JP2013503171A - がんの処置および予防におけるメトホルミンの使用 - Google Patents

がんの処置および予防におけるメトホルミンの使用 Download PDF

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JP2013503171A
JP2013503171A JP2012526936A JP2012526936A JP2013503171A JP 2013503171 A JP2013503171 A JP 2013503171A JP 2012526936 A JP2012526936 A JP 2012526936A JP 2012526936 A JP2012526936 A JP 2012526936A JP 2013503171 A JP2013503171 A JP 2013503171A
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metformin
cancer
tumor
cells
agents
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Japanese (ja)
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ケビン ストルール
ヘザー ヒルシュ
ディミトリオス イリオプロス
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プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/17Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2012526936A 2009-08-25 2010-08-25 がんの処置および予防におけるメトホルミンの使用 Pending JP2013503171A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23677809P 2009-08-25 2009-08-25
US61/236,778 2009-08-25
PCT/US2010/046616 WO2011031474A2 (en) 2009-08-25 2010-08-25 Use of metformin in cancer treatment and prevention

Publications (1)

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JP2013503171A true JP2013503171A (ja) 2013-01-31

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JP2012526936A Pending JP2013503171A (ja) 2009-08-25 2010-08-25 がんの処置および予防におけるメトホルミンの使用

Country Status (14)

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US (1) US20120220664A1 (enExample)
EP (1) EP2470170A4 (enExample)
JP (1) JP2013503171A (enExample)
KR (1) KR20120080579A (enExample)
CN (1) CN102596192A (enExample)
AU (1) AU2010292599A1 (enExample)
BR (1) BR112012004281A2 (enExample)
CA (1) CA2772120A1 (enExample)
IL (1) IL218287A0 (enExample)
IN (1) IN2012DN01964A (enExample)
MX (1) MX2012002337A (enExample)
SG (1) SG178556A1 (enExample)
WO (1) WO2011031474A2 (enExample)
ZA (1) ZA201201434B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014214093A (ja) * 2013-04-23 2014-11-17 国立大学法人岡山大学 免疫疲弊cd8+t細胞の機能改善薬、がん治療薬及びメタボリック症候群の予防または治療薬
EP3232199A2 (en) 2014-08-19 2017-10-18 National University Corporation Okayama University Method for enhancing immune cell function and method for assessing immune cell multifunctionality
JP2023528059A (ja) * 2020-06-05 2023-07-03 フロントバイオ インコーポレーテッド 抗ウイルス剤及び抗うつ剤を有効成分として含有する癌の予防または治療用薬学的組成物

