JP2013179943A5 - - Google Patents

Download PDF

Info

Publication number
JP2013179943A5
JP2013179943A5 JP2013089445A JP2013089445A JP2013179943A5 JP 2013179943 A5 JP2013179943 A5 JP 2013179943A5 JP 2013089445 A JP2013089445 A JP 2013089445A JP 2013089445 A JP2013089445 A JP 2013089445A JP 2013179943 A5 JP2013179943 A5 JP 2013179943A5
Authority
JP
Japan
Prior art keywords
virus
influenza
amino acid
acid substitution
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013089445A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013179943A (ja
Filing date
Publication date
Application filed filed Critical
Publication of JP2013179943A publication Critical patent/JP2013179943A/ja
Publication of JP2013179943A5 publication Critical patent/JP2013179943A5/ja
Pending legal-status Critical Current

Links

JP2013089445A 2002-04-26 2013-04-22 インフルエンザウイルスの生産用多重プラスミドシステム Pending JP2013179943A (ja)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US37567502P 2002-04-26 2002-04-26
US60/375,675 2002-04-26
US39498302P 2002-07-09 2002-07-09
US60/394,983 2002-07-09
US41057602P 2002-09-12 2002-09-12
US60/410,576 2002-09-12
US41980202P 2002-10-18 2002-10-18
US60/419,802 2002-10-18
US42070802P 2002-10-23 2002-10-23
US60/420,708 2002-10-23
US45769903P 2003-03-24 2003-03-24
US60/457,699 2003-03-24
US46236103P 2003-04-10 2003-04-10
US60/462,361 2003-04-10

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2011103852A Division JP5303603B2 (ja) 2002-04-26 2011-05-06 インフルエンザウイルスの生産用多重プラスミドシステム

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013131951A Division JP2013230156A (ja) 2002-04-26 2013-06-24 インフルエンザウイルスの生産用多重プラスミドシステム

Publications (2)

Publication Number Publication Date
JP2013179943A JP2013179943A (ja) 2013-09-12
JP2013179943A5 true JP2013179943A5 (https=) 2013-11-21

Family

ID=29273967

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2003587937A Withdrawn JP2005523698A (ja) 2002-04-26 2003-04-25 インフルエンザウイルスの生産用多重プラスミドシステム
JP2011103852A Expired - Lifetime JP5303603B2 (ja) 2002-04-26 2011-05-06 インフルエンザウイルスの生産用多重プラスミドシステム
JP2013089445A Pending JP2013179943A (ja) 2002-04-26 2013-04-22 インフルエンザウイルスの生産用多重プラスミドシステム
JP2013131951A Pending JP2013230156A (ja) 2002-04-26 2013-06-24 インフルエンザウイルスの生産用多重プラスミドシステム

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JP2003587937A Withdrawn JP2005523698A (ja) 2002-04-26 2003-04-25 インフルエンザウイルスの生産用多重プラスミドシステム
JP2011103852A Expired - Lifetime JP5303603B2 (ja) 2002-04-26 2011-05-06 インフルエンザウイルスの生産用多重プラスミドシステム

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2013131951A Pending JP2013230156A (ja) 2002-04-26 2013-06-24 インフルエンザウイルスの生産用多重プラスミドシステム

Country Status (12)

