための方法および組成物
JP2015222609A Active JP6138891B2 (ja) 2009-11-11 2015-11-13 外耳炎の迅速な治療のための方法および組成物

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EP (1) EP2498792B1 (enExample)
JP (2) JP2013510861A (enExample)
KR (2) KR20120116398A (enExample)
CN (1) CN102612372B (enExample)
AU (1) AU2010319538B2 (enExample)
BR (1) BR112012011017A2 (enExample)
CA (1) CA2780160C (enExample)
CL (1) CL2012001227A1 (enExample)
CO (1) CO6540004A2 (enExample)
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EC (1) ECSP12011967A (enExample)
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HU (1) HUE034617T2 (enExample)
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MX (1) MX2012005521A (enExample)
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NO (1) NO2498792T3 (enExample)
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PT (1) PT2498792T (enExample)
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SI (1) SI2498792T1 (enExample)
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WO (1) WO2011060083A1 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021503002A (ja) * 2017-11-14 2021-02-04 プロフェム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングProFem GmbH 皮膚および粘膜感染症の局所治療用エマルション

Families Citing this family (8)

* Cited by examiner, † Cited by third party
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WO2014036165A1 (en) * 2012-08-29 2014-03-06 Bayer Healthcare, Llc Aqueous based compositions for treating otitis externa
CN104337952A (zh) * 2013-08-10 2015-02-11 李谊 一种中西医结合治疗爆震性耳聋的组合药物
CN104739768A (zh) * 2013-12-27 2015-07-01 河南惠通天下生物工程有限公司 一种甲砜霉素纳米脂质体及其制备方法
EP3482744A1 (de) * 2017-11-14 2019-05-15 ProFem GmbH Emulsionen zur topischen behandlung urogenitaler und dermaler infektionen
BR112022005354A2 (pt) * 2019-09-23 2022-08-23 Dds Res Inc Composições de vesícula lipídica com agentes potencializadores de penetração
EP4041153A4 (en) * 2019-10-11 2023-10-25 Piedmont Animal Health Inc. OTIC FORMULATIONS, METHODS AND DEVICES
CA3213099A1 (en) 2021-03-24 2022-09-29 Robert A. Love Peptides and methods for reducing skin pigmentation
CN113876658B (zh) * 2021-11-01 2023-10-20 仙乐健康科技股份有限公司 水包油型乳液组合物及其制备方法

Citations (7)

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JPH09508414A (ja) * 1994-02-04 1997-08-26 スコーツイア・リピツドテクニク・アクチエボラーグ 二重層製剤
WO1999020259A2 (en) * 1997-10-21 1999-04-29 Fatro S.P.A. Compositions containing thiamphenicol and diclofenac
WO2005077360A2 (en) * 2004-02-05 2005-08-25 Fairfield Clinical Trials, Llc Topical treatment of otitis externa with antifungals or antibacterials
JP2007500691A (ja) * 2003-07-31 2007-01-18 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗炎症剤の分散性製剤
WO2008036292A2 (en) * 2006-09-21 2008-03-27 Fairfield Clinical Trials, Llc Method for treating otitis externa
JP2008512383A (ja) * 2004-09-03 2008-04-24 ピードモント ファーマシューティカルズ エルエルシー 中耳炎の経膜治療方法および予防方法
JP2008533048A (ja) * 2005-03-10 2008-08-21 スリーエム イノベイティブ プロパティズ カンパニー 耳の感染症の治療方法

