SG178613A1 - Cells and methods for obtaining them - Google Patents
Cells and methods for obtaining themInfo
- Publication number
- SG178613A1 SG178613A1 SG2012015343A SG2012015343A SG178613A1 SG 178613 A1 SG178613 A1 SG 178613A1 SG 2012015343 A SG2012015343 A SG 2012015343A SG 2012015343 A SG2012015343 A SG 2012015343A SG 178613 A1 SG178613 A1 SG 178613A1
- Authority
- SG
- Singapore
- Prior art keywords
- gene product
- retinoic acid
- cells
- agonist
- family member
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000000556 agonist Substances 0.000 abstract 3
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 abstract 3
- 230000008672 reprogramming Effects 0.000 abstract 3
- 229930002330 retinoic acid Natural products 0.000 abstract 3
- 229960001727 tretinoin Drugs 0.000 abstract 3
- 239000005557 antagonist Substances 0.000 abstract 2
- 102000003702 retinoic acid receptors Human genes 0.000 abstract 2
- 108090000064 retinoic acid receptors Proteins 0.000 abstract 2
- 210000001082 somatic cell Anatomy 0.000 abstract 2
- 101100405132 Mus musculus Nr5a2 gene Proteins 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Developmental Biology & Embryology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24028209P | 2009-09-07 | 2009-09-07 | |
| GBGB0915523.5A GB0915523D0 (en) | 2009-09-07 | 2009-09-07 | Cells and methods for obtaining them |
| US27620309P | 2009-09-08 | 2009-09-08 | |
| PCT/GB2010/051493 WO2011027180A1 (en) | 2009-09-07 | 2010-09-07 | Cells and methods for obtaining them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG178613A1 true SG178613A1 (en) | 2012-04-27 |
Family
ID=41203246
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201405455UA SG10201405455UA (en) | 2009-09-07 | 2010-09-07 | Cells and methods for obtaining them |
| SG2012015343A SG178613A1 (en) | 2009-09-07 | 2010-09-07 | Cells and methods for obtaining them |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201405455UA SG10201405455UA (en) | 2009-09-07 | 2010-09-07 | Cells and methods for obtaining them |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9512407B2 (enExample) |
| EP (1) | EP2475774A1 (enExample) |
| JP (1) | JP5944315B2 (enExample) |
| CN (1) | CN102822345B (enExample) |
| CA (1) | CA2773291A1 (enExample) |
| GB (1) | GB0915523D0 (enExample) |
| SG (2) | SG10201405455UA (enExample) |
| WO (1) | WO2011027180A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5880868B2 (ja) | 2009-09-30 | 2016-03-09 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 核内受容体及びその変異体、並びに細胞の再プログラミングにおけるその使用 |
| EP2627342B1 (en) * | 2010-10-14 | 2016-08-24 | University Of Central Florida Research Foundation, Inc. | Cardiac induced pluripotent stem cells and methods of use in repair and regeneration of myocardium |
| GB2496375A (en) | 2011-10-28 | 2013-05-15 | Kymab Ltd | A non-human assay vertebrate comprising human antibody loci and human epitope knock-in, and uses thereof |
| GB201122047D0 (en) | 2011-12-21 | 2012-02-01 | Kymab Ltd | Transgenic animals |
| US10745668B2 (en) * | 2013-09-20 | 2020-08-18 | Lonza Ltd | Methods for nuclear reprogramming of cells |
| US10023879B2 (en) * | 2014-06-04 | 2018-07-17 | Fate Therapeutics, Inc. | Minimal volume reprogramming of mononuclear cells |
| US20190282624A1 (en) * | 2015-11-30 | 2019-09-19 | Beihao Stem Cell And Regenerative Medicine Research Institute Co., Ltd. | Improved methods for reprograming non-pluripotent cells into pluripotent stem cells |
