CA2772120A1 - Use of metformin in cancer treatment and prevention - Google Patents
Use of metformin in cancer treatment and prevention Download PDFInfo
- Publication number
- CA2772120A1 CA2772120A1 CA2772120A CA2772120A CA2772120A1 CA 2772120 A1 CA2772120 A1 CA 2772120A1 CA 2772120 A CA2772120 A CA 2772120A CA 2772120 A CA2772120 A CA 2772120A CA 2772120 A1 CA2772120 A1 CA 2772120A1
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- metformin
- cancer
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
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- Molecular Biology (AREA)
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- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| CA2772120A1 true CA2772120A1 (en) | 2011-03-17 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2011084523A2 (en) * | 2009-12-15 | 2011-07-14 | The Salk Institute For Biological Studies | Ulk1 compositions, inhibitors, screening and methods of use |
| CN103347521B (zh) * | 2010-12-06 | 2018-05-25 | 全球癌症治疗有限责任公司 | 用于治疗癌症的使用化疗和免疫治疗的代谢靶向癌细胞的方法 |
| US9532984B2 (en) * | 2011-06-10 | 2017-01-03 | The Translational Genomics Research Institute | Therapeutic combination for cancer treatment |
| CN102327256B (zh) * | 2011-09-22 | 2014-01-29 | 上海交通大学医学院附属瑞金医院 | 二甲双胍在制备治疗淋巴瘤疾病药物中的应用 |
| WO2013086002A1 (en) * | 2011-12-05 | 2013-06-13 | Cellworks Research India Private Limited | Compositions, process of preparation of said compositions and method of treating cancer |
| EP2943193A2 (en) | 2013-01-14 | 2015-11-18 | Health Clinics Limited | Cancer drug and uses |
| SG11201509707QA (en) | 2013-04-12 | 2015-12-30 | Rebecca Lambert Bent | Cancer therapy |
| JP6242071B2 (ja) * | 2013-04-23 | 2017-12-06 | 国立大学法人 岡山大学 | 免疫疲弊ｃｄ８＋ｔ細胞の機能改善薬、がん治療薬及びメタボリック症候群の予防または治療薬 |
| CN105263484B (zh) * | 2013-05-24 | 2018-08-03 | 株式会社加龄.营养研究所 | 包含二甲双胍和二氢槲皮素的药物组合及其用于治疗癌症的用途 |
| WO2015183794A1 (en) | 2014-05-27 | 2015-12-03 | City Of Hope | Tgr5 agonist complexes for treating diabetes and cancer |
| EP3179994B1 (en) * | 2014-08-14 | 2019-04-24 | The Medical College of Wisconsin, Inc. | Modified mito-metformin compounds and methods of synthesis and use thereof |
| SG11201700978SA (en) * | 2014-08-19 | 2017-03-30 | Univ Okayama Nat Univ Corp | Method for enhancing immune cell function and method for assessing immune cell multifunctionality |
| WO2016026933A1 (en) * | 2014-08-21 | 2016-02-25 | Centre National De La Recherche Scientifique - Cnrs - | Adjuvant or neoadjuvant therapy for sensitizing cancer stem cells to chemotherapy |
| CN109072312A (zh) * | 2016-02-16 | 2018-12-21 | 新加坡科技研究局 | 癌症表观遗传谱分析 |
| WO2018044369A2 (en) * | 2016-05-19 | 2018-03-08 | The Regents Of The University Of California | Triple drug combination (metformin, simvastatin, digoxin) for targeted treatment of pancreatic cancer |
| CN106727468A (zh) * | 2017-04-01 | 2017-05-31 | 四川大学 | 二甲双胍及联合二甲双胍和长春新碱在制备治疗白血病药物中的应用及药物组合物 |
| US11229657B2 (en) | 2017-04-21 | 2022-01-25 | Lunella Biotech, Inc. | Targeting hypoxic cancer stem cells (CSCs) with doxycycline: implications for improving anti-angiogenic therapy |
