|
US4187852A
(en)
*
|
1976-07-09 |
1980-02-12 |
The University Of Alabama |
Synthetic elastomeric insoluble cross-linked polypentapeptide
|
|
US4132746A
(en)
|
1976-07-09 |
1979-01-02 |
University Of Alabama, Birmingham Medical & Education Foundation |
Synthetic elastomeric insoluble cross-linked polypentapeptide
|
|
US4474851A
(en)
*
|
1981-10-02 |
1984-10-02 |
The University Of Alabama In Birmingham |
Elastomeric composite material comprising a polypeptide
|
|
US4500700A
(en)
*
|
1981-10-02 |
1985-02-19 |
The Board Of Trustees Of The University Of Alabama For The University Of Alabama In Birmingham |
Elastomeric composite material comprising a polypentapeptide having an amino acid of opposite chirality in position three
|
|
US4589882A
(en)
|
1983-09-19 |
1986-05-20 |
Urry Dan W |
Enzymatically crosslinked bioelastomers
|
|
US4752638A
(en)
*
|
1983-11-10 |
1988-06-21 |
Genetic Systems Corporation |
Synthesis and use of polymers containing integral binding-pair members
|
|
US4749647A
(en)
*
|
1984-06-22 |
1988-06-07 |
Genetic Systems Corporation |
Polymerization-induced separation assay using recognition pairs
|
|
US4734400A
(en)
|
1984-10-09 |
1988-03-29 |
Hoffmann-La Roche Inc. |
Synthetic vasoactive intestinal peptide analogs
|
|
US4605641A
(en)
|
1984-10-09 |
1986-08-12 |
Hoffmann-La Roche Inc. |
Synthetic vasoactive intestinal peptide analogs
|
|
US4870055A
(en)
|
1986-04-17 |
1989-09-26 |
University Of Alabama At Birmingham |
Segmented polypeptide bioelastomers to modulate elastic modulus
|
|
US4783523A
(en)
*
|
1986-08-27 |
1988-11-08 |
Urry Dan W |
Temperature correlated force and structure development of elastin polytetrapeptides and polypentapeptides
|
|
US7138486B2
(en)
|
1986-05-05 |
2006-11-21 |
The General Hospital Corporation |
Insulinotropic hormone derivatives and uses thereof
|
|
US4898926A
(en)
*
|
1987-06-15 |
1990-02-06 |
The University Of Alabama At Birmingham/Research Foundation |
Bioelastomer containing tetra/penta-peptide units
|
|
US5641648A
(en)
*
|
1986-11-04 |
1997-06-24 |
Protein Polymer Technologies, Inc. |
Methods for preparing synthetic repetitive DNA
|
|
US5514581A
(en)
*
|
1986-11-04 |
1996-05-07 |
Protein Polymer Technologies, Inc. |
Functional recombinantly prepared synthetic protein polymer
|
|
US5830713A
(en)
*
|
1986-11-04 |
1998-11-03 |
Protein Polymer Technologies, Inc. |
Methods for preparing synthetic repetitive DNA
|
|
US5773249A
(en)
*
|
1986-11-04 |
1998-06-30 |
Protein Polymer Technologies, Inc. |
High molecular weight collagen-like protein polymers
|
|
US6184348B1
(en)
*
|
1986-11-04 |
2001-02-06 |
Protein Polymer Technologies |
Functional recombinantly prepared synthetic protein polymer
|
|
US6018030A
(en)
*
|
1986-11-04 |
2000-01-25 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US5243038A
(en)
*
|
1986-11-04 |
1993-09-07 |
Protein Polymer Technologies, Inc. |
Construction of synthetic DNA and its use in large polypeptide synthesis
|
|
US5496712A
(en)
*
|
1990-11-06 |
1996-03-05 |
Protein Polymer |
High molecular weight collagen-like protein polymers