Country Link
US (3) US8012736B2 (https=)
EP (2) EP1499348B1 (https=)
JP (4) JP2005523698A (https=)
KR (2) KR101169468B1 (https=)
CN (4) CN1678345A (https=)
AR (2) AR039465A1 (https=)
AU (2) AU2003231083A1 (https=)
CA (1) CA2482946C (https=)
DK (1) DK1499348T3 (https=)
ES (1) ES2526191T3 (https=)
TW (2) TWI347363B (https=)
WO (1) WO2003091401A2 (https=)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02010642A (es) * 2000-04-28 2004-05-17 St Jude Children S Res Hospital Sistema de transfeccion de adn para la generacion de virus de influenza infeccioso.
ATE490267T1 (de) 2001-06-05 2010-12-15 Curevac Gmbh Stabilisierte mrna mit erhöhtem g/c-gehalt, kodierend für ein virales antigen
ES2526191T3 (es) 2002-04-26 2015-01-08 Medimmune, Llc Método para producir virus influenza B infeccioso en cultivo celular
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
US7262045B2 (en) 2003-02-25 2007-08-28 Medimmune Vaccines, Inc. Methods of producing influenza vaccine compositions
US20060110406A1 (en) 2003-02-25 2006-05-25 Medimmune Vaccines, Inc. Refrigerator-temperature stable influenza vaccine compositions
KR20060026854A (ko) * 2003-05-28 2006-03-24 위스콘신 얼럼나이 리서어치 화운데이션 PolⅡ 프로모터 및 리보자임을 갖는 재조합 인플루엔자벡터
US7566458B2 (en) 2003-06-16 2009-07-28 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
ATE469972T1 (de) * 2003-12-23 2010-06-15 Medimmune Llc Multiplasmid-system zur erzeugung des grippevirus
EP2995678A1 (en) * 2004-05-24 2016-03-16 MedImmune, LLC Multi plasmid system for the production of attenuated influenza b virus
CA2879182C (en) 2004-05-25 2017-02-14 Medimmune, Inc. Influenza hemagglutinin and neuraminidase variants
EP1797189A4 (en) * 2004-09-02 2010-05-19 Qun Chen ENCAPSIDATION SYSTEM FOR THE PRODUCTION OF RECOMBINANT VIRUSELY PARTICLES
JP2008512443A (ja) * 2004-09-09 2008-04-24 カイロン ベーリング ゲーエムベーハー アンド カンパニー インフルエンザワクチンに関連する潜在的医原性リスクの減少
RU2420577C2 (ru) * 2004-11-11 2011-06-10 Эбботт Байолоджикалз Б.В. Условно дефектная частица вируса гриппа и способы ее получения (варианты)
AU2005303817B8 (en) * 2004-11-11 2010-09-30 Abbott Biologicals B.V. Defective influenza virus particles
CN101103103A (zh) 2004-11-19 2008-01-09 威斯康星旧生研究基金会 具有串联转录单位的重组流感病毒载体
ES2536745T3 (es) 2004-12-08 2015-05-28 Medimmune, Llc Métodos de producción de composiciones de vacuna contra la gripe
ATE547511T1 (de) 2004-12-23 2012-03-15 Medimmune Llc Nichttumorbildende mdck-zellinie zur vermehrung von viren
EP2295542B1 (en) * 2004-12-24 2013-01-30 Abbott Biologicals B.V. Rescue of influenza virus
EP2441471B1 (en) 2005-03-08 2014-10-08 MedImmune, LLC Reassortant influenza viruses
US11865172B2 (en) 2005-04-21 2024-01-09 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
US7959929B2 (en) 2005-04-21 2011-06-14 University Of Florida Research Foundation, Inc. Materials and methods for respiratory disease control in canines
RU2008101367A (ru) 2005-06-21 2009-08-10 Медиммун, Ллк (Us) Способы и композиции для экспрессии отрицательной смысловой вирусной рнк в собачьих клетках
US8354114B2 (en) * 2005-10-17 2013-01-15 Medimmune, Llc Multi plasmid system for the production of influenza virus
ES2496315T3 (es) * 2005-10-19 2014-09-18 University Of Florida Research Foundation, Incorporated Materiales para el control de la enfermedad respiratoria en caninos
CA2627971A1 (en) 2005-11-01 2007-05-10 Novartis Vaccines And Diagnostics Gmbh & Co Kg. Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment
EP2202239A1 (en) * 2005-11-01 2010-06-30 Alnylam Pharmaceuticals Inc. RNAI inhibition of influenza virus replication
WO2007126810A2 (en) * 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
PT2016194E (pt) * 2006-04-19 2015-07-20 Medimmune Llc Métodos e composições para expressar arn viral de polaridade negativa em células caninas
US9072701B2 (en) 2006-04-21 2015-07-07 St. Jude Children's Research Hospital Avian influenza viruses, vaccines, compositions, formulations, and methods
US7507411B2 (en) * 2006-06-23 2009-03-24 University Of Saskatchewan Attenuated influenza NS1 variants
WO2008133701A1 (en) * 2006-07-21 2008-11-06 Medimmune, Llc. Methods and compositions for increasing replication capacity of an influenza virus
EP2056872A4 (en) * 2006-08-09 2016-12-21 Medimmune Llc INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS
WO2008105931A2 (en) 2006-09-15 2008-09-04 Medimmune Vaccines, Inc. Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
CA2690196A1 (en) 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
EP2045323A1 (en) * 2007-10-05 2009-04-08 Avir Green Hills Biotechnology Research Development Trade Ag Linear expression constructs for production of influenza virus particles
EP2217064A4 (en) * 2007-11-12 2012-10-03 Univ Pennsylvania NEW VACCINES FOR FIGHT AGAINST SEVERAL SUBTYPES OF INFLUENZA VIRUSES
WO2010006144A2 (en) * 2008-07-11 2010-01-14 Medlmmune, Llc. Influenza hemagglutinin and neuraminidase variants
CN102215865B (zh) 2008-09-24 2013-10-30 米迪缪尼有限公司 病毒纯化方法
WO2010046335A1 (en) * 2008-10-21 2010-04-29 Crucell Holland B.V. Production of influenza virus by reverse genetics in per.c6 cells under serum free conditions
JP5686741B2 (ja) 2008-12-16 2015-03-18 バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated インフルエンザワクチンの生成
EP2233152A1 (en) 2009-03-24 2010-09-29 Avir Green Hills Biotechnology Research Development Trade Ag High growth reassortant influenza A virus
CN102361649A (zh) * 2009-02-12 2012-02-22 米迪缪尼有限公司 流感血凝素和神经氨酸酶变体
CN102741399A (zh) 2009-10-20 2012-10-17 诺华有限公司 用于病毒拯救的改良反向遗传方法
EP2493912B1 (en) 2009-10-26 2020-07-29 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
KR101183199B1 (ko) 2009-11-16 2012-09-14 (주)지노믹트리 지노타이핑 방법
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
KR101323582B1 (ko) * 2011-03-17 2013-10-30 충북대학교 산학협력단 Vero 세포 유래의 polⅠ 프로모터 및 이를 포함하는 재조합 벡터
US20130189303A1 (en) 2011-08-02 2013-07-25 Yan Zhou Recombinant swine influenza virus and uses thereof
ES2655051T3 (es) 2011-08-26 2018-02-16 Wisconsin Alumni Research Foundation Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas
CN102864130A (zh) * 2011-09-08 2013-01-09 中国农业科学院上海兽医研究所 高效表达ha蛋白的重组流感病毒及其制备方法和应用
CN102864127A (zh) * 2011-09-08 2013-01-09 中国农业科学院上海兽医研究所 高效表达ha蛋白的重组流感病毒及其制备方法和应用
CN102851258A (zh) * 2011-09-08 2013-01-02 中国农业科学院上海兽医研究所 高效表达ha蛋白的重组流感病毒及其制备方法和应用
US9017694B2 (en) 2011-10-07 2015-04-28 Medimmune, Llc Swine influenza hemagglutinin variants
US11028408B2 (en) 2012-05-25 2021-06-08 University Of Maryland, College Park Recombinant influenza viruses and constructs and uses thereof
KR101443983B1 (ko) * 2012-12-04 2014-11-03 충북대학교 산학협력단 Mdck 세포 특이적으로 증식성이 향상된 다중 돌연변이 인플루엔자 a 바이러스
FR3004726A1 (fr) * 2013-04-18 2014-10-24 Agronomique Inst Nat Rech Mutants thermosensibles de virus influenza
US9950057B2 (en) 2013-07-15 2018-04-24 Wisconsin Alumni Research Foundation (Warf) High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs
WO2015010073A1 (en) * 2013-07-19 2015-01-22 University Of Rochester Attenuated influenza vaccines and uses thereof
WO2015196150A2 (en) 2014-06-20 2015-12-23 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
CN104450695B (zh) * 2014-11-26 2017-08-25 扬州大学 A型流感病毒基因pcr扩增引物及其快速克隆方法
CN104592367B (zh) * 2014-12-24 2019-01-18 中国科学院微生物研究所 流感病毒np蛋白突变体及其编码基因与应用
US10323231B2 (en) 2015-04-24 2019-06-18 University Of Rochester Attenuated influenza vaccines and uses thereof
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
WO2017007839A1 (en) 2015-07-06 2017-01-12 Wisconsin Alumni Research Foundation (Warf) Improved influenza virus replication for vaccine development
CA3014435C (en) 2016-02-19 2023-04-18 Wisconsin Alumni Research Foundation (Warf) Improved influenza b virus replication for vaccine development
US11596683B2 (en) 2016-07-12 2023-03-07 Duke University Engineered influenza polynucleotides, viruses, vaccines and methods of making and using the same
WO2019084310A1 (en) 2017-10-25 2019-05-02 Yoshihiro Kawaoka HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION
JP2021508696A (ja) 2017-12-22 2021-03-11 コーダ−ジェニックス・インコーポレイテッドCoda−Genix, Inc. がん処置のためのコドン対脱最適化領域を有する組換え型ウイルス及びその使用法
CN112040977A (zh) 2018-03-08 2020-12-04 科达金尼克斯有限公司 减毒黄病毒
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン(ha)タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
CN111363017B (zh) * 2018-12-25 2022-03-15 中国科学院微生物研究所 A型流感病毒核蛋白s69位突变序列及其突变体与应用
US11241492B2 (en) 2019-01-23 2022-02-08 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to genes in influenza viruses
US12419946B2 (en) 2019-02-07 2025-09-23 Duke University Stabilized 9 and 10 segmented influenza viruses as a vaccine platform and methods of making and using same