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130040310A1 (en) * 2009-12-15 2013-02-14 Salk Institute For Biological Studies Ulk1 compositions, inhibitors, screening and methods of use
BR112013014076A2 (pt) * 2010-12-06 2016-11-22 Cure Cancer Worldwide Corp métodos de direcionamento metabólico de células de câncer usando quimio- e imunotherapia para tratamento de câncer
US9532984B2 (en) * 2011-06-10 2017-01-03 The Translational Genomics Research Institute Therapeutic combination for cancer treatment
CN102327256B (zh) * 2011-09-22 2014-01-29 上海交通大学医学院附属瑞金医院 二甲双胍在制备治疗淋巴瘤疾病药物中的应用
WO2013086002A1 (en) * 2011-12-05 2013-06-13 Cellworks Research India Private Limited Compositions, process of preparation of said compositions and method of treating cancer
CA3159085A1 (en) * 2013-01-14 2014-07-17 Clinics Operations Limited Combination cancer therapeutics and uses thereof
BR112015024537B1 (pt) * 2013-04-12 2022-09-06 Ned Biosystems, Inc Uso de (i) ciclofosfamida, (ii) metformina, (iii) curcumina, (iv) melatonina, (v) naltrexona, (vi) ácido alfa lipoico e (vii) genisteína e combinação no tratamento de câncer
JP6440212B2 (ja) 2013-05-24 2018-12-19 株式会社加齢・栄養研究所 メトホルミン及びジヒドロケルセチンを含む組み合わせ医薬、及びがんの治療のための使用
WO2015183794A1 (en) 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
CN107205968B (zh) * 2014-08-14 2021-08-20 威斯康星州医药大学股份有限公司 修饰的线粒体-二甲双胍化合物及其合成和使用方法
WO2016026933A1 (en) * 2014-08-21 2016-02-25 Centre National De La Recherche Scientifique - Cnrs - Adjuvant or neoadjuvant therapy for sensitizing cancer stem cells to chemotherapy
WO2017142485A1 (en) * 2016-02-16 2017-08-24 Agency For Science, Technology And Research Cancer epigenetic profiling
CA3059210C (en) * 2016-05-19 2022-07-19 The Regents Of The University Of California Triple drug combination (metformin, simvastatin, digoxin) for targeted treatment of pancreatic cancer
CN106727468A (zh) * 2017-04-01 2017-05-31 四川大学 二甲双胍及联合二甲双胍和长春新碱在制备治疗白血病药物中的应用及药物组合物
EP3612177A4 (en) 2017-04-21 2021-01-13 Lunella Biotech, Inc. TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY
WO2018195434A1 (en) 2017-04-21 2018-10-25 Lisanti Michael P Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs)
WO2018213764A1 (en) 2017-05-19 2018-11-22 Lunella Biotech, Inc. Companion diagnostics for mitochondrial inhibitors
CA3063717C (en) 2017-05-19 2021-08-24 Lunella Biotech, Inc. Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells
WO2019183003A1 (en) * 2018-03-18 2019-09-26 The University Of North Carolina At Chapel Hill Methods and assays for endometrial diseases
CN117338938A (zh) * 2019-02-28 2024-01-05 北京强新生物科技有限公司 用于治疗中枢神经系统紊乱的组合疗法
WO2024233616A1 (en) * 2023-05-11 2024-11-14 Wainer Irving W Method for treating cancer
WO2025085311A1 (en) * 2023-10-16 2025-04-24 Board Of Regents, The University Of Texas System Methods and compositions for the treatment of kmt2d-deficient cancers
WO2025157212A1 (zh) * 2024-01-23 2025-07-31 成都夸常奥普医疗科技有限公司 包含n,n-二甲基亚双胍的制剂、和包含n,n-二甲基亚双胍与药物的药物组合、组合物、试剂盒及其用途和制备方法

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Publication number Priority date Publication date Assignee Title
EP1799263A4 (en) * 2004-09-15 2009-07-29 Harvard College REDUCTION OF ER-STRESS IN THE TREATMENT OF ADIPOSITAS AND DIABETES
US7465804B2 (en) * 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
DE102006026026A1 (de) * 2006-06-01 2007-12-06 Grünenthal GmbH Arzneimittel
US20080188457A1 (en) * 2007-02-02 2008-08-07 Braincells, Inc. Modulation of Neurogenesis with Biguanides and GSK3-beta Agents
WO2008110491A2 (en) * 2007-03-09 2008-09-18 University Of Basel Chemotherapy of neoplastic diseases using combinations of rapamycin and compounds modulating mtor pathway alone or in combination with heat
WO2009101199A2 (en) * 2008-02-15 2009-08-20 Bodo Melnik Treatment of acne vulgaris; rosacea and rhinophym

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014214093A (ja) * 2013-04-23 2014-11-17 国立大学法人岡山大学 免疫疲弊cd8+t細胞の機能改善薬、がん治療薬及びメタボリック症候群の予防または治療薬
EP3232199A2 (en) 2014-08-19 2017-10-18 National University Corporation Okayama University Method for enhancing immune cell function and method for assessing immune cell multifunctionality
JP2023528059A (ja) * 2020-06-05 2023-07-03 フロントバイオ インコーポレーテッド 抗ウイルス剤及び抗うつ剤を有効成分として含有する癌の予防または治療用薬学的組成物

Also Published As

Publication number Publication date
KR20120080579A (ko) 2012-07-17
SG178556A1 (en) 2012-03-29
US20120220664A1 (en) 2012-08-30
CN102596192A (zh) 2012-07-18
IL218287A0 (en) 2012-04-30
WO2011031474A2 (en) 2011-03-17
CA2772120A1 (en) 2011-03-17
IN2012DN01964A (enExample) 2015-08-21
BR112012004281A2 (pt) 2016-03-08
EP2470170A4 (en) 2013-01-02
AU2010292599A1 (en) 2012-03-15
EP2470170A2 (en) 2012-07-04
MX2012002337A (es) 2012-06-25
WO2011031474A3 (en) 2011-06-16
ZA201201434B (en) 2013-05-29

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