|
|
US5770697A
(en)
*
|
1986-11-04 |
1998-06-23 |
Protein Polymer Technologies, Inc. |
Peptides comprising repetitive units of amino acids and DNA sequences encoding the same
|
|
US4835252A
(en)
|
1987-02-26 |
1989-05-30 |
The Salk Institute Biotechnology/Industrial Associates, Inc. |
Vasoactive intestinal peptide analogs
|
|
US4939224A
(en)
|
1987-02-26 |
1990-07-03 |
The Salk Institute Biotechnology/Industrial Associates, Inc. |
Vasoactive intestinal peptide analogs
|
|
US5606019A
(en)
*
|
1987-10-29 |
1997-02-25 |
Protien Polymer Technologies, Inc. |
Synthetic protein as implantables
|
|
IL87055A
(en)
*
|
1988-07-08 |
1994-06-24 |
Illana Gozes |
Conjugates of vasoactive intestinal peptide (vip) and of fragments thereof and pharmaceutical compositions comprising them
|
|
US5766883A
(en)
|
1989-04-29 |
1998-06-16 |
Delta Biotechnology Limited |
Polypeptides
|
|
US5143854A
(en)
*
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
US5141924A
(en)
|
1989-06-30 |
1992-08-25 |
Hoffmann-La Roche, Inc. |
Synthetic vasoactive intestinal peptide analogs
|
|
US5234907A
(en)
*
|
1989-06-30 |
1993-08-10 |
Hoffmann-La Roche Inc. |
Synthetic vasoactive intestinal peptide analogs
|
|
US5447912A
(en)
*
|
1989-09-18 |
1995-09-05 |
Senetek, Plc |
Erection-inducing methods and compositions
|
|
US5236904A
(en)
*
|
1989-09-18 |
1993-08-17 |
Senetek, Plc |
Erection-inducing methods and compositions
|
|
ES2067150T3
(es)
|
1990-03-27 |
1995-03-16 |
Bioelastics Res Ltd |
Sistema de suministro de drogas bioelastomericas.
|
|
DE69101187T2
(de)
*
|
1990-06-26 |
1994-09-29 |
Sanwa Kagaku Kenkyusho Co |
VIP-Analogen und ihre Verwendung.
|
|
JPH07108232B2
(ja)
*
|
1990-10-09 |
1995-11-22 |
エム・ディ・リサーチ株式会社 |
ペプチド又は蛋白質の製造方法
|
|
US5235041A
(en)
*
|
1990-12-28 |
1993-08-10 |
Protein Polymer Technologies, Inc. |
Purification of structurally ordered recombinant protein polymers
|
|
US5595732A
(en)
*
|
1991-03-25 |
1997-01-21 |
Hoffmann-La Roche Inc. |
Polyethylene-protein conjugates
|
|
US5393602A
(en)
|
1991-04-19 |
1995-02-28 |
Bioelastics Research Ltd. |
Superabsorbent materials and uses thereof
|
|
JPH05238950A
(ja)
*
|
1991-04-22 |
1993-09-17 |
Sanwa Kagaku Kenkyusho Co Ltd |
易吸収性ｖｉｐ製剤
|
|
US5958881A
(en)
*
|
1991-04-25 |
1999-09-28 |
Korman; Louis Y. |
Composition containing VIP for injection and a method of enhancing visualization of tissues during medical procedures
|
|
AU656230B2
(en)
|
1991-10-11 |
1995-01-27 |
F. Hoffmann-La Roche Ag |
Cyclic vasoactive peptides
|
|
US5681816A
(en)
*
|
1992-04-24 |
1997-10-28 |
Korman; Louis Y. |
Method of inducing temporary paralysis of the gastrointestinal tract during medical procedure
|
|
US5288514A
(en)
*
|
1992-09-14 |
1994-02-22 |
The Regents Of The University Of California |
Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
|
|
US5972883A
(en)
|
1993-03-16 |
1999-10-26 |
Yeda Research And Development Co. Ltd. |
Method for the treatment of neurodegenerative diseases by administering VIP, an analogue, fragment or a conjugate thereof
|
|
US5545617A
(en)
*
|
1993-11-12 |
