JP2013503148A5 - - Google Patents

Download PDF

Info

Publication number
JP2013503148A5
JP2013503148A5 JP2012526141A JP2012526141A JP2013503148A5 JP 2013503148 A5 JP2013503148 A5 JP 2013503148A5 JP 2012526141 A JP2012526141 A JP 2012526141A JP 2012526141 A JP2012526141 A JP 2012526141A JP 2013503148 A5 JP2013503148 A5 JP 2013503148A5
Authority
JP
Japan
Prior art keywords
composition
oligonucleotide
polymer
aluminum salt
immunogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP2012526141A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013503148A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2010/002259 external-priority patent/WO2011024071A1/en
Publication of JP2013503148A publication Critical patent/JP2013503148A/ja
Publication of JP2013503148A5 publication Critical patent/JP2013503148A5/ja
Ceased legal-status Critical Current

Links

JP2012526141A 2009-08-27 2010-08-27 アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント Ceased JP2013503148A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23759509P 2009-08-27 2009-08-27
US61/237,595 2009-08-27
PCT/IB2010/002259 WO2011024071A1 (en) 2009-08-27 2010-08-27 Adjuvant comprising aluminium, oligonucleotide and polycation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015236813A Division JP2016034980A (ja) 2009-08-27 2015-12-03 アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント

Publications (2)

Publication Number Publication Date
JP2013503148A JP2013503148A (ja) 2013-01-31
JP2013503148A5 true JP2013503148A5 (https=) 2013-07-25

Family

ID=43428549

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2012526141A Ceased JP2013503148A (ja) 2009-08-27 2010-08-27 アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント
JP2015236813A Pending JP2016034980A (ja) 2009-08-27 2015-12-03 アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2015236813A Pending JP2016034980A (ja) 2009-08-27 2015-12-03 アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント

Country Status (9)

Country Link
US (1) US8858958B2 (https=)
EP (1) EP2470205A1 (https=)
JP (2) JP2013503148A (https=)
CN (1) CN102740882A (https=)
AU (1) AU2010288239B2 (https=)
BR (1) BR112012004276A2 (https=)
CA (1) CA2772103A1 (https=)
NZ (1) NZ598459A (https=)
WO (1) WO2011024071A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010032138A2 (en) * 2008-09-18 2010-03-25 Novartis Ag Vaccine adjuvant combinations
WO2014016152A1 (en) 2012-07-27 2014-01-30 Institut National De La Sante Et De La Recherche Medicale Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
JP6700512B2 (ja) * 2014-08-04 2020-05-27 オンコセラピー・サイエンス株式会社 Cdca1由来ペプチドおよびそれを含むワクチン
CN112138155B (zh) * 2019-06-28 2022-04-12 怡道生物科技(苏州)有限公司 一种复合佐剂系统及制备该佐剂的方法

