JP2013500255A5 - - Google Patents
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- JP2013500255A5 JP2013500255A5 JP2012521755A JP2012521755A JP2013500255A5 JP 2013500255 A5 JP2013500255 A5 JP 2013500255A5 JP 2012521755 A JP2012521755 A JP 2012521755A JP 2012521755 A JP2012521755 A JP 2012521755A JP 2013500255 A5 JP2013500255 A5 JP 2013500255A5
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- Prior art keywords
- lower alkyl
- autophagy
- cancer
- cells
- mbcq
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| CN103857288B (zh) | 2011-03-04 | 2016-09-21 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为激酶抑制剂的氨基-喹啉 |
| TWI547494B (zh) | 2011-08-18 | 2016-09-01 | 葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之胺基喹唑啉類 |
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| AR092529A1 (es) | 2012-09-13 | 2015-04-22 | Glaxosmithkline Llc | Compuesto de aminoquinazolina, composicion farmaceutica que lo comprende y uso de dicho compuesto para la preparacion de un medicamento |
| JP2016504365A (ja) * | 2012-12-28 | 2016-02-12 | アメリカ合衆国 | Usp1/uaf1デユビキチナーゼ複合体阻害剤及びその使用 |
| KR102205202B1 (ko) | 2013-02-01 | 2021-01-21 | 웰스태트 테러퓨틱스 코포레이션 | 항염증, 항진균, 항기생충, 및 항암 활성을 갖는 아민 화합물 |
| EP2958911B1 (en) | 2013-02-21 | 2017-10-18 | GlaxoSmithKline Intellectual Property Development Limited | Quinazolines as kinase inhibitors |
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| EP2970975A4 (en) | 2013-03-15 | 2016-11-02 | Univ Leland Stanford Junior | TREATMENT OF CHROMATIN MODIFIERS FOR THE TREATMENT OF DISEASES |
| WO2014145512A2 (en) * | 2013-03-15 | 2014-09-18 | President And Fellows Of Harvard College | Potent small molecule inhibitors of autophagy, and methods of use thereof |
| US9393244B2 (en) | 2013-03-15 | 2016-07-19 | Georgetown University | Increasing parkin activity by administering a deubiquitinating enzyme inhibitor |
| US11306328B2 (en) * | 2013-07-26 | 2022-04-19 | President And Fellows Of Harvard College | Genome engineering |
| CN104164471A (zh) * | 2013-11-04 | 2014-11-26 | 复旦大学 | 基于细胞自噬的抗肿瘤药物的筛选方法 |
| HK1250658A1 (zh) * | 2015-05-08 | 2019-01-11 | 得克萨斯州大学系统董事会 | 用於治疗阿尔茨海默病的神经元钙池操纵的钙进入途径的活化 |
| EP3359526A4 (en) * | 2015-10-05 | 2019-04-03 | The Trustees of Columbia University in the City of New York | ACTIVATORS OF AUTOPHAGIC RIVER AND PHOSPHOLIPASE D AND PURIFICATION OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES |
| EP3184514A1 (en) * | 2015-12-23 | 2017-06-28 | Deutsches Krebsforschungszentrum | Autophagy inhibitors |
| GB201700814D0 (en) | 2017-01-17 | 2017-03-01 | Liverpool School Tropical Medicine | Compounds |
| CN108929373A (zh) * | 2017-05-22 | 2018-12-04 | 苏州偶领生物医药有限公司 | 一种共价键修饰哺乳动物atg8 同源物的方法 |
| IL280213B2 (en) | 2018-07-26 | 2024-06-01 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| CN109721554A (zh) * | 2019-01-08 | 2019-05-07 | 贵州大学 | 一类4-氨基喹唑啉类化合物及其制备方法和应用 |
| HUE065486T2 (hu) | 2019-05-10 | 2024-05-28 | Deciphera Pharmaceuticals Llc | Fenilaminopirimidinamid autophágia inhibitorok és azok felhasználási eljárásai |
| PL3966206T3 (pl) | 2019-05-10 | 2024-01-29 | Deciphera Pharmaceuticals, Llc | Heteroaryloaminopirymidynoamidowe inhibitory autofagii i sposoby ich zastosowania |
| AU2020297422B2 (en) | 2019-06-17 | 2024-03-21 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| US20210215710A1 (en) * | 2019-12-23 | 2021-07-15 | University Health Network | Methods for use of cdx2 as a biomarker to guide use of autophagy inhibitors in ovarian cancer |
| WO2021178556A1 (en) | 2020-03-04 | 2021-09-10 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for sensitization of tumor cells to immune therapy |
| CN112608302B (zh) * | 2020-12-28 | 2022-05-24 | 郑州大学第一附属医院 | 低氧还原激活靶向泛素化降解egfr蛋白的喹唑啉类衍生物及其应用 |