| EP3612187B1 (en) | 2017-04-21 | 2022-04-13 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| US12006553B2 (en) | 2017-05-19 | 2024-06-11 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| EP3624840A4 (en) | 2017-05-19 | 2021-03-10 | Lunella Biotech, Inc. | ANTIMITOSCINE: TARGETED INHIBITORS OF MITOCHONDRIAL BIOGENESIS TO DESCRIBE CANCER STEM CELLS |
| WO2019183003A1 (en) * | 2018-03-18 | 2019-09-26 | The University Of North Carolina At Chapel Hill | Methods and assays for endometrial diseases |
| CN117338938A (zh) * | 2019-02-28 | 2024-01-05 | 北京强新生物科技有限公司 | 用于治疗中枢神经系统紊乱的组合疗法 |
| KR102312100B1 (ko) * | 2020-06-05 | 2021-10-14 | (주)프론트바이오 | 항바이러스제 및 항우울제를 유효성분으로 함유하는 암 예방 또는 치료용 약학적 조성물 |
| WO2024233616A1 (en) * | 2023-05-11 | 2024-11-14 | Wainer Irving W | Method for treating cancer |
| WO2025085311A1 (en) * | 2023-10-16 | 2025-04-24 | Board Of Regents, The University Of Texas System | Methods and compositions for the treatment of kmt2d-deficient cancers |
| WO2025157212A1 (zh) * | 2024-01-23 | 2025-07-31 | 成都夸常奥普医疗科技有限公司 | 包含n，n-二甲基亚双胍的制剂、和包含n,n-二甲基亚双胍与药物的药物组合、组合物、试剂盒及其用途和制备方法 |
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| CN101056656A (zh) * | 2004-09-15 | 2007-10-17 | 哈佛大学校长及研究员协会 | 在治疗肥胖症和糖尿病中降低er应力 |
| US7465804B2 (en) * | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| DE102006026026A1 (de) * | 2006-06-01 | 2007-12-06 | Grünenthal GmbH | Arzneimittel |
| WO2008097861A2 (en) * | 2007-02-02 | 2008-08-14 | Braincells, Inc. | MODULATION OF NEUROGENESIS WITH BIGUANIDES AND GSK3-ß AGENTS |
| WO2008110491A2 (en) * | 2007-03-09 | 2008-09-18 | University Of Basel | Chemotherapy of neoplastic diseases using combinations of rapamycin and compounds modulating mtor pathway alone or in combination with heat |
| WO2009101199A2 (en) * | 2008-02-15 | 2009-08-20 | Bodo Melnik | Treatment of acne vulgaris; rosacea and rhinophym |
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- 2010-08-25 KR KR1020127007261A patent/KR20120080579A/ko not_active Withdrawn
- 2010-08-25 CA CA2772120A patent/CA2772120A1/en not_active Abandoned
- 2010-08-25 CN CN2010800480600A patent/CN102596192A/zh active Pending
- 2010-08-25 WO PCT/US2010/046616 patent/WO2011031474A2/en not_active Ceased
- 2010-08-25 JP JP2012526936A patent/JP2013503171A/ja active Pending
- 2010-08-25 EP EP10815838A patent/EP2470170A4/en not_active Withdrawn
- 2010-08-25 SG SG2012013017A patent/SG178556A1/en unknown
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- 2012-02-27 ZA ZA2012/01434A patent/ZA201201434B/en unknown
Also Published As
| Publication number | Publication date |
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| MX2012002337A (es) | 2012-06-25 |
| JP2013503171A (ja) | 2013-01-31 |
| IL218287A0 (en) | 2012-04-30 |
| US20120220664A1 (en) | 2012-08-30 |
| EP2470170A2 (en) | 2012-07-04 |
| CN102596192A (zh) | 2012-07-18 |
| IN2012DN01964A (enExample) | 2015-08-21 |
| BR112012004281A2 (pt) | 2016-03-08 |
| ZA201201434B (en) | 2013-05-29 |
| SG178556A1 (en) | 2012-03-29 |
| AU2010292599A1 (en) | 2012-03-15 |
| KR20120080579A (ko) | 2012-07-17 |
| EP2470170A4 (en) | 2013-01-02 |
| WO2011031474A2 (en) | 2011-03-17 |
| WO2011031474A3 (en) | 2011-06-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20140826 |