WO2020163804A1 (en) 2019-02-08 2020-08-13 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
US11214799B2 (en) * 2019-03-12 2022-01-04 The University Court Of The University Of Edinburg Old College HA-specific influenza virus attenuated vaccine comprising mutations in segment 7, and uses therefor
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
CN110713988A (zh) * 2019-05-13 2020-01-21 广州医科大学附属第一医院(广州呼吸中心) 一种防止接种于鸡蛋的季节性人流感h3n2病毒抗原性降低的方法
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
WO2021150874A1 (en) 2020-01-24 2021-07-29 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized na
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
CN116134137A (zh) 2020-07-21 2023-05-16 复尔健有限公司 流感病毒骨架
CN117946982B (zh) * 2022-12-30 2025-06-03 中国科学院微生物研究所 H1n1流感病毒冷适应疫苗骨架毒株cv1-pr8及其构建方法和应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB660109A (en) 1946-10-01 1951-10-31 American Cyanamid Co Improvements in or relating to the treatment of allantoic fluid containing a propagated virus together with non-viral proteins to obtain the virus in purified and viable from for use in a vaccine
US3992522A (en) 1973-01-24 1976-11-16 The United States Of America As Represented By The Department Of Health, Education And Welfare Temperature-sensitive recombinant mutant viruses and a process for producing same
US3874999A (en) 1973-10-31 1975-04-01 American Cyanamid Co Process for the purification of virus vaccine
US4071618A (en) 1974-09-03 1978-01-31 Research Foundation For Microbial Diseases Of Osaka University Process for preparing virus disease live vaccines
US4000257A (en) 1975-12-22 1976-12-28 American Cyanamid Company Process for the purification of influenza virus vaccine
US4057626A (en) 1976-10-08 1977-11-08 Richardson-Merrell Inc. Process for detoxifying influenza B virus
US4338296A (en) 1979-10-16 1982-07-06 Smithkline-Rit Influenza virus and process of producing a vaccine therefrom
US4337242A (en) 1980-02-05 1982-06-29 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4512972A (en) 1980-06-30 1985-04-23 Kureha Chemical Industry Co., Ltd. Nasal preparation and processes for their production
JPS57136528A (en) 1981-02-09 1982-08-23 Hayashibara Biochem Lab Inc Preparation of viral vaccine
FR2505657A1 (fr) 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
US4512285A (en) 1983-12-27 1985-04-23 Gof Manufacturing Company, Inc. Apparatus and method for egg turning during incubation
US4634666A (en) 1984-01-06 1987-01-06 The Board Of Trustees Of The Leland Stanford Junior University Human-murine hybridoma fusion partner
GB8914968D0 (en) 1989-06-29 1989-08-23 Connaught Lab Production of virus and purification of viral envelope proteins for vaccine use
US5166057A (en) 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
US5840520A (en) 1989-08-28 1998-11-24 Aviron Recombinant negative strand RNA virus expression systems
US5854037A (en) 1989-08-28 1998-12-29 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand RNA virus expression systems and vaccines
US6887699B1 (en) 1990-05-22 2005-05-03 Medimmune Vaccines, Inc. Recombinant negative strand RNA virus expression systems and vaccines
EP0636172B1 (en) 1992-04-14 2005-08-17 The Mount Sinai School of Medicine of the City University of New York Genetically engineered attenuated viruses
IL105456A (en) 1992-04-21 1996-12-05 American Home Prod Vaccines of attenuated respiratory syncytial virus
CA2075521C (en) 1992-05-05 1995-11-28 Kuniaki Koyama Stabilized live vaccine
PT702085E (pt) 1994-07-18 2004-04-30 Karl Klaus Conzelmann Virus de arn de cadeia negativa nao segmentada infeccioso recombinante
US5824536A (en) 1994-08-23 1998-10-20 St. Jude Children's Research Hospital Influenza virus replicated in mammalian cell culture and vaccine production
US5789229A (en) 1994-09-30 1998-08-04 Uab Research Foundation Stranded RNA virus particles
US5716821A (en) 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
WO1996010633A1 (en) 1994-09-30 1996-04-11 Aviron Chimeric influenza virus and electroporation method
US6146873A (en) * 1994-11-10 2000-11-14 Baxter Aktiengesellschaft Production of orthomyxoviruses in monkey kidney cells using protein-free media
US7153510B1 (en) 1995-05-04 2006-12-26 Yale University Recombinant vesiculoviruses and their uses