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2848965A1 (de) 1978-11-11 1980-05-22 Behringwerke Ag Verfahren zur herstellung von membranproteinen aus neisseria meningitidis und diese enthaltende vaccine
US6699474B1 (en) 1990-08-20 2004-03-02 Erich Hugo Cerny Vaccine and immunserum against drugs of abuse
DE69333110T2 (de) 1992-03-02 2004-05-06 Chiron S.P.A. Mit dem cytotoxin von helicobacter pylori assoziiertes, immunodominantes antigen verwendbar in impfstoffen und zur diagnose
NL9201716A (nl) 1992-10-02 1994-05-02 Nederlanden Staat Buitenmembraanvesikel dat voorzien is van een groep polypeptiden welke ten minste de immuunwerking van aan membraan gebonden buitenmembraaneiwitten (OMP's) hebben, werkwijze ter bereiding ervan alsmede een vaccin dat een dergelijk buitenmembraanvesikel omvat.
FR2718452B1 (fr) 1994-04-06 1996-06-28 Pf Medicament Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation.
JPH10502366A (ja) 1994-07-01 1998-03-03 リカン・リミテッド ヘリコバクター・ピロリ抗原タンパク質調製品およびイムノアッセイ
US6429199B1 (en) 1994-07-15 2002-08-06 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules for activating dendritic cells
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
US6239116B1 (en) 1994-07-15 2001-05-29 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
IL117483A (en) 1995-03-17 2008-03-20 Bernard Brodeur MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K.
US6180111B1 (en) 1995-05-18 2001-01-30 University Of Maryland Vaccine delivery system
US6165774A (en) * 1995-09-22 2000-12-26 Connaught Laboratories Limited Parainfluenza virus glycoproteins and vaccines
GB2324093A (en) 1996-01-04 1998-10-14 Rican Limited Helicobacter pylori bacterioferritin
RS50101B (sr) 1996-02-24 2009-01-22 Boehringer Ingelheim International Gmbh., Farmaceutski preparati za imunomodulaciju
DK1005368T3 (da) 1997-03-10 2010-01-04 Ottawa Hospital Res Inst Anvendelse af nukleinsyrer, der indeholder ikke-metyleret CpG dinukleotid i kombination med alun som hjælpestoffer
WO1998053851A1 (en) 1997-05-28 1998-12-03 University Of Iowa Research Foundation Laft mutants of pathogenic gram-negative bacteria
GB9711964D0 (en) 1997-06-09 1997-08-06 Medical Res Council Live attenuated vaccines
ES2301181T3 (es) 1997-08-21 2008-06-16 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezondheid En Cultuur Mutantes nuevos de bacterias mucosas gram negativas y su aplicacion en vacunas.
DE19803453A1 (de) 1998-01-30 1999-08-12 Boehringer Ingelheim Int Vakzine
US6645503B1 (en) 1998-03-10 2003-11-11 Wyeth Holdings Corporation Antigenic conjugates of conserved lipopolysaccharides of gram negative bacteria
EP2261338A3 (en) 1998-05-01 2012-01-04 Novartis Vaccines and Diagnostics, Inc. Neisseria meningitidis antigens and compositions
WO2000023595A1 (en) 1998-10-22 2000-04-27 The University Of Montana Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof
GB9823978D0 (en) 1998-11-02 1998-12-30 Microbiological Res Authority Multicomponent meningococcal vaccine
AU762369B2 (en) 1998-11-03 2003-06-26 De Staat Der Nederlanden Vertegenwoordigd Door De Minister Van Welzijn, Volksgezonheid En Cultuur LPS with reduced toxicity from genetically modified gram negative bacteria
WO2000066741A2 (en) 1999-04-30 2000-11-09 Chiron S.P.A. Conserved neisserial antigens
GB9918319D0 (en) 1999-08-03 1999-10-06 Smithkline Beecham Biolog Vaccine composition
US6531131B1 (en) 1999-08-10 2003-03-11 The United States Of America As Represented By The Department Of Health And Human Services Conjugate vaccine for Neisseria meningitidis
AU1917501A (en) 1999-11-12 2001-06-06 University Of Iowa Research Foundation, The Control of neisserial membrane synthesis
BR0015961A (pt) 1999-11-29 2003-06-10 Chiron Spa Antìgeno de neisseria de 85kda
PT2289545T (pt) 2000-01-17 2016-09-06 Glaxosmithkline Biologicals Sa Vacina de omv suplementada contra meningococos
NZ520445A (en) 2000-01-25 2004-02-27 Univ Queensland Proteins comprising conserved regions of neisseria meningitidis surface antigen NhhA
NO20002828D0 (no) 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
RU2413520C2 (ru) 2000-06-08 2011-03-10 Интерселл Аг Вакцинная композиция, содержащая иммуностимулирующие олигодезоксинуклеотиды
JP2004502415A (ja) 2000-07-03 2004-01-29 カイロン エセ.ピー.アー. Chlamydiapneumoniaeに対する免疫化
ES2519440T3 (es) 2000-07-27 2014-11-07 Children's Hospital & Research Center At Oakland Vacunas para la protección de amplio espectro contra enfermedades causadas por Neisseria meningitidis
GB0103170D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
AT410635B (de) 2000-10-18 2003-06-25 Cistem Biotechnologies Gmbh Vakzin-zusammensetzung
GB0103171D0 (en) 2001-02-08 2001-03-28 Smithkline Beecham Biolog Vaccine composition
FR2827605B1 (fr) 2001-07-20 2004-07-16 Pf Medicament Nouveaux peptides derives de la proteine g du vrs et leur utilisation dans un vaccin
RU2323002C2 (ru) * 2001-07-26 2008-04-27 Чирон Срл. Вакцины, содержащие алюминиевые адъюванты и гистидин
MX339524B (es) 2001-10-11 2016-05-30 Wyeth Corp Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
RU2331435C2 (ru) 2001-12-12 2008-08-20 Чирон Срл. Иммунизация против chlamydia trachomatis
AU2003206532A1 (en) 2002-02-22 2003-09-09 National Research Council Of Canada Synthesis of lipopolysaccharide-protein conjugate vaccines via the lipid a region following removal of the glycosidic phosphate residue
GB0211118D0 (en) 2002-05-15 2002-06-26 Polonelli Luciano Vaccines
GB0213622D0 (en) 2002-06-13 2002-07-24 Glaxosmithkline Biolog Sa Vaccine Corporation
US20060057160A1 (en) 2002-08-02 2006-03-16 Ralph Biemans Vaccine composition
GB0220194D0 (en) 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
HUE031886T2 (en) 2002-10-11 2017-08-28 Glaxosmithkline Biologicals Sa Polypeptide vaccines for extensive protection against hypervirulent meningococcal lines
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
EP1608402B1 (en) * 2003-03-24 2010-10-20 Intercell AG Improved vaccines
CN1764473A (zh) 2003-03-24 2006-04-26 英特塞尔股份公司 矾与Th1免疫应答诱导佐剂用于增强免疫应答的用途
MXPA05013260A (es) 2003-06-26 2006-03-09 Chiron Corp Composiciones inmunogenicas para chlamydia trachomatis.
GB0316560D0 (en) 2003-07-15 2003-08-20 Chiron Srl Vesicle filtration
BRPI0508365A (pt) 2004-03-02 2007-07-24 Chiron Corp composições imunogênicas para chlamydia pneumoniae
GB0419408D0 (en) 2004-09-01 2004-10-06 Chiron Srl 741 chimeric polypeptides
GB0419627D0 (en) 2004-09-03 2004-10-06 Chiron Srl Immunogenic bacterial vesicles with outer membrane proteins
WO2006081259A2 (en) 2005-01-27 2006-08-03 Children's Hospital & Research Center At Oakland Gna1870-based vesicle vaccines for broad spectrum protection against diseases caused by neisseria meningitidis
SI1858920T1 (sl) * 2005-02-18 2016-07-29 Glaxosmithkline Biologicals S.A. Proteini in nukleinske kisline iz escherichia coli, povezane z meningitisom/sepso
JP2008530245A (ja) 2005-02-18 2008-08-07 ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド 尿路病原性菌株由来の抗原
RU2007146137A (ru) 2005-05-12 2009-06-27 Новартис Вэксинес Энд Дайэгностикс, Инк. (Us) Иммуногенные композиции на основе chlamydia trachomatis
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
CA2633142A1 (en) 2005-12-22 2007-10-04 Novartis Vaccines And Diagnostics, S.R.L. Chlamydial antigens
EP1940462A2 (en) * 2005-12-23 2008-07-09 GlaxoSmithKline Biologicals S.A. Conjugate vaccines
CA2654706A1 (en) 2006-06-12 2007-12-21 Nathalie Devos Neisseria meningitidis lipooligosaccharide vaccine
EP2586790A3 (en) 2006-08-16 2013-08-14 Novartis AG Immunogens from uropathogenic Escherichia coli
US20100266626A1 (en) 2007-11-26 2010-10-21 Francesco Berti Adjuvanted glucans
AU2008339631B2 (en) 2007-12-24 2014-07-24 Novartis Ag Assays for adsorbed influenza vaccines
CN102356089B (zh) 2008-02-21 2014-02-19 诺华股份有限公司 脑膜炎球菌fHBP多肽
ITMI20081249A1 (it) 2008-07-09 2010-01-09 Novartis Vaccines & Diagnostic Immunogeni di escherichia coli con solubilità migliorata.
WO2010032138A2 (en) 2008-09-18 2010-03-25 Novartis Ag Vaccine adjuvant combinations