1996-08-13 |
The Schepens Eye Research Institute, Inc. |
Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion
|
|
US5705483A
(en)
*
|
1993-12-09 |
1998-01-06 |
Eli Lilly And Company |
Glucagon-like insulinotropic peptides, compositions and methods
|
|
US5900405A
(en)
*
|
1994-01-24 |
1999-05-04 |
Bioelastics Research, Ltd. |
Polymers responsive to electrical energy
|
|
AU709559B2
(en)
*
|
1994-04-07 |
1999-09-02 |
Proteinix Company |
Vasoactive intestinal polypeptide
|
|
US5527610A
(en)
*
|
1994-05-20 |
1996-06-18 |
The Uab Research Foundation |
Elastomeric polypeptide matrices for preventing adhesion of biological materials
|
|
US6004782A
(en)
|
1995-04-14 |
1999-12-21 |
Bioelastics Research Ltd. |
Hyperexpression of bioelastic polypeptides
|
|
US5854387A
(en)
|
1995-04-14 |
1998-12-29 |
Bioelastics Research, Ltd. |
Simple method for the purification of a bioelastic polymer
|
|
US5972406A
(en)
*
|
1995-04-14 |
1999-10-26 |
Bioelastics Research Ltd. |
Bioelastomers suitable as food product additives
|
|
US5624711A
(en)
*
|
1995-04-27 |
1997-04-29 |
Affymax Technologies, N.V. |
Derivatization of solid supports and methods for oligomer synthesis
|
|
US6037321A
(en)
*
|
1995-05-03 |
2000-03-14 |
Biostar Inc. |
Fusion proteins comprising vasoactive intestinal peptide or PACAP
|
|
JP2000500733A
(ja)
|
1995-09-01 |
2000-01-25 |
ユニバーシティ オブ ワシントン |
相互作用分子結合体
|
|
US5702717A
(en)
|
1995-10-25 |
1997-12-30 |
Macromed, Inc. |
Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
|
|
BRPI9707379B8
(pt)
*
|
1996-02-09 |
2015-07-07 |
Abbvie Biotechnology Ltd |
Composições farmacêuticas compreendendo anticorpo humano recombinante geneticamente engenheirado, e anticorpo humano recombinante geneticamente engenheirado.
|
|
KR100493795B1
(ko)
|
1996-02-09 |
2005-09-09 |
에프. 호프만-라 로슈 아게 |
혈관활성장펩타이드유사체의합성방법
|
|
US6063061A
(en)
|
1996-08-27 |
2000-05-16 |
Fusion Medical Technologies, Inc. |
Fragmented polymeric compositions and methods for their use
|
|
US5816259A
(en)
*
|
1997-01-13 |
1998-10-06 |
Rose; Samuel |
Method for the diagnosis and treatment of cancer by the accumulation of radioactive precipitates in targeted cells
|
|
US20020099003A1
(en)
*
|
1997-10-28 |
2002-07-25 |
Wilson Leland F. |
Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof
|
|
US6703359B1
(en)
*
|
1998-02-13 |
2004-03-09 |
Amylin Pharmaceuticals, Inc. |
Inotropic and diuretic effects of exendin and GLP-1
|
|
EP1056413A4
(en)
|
1998-02-27 |
2003-08-20 |
Bioelastics Res Ltd |
INJECTABLE IMPLANTS FOR TISSUE ENHANCEMENT AND RESTORATION
|
|
US6998387B1
(en)
*
|
1998-03-19 |
2006-02-14 |
Amylin Pharmaceuticals, Inc. |
Human appetite control by glucagon-like peptide receptor binding compounds
|
|
FR2776520B1
(fr)
*
|
1998-03-25 |
2000-05-05 |
Sod Conseils Rech Applic |
Nouvelles compositions pharmaceutiques destinees a la liberation prolongee de peptides et leur procede de preparation
|
|
ES2138561B1
(es)
*
|
1998-04-17 |
2000-07-01 |
Univ Madrid Complutense |
Uso de los peptidos vip y pacap en el tratamiento del shock endotoxico en mamiferos.