| CN109750000A (zh) * | 2017-11-06 | 2019-05-14 | 内蒙古赛科星家畜种业与繁育生物技术研究院有限公司 | 利用XistTale抑制性转录因子R6制备新型动物细胞系R6-MEFs方法及用途 |
| CN109913494A (zh) * | 2019-02-12 | 2019-06-21 | 北京呈诺医学科技有限公司 | 一种新的ips细胞的诱导方法 |
| CN110218741B (zh) * | 2019-05-31 | 2020-12-25 | 华中农业大学 | 采用串联sgRNA同步激活多个猪内源性干细胞因子转录活性的方法 |
| CN110592014A (zh) * | 2019-08-14 | 2019-12-20 | 广东美赛尔细胞生物科技有限公司 | 一种在nk细胞治疗中免辐照体外体内持续去除饲养细胞的方法 |
| CN114703227B (zh) * | 2022-01-27 | 2023-11-10 | 中国科学院生态环境研究中心 | 基于MCF-7细胞系构建的RARα效应物体外筛选方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0411323A3 (en) | 1989-06-30 | 1991-08-21 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Human and mouse retinoic acid receptors and genes encoding for them |
| US5663303A (en) | 1991-11-04 | 1997-09-02 | Institut National De La Sante Et De La Recherche Medicale | Antibodies specific for retinoic acid receptor-γ |
| CN100374416C (zh) | 2000-04-28 | 2008-03-12 | 霍夫曼-拉罗奇有限公司 | 对(磺酰基)芳基和杂芳基类化合物 |
| US20070224615A1 (en) * | 2003-07-09 | 2007-09-27 | Invitrogen Corporation | Methods for assaying protein-protein interactions |
| US7476673B2 (en) | 2003-12-30 | 2009-01-13 | Allergan, Inc. | Disubstituted chalcone oximes as selective agonists of RARγ retinoid receptors |
| WO2005080973A1 (en) | 2004-02-13 | 2005-09-01 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with human nuclear receptor nr5a1 (nr5a1) |
| WO2005082344A1 (en) | 2004-02-24 | 2005-09-09 | Smithkline Beecham Corporation | Lhr1 activators as medicaments |
| CA2617611A1 (en) | 2005-08-01 | 2007-02-08 | Nupotential, Llc | Production of reprogrammed cells with restored potential |
| EP4223769A3 (en) | 2005-12-13 | 2023-11-01 | Kyoto University | Nuclear reprogramming factor |
| WO2008064136A2 (en) | 2006-11-17 | 2008-05-29 | Acadia Pharmaceuticals Inc. | Compounds with activity at retinoic acid receptors |
| AU2008326800A1 (en) | 2007-11-16 | 2009-05-28 | Baylor College Of Medicine | Phospholipid compositions and uses thereof |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| AU2008286249B2 (en) | 2007-12-10 | 2013-10-10 | Kyoto University | Efficient method for nuclear reprogramming |
| CN101250502A (zh) * | 2008-04-01 | 2008-08-27 | 中国科学院上海生命科学研究院 | 一种诱导的多潜能干细胞的制备方法 |
| JP5880868B2 (ja) * | 2009-09-30 | 2016-03-09 | エージェンシー フォー サイエンス，テクノロジー アンド リサーチ | 核内受容体及びその変異体、並びに細胞の再プログラミングにおけるその使用 |
-
2009
- 2009-09-07 GB GBGB0915523.5A patent/GB0915523D0/en not_active Ceased
-
2010
- 2010-09-07 CA CA2773291A patent/CA2773291A1/en not_active Abandoned
- 2010-09-07 SG SG10201405455UA patent/SG10201405455UA/en unknown
- 2010-09-07 CN CN201080050341.XA patent/CN102822345B/zh not_active Expired - Fee Related
- 2010-09-07 JP JP2012527396A patent/JP5944315B2/ja not_active Expired - Fee Related
- 2010-09-07 US US13/394,481 patent/US9512407B2/en not_active Expired - Fee Related
- 2010-09-07 WO PCT/GB2010/051493 patent/WO2011027180A1/en not_active Ceased
- 2010-09-07 EP EP10754364A patent/EP2475774A1/en not_active Withdrawn
- 2010-09-07 SG SG2012015343A patent/SG178613A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2475774A1 (en) | 2012-07-18 |
| JP5944315B2 (ja) | 2016-07-05 |
| GB0915523D0 (en) | 2009-10-07 |
| CN102822345A (zh) | 2012-12-12 |
| CN102822345B (zh) | 2016-06-08 |
| SG10201405455UA (en) | 2014-10-30 |
| WO2011027180A1 (en) | 2011-03-10 |
| US9512407B2 (en) | 2016-12-06 |
| CA2773291A1 (en) | 2011-03-10 |
| JP2013503622A (ja) | 2013-02-04 |
| US20120315703A1 (en) | 2012-12-13 |
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