US5690937A (en) 1995-06-05 1997-11-25 Aviron Temperature sensitive clustered changed-to-alanine mutants of influenza virus PB2 gene
ATE181112T1 (de) 1995-08-09 1999-06-15 Schweiz Serum & Impfinst Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren
AU727923B2 (en) 1995-09-27 2001-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Production of infectious respiratory syncytial virus from cloned nucleotide sequences
EP0865296B1 (en) 1995-10-20 2002-02-27 Yissum Research Development Company Of The Hebrew University Of Jerusalem Influenza vaccine
DK0864645T3 (da) 1995-10-31 2005-10-24 Dnavec Research Inc Negativstrenget RNA-virusvektor med autonom replikeringsaktivitet
DK0863202T3 (da) 1995-11-01 2010-09-27 Dnavec Research Inc Rekombinant Sendai-virus
US6090391A (en) 1996-02-23 2000-07-18 Aviron Recombinant tryptophan mutants of influenza
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
EP0933422A4 (en) * 1996-06-13 2005-02-02 Fujisawa Pharmaceutical Co CYCLIC LIPOPEPTIDE ACYLASE
EP0912724B1 (en) 1996-07-15 2009-12-09 The Government of The United States of America, as represented by The Department of Health and Human Services Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
KR20000048628A (ko) 1996-09-27 2000-07-25 윌리암 에이취 캘넌, 에곤 이 버그 모노네가비랄레스 목의 바이러스에서 감쇠를 책임지는 3' 게놈프로모터 영역 및 폴리머라제 유전자 돌연변이
KR100702523B1 (ko) 1997-05-23 2007-04-04 더 가번먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 에즈 레프리젠티드 바이 더 디파트먼트 오브 헬쓰 앤드 휴먼 서비시즈 클로닝된 뉴클레오타이드 서열로부터 약독화된파라인플루엔자 바이러스를 제조하는 방법
PT1012244E (pt) 1997-07-11 2007-08-21 Univ Yale ''rabdovírus com revestimentos remanipulados''
CN1273603A (zh) 1997-09-19 2000-11-15 美国氰胺公司 减毒的呼吸道合胞病毒
US6177082B1 (en) 1998-08-13 2001-01-23 The University Of Pittsburgh-Of The Commonwealth System Of Higher Education Cold-adapted equine influenza viruses
US6146642A (en) 1998-09-14 2000-11-14 Mount Sinai School Of Medicine, Of The City University Of New York Recombinant new castle disease virus RNA expression systems and vaccines
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
EP1117391A2 (en) * 1998-10-09 2001-07-25 L. Sai Latha Shankar Methods for treating multiple sclerosis
EP1035209A1 (en) 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stable recombinant influenza viruses free of helper viruses
EP1820853B1 (en) * 1999-04-06 2011-09-21 Wisconsin Alumni Research Foundation Recombinant influenza viruses for vaccines and gene therapy
US8715940B2 (en) * 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
GB9923176D0 (en) 1999-09-30 1999-12-01 Smithkline Beecham Biolog Novel composition
WO2001064860A2 (en) 2000-03-02 2001-09-07 Polymun Scientific Immunbiologische Forschung Gmbh Recombinant influenza a viruses
MXPA02010642A (es) 2000-04-28 2004-05-17 St Jude Children S Res Hospital Sistema de transfeccion de adn para la generacion de virus de influenza infeccioso.
US7494659B2 (en) 2000-09-25 2009-02-24 Polymun Scientific Immunbiologische Forschung Gmbh Live attenuated influenza vaccine
US7195905B2 (en) 2001-12-10 2007-03-27 Baxter Healthcare S.A. Enveloped virus vaccine and method for production
ES2526191T3 (es) 2002-04-26 2015-01-08 Medimmune, Llc Método para producir virus influenza B infeccioso en cultivo celular
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
US20060110406A1 (en) 2003-02-25 2006-05-25 Medimmune Vaccines, Inc. Refrigerator-temperature stable influenza vaccine compositions
US7262045B2 (en) 2003-02-25 2007-08-28 Medimmune Vaccines, Inc. Methods of producing influenza vaccine compositions
US7566458B2 (en) 2003-06-16 2009-07-28 Medimmune, Llc Influenza hemagglutinin and neuraminidase variants
US7037707B2 (en) 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
ATE469972T1 (de) 2003-12-23 2010-06-15 Medimmune Llc Multiplasmid-system zur erzeugung des grippevirus
EP2995678A1 (en) 2004-05-24 2016-03-16 MedImmune, LLC Multi plasmid system for the production of attenuated influenza b virus
JP5147405B2 (ja) 2004-10-06 2013-02-20 メディミューン,エルエルシー 冷蔵温度安定型インフルエンザワクチン組成物
ES2382446T3 (es) 2004-11-01 2012-06-08 Eiken Kagaku Kabushiki Kaisha Método de detección del virus de la gripe aviar H5
CA2690196A1 (en) 2007-06-18 2008-12-24 Medimmune, Llc Influenza b viruses having alterations in the hemaglutinin polypeptide
CN102026628A (zh) * 2008-02-15 2011-04-20 太阳医药高级研发有限公司 具有降低崩裂效果的口服控释片剂

