JP2013505701A5 - - Google Patents
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- Publication number
- JP2013505701A5 JP2013505701A5 JP2012510468A JP2012510468A JP2013505701A5 JP 2013505701 A5 JP2013505701 A5 JP 2013505701A5 JP 2012510468 A JP2012510468 A JP 2012510468A JP 2012510468 A JP2012510468 A JP 2012510468A JP 2013505701 A5 JP2013505701 A5 JP 2013505701A5
- Authority
- JP
- Japan
- Prior art keywords
- lin28b
- nuclear reprogramming
- somatic
- ips cells
- reprogramming substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims description 10
- 230000008672 reprogramming Effects 0.000 claims description 8
- 210000001082 somatic cell Anatomy 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 7
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims description 3
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims description 3
- 101150086694 SLC22A3 gene Proteins 0.000 claims description 3
- 101150111214 lin-28 gene Proteins 0.000 claims description 3
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 239000000126 substance Substances 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 108091057508 Myc family Proteins 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 1
- 239000000411 inducer Substances 0.000 claims 1
- 238000011419 induction treatment Methods 0.000 claims 1
- 230000000392 somatic effect Effects 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 3
- 101100074846 Caenorhabditis elegans lin-2 gene Proteins 0.000 description 1
- 101000984033 Homo sapiens Protein lin-28 homolog B Proteins 0.000 description 1
- 101100497386 Mus musculus Cask gene Proteins 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24547809P | 2009-09-24 | 2009-09-24 | |
| US61/245,478 | 2009-09-24 | ||
| PCT/JP2010/067016 WO2011037270A1 (en) | 2009-09-24 | 2010-09-22 | Method of efficiently establishing induced pluripotent stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505701A JP2013505701A (ja) | 2013-02-21 |
| JP2013505701A5 true JP2013505701A5 (enExample) | 2013-11-07 |
| JP5773393B2 JP5773393B2 (ja) | 2015-09-02 |
Family
ID=43796007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012510468A Active JP5773393B2 (ja) | 2009-09-24 | 2010-09-22 | 効率的な人工多能性幹細胞の樹立方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8993329B2 (enExample) |
| EP (1) | EP2480657B1 (enExample) |
| JP (1) | JP5773393B2 (enExample) |
| WO (1) | WO2011037270A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014037574A1 (en) * | 2012-09-10 | 2014-03-13 | Sanofi | Methods for reprogramming a somatic cell |
| JP7215994B2 (ja) | 2016-09-06 | 2023-01-31 | ザ チルドレンズ メディカル センター コーポレーション | 人工多能性幹細胞由来の免疫細胞 |
| US20200190475A1 (en) * | 2017-02-23 | 2020-06-18 | San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation | Methods for identifying and isolating cardiac stem cells and methods for making and using them |
| US11572544B2 (en) | 2017-06-14 | 2023-02-07 | The Children's Medical Center Corporation | Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells by episomal plasmid gene transfer |
| CN115397974A (zh) | 2020-01-23 | 2022-11-25 | 儿童医疗中心有限公司 | 由人类多能干细胞进行无基质t细胞分化 |
| US12492372B2 (en) | 2020-11-24 | 2025-12-09 | Monash University | Induced stem cells |
| AU2021388074A1 (en) | 2020-11-24 | 2023-06-22 | Monash University | Methods and cellular structures |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
| DK1186667T3 (da) | 1999-05-18 | 2007-10-22 | Dnavec Research Inc | Kappegendeficient virusvektor af Paramyxoviridae |
| CN101356270B (zh) | 2005-12-13 | 2014-02-12 | 国立大学法人京都大学 | 核重新编程因子 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| AU2008231020B2 (en) | 2007-03-23 | 2013-09-05 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
| EP2096169B1 (en) | 2007-10-31 | 2020-11-18 | Kyoto University | Nuclear reprogramming method |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| JP5626619B2 (ja) | 2008-12-08 | 2014-11-19 | 国立大学法人京都大学 | 効率的な核初期化方法 |
| WO2009096049A1 (ja) * | 2008-02-01 | 2009-08-06 | Kyoto University | 人工多能性幹細胞由来分化細胞 |
| CN102625837B (zh) * | 2009-08-07 | 2015-01-14 | 国立大学法人京都大学 | 有效建立诱导的多能干细胞的方法 |
-
2010
- 2010-09-22 EP EP10818938.2A patent/EP2480657B1/en active Active
- 2010-09-22 US US13/393,158 patent/US8993329B2/en active Active
- 2010-09-22 JP JP2012510468A patent/JP5773393B2/ja active Active
- 2010-09-22 WO PCT/JP2010/067016 patent/WO2011037270A1/en not_active Ceased
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