Similar Documents

Publication Publication Date Title
JP6101330B2 (ja) アジュバント添加した髄膜炎菌h因子結合タンパク質
JP5344558B2 (ja) カチオン性ナノゲルを用いる粘膜ワクチン
WO2017143024A2 (en) Pathogen vaccines and methods of producing and using the same
JP2014525429A5 (https=)
JP2013522287A5 (https=)
CN110520154A (zh) 多价肺炎链球菌疫苗组合物
CN104093418A (zh) 金黄色葡萄球菌抗原的含佐剂制剂
JP2013501071A5 (https=)
JP2010508276A5 (https=)
US20250152700A1 (en) Aluminum nanocrystal delivery system, and self-assembled particle adjuvant vaccine based on binding of aluminum nanocrystal delivery system and vaccine antigen molecule
JP2013503148A5 (https=)
US20220331424A1 (en) Composite adjuvant system and method for preparing adjuvant
WO2023131356A2 (zh) 四氧化三锰颗粒在制备疫苗佐剂中的应用
Liao et al. Carbopol dispersed PAA-modified UIO-66 with high colloidal stability as a combination nano-adjuvant boosts immune response and protection against pseudorabies virus in mice and pigs
JP2016034980A (ja) アルミニウム、オリゴヌクレオチドおよびポリカチオンを含むアジュバント
EP2221050A1 (en) Use of microparticles for vaccines and the release of biologically active molecules
US20140248310A1 (en) Cationic metal oxides for use as vaccine adjuvants
Rosales-Mendoza et al. Silica-based mucosal nanovaccines
JP4711964B2 (ja) ワクチンのアジュバントとしてリン酸鉄を含むワクチン組成物
Ohta Cholesteryl Pullulan Nanoparticles-Encapsulated TNF-a: An Effective Mucosal Vaccine Adjuvant Against
RU2779622C9 (ru) Комплекс для усиления иммунного ответа
RU2779622C2 (ru) Комплекс для усиления иммунного ответа
Herbert et al. COORDINATION POLYMER MATRIXES INTENSIFY IMMUNITY AGAINST BLADDER INFECTION
HK40119504A (en) Aluminum nanocrystal delivery system, and self-assembled particle adjuvant vaccine based on binding of aluminum nanocrystal delivery system and vaccine antigen molecule
HK40011275B (zh) 多价肺炎链球菌疫苗组合物