Similar Documents

Publication Publication Date Title
JP2013179943A5 (https=)
Shi et al. Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan
Pu et al. Reassortment with dominant chicken H9N2 influenza virus contributed to the fifth H7N9 virus human epidemic
Francis et al. Back to the future for influenza preimmunity—Looking back at influenza virus history to infer the outcome of future infections
Thomas et al. Cell-mediated protection in influenza infection
Westgeest et al. Genomewide analysis of reassortment and evolution of human influenza A (H3N2) viruses circulating between 1968 and 2011
Mänz et al. Pandemic influenza A viruses escape from restriction by human MxA through adaptive mutations in the nucleoprotein
Van den Hoecke et al. Analysis of the genetic diversity of influenza A viruses using next-generation DNA sequencing
EP3022296B1 (en) High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
JP2015119730A5 (https=)
Jakhesara et al. Isolation and characterization of H9N2 influenza virus isolates from poultry respiratory disease outbreak
Devarajan et al. New insights into the generation of CD4 memory may shape future vaccine strategies for influenza
Selim et al. Molecular characterization of full fusion protein (F) of Newcastle disease virus genotype VIId isolated from Egypt during 2012-2016
Zhu et al. Genetic and biological characterization of H9N2 avian influenza viruses isolated in China from 2011 to 2014
JP2016509864A5 (https=)
Yehia et al. Genetic variability of avian influenza virus subtype H5N8 in Egypt in 2017 and 2018: N. Yehia et al.
Fan et al. Structural and biochemical analyses of swine major histocompatibility complex class I complexes and prediction of the epitope map of important influenza A virus strains
JP2016501020A5 (https=)
JP2009297040A5 (https=)
JP2016104045A5 (https=)
BRPI0809842B8 (pt) processo para a obtenção de linhagens de células aviárias diploides contínuas, processo de replicação de um vírus em uma linhagem de células aviárias diploides contínuas e processo de produção de peptídeos e proteínas recombinantes
Wang et al. Generation of a live attenuated influenza vaccine that elicits broad protection in mice and ferrets
WO2007048089A3 (en) Multi-plasmid system for the production of influenza virus
Wasik et al. Cell culture-based production of defective interfering particles for influenza antiviral therapy
MX387420B (es) Producción de virus en cultivos celulares.