JP2013504554A5 - - Google Patents
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- Publication number
- JP2013504554A5 JP2013504554A5 JP2012528455A JP2012528455A JP2013504554A5 JP 2013504554 A5 JP2013504554 A5 JP 2013504554A5 JP 2012528455 A JP2012528455 A JP 2012528455A JP 2012528455 A JP2012528455 A JP 2012528455A JP 2013504554 A5 JP2013504554 A5 JP 2013504554A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- guaifenesin
- group
- maleate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 25
- 230000028327 secretion Effects 0.000 claims 7
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 claims 6
- 229960002146 Guaifenesin Drugs 0.000 claims 6
- 210000003097 Mucus Anatomy 0.000 claims 5
- 230000001387 anti-histamine Effects 0.000 claims 4
- 239000000739 antihistaminic agent Substances 0.000 claims 4
- 239000003434 antitussive agent Substances 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 239000000850 decongestant Substances 0.000 claims 4
- 239000007788 liquid Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 230000001629 suppression Effects 0.000 claims 3
- WFXURHIXPXVPGM-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine Chemical compound OC(=O)C(O)C(O)C(O)=O.C1N(C)CCC(C2=CC=CC=C22)=C1C2C1=CC=CC=C1 WFXURHIXPXVPGM-UHFFFAOYSA-N 0.000 claims 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K 2qpq Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- 229960003108 Brompheniramine Maleate Drugs 0.000 claims 2
- 229940046978 Chlorpheniramine Maleate Drugs 0.000 claims 2
- DBAKFASWICGISY-BTJKTKAUSA-N Chlorpheniramine maleate Chemical group OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 DBAKFASWICGISY-BTJKTKAUSA-N 0.000 claims 2
- 229940001468 Citrate Drugs 0.000 claims 2
- 229960002689 Clemastine Fumarate Drugs 0.000 claims 2
- 229960003782 Dextromethorphan Hydrobromide Drugs 0.000 claims 2
- STTADZBLEUMJRG-IKNOHUQMSA-N Dextromethorphan hydrobromide monohydrate Chemical compound O.Br.C([C@@H]12)CCC[C@]11CCN(C)[C@H]2CC2=CC=C(OC)C=C21 STTADZBLEUMJRG-IKNOHUQMSA-N 0.000 claims 2
- 229960000525 Diphenhydramine Hydrochloride Drugs 0.000 claims 2
- KBAUFVUYFNWQFM-UHFFFAOYSA-N Doxylamine succinate Chemical compound OC(=O)CCC(O)=O.C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 KBAUFVUYFNWQFM-UHFFFAOYSA-N 0.000 claims 2
- RWTNPBWLLIMQHL-UHFFFAOYSA-N Fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 claims 2
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 claims 2
- 102000015728 Mucins Human genes 0.000 claims 2
- 108010063954 Mucins Proteins 0.000 claims 2
- 229960003956 Phenindamine tartrate Drugs 0.000 claims 2
- 229960003733 Phenylephrine Hydrochloride Drugs 0.000 claims 2
- KWGRBVOPPLSCSI-WCBMZHEXSA-N Pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 claims 2
- 229960003447 Pseudoephedrine Hydrochloride Drugs 0.000 claims 2
- 230000000954 anitussive Effects 0.000 claims 2
- SRGKFVAASLQVBO-BTJKTKAUSA-N brompheniramine maleate Chemical compound OC(=O)\C=C/C(O)=O.C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 SRGKFVAASLQVBO-BTJKTKAUSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229960003291 chlorphenamine Drugs 0.000 claims 2
- PMGQWSIVQFOFOQ-YKVZVUFRSA-N clemastine fumarate Chemical compound OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 PMGQWSIVQFOFOQ-YKVZVUFRSA-N 0.000 claims 2
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 229960005008 doxylamine succinate Drugs 0.000 claims 2
- 229960003592 fexofenadine Drugs 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-L maleate(2-) Chemical compound [O-]C(=O)\C=C/C([O-])=O VZCYOOQTPOCHFL-UPHRSURJSA-L 0.000 claims 2
- OCYSGIYOVXAGKQ-FVGYRXGTSA-N phenylephrine hydrochloride Chemical compound [H+].[Cl-].CNC[C@H](O)C1=CC=CC(O)=C1 OCYSGIYOVXAGKQ-FVGYRXGTSA-N 0.000 claims 2
- 229960003910 promethazine Drugs 0.000 claims 2