| US20240092800A1 (en) * | 2021-01-14 | 2024-03-21 | Georgetown University | Usp13 inhibitors and methods of use thereof |
| WO2022187411A1 (en) * | 2021-03-02 | 2022-09-09 | Kumquat Biosciences Inc. | Heterocycles and uses thereof |
| WO2023034411A1 (en) | 2021-09-01 | 2023-03-09 | Oerth Bio Llc | Compositions and methods for targeted degradation of proteins in a plant cell |
| CN114224895B (zh) * | 2022-01-06 | 2023-06-30 | 山东农业大学 | 3-甲基腺嘌呤在清除牛乳腺上皮细胞内无乳链球菌中的应用 |
| CA3246750A1 (en) | 2022-04-20 | 2023-10-26 | Kumquat Biosciences Inc | MACROCYCLES AND HETEROCYCLES AND THEIR USES |
| CN116179494B (zh) * | 2022-10-13 | 2024-01-26 | 武汉生物制品研究所有限责任公司 | 低成瘤性的mdck细胞株及其构建方法和应用 |
| DE102022131212A1 (de) | 2022-11-25 | 2024-05-29 | Dr. Ing. H.C. F. Porsche Aktiengesellschaft | Luftzufuhrvorrichtung einer Kraftfahrzeugkarosserie eines Kraftfahrzeugs |
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| JPS542325A (en) * | 1977-06-07 | 1979-01-09 | Sankyo Co Ltd | Agricultural and horticultural pesticide |
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| IL89027A (en) * | 1988-01-29 | 1993-01-31 | Lilly Co Eli | Quinazoline derivatives, process for their preparation and fungicidal, insecticidal and miticidal compositions containing them |
| US5034393A (en) * | 1989-07-27 | 1991-07-23 | Dowelanco | Fungicidal use of pyridopyrimidine, pteridine, pyrimidopyrimidine, pyrimidopyridazine, and pyrimido-1,2,4-triazine derivatives |
| US5227387A (en) * | 1991-09-03 | 1993-07-13 | Dowelanco | Quinoline nematicidal method |
| PT100905A (pt) * | 1991-09-30 | 1994-02-28 | Eisai Co Ltd | Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem |
| US6046206A (en) * | 1995-06-07 | 2000-04-04 | Cell Pathways, Inc. | Method of treating a patient having a precancerous lesions with amide quinazoline derivatives |
| US6262059B1 (en) * | 1995-06-07 | 2001-07-17 | Cell Pathways, Inc. | Method of treating a patient having precancerous lesions with quinazoline derivatives |
| DE10042060A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
| WO2003066602A1 (en) * | 2002-02-06 | 2003-08-14 | Ube Industries, Ltd. | Process for producing 4-aminoquinazoline compound |
| JP2004059454A (ja) * | 2002-07-25 | 2004-02-26 | Japan Energy Corp | キナゾリン誘導体及びNF−κB活性化阻害剤 |
| JP4934432B2 (ja) * | 2004-02-19 | 2012-05-16 | レクサン ファーマシューティカルズ インコーポレイテッド | キナゾリン誘導体およびキナゾリン誘導体の治療への使用 |
| EP1844023A1 (en) * | 2004-12-31 | 2007-10-17 | Sk Chemicals Co., Ltd. | Quinazoline derivatives for the treatment and prevention of diabetes and obesity |
| US20080269259A1 (en) | 2005-01-19 | 2008-10-30 | The Trustees Of The University Of Pennsylvania | Regulation of Autophagy and Cell Survival |
| WO2008122038A1 (en) * | 2007-04-02 | 2008-10-09 | President And Fellows Of Harvard College | Regulating autophagy |
| US8039502B2 (en) | 2007-07-24 | 2011-10-18 | The Ohio State University Research Foundation | Anti-infective agents against intracellular pathogens |
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- 2010-07-21 BR BR112012001316A patent/BR112012001316A2/pt not_active IP Right Cessation
- 2010-07-21 PE PE2012000085A patent/PE20120798A1/es not_active Application Discontinuation
- 2010-07-21 KR KR1020127004431A patent/KR20120100886A/ko not_active Withdrawn
- 2010-07-21 JP JP2012521755A patent/JP2013500255A/ja active Pending
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- 2010-07-21 IN IN1478DEN2012 patent/IN2012DN01478A/en unknown
- 2010-07-21 WO PCT/US2010/042759 patent/WO2011011522A2/en not_active Ceased
- 2010-07-21 SG SG2012000253A patent/SG177486A1/en unknown
- 2010-07-21 CA CA2767772A patent/CA2767772A1/en not_active Abandoned
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