JP2013503622A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013503622A5 JP2013503622A5 JP2012527396A JP2012527396A JP2013503622A5 JP 2013503622 A5 JP2013503622 A5 JP 2013503622A5 JP 2012527396 A JP2012527396 A JP 2012527396A JP 2012527396 A JP2012527396 A JP 2012527396A JP 2013503622 A5 JP2013503622 A5 JP 2013503622A5
- Authority
- JP
- Japan
- Prior art keywords
- gene product
- nrf
- acid encoding
- nucleic acid
- protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 23
- 102000040430 polynucleotide Human genes 0.000 claims description 11
- 108091033319 polynucleotide Proteins 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 9
- 101100405132 Mus musculus Nr5a2 gene Proteins 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 210000001082 somatic cell Anatomy 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 claims 6
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 claims 6
- 239000000556 agonist Substances 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 230000008672 reprogramming Effects 0.000 claims 5
- 102100023606 Retinoic acid receptor alpha Human genes 0.000 claims 4
- 102100033912 Retinoic acid receptor gamma Human genes 0.000 claims 4
- 239000002157 polynucleotide Substances 0.000 claims 4
- 102000003702 retinoic acid receptors Human genes 0.000 claims 4
- 108090000064 retinoic acid receptors Proteins 0.000 claims 4
- 108091008726 retinoic acid receptors α Proteins 0.000 claims 4
- 108091008760 retinoic acid receptors γ Proteins 0.000 claims 4
- 101100239628 Danio rerio myca gene Proteins 0.000 claims 2
- 101100411708 Danio rerio rarga gene Proteins 0.000 claims 2
- 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 claims 2
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 claims 2
- 102100020677 Krueppel-like factor 4 Human genes 0.000 claims 2
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 claims 2
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 claims 2
- 102100024270 Transcription factor SOX-2 Human genes 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- -1 Nanog Proteins 0.000 claims 1
- 101710150336 Protein Rex Proteins 0.000 claims 1
- 206010043276 Teratoma Diseases 0.000 claims 1
- 230000017858 demethylation Effects 0.000 claims 1
- 238000010520 demethylation reaction Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 101150095164 rex1 gene Proteins 0.000 claims 1
- 230000003595 spectral effect Effects 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
- 101001109685 Homo sapiens Nuclear receptor subfamily 5 group A member 2 Proteins 0.000 description 2
- 102100022669 Nuclear receptor subfamily 5 group A member 2 Human genes 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000007792 addition Methods 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24028209P | 2009-09-07 | 2009-09-07 | |
| GB0915523.5 | 2009-09-07 | ||
| US61/240,282 | 2009-09-07 | ||
| GBGB0915523.5A GB0915523D0 (en) | 2009-09-07 | 2009-09-07 | Cells and methods for obtaining them |
| US27620309P | 2009-09-08 | 2009-09-08 | |
| US61/276,203 | 2009-09-08 | ||
| PCT/GB2010/051493 WO2011027180A1 (en) | 2009-09-07 | 2010-09-07 | Cells and methods for obtaining them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013503622A JP2013503622A (ja) | 2013-02-04 |
| JP2013503622A5 true JP2013503622A5 (enExample) | 2015-08-06 |
| JP5944315B2 JP5944315B2 (ja) | 2016-07-05 |
Family
ID=41203246