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WO1996039146A1 (en) * 1995-06-06 1996-12-12 Bayer Corporation Non-irritation, non-sensitizing, non-ototoxic otic antibacterial compositions
US6433024B1 (en) * 2000-05-08 2002-08-13 Karl F. Popp Topical anti-acne composition
AUPR798901A0 (en) * 2001-09-28 2001-10-25 Medvet Science Pty. Ltd. Spheroidal hdl particles with a defined phospholipid composition
US20080206161A1 (en) * 2002-10-25 2008-08-28 Dov Tamarkin Quiescent foamable compositions, steroids, kits and uses thereof
US20050013854A1 (en) * 2003-04-09 2005-01-20 Mannino Raphael J. Novel encochleation methods, cochleates and methods of use
US20070078116A1 (en) 2003-08-20 2007-04-05 Fairfield Clinical Trials, Llc Method of treatment of otitis externa
US20090082337A1 (en) 2007-09-21 2009-03-26 Srini Venkastesh Compositions Comprising Quinolone and Methods for Treating or Controlling Infections
US20090111780A1 (en) * 2007-10-31 2009-04-30 Everett Laboratories, Inc. Compositions and methods for treatment of ear canal infection and inflammation

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09508414A (ja) * 1994-02-04 1997-08-26 スコーツイア・リピツドテクニク・アクチエボラーグ 二重層製剤
WO1999020259A2 (en) * 1997-10-21 1999-04-29 Fatro S.P.A. Compositions containing thiamphenicol and diclofenac
JP2007500691A (ja) * 2003-07-31 2007-01-18 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗炎症剤の分散性製剤
WO2005077360A2 (en) * 2004-02-05 2005-08-25 Fairfield Clinical Trials, Llc Topical treatment of otitis externa with antifungals or antibacterials
JP2008512383A (ja) * 2004-09-03 2008-04-24 ピードモント ファーマシューティカルズ エルエルシー 中耳炎の経膜治療方法および予防方法
JP2008533048A (ja) * 2005-03-10 2008-08-21 スリーエム イノベイティブ プロパティズ カンパニー 耳の感染症の治療方法
WO2008036292A2 (en) * 2006-09-21 2008-03-27 Fairfield Clinical Trials, Llc Method for treating otitis externa

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021503002A (ja) * 2017-11-14 2021-02-04 プロフェム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングProFem GmbH 皮膚および粘膜感染症の局所治療用エマルション
JP7378409B2 (ja) 2017-11-14 2023-11-13 プロフェム・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 皮膚および粘膜感染症の局所治療用エマルション

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NZ599559A (en) 2014-08-29
SI2498792T1 (sl) 2017-11-30
US20110281809A1 (en) 2011-11-17
ZA201203239B (en) 2013-07-31
IL219483A (en) 2017-12-31
RU2680137C2 (ru) 2019-02-18
RU2012124067A (ru) 2013-12-20
LT2498792T (lt) 2017-10-25
CA2780160A1 (en) 2011-05-19
UA111147C2 (uk) 2016-04-11
ECSP12011967A (es) 2012-08-31
PH12012500913A1 (en) 2012-11-26
NO2498792T3 (enExample) 2017-12-30
HUE034617T2 (en) 2018-02-28
AU2010319538A1 (en) 2012-05-17
JP6138891B2 (ja) 2017-05-31
MY162687A (en) 2017-07-14
PL2498792T3 (pl) 2018-01-31
DK2498792T3 (da) 2017-11-06
WO2011060083A1 (en) 2011-05-19
HRP20171520T1 (hr) 2017-11-17
KR20170100680A (ko) 2017-09-04
PT2498792T (pt) 2017-10-18
ES2645200T3 (es) 2017-12-04
EP2498792A4 (en) 2013-06-12
CO6540004A2 (es) 2012-10-16
KR20120116398A (ko) 2012-10-22
KR101901083B1 (ko) 2018-09-20
EP2498792A1 (en) 2012-09-19
BR112012011017A2 (pt) 2015-09-15
EP2498792B1 (en) 2017-08-02
JP2016102112A (ja) 2016-06-02
CN102612372B (zh) 2016-01-20
MX2012005521A (es) 2012-06-19
CL2012001227A1 (es) 2012-08-24
IL219483A0 (en) 2012-06-28
AU2010319538B2 (en) 2015-04-09
US8927006B2 (en) 2015-01-06
CA2780160C (en) 2018-03-06
CN102612372A (zh) 2012-07-25

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