JP2013501774A5 - - Google Patents
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- Publication number
- JP2013501774A5 JP2013501774A5 JP2012524326A JP2012524326A JP2013501774A5 JP 2013501774 A5 JP2013501774 A5 JP 2013501774A5 JP 2012524326 A JP2012524326 A JP 2012524326A JP 2012524326 A JP2012524326 A JP 2012524326A JP 2013501774 A5 JP2013501774 A5 JP 2013501774A5
- Authority
- JP
- Japan
- Prior art keywords
- extract
- centella asiatica
- use according
- asiatica
- proanthocyanidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000284 extract Substances 0.000 claims description 22
- 239000000419 plant extract Substances 0.000 claims description 10
- 229920002770 condensed tannin Polymers 0.000 claims description 9
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 claims description 8
- 229920001991 Proanthocyanidin Polymers 0.000 claims description 8
- 235000010204 pine bark Nutrition 0.000 claims description 4
- 244000144725 Amygdalus communis Species 0.000 claims description 3
- 235000017060 Arachis glabrata Nutrition 0.000 claims description 3
- 244000105624 Arachis hypogaea Species 0.000 claims description 3
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 3
- 235000018262 Arachis monticola Nutrition 0.000 claims description 3
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims description 3
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims description 3
- 235000009685 Crataegus X maligna Nutrition 0.000 claims description 3
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims description 3
- 235000009486 Crataegus bullatus Nutrition 0.000 claims description 3
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims description 3
- 235000009682 Crataegus limnophila Nutrition 0.000 claims description 3
- 235000004423 Crataegus monogyna Nutrition 0.000 claims description 3
- 240000000171 Crataegus monogyna Species 0.000 claims description 3
- 235000002313 Crataegus paludosa Nutrition 0.000 claims description 3
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims description 3
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims description 3
- 244000294611 Punica granatum Species 0.000 claims description 3
- 235000014360 Punica granatum Nutrition 0.000 claims description 3
- 240000003768 Solanum lycopersicum Species 0.000 claims description 3
- 244000269722 Thea sinensis Species 0.000 claims description 3
- 235000009470 Theobroma cacao Nutrition 0.000 claims description 3
- 244000299461 Theobroma cacao Species 0.000 claims description 3
- 235000020224 almond Nutrition 0.000 claims description 3
- 235000020232 peanut Nutrition 0.000 claims description 3
- 235000013616 tea Nutrition 0.000 claims description 3
- 235000020234 walnut Nutrition 0.000 claims description 3
- 241000758791 Juglandaceae Species 0.000 claims description 2
- 229940087559 grape seed Drugs 0.000 claims description 2
- 244000146462 Centella asiatica Species 0.000 claims 22
- 235000004032 Centella asiatica Nutrition 0.000 claims 22
- 230000002265 prevention Effects 0.000 claims 7
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 210000001367 artery Anatomy 0.000 claims 5
- 230000003902 lesion Effects 0.000 claims 5
- 230000003143 atherosclerotic effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 241001236212 Pinus pinaster Species 0.000 claims 3
- 235000005105 Pinus pinaster Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 208000037260 Atherosclerotic Plaque Diseases 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- 235000015872 dietary supplement Nutrition 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 235000020510 functional beverage Nutrition 0.000 claims 2
- 235000013376 functional food Nutrition 0.000 claims 2
- 229940106587 pine bark extract Drugs 0.000 claims 2
