JP2013500255A5 - - Google Patents

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Publication number
JP2013500255A5
JP2013500255A5 JP2012521755A JP2012521755A JP2013500255A5 JP 2013500255 A5 JP2013500255 A5 JP 2013500255A5 JP 2012521755 A JP2012521755 A JP 2012521755A JP 2012521755 A JP2012521755 A JP 2012521755A JP 2013500255 A5 JP2013500255 A5 JP 2013500255A5
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JP
Japan
Prior art keywords
lower alkyl
autophagy
cancer
cells
mbcq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2012521755A
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English (en)
Japanese (ja)
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JP2013500255A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2010/042759 external-priority patent/WO2011011522A2/en
Publication of JP2013500255A publication Critical patent/JP2013500255A/ja
Publication of JP2013500255A5 publication Critical patent/JP2013500255A5/ja
Pending legal-status Critical Current

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JP2012521755A 2009-07-21 2010-07-21 自食作用の強力な小分子阻害剤、およびそれの使用方法 Pending JP2013500255A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US22716409P 2009-07-21 2009-07-21
US61/227,164 2009-07-21
US29673510P 2010-01-20 2010-01-20
US61/296,735 2010-01-20
PCT/US2010/042759 WO2011011522A2 (en) 2009-07-21 2010-07-21 Potent small molecule inhibitors of autophagy, and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2013500255A JP2013500255A (ja) 2013-01-07
JP2013500255A5 true JP2013500255A5 (enExample) 2013-08-22

Family

ID=42829077

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012521755A Pending JP2013500255A (ja) 2009-07-21 2010-07-21 自食作用の強力な小分子阻害剤、およびそれの使用方法

Country Status (18)

Country Link
US (1) US20120258975A1 (enExample)
EP (1) EP2456761A2 (enExample)
JP (1) JP2013500255A (enExample)
KR (1) KR20120100886A (enExample)
CN (1) CN102574816A (enExample)
AU (1) AU2010276223A1 (enExample)
BR (1) BR112012001316A2 (enExample)
CA (1) CA2767772A1 (enExample)
CL (1) CL2012000163A1 (enExample)
IL (1) IL217502A0 (enExample)
IN (1) IN2012DN01478A (enExample)
MX (1) MX2012000940A (enExample)
PE (1) PE20120798A1 (enExample)
PH (1) PH12012500097A1 (enExample)
RU (1) RU2012105914A (enExample)
SG (1) SG177486A1 (enExample)
WO (1) WO2011011522A2 (enExample)
ZA (1) ZA201201224B (enExample)

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TWI547494B (zh) 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
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KR102205202B1 (ko) 2013-02-01 2021-01-21 웰스태트 테러퓨틱스 코포레이션 항염증, 항진균, 항기생충, 및 항암 활성을 갖는 아민 화합물
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HK1250658A1 (zh) * 2015-05-08 2019-01-11 得克萨斯州大学系统董事会 用於治疗阿尔茨海默病的神经元钙池操纵的钙进入途径的活化
EP3359526A4 (en) * 2015-10-05 2019-04-03 The Trustees of Columbia University in the City of New York ACTIVATORS OF AUTOPHAGIC RIVER AND PHOSPHOLIPASE D AND PURIFICATION OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES
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CN108929373A (zh) * 2017-05-22 2018-12-04 苏州偶领生物医药有限公司 一种共价键修饰哺乳动物atg8 同源物的方法
IL280213B2 (en) 2018-07-26 2024-06-01 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4
CN109721554A (zh) * 2019-01-08 2019-05-07 贵州大学 一类4-氨基喹唑啉类化合物及其制备方法和应用
HUE065486T2 (hu) 2019-05-10 2024-05-28 Deciphera Pharmaceuticals Llc Fenilaminopirimidinamid autophágia inhibitorok és azok felhasználási eljárásai
PL3966206T3 (pl) 2019-05-10 2024-01-29 Deciphera Pharmaceuticals, Llc Heteroaryloaminopirymidynoamidowe inhibitory autofagii i sposoby ich zastosowania
AU2020297422B2 (en) 2019-06-17 2024-03-21 Deciphera Pharmaceuticals, Llc Aminopyrimidine amide autophagy inhibitors and methods of use thereof
US20210215710A1 (en) * 2019-12-23 2021-07-15 University Health Network Methods for use of cdx2 as a biomarker to guide use of autophagy inhibitors in ovarian cancer
WO2021178556A1 (en) 2020-03-04 2021-09-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for sensitization of tumor cells to immune therapy
CN112608302B (zh) * 2020-12-28 2022-05-24 郑州大学第一附属医院 低氧还原激活靶向泛素化降解egfr蛋白的喹唑啉类衍生物及其应用
US20240092800A1 (en) * 2021-01-14 2024-03-21 Georgetown University Usp13 inhibitors and methods of use thereof
WO2022187411A1 (en) * 2021-03-02 2022-09-09 Kumquat Biosciences Inc. Heterocycles and uses thereof
WO2023034411A1 (en) 2021-09-01 2023-03-09 Oerth Bio Llc Compositions and methods for targeted degradation of proteins in a plant cell
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