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012527396A Expired - Fee Related JP5944315B2 (ja) | 2009-09-07 | 2010-09-07 | 細胞およびそれらを得るための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9512407B2 (enExample) |
| EP (1) | EP2475774A1 (enExample) |
| JP (1) | JP5944315B2 (enExample) |
| CN (1) | CN102822345B (enExample) |
| CA (1) | CA2773291A1 (enExample) |
| GB (1) | GB0915523D0 (enExample) |
| SG (2) | SG10201405455UA (enExample) |
| WO (1) | WO2011027180A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9422525B2 (en) | 2009-09-30 | 2016-08-23 | Agency For Science, Technology And Research | Nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells |
| JP5921558B2 (ja) * | 2010-10-14 | 2016-05-24 | ユニバーシティ オブ セントラル フロリダ リサーチ ファウンデーション，インコーポレイテッド | 心臓人工多能性幹細胞ならびに心筋の修復および再生に使用する方法 |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| CA2924735C (en) * | 2013-09-20 | 2023-02-28 | Lonza Ltd | Methods for nuclear reprogramming of cells |
| US10023879B2 (en) * | 2014-06-04 | 2018-07-17 | Fate Therapeutics, Inc. | Minimal volume reprogramming of mononuclear cells |
| EP3384007B1 (en) | 2015-11-30 | 2024-03-27 | Beihao Stem Cell and Regenerative Medicine Research Institute Co., Ltd. | Improved methods for reprograming non-pluripotent cells into pluripotent stem cells |
| CN109750000A (zh) * | 2017-11-06 | 2019-05-14 | 内蒙古赛科星家畜种业与繁育生物技术研究院有限公司 | 利用XistTale抑制性转录因子R6制备新型动物细胞系R6-MEFs方法及用途 |
| CN109913494A (zh) * | 2019-02-12 | 2019-06-21 | 北京呈诺医学科技有限公司 | 一种新的ips细胞的诱导方法 |
| CN110218741B (zh) * | 2019-05-31 | 2020-12-25 | 华中农业大学 | 采用串联sgRNA同步激活多个猪内源性干细胞因子转录活性的方法 |
| CN110592014A (zh) * | 2019-08-14 | 2019-12-20 | 广东美赛尔细胞生物科技有限公司 | 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法 |
| CN114703227B (zh) * | 2022-01-27 | 2023-11-10 | 中国科学院生态环境研究中心 | 基于MCF-7细胞系构建的RARα效应物体外筛选方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03130081A (ja) | 1989-06-30 | 1991-06-03 | Inst Natl Sante & Rech Med <Inserm> | ヒトおよびマウスレチノイン酸レセプターおよびそれをコードする遺伝子 |
| US5663303A (en) | 1991-11-04 | 1997-09-02 | Institut National De La Sante Et De La Recherche Medicale | Antibodies specific for retinoic acid receptor-γ |
| KR20030017502A (ko) | 2000-04-28 | 2003-03-03 | 에프. 호프만-라 로슈 아게 | 파라(설포닐)아릴 및 헤테로아릴 |
| US20070224615A1 (en) * | 2003-07-09 | 2007-09-27 | Invitrogen Corporation | Methods for assaying protein-protein interactions |
| US7476673B2 (en) | 2003-12-30 | 2009-01-13 | Allergan, Inc. | Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors |
| WO2005080973A1 (en) | 2004-02-13 | 2005-09-01 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human nuclear receptor nr5a1 (nr5a1) |
| WO2005082344A1 (en) | 2004-02-24 | 2005-09-09 | Smithkline Beecham Corporation | Lhr1 activators as medicaments |
| JP4395193B2 (ja) | 2005-08-01 | 2010-01-06 | ニューポテンシャル，インコーポレイテッド | 回復能を有する再プログラムされた細胞の作製 |
| ZA200804673B (en) * | 2005-12-13 | 2009-11-25 | Univ Kyoto | Nuclear reprogramming factor |
| WO2008064136A2 (en) | 2006-11-17 | 2008-05-29 | Acadia Pharmaceuticals Inc. | Compounds with activity at retinoic acid receptors |
| ATE554775T1 (de) | 2007-11-16 | 2012-05-15 | Baylor College Medicine | Phospholipid-zusammensetzungen und ihre verwendungen |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| KR101532442B1 (ko) | 2007-12-10 | 2015-06-29 | 고쿠리츠 다이가쿠 호진 교토 다이가쿠 | 효율적인 핵 초기화 방법 |
| CN101250502A (zh) * | 2008-04-01 | 2008-08-27 | 中国科学院上海生命科学研究院 | 一种诱导的多潜能干细胞的制备方法 |
| US9422525B2 (en) * | 2009-09-30 | 2016-08-23 | Agency For Science, Technology And Research | Nuclear receptor and mutant thereof and the use of the same in the reprogramming of cells |