|
|
US20020151458A1
(en)
*
|
1998-04-17 |
2002-10-17 |
Perez Gomariz Rosa Maria |
Method for treating and preventing septic shock with VPAC1R, VPAC2R and PAC1R agonists
|
|
US6153655A
(en)
*
|
1998-04-17 |
2000-11-28 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
|
US6200598B1
(en)
*
|
1998-06-18 |
2001-03-13 |
Duke University |
Temperature-sensitive liposomal formulation
|
|
US6541033B1
(en)
*
|
1998-06-30 |
2003-04-01 |
Amgen Inc. |
Thermosensitive biodegradable hydrogels for sustained delivery of leptin
|
|
US6406921B1
(en)
|
1998-07-14 |
2002-06-18 |
Zyomyx, Incorporated |
Protein arrays for high-throughput screening
|
|
WO2000056774A1
(en)
*
|
1999-03-19 |
2000-09-28 |
Duke University |
Methods of using bioelastomers
|
|
US20090175821A1
(en)
*
|
1999-05-17 |
2009-07-09 |
Bridon Dominique P |
Modified therapeutic peptides with extended half-lives in vivo
|
|
JP2004500906A
(ja)
*
|
1999-11-12 |
2004-01-15 |
ルーベン， レオ |
電気的調節および化学的調節のための心臓デバイス、ならびに心肺障害の処置のための血管作用性腸ペプチド
|
|
US6235264B1
(en)
*
|
1999-12-01 |
2001-05-22 |
General Electric Company |
Medical imaging method for characterizing tumor angiogenesis using polymeric contrast agents
|
|
US6593394B1
(en)
*
|
2000-01-03 |
2003-07-15 |
Prosperous Kingdom Limited |
Bioactive and osteoporotic bone cement
|
|
US7833992B2
(en)
*
|
2001-05-18 |
2010-11-16 |
Merck Sharpe & Dohme |
Conjugates and compositions for cellular delivery
|
|
EP1257575B1
(en)
|
2000-02-18 |
2007-02-28 |
Dabur Research Foundation |
Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
|
|
US6489297B1
(en)
|
2000-02-18 |
2002-12-03 |
Dabur Research Foundation |
Vasoactive intestinal peptide analogs
|
|
US6852834B2
(en)
*
|
2000-03-20 |
2005-02-08 |
Ashutosh Chilkoti |
Fusion peptides isolatable by phase transition
|
|
US20050255554A1
(en)
*
|
2000-03-20 |
2005-11-17 |
Ashutosh Chilkoti |
Fusion peptides isolatable by phase transition
|
|
KR100847615B1
(ko)
*
|
2000-06-16 |
2008-07-21 |
일라이 릴리 앤드 캄파니 |
글루카곤-유사 펩티드-1 유사체
|
|
WO2002000149A1
(en)
|
2000-06-23 |
2002-01-03 |
Drexel University |
Polymeric, fiber matrix delivery systems for bioactive compounds
|
|
AU2002220720B2
(en)
*
|
2000-11-28 |
2006-09-14 |
Mondobiotech Ag |
Compounds with the biological activity of vasoactive intestinal peptide for the treatment of pulmonary and arteriolar hypertension
|
|
ATE406384T1
(de)
*
|
2000-12-07 |
2008-09-15 |
Lilly Co Eli |