- 235000000673 shore pine Nutrition 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 150000003648 triterpenes Chemical group 0.000 claims 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims 1
- 235000011437 Amygdalus communis Nutrition 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 240000007049 Juglans regia Species 0.000 claims 1
- 235000009496 Juglans regia Nutrition 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 235000014787 Vitis vinifera Nutrition 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 230000000702 anti-platelet effect Effects 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000007211 cardiovascular event Effects 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 244000301850 Cupressus sempervirens Species 0.000 description 1
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 1
- 229930014669 anthocyanidin Natural products 0.000 description 1
- 235000008758 anthocyanidins Nutrition 0.000 description 1
- NWKFECICNXDNOQ-UHFFFAOYSA-N flavylium Chemical compound C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=[O+]1 NWKFECICNXDNOQ-UHFFFAOYSA-N 0.000 description 1
- 235000018192 pine bark supplement Nutrition 0.000 description 1
- 229920002414 procyanidin Polymers 0.000 description 1
- 229940106796 pycnogenol Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IBPCT/IB2009/006525 | 2009-08-12 | ||
| IB2009006525 | 2009-08-12 | ||
| PCT/IB2010/053637 WO2011018763A1 (en) | 2009-08-12 | 2010-08-11 | Combination of proantocycidins such as pycnogenol or grape seeds and centella asiatica for the treatment of cardiovascular disorders such as atherosclerosis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013501774A JP2013501774A (ja) | 2013-01-17 |
| JP2013501774A5 true JP2013501774A5 (enExample) | 2014-09-25 |
| JP5711231B2 JP5711231B2 (ja) | 2015-04-30 |
Family
ID=42083898
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012524326A Active JP5711231B2 (ja) | 2009-08-12 | 2010-08-11 | アテローム性動脈硬化症などの心血管障害の処置のためのピクノジェノールまたはブドウ種子などのプロアントシアニジンとＣｅｎｔｅｌｌａａｓｉａｔｉｃａとの組み合わせ |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US9308230B2 (enExample) |
| EP (1) | EP2464348B1 (enExample) |
| JP (1) | JP5711231B2 (enExample) |
| KR (1) | KR101678254B1 (enExample) |
| CN (1) | CN102573834B (enExample) |
| AU (1) | AU2010283453B2 (enExample) |
| BR (1) | BR112012002935A2 (enExample) |
| CA (1) | CA2769764C (enExample) |
| CL (1) | CL2012000347A1 (enExample) |
| DK (1) | DK2464348T3 (enExample) |
| ES (1) | ES2426314T3 (enExample) |
| MX (1) | MX2012001111A (enExample) |
| MY (1) | MY162572A (enExample) |
| PH (1) | PH12012500291A1 (enExample) |
| RU (1) | RU2570733C2 (enExample) |
| SG (1) | SG178203A1 (enExample) |
| WO (1) | WO2011018763A1 (enExample) |
| ZA (1) | ZA201200755B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103027908A (zh) * | 2012-11-19 | 2013-04-10 | 何晓涛 | Aphanamixoid A在制备治疗动脉粥样硬化药物中的应用 |
| EP2829277A1 (en) | 2013-07-26 | 2015-01-28 | Natac Biotech, S.L. | Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease |
| WO2015184101A1 (en) * | 2014-05-29 | 2015-12-03 | Jaguar Animal Health, Inc. | Methods of treating diarrhea in neonatal and young non-human animals |
| WO2015184109A1 (en) * | 2014-05-29 | 2015-12-03 | Jaguar Animal Health, Inc. | Methods of treating diarrhea in adult non-human animals |
| WO2016046375A1 (en) * | 2014-09-25 | 2016-03-31 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Theobroma cacao extract for use in the treatment or prevention of receptor tyrosine kinases related disorders |
| US20180021297A1 (en) * | 2015-02-26 | 2018-01-25 | Jaguar Health, Inc. | Use Of Croton- Or Calophyllum-Derived Proanthocyanidin Polymers Or Botanical Extracts In Combination With Rifaximin For The Treatment Of Diarrhea In Non-Human Animals |