-
2009
- 2009-09-07 GB GBGB0915523.5A patent/GB0915523D0/en not_active Ceased
-
2010
- 2010-09-07 SG SG10201405455UA patent/SG10201405455UA/en unknown
- 2010-09-07 JP JP2012527396A patent/JP5944315B2/ja not_active Expired - Fee Related
- 2010-09-07 CN CN201080050341.XA patent/CN102822345B/zh not_active Expired - Fee Related
- 2010-09-07 CA CA2773291A patent/CA2773291A1/en not_active Abandoned
- 2010-09-07 SG SG2012015343A patent/SG178613A1/en unknown
- 2010-09-07 EP EP10754364A patent/EP2475774A1/en not_active Withdrawn
- 2010-09-07 WO PCT/GB2010/051493 patent/WO2011027180A1/en not_active Ceased
- 2010-09-07 US US13/394,481 patent/US9512407B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2013503622A5 (enExample) | ||
| ES2670718T3 (es) | Métodos y composiciones para la modificación de ADN objetivo dirigida por ARN y para la modulación de la transcripción dirigida por ARN | |
| AU2018253496A1 (en) | Isolated Polynucleotides and Polypeptides and Methods of Using Same for Increasing Plant Yield, Biomass, Growth Rate, Vigor, Oil Content, Abiotic Stress Tolerance of Plants and Nitrogen Use Efficiency | |
| MX2021012596A (es) | Polinucleotidos y polipeptidos aislados, sus metodos de utilizacion para mejorar la eficacia en el uso del nitrogeno, rendimiento, tasa de crecimiento, vigor, biomasa, contenido de aceite y/o tolerancia al estres abiotico. | |
| MX2011013339A (es) | Polinucleotidos y polipeptidos aislados, y metodos para utilizarlos para mejorar la eficacia en el uso de nitrogeno, rendimiento, tasa de crecimiento, vigor, biomasa, contenido de aceite y/o tolerancia al estres abiotico. | |
| JP2015165810A5 (enExample) | ||
| ZA201607061B (en) | Transgene genetic tags and methods of use | |
| JP2016521541A5 (enExample) | ||
| MX355387B (es) | Polinucleotidos y polipeptidos aislados y metodos para utilizarlos para mejorar el rendimiento de la planta, biomasa, tasa de crecimiento, vigor, contenido de aceite, tolerancia al estres abiotico de las plantas y eficacia en el uso de nitrogeno. | |
| MX2011011453A (es) | Plantas que tienen mejores rasgos relacionados con el rendimiento y un metodo para producirlas. | |
| PH12012502520A1 (en) | Plants having enhanced yield-related traits and method for making the same | |
| JP2016500260A5 (enExample) | ||
| JP2013538038A5 (enExample) | ||
| IN2014DN00094A (enExample) | ||
| EP2835427A3 (en) | Plants having enhanced yield-related traits and a method for making the same | |
| PH12017502080A1 (en) | Epidermal growth factor receptor variant iii-mesothelin fusions and methods of using the same | |
| RU2014129220A (ru) | Новый аттенуированный полиовирус: pv-1 mono-cre-x | |
| MY182341A (en) | Nucleotide sequence encoding homeobox-leucine zipper protein hat22 (hd-zip protein 22) from corchorus olitorius and corchorus capsularis and methods of use | |
| Adamo et al. | LSD1 and pluripotency: a new player in the network | |
| WO2012007945A3 (en) | Isolated polynucleotides and methods and plants using same for regulating plant acidity | |
| Heffernan et al. | Temporal requirements of cMyc protein for reprogramming mouse fibroblasts | |
| KR101957370B1 (ko) | 자살유전자를 포함한 에피솜 벡터 및 이를 이용한 리프로그래밍 방법 | |
| MY179538A (en) | Compositions and methods for producing plants with improved stress tolerance | |
| PH12016500074A1 (en) | Plants having enhanced yield-related traits and a method of making the same |