Glp-1 fusion proteine
|
|
US7259233B2
(en)
*
|
2000-12-13 |
2007-08-21 |
Eli Lilly And Company |
Chronic treatment regimen using glucagon-like insulinotropic peptides
|
|
JP2005506956A
(ja)
|
2001-06-01 |
2005-03-10 |
イーライ・リリー・アンド・カンパニー |
長時間作用性ｇｌｐ−１製剤
|
|
BR0212080A
(pt)
*
|
2001-08-23 |
2006-04-04 |
Lilly Co Eli |
composto de glp-1, método de estimulação de receptor de glp-1 em um indivìduo necessitando de tal estimulação, e, uso de um composto de glp-1
|
|
US7176278B2
(en)
|
2001-08-30 |
2007-02-13 |
Biorexis Technology, Inc. |
Modified transferrin fusion proteins
|
|
EP1462112B1
(en)
|
2001-11-06 |
2009-03-18 |
Senju Pharmaceutical Co., Ltd. |
Remedies for dry eye and diseases associated with dry eye
|
|
AU2002364586A1
(en)
|
2001-12-21 |
2003-07-30 |
Delta Biotechnology Limited |
Albumin fusion proteins
|
|
DK1515745T3
(da)
|
2002-06-10 |
2009-07-13 |
Mondobiotech Ag |
Anvendelse af forbindelser med biologiskaktivitet af vasoaktivt intestinalt peptid til behandlingen af sarkoidose
|
|
ATE521624T1
(de)
*
|
2002-11-27 |
2011-09-15 |
Ils Inc |
Peptide und medizinische zusammensetzungen mit denselben
|
|
EP1633382A4
(en)
*
|
2003-05-14 |
2009-08-05 |
Dow Corning |
REPEAT SEQUENCE PROTEIN-POLYMER-ACTIVE CONJUGATE, METHOD AND USES
|
|
JP2007524592A
(ja)
|
2003-06-03 |
2007-08-30 |
ノボ・ノルデイスク・エー／エス |
安定化された薬学的ペプチド組成物
|
|
AU2004255379B2
(en)
|
2003-07-14 |
2007-08-16 |
Mondobiotech Ag |
Biologically active substance of a vasoactive intestinal peptide for treating interstitial lung infections
|
|
WO2005014030A1
(en)
*
|
2003-07-24 |
2005-02-17 |
Lutz-Henning Block |
Method for treating lung diseases associated with ventilation-perfusion mismatches
|
|
US7776815B2
(en)
*
|
2004-02-24 |
2010-08-17 |
Wisconsin Alumni Research Foundation |
Use of neuropeptides for ligament healing
|
|
US7928059B2
(en)
|
2004-02-24 |
2011-04-19 |
Wisconsin Alumni Research Foundation |
Use of neuropeptides for traumatic cartilage injury
|
|
US20050203009A1
(en)
*
|
2004-03-12 |
2005-09-15 |
Bayer Pharmaceuticals Corporation |
VPAC1 selective antagonists and their pharmacological methods of use
|
|
WO2005097158A1
(en)
*
|
2004-03-29 |
2005-10-20 |
The Arizona Board Of Regents On Behalf Of The University Of Arizona |
Amphipathic glycopeptides
|
|
ES2302201T3
(es)
*
|
2004-05-21 |
2008-07-01 |
Eli Lilly And Company |
Agonistas peptidicos del receptor vpac2 selectivos.