| GB201801986D0 (en) * | 2018-02-07 | 2018-03-28 | Ip Science Ltd | Anthocyanins and used thereof |
| US10849948B2 (en) | 2019-04-16 | 2020-12-01 | The Procter & Gamble Company | Supplement for menopause |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1427100A (fr) | 1964-12-14 | 1966-02-04 | Ile De Rech Pharma Et Therapeu | Procédé pour l'obtention d'hydroxyflavanne-3-4-diols |
| BE897965A (fr) * | 1983-10-11 | 1984-01-30 | Bago Sa Labor | Composition therapeutique exercant une activite anti-agglomeration des plaquettes |
| US5720956A (en) | 1996-04-10 | 1998-02-24 | Rohdewald; Peter | Method of controlling the reactivity of human blood platelets by oral administration of the extract of the maritime pine (pycnogenol) |
| JP3510526B2 (ja) * | 1999-05-24 | 2004-03-29 | キッコーマン株式会社 | 抗動脈硬化症食品 |
| AU776037B2 (en) * | 1999-09-10 | 2004-08-26 | Ceteris Holding B.V.-Amsterdam (Olanda) -Succursale Di Lugano | An anti-oxidant preparation based on plant extracts for the treatment of circulation and adiposity problems |
| JP3260134B2 (ja) | 1999-10-08 | 2002-02-25 | 信孝 鈴木 | 月経困難症、子宮内膜症の治療薬 |
| JP3495712B2 (ja) | 2001-02-19 | 2004-02-09 | 株式会社ファンケル | 食品組成物 |
| ITMI20011182A1 (it) * | 2001-06-05 | 2002-12-05 | Indena Spa | Composizioni farmaceutiche e/o cosmetiche per il trattamento di adiposita' localizzate e della cellulite |
| ITGE20020026A1 (it) * | 2002-03-25 | 2003-09-25 | Segre Silvia Perella | Composto da impiegare nel trattamento scleroterapico,nell'insufficienza venosa e nelle alterazioni del microcircolo. |
| JP2005023032A (ja) * | 2003-07-03 | 2005-01-27 | Toyo Shinyaku:Kk | 動脈硬化予防剤 |
| EP1523894B1 (de) * | 2003-10-18 | 2007-02-21 | Cognis IP Management GmbH | Zubereitung zur oralen Aufnahme |
| JP2005237203A (ja) * | 2004-02-24 | 2005-09-08 | Haba Laboratories Inc | ：喫煙によって生ずるｄｎａ酸化損傷を抑制するに有効な食品組成物 |
| EP2266586A1 (en) * | 2004-03-23 | 2010-12-29 | Lifeline Nutraceuticals Corporation | Compositions and method for alleviating inflammation and oxidative stress in a mammal |
| JP4708744B2 (ja) * | 2004-07-15 | 2011-06-22 | 株式会社シールド・ラボ | 血小板凝集抑制組成物 |
| JP5139629B2 (ja) * | 2005-06-28 | 2013-02-06 | 江崎グリコ株式会社 | ＴＮＦ−αおよび一酸化窒素産生抑制剤 |
| WO2007084648A2 (en) | 2006-01-20 | 2007-07-26 | Mars, Incorporated | Mixed 4→6 procyanidin dimers and their use |
| US20070265211A1 (en) | 2006-05-12 | 2007-11-15 | Matthias Rath | Novel composition and method effective in inhibiting the atherogenic process |
| KR100846292B1 (ko) | 2007-07-20 | 2008-07-16 | 인타글리오주식회사 | 비수계 분산형 클렌징밤 조성물 |
-
2010
- 2010-08-11 SG SG2012006961A patent/SG178203A1/en unknown
- 2010-08-11 WO PCT/IB2010/053637 patent/WO2011018763A1/en not_active Ceased
- 2010-08-11 DK DK10754373.8T patent/DK2464348T3/da active
- 2010-08-11 JP JP2012524326A patent/JP5711231B2/ja active Active
- 2010-08-11 CN CN201080035783.7A patent/CN102573834B/zh not_active Expired - Fee Related
- 2010-08-11 EP EP10754373.8A patent/EP2464348B1/en active Active
- 2010-08-11 ES ES10754373T patent/ES2426314T3/es active Active
- 2010-08-11 MY MYPI2012700021A patent/MY162572A/en unknown
- 2010-08-11 BR BR112012002935A patent/BR112012002935A2/pt active Search and Examination
- 2010-08-11 PH PH1/2012/500291A patent/PH12012500291A1/en unknown
- 2010-08-11 RU RU2012104215/15A patent/RU2570733C2/ru not_active IP Right Cessation
- 2010-08-11 AU AU2010283453A patent/AU2010283453B2/en not_active Ceased
- 2010-08-11 US US13/390,118 patent/US9308230B2/en active Active
- 2010-08-11 KR KR1020127006415A patent/KR101678254B1/ko active Active
- 2010-08-11 MX MX2012001111A patent/MX2012001111A/es active IP Right Grant
- 2010-08-11 CA CA2769764A patent/CA2769764C/en active Active
-
2012
- 2012-01-31 ZA ZA2012/00755A patent/ZA201200755B/en unknown
- 2012-02-10 CL CL2012000347A patent/CL2012000347A1/es unknown
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