- BALXUFOVQVENIU-KXNXZCPBSA-N pseudoephedrine hydrochloride Chemical compound [H+].[Cl-].CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-KXNXZCPBSA-N 0.000 claims 2
- 210000002345 respiratory system Anatomy 0.000 claims 2
- 230000002459 sustained Effects 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/558,517 | 2009-09-12 | ||
| US12/558,517 US20110065744A1 (en) | 2009-09-12 | 2009-09-12 | Method Of Inhibiting Mucin Secretion |
| GBGB1002039.4A GB201002039D0 (en) | 2010-02-09 | 2010-02-09 | Method of inhibiting mucin secretion |
| GB1002039.4 | 2010-02-09 | ||
| PCT/GB2010/051525 WO2011030163A1 (fr) | 2009-09-12 | 2010-09-13 | Utilisation de guaifénésine pour inhiber la sécrétion de mucine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013504554A JP2013504554A (ja) | 2013-02-07 |
| JP2013504554A5 true JP2013504554A5 (fr) | 2013-10-31 |
Family
ID=42941393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012528455A Pending JP2013504554A (ja) | 2009-09-12 | 2010-09-13 | ムチン分泌を抑制するためのグアイフェネシンの使用 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2475360A1 (fr) |
| JP (1) | JP2013504554A (fr) |
| KR (1) | KR20120068889A (fr) |
| CN (1) | CN102596189A (fr) |
| AU (1) | AU2010294008B2 (fr) |
| BR (1) | BR112012005517A2 (fr) |
| CA (1) | CA2773611A1 (fr) |
| MX (1) | MX2012003042A (fr) |
| MY (1) | MY161187A (fr) |
| RU (1) | RU2012114323A (fr) |
| WO (1) | WO2011030163A1 (fr) |
| ZA (1) | ZA201201822B (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20150065539A1 (en) * | 2012-04-06 | 2015-03-05 | The Uab Research Foundation | Methods for Increasing CFTR Activity |
| KR102211605B1 (ko) * | 2018-02-26 | 2021-02-04 | 대한민국 | 개구리 배아를 이용한 기도 뮤신 분비 억제제의 스크리닝 방법 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA963590B (en) * | 1995-05-10 | 1996-11-19 | Adcock Ingram Ltd | Pharmaceutical composition |
| US6846799B1 (en) * | 1998-08-18 | 2005-01-25 | The Regents Of The University Of California | Preventing airway mucus production by administration of EGF-R antagonists |
| US7985420B2 (en) * | 2000-04-28 | 2011-07-26 | Reckitt Benckiser Inc. | Sustained release of guaifenesin combination drugs |
| BR0307755A (pt) * | 2002-02-04 | 2004-12-07 | Pharmacia Corp | Tratamento de resfriados e tosse com uma combinação de um inibidor seletivo da ciclooxigenase-2 e um ingrediente ativo contra resfriados e tosse e composições dos mesmos |
| AU2004249775A1 (en) * | 2003-06-19 | 2004-12-29 | Genaera Corporation | Mucin synthesis inhibitors |
| US20050095288A1 (en) * | 2003-11-03 | 2005-05-05 | Andrx Labs, Llc | Decongestant and expectorant tablets |
| US20050266032A1 (en) * | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
| US20080014261A1 (en) * | 2006-07-12 | 2008-01-17 | Giordano John A | Non-narcotic biphasic release compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction |
| US20090202633A1 (en) * | 2008-01-03 | 2009-08-13 | Siva Ramakrishna Velaga | Extended release formulations of guaifenesin |
-
2010
- 2010-09-13 RU RU2012114323/15A patent/RU2012114323A/ru unknown
- 2010-09-13 KR KR1020127007996A patent/KR20120068889A/ko not_active Application Discontinuation
- 2010-09-13 BR BR112012005517A patent/BR112012005517A2/pt not_active Application Discontinuation
- 2010-09-13 EP EP10757117A patent/EP2475360A1/fr not_active Ceased
- 2010-09-13 WO PCT/GB2010/051525 patent/WO2011030163A1/fr active Application Filing
- 2010-09-13 CN CN2010800492171A patent/CN102596189A/zh active Pending
- 2010-09-13 CA CA2773611A patent/CA2773611A1/fr not_active Abandoned
- 2010-09-13 MY MYPI2012001112A patent/MY161187A/en unknown
- 2010-09-13 AU AU2010294008A patent/AU2010294008B2/en active Active
- 2010-09-13 JP JP2012528455A patent/JP2013504554A/ja active Pending
- 2010-09-13 MX MX2012003042A patent/MX2012003042A/es unknown
-
2012
- 2012-03-13 ZA ZA2012/01822A patent/ZA201201822B/en unknown
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