|
|
AU2005251386B8
(en)
*
|
2004-06-11 |
2010-10-14 |
Vectus Biosystems Pty Limited |
Compositions and methods for treatment of cardiovascular disease
|
|
WO2005123109A2
(en)
*
|
2004-06-12 |
2005-12-29 |
Bayer Pharmaceuticals Corporation |
Pegylation of vasoactive intestinal peptide (vip)/pituitary adenylate cyclase activating peptide (pacap) receptor 2 (vpac2) agonists and methods of use
|
|
WO2006023359A2
(en)
*
|
2004-08-18 |
2006-03-02 |
Eli Lilly And Company |
Selective vpac2 receptor peptide agonists
|
|
US20080085860A1
(en)
*
|
2004-08-18 |
2008-04-10 |
Eli Lilly And Company |
Selective Vpac2 Receptor Peptide Agonists
|
|
KR20070067136A
(ko)
*
|
2004-10-08 |
2007-06-27 |
포베스 메디-테크 (리서치) 인코포레이티드 |
혈관작용성 장내 폴리펩티드 제약
|
|
US7723472B2
(en)
*
|
2005-02-28 |
2010-05-25 |
The Regents Of The University Of California |
Extracellular matrix binding chimeric proteins and methods of use thereof
|
|
US20070009602A1
(en)
*
|
2005-06-24 |
2007-01-11 |
Setton Lori A |
Direct drug delivery system based on thermally responsive biopolymers
|
|
WO2007050651A1
(en)
*
|
2005-10-26 |
2007-05-03 |
Eli Lilly And Company |
Selective vpac2 receptor peptide agonists
|
|
WO2007057922A1
(en)
*
|
2005-11-18 |
2007-05-24 |
Dabur Pharma Limited |
Targeted fusion proteins for cancer therapy
|
|
PL1976548T3
(pl)
*
|
2005-12-09 |
2015-01-30 |
Vectus Biosystems Ltd |
Fragmenty VIP i ich kompozycje
|
|
US8841255B2
(en)
*
|
2005-12-20 |
2014-09-23 |
Duke University |
Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
|
|
US8334257B2
(en)
*
|
2005-12-20 |
2012-12-18 |
Duke University |
Methods and compositions for delivering active agents with enhanced pharmacological properties
|
|
US8367626B2
(en)
*
|
2006-05-12 |
2013-02-05 |
Wisconsin Alumni Research Foundation |
Elastin-like polymer delivery vehicles
|
|
US20110039776A1
(en)
|
2006-09-06 |
2011-02-17 |
Ashutosh Chilkoti |
Fusion peptide therapeutic compositions
|
|
CA2687602C
(en)
|
2007-05-21 |
2014-07-15 |
Res International Sarl |
Peptides with improved properties having the biological activity of vasoactive intestinal peptide (vip) and their use for the treatment of lung diseases
|
|
US8933197B2
(en)
*
|
2007-08-15 |
2015-01-13 |
Amunix Operating Inc. |
Compositions comprising modified biologically active polypeptides
|
|
CN105727261A
(zh)
*
|
2008-06-27 |
2016-07-06 |
杜克大学 |
包含弹性蛋白样肽的治疗剂
|
|
JP5645834B2
(ja)
|
2008-10-23 |
2014-12-24 |
バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ |
嚢胞性線維症膜コンダクタンス制御因子の修飾因子
|
|
WO2010080578A1
(en)
*
|
2008-12-18 |
2010-07-15 |
Phasebio Pharmaceuticals, Inc. |
Biologically active proteins activatable by peptidase
|
|
KR101943420B1
(ko)
*
|
2009-08-14 |
2019-04-17 |
파세비오 파마수티컬스 인코포레이티드 |
변형된 혈관활성 장 펩티드
|
|
HUE047354T2
(hu)
|
2011-05-18 |
2020-04-28 |
Vertex Pharmaceuticals Europe Ltd |
Ivacaftor deuterizált származékai
|
|
EP2717902B1
(en)
|
2011-06-06 |
2018-01-24 |
Phasebio Pharmaceuticals, Inc. |
Use of modified vasoactive intestinal peptides in the treatment of hypertension
|
|
US9605186B2
(en)
|
2012-09-19 |
2017-03-28 |
Exxonmobil Chemical Patents Inc. |
Adhesive compositions of ethylene-based and propylene-based polymers
|
|
CA2947982C
(en)
|
2014-05-08 |
2022-11-29 |
Phasebio Pharmaceuticals, Inc. |
Methods and compositions for treating cystic fibrosis
|