JP2013500726A - 改変第ｉｘ因子ポリペプチドおよびその使用 - Google Patents
改変第ｉｘ因子ポリペプチドおよびその使用 Download PDFInfo
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Images
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| PCT/US2010/044177 WO2011014890A1 (en) | 2009-07-31 | 2010-08-02 | Modified factor ix polypeptides and uses thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016514144A (ja) * | 2013-03-13 | 2016-05-19 | イーライ リリー アンド カンパニー | 修飾されたイヌレプチンポリペプチド |
| JP2016519120A (ja) * | 2013-04-28 | 2016-06-30 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | 凝固因子タンパク質に対する免疫寛容を誘導するための組成物 |
| JP2019525764A (ja) * | 2016-07-27 | 2019-09-12 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ | 第ｉｘ因子の機能を調節するための組成物及び方法 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2101821T3 (da) | 2006-12-15 | 2014-10-06 | Baxter Healthcare Sa | Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo |
| ES2985035T3 (es) | 2008-09-15 | 2024-11-04 | Uniqure Biopharma B V | Mutante de polipéptido de factor IX, sus usos y su procedimiento de producción |
| RU2744370C2 (ru) | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| EP3081233B1 (en) | 2009-07-27 | 2020-12-23 | Baxalta GmbH | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| BR112012001814A8 (pt) | 2009-07-27 | 2018-02-06 | Baxalta GmbH | Conjugados de proteína de coagulação sanguínea |
| TWI534152B (zh) * | 2010-07-30 | 2016-05-21 | 巴克斯特國際公司 | 用於肟連接的親核性催化劑 |
| ES2800983T3 (es) | 2010-12-22 | 2021-01-07 | Baxalta GmbH | Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína |
| DK2794665T3 (da) * | 2011-12-19 | 2018-01-29 | Dilafor Ab | Ikke-antikoagulative glycosaminoglycaner omfattende disaccharid-gentagelsesenhed og medicinsk anvendelse deraf |
| WO2014081831A1 (en) * | 2012-11-20 | 2014-05-30 | The University Of North Carolina At Chapel Hill | Methods and compositions for modified factor ix proteins |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| UA126016C2 (uk) | 2015-08-03 | 2022-08-03 | Біовератів Терапеутікс Інк. | Злитий білок фактора іх |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| JP7578590B2 (ja) | 2018-10-18 | 2024-11-06 | インテリア セラピューティクス，インコーポレーテッド | 第ｉｘ因子を発現するための組成物及び方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007513190A (ja) * | 2003-12-03 | 2007-05-24 | ネオス テクノロジーズ インコーポレイテッド | ＧｌｙｃｏＰＥＧ化された第ＩＸ因子 |
| US20080102115A1 (en) * | 2006-06-19 | 2008-05-01 | Jorge Oyhenart | Modified coagulation factor IX polypeptides and use thereof for treatment |
| WO2008118507A2 (en) * | 2007-01-09 | 2008-10-02 | Wu, Karl | Recombinant human factor ix and use thereof |
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| CN1520259A (zh) * | 2001-04-25 | 2004-08-11 | ���ݴ�ѧУ��ίԱ�� | 利用球状载体将第八因子/第九因子进行肝脏基因转移治疗血友病的方法 |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
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2010
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- 2010-08-02 SG SG2012005757A patent/SG178119A1/en unknown
- 2010-08-02 WO PCT/US2010/044177 patent/WO2011014890A1/en not_active Ceased
- 2010-08-02 PE PE2012000114A patent/PE20121643A1/es not_active Application Discontinuation
- 2010-08-02 CA CA2769258A patent/CA2769258A1/en not_active Abandoned
- 2010-08-02 AU AU2010278721A patent/AU2010278721A1/en not_active Abandoned
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2012
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- 2012-01-30 CL CL2012000238A patent/CL2012000238A1/es unknown
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- 2012-01-30 ZA ZA2012/00716A patent/ZA201200716B/en unknown
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2013
- 2013-04-19 CU CU2013000058A patent/CU20130058A7/es unknown
- 2013-04-19 CU CU2013000057A patent/CU20130057A7/es unknown
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| JP2007513190A (ja) * | 2003-12-03 | 2007-05-24 | ネオス テクノロジーズ インコーポレイテッド | ＧｌｙｃｏＰＥＧ化された第ＩＸ因子 |
| US20080102115A1 (en) * | 2006-06-19 | 2008-05-01 | Jorge Oyhenart | Modified coagulation factor IX polypeptides and use thereof for treatment |
| WO2008118507A2 (en) * | 2007-01-09 | 2008-10-02 | Wu, Karl | Recombinant human factor ix and use thereof |
Non-Patent Citations (1)
| Title |
|---|
| JPN6014043188; Ｓｃｈｕｅｔｔｒｕｍｐｆ ｅｔ ａｌ．: Ｂｌｏｏｄ Ｖｏｌ．１０５， Ｎｏ．６, ｐ．２３１６-２３２３（２００５） * |
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| JP2016514144A (ja) * | 2013-03-13 | 2016-05-19 | イーライ リリー アンド カンパニー | 修飾されたイヌレプチンポリペプチド |
| JP2017110024A (ja) * | 2013-03-13 | 2017-06-22 | イーライ リリー アンド カンパニー | 修飾されたイヌレプチンポリペプチド |
| US10105447B2 (en) | 2013-03-13 | 2018-10-23 | Elanco Us Inc. | Method of treating obesity in a companion animal comprising administering a modified canine leptin polypeptide |
| JP2016519120A (ja) * | 2013-04-28 | 2016-06-30 | バイエル・ヘルスケア・エルエルシーＢａｙｅｒ ＨｅａｌｔｈＣａｒｅ ＬＬＣ | 凝固因子タンパク質に対する免疫寛容を誘導するための組成物 |
| JP2019525764A (ja) * | 2016-07-27 | 2019-09-12 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィアＴｈｅ Ｃｈｉｌｄｒｅｎ’Ｓ Ｈｏｓｐｉｔａｌ Ｏｆ Ｐｈｉｌａｄｅｌｐｈｉａ | 第ｉｘ因子の機能を調節するための組成物及び方法 |
| JP7181855B2 (ja) | 2016-07-27 | 2022-12-01 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | 第ｉｘ因子の機能を調節するための組成物及び方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| PE20121643A1 (es) | 2012-11-25 |
| WO2011014890A1 (en) | 2011-02-03 |
| EA201290069A1 (ru) | 2012-07-30 |
| CL2012000238A1 (es) | 2012-10-05 |
| CA2769258A1 (en) | 2011-02-03 |
| ECSP12011637A (es) | 2012-02-29 |
| GT201200023A (es) | 2014-01-27 |
| EP2461821A1 (en) | 2012-06-13 |
| CR20120052A (es) | 2012-06-04 |
| CN102573890A (zh) | 2012-07-11 |
| ZA201200716B (en) | 2013-07-31 |
| US20120164130A1 (en) | 2012-06-28 |
| CU20130057A7 (es) | 2013-06-28 |
| AU2010278721A1 (en) | 2012-02-16 |
| IN2012DN00908A (enExample) | 2015-04-03 |
| EP2461821A4 (en) | 2013-07-03 |
| SG178119A1 (en) | 2012-03-29 |
| KR20120060209A (ko) | 2012-06-11 |
| DOP2012000030A (es) | 2012-02-29 |
| CU20120018A7 (es) | 2012-06-21 |
| MX2012001346A (es) | 2012-02-17 |
| BR112012002072A2 (pt) | 2016-11-08 |
| CU20130058A7 (es) | 2013-06-28 |
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