JP2013507449A - ＴＢＫ１および／またはＩＫＫεの阻害剤としてのアミノ−ピリミジン化合物 - Google Patents

ＴＢＫ１および／またはＩＫＫεの阻害剤としてのアミノ−ピリミジン化合物 Download PDF

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JP2013507449A
JP2013507449A JP2012534299A JP2012534299A JP2013507449A JP 2013507449 A JP2013507449 A JP 2013507449A JP 2012534299 A JP2012534299 A JP 2012534299A JP 2012534299 A JP2012534299 A JP 2012534299A JP 2013507449 A JP2013507449 A JP 2013507449A
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amino
pyrimidin
phenyl
yloxy
benzonitrile
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JP2013507449A5 (enExample
Inventor
ライアン ホルコム，
和之 鈴木
ロバート ジェイ． ハルター，
ポール アール． セバハー，
ドナルド エー． マクリオド，
マーク ディー． シェンデロビッチ，
クレイグ エム． ヤイガー，
マシュー グレゴリー バーサビッチ，
アシャンタイ ジェイ． ユンガイ，
バート リチャーズ，
ポール エル． バーテル，
ダニエル エー． ウェットスタイン，
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ミレクシス， インコーポレイテッド
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Publication of JP2013507449A publication Critical patent/JP2013507449A/ja
Publication of JP2013507449A5 publication Critical patent/JP2013507449A5/ja
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
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  • Biomedical Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
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  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2012534299A 2009-10-12 2010-10-12 ＴＢＫ１および／またはＩＫＫεの阻害剤としてのアミノ−ピリミジン化合物 Pending JP2013507449A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25084209P 2009-10-12 2009-10-12
US61/250,842 2009-10-12
US32524510P 2010-04-16 2010-04-16
US61/325,245 2010-04-16
PCT/US2010/052385 WO2011046970A1 (en) 2009-10-12 2010-10-12 Amino - pyrimidine compounds as inhibitors of tbkl and/or ikk epsilon

Publications (2)

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JP2013507449A true JP2013507449A (ja) 2013-03-04
JP2013507449A5 JP2013507449A5 (enExample) 2013-11-28

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US (2) US20120238540A1 (enExample)
EP (1) EP2488503A1 (enExample)
JP (1) JP2013507449A (enExample)
KR (1) KR20120114224A (enExample)
CN (1) CN102791697A (enExample)
AU (1) AU2010306927A1 (enExample)
BR (1) BR112012008677A2 (enExample)
CA (1) CA2777762A1 (enExample)
MX (1) MX2012004313A (enExample)
NZ (1) NZ599826A (enExample)
WO (1) WO2011046970A1 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014509661A (ja) * 2011-04-01 2014-04-21 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション Ａｘｌキナーゼの阻害剤としての置換ｎ−フェニルピリミジン−２−アミン類似体
JP2017516814A (ja) * 2014-06-03 2017-06-22 ギリアード サイエンシーズ， インコーポレイテッド Ｔａｎｋ結合キナーゼインヒビター化合物
JP2020508341A (ja) * 2017-02-23 2020-03-19 ドメイネクス リミテッド Ｉｋｋｅ、ｔｂｋ１及び／又はｓｉｋ２キナーゼ阻害剤としての５−（ピリミジン−４−イル）−２−（ピロリジン−１−イル）ニコチノニトリル化合物
JP2020537671A (ja) * 2017-10-17 2020-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ピリミジンＴＢＫ／ＩＫＫεインヒビター化合物およびそれらの使用

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201012105D0 (en) 2010-07-19 2010-09-01 Domainex Ltd Novel pyrimidine compounds
KR20140048873A (ko) * 2011-04-12 2014-04-24 알츠하이머즈 인스티튜트 오브 아메리카, 인크. Ｉｋｋ－관련 키나제 엡실론 및 ｔａｎｋ 결합 키나제 1 억제제의 조성물 및 치료학적 용도
AU2012244745A1 (en) 2011-04-19 2013-09-19 Bayer Intellectual Property Gmbh Substituted 4-Aryl-N-phenyl-1,3,5-triazin-2-amines
TW201636330A (zh) 2011-05-24 2016-10-16 拜耳知識產權公司 含有硫醯亞胺基團之４－芳基－ｎ－苯基－１，３，５－三氮雜苯－２－胺
GB201114051D0 (en) 2011-08-15 2011-09-28 Domainex Ltd Compounds and their uses
DE102011112978A1 (de) * 2011-09-09 2013-03-14 Merck Patent Gmbh Benzonitrilderivate
CN103917527B (zh) 2011-09-16 2017-05-31 拜耳知识产权有限责任公司 二取代的5‑氟‑嘧啶
CN103930399B (zh) 2011-09-16 2016-03-16 拜耳知识产权有限责任公司 包含亚氨基亚磺酰基的二取代的5-氟嘧啶衍生物
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