JP2013151534A - ミュータンス・ストレプトコッキィによって引き起こされる齲蝕を予防および/または治療するための使用および方法 - Google Patents
ミュータンス・ストレプトコッキィによって引き起こされる齲蝕を予防および/または治療するための使用および方法 Download PDFInfo
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- JP2013151534A JP2013151534A JP2013056953A JP2013056953A JP2013151534A JP 2013151534 A JP2013151534 A JP 2013151534A JP 2013056953 A JP2013056953 A JP 2013056953A JP 2013056953 A JP2013056953 A JP 2013056953A JP 2013151534 A JP2013151534 A JP 2013151534A
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- streptococcus
- mutans
- lactobacillus
- microorganism
- dsm
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Abstract
【解決手段】ストレプトコッカス・ソブリヌス(Streptococcus sobrinus)に特異的に結合することを特徴とする乳酸菌群に属する微生物またはその変異体もしくは誘導体の使用であって、前記ストレプトコッカス・ソブリヌス(Streptococcus sobrinus)によって引き起こされる齲蝕を治療または予防するための抗齲蝕原性組成物の調製のための、ラクトバチルス属に属する微生物またはその変異体もしくは誘導体の使用。
【選択図】なし
Description
(a) 上記の微生物を静止期まで増殖させ;
(b) 上記の微生物を、静止期まで増殖させたミュータンス・ストレプトコッキィ群に属する細菌と混合し;
(c) ステップ(b)で得た混合物を、上記の微生物とミュータンス・ストレプトコッキィ群の細菌との凝集体の形成を可能とする条件下でインキュベートし;さらに
(d) ペレットの発生により凝集体を検出する
ステップでアッセイすることができる。
(a) 上記の微生物を静止期まで増殖させ;
(b) 上記の微生物を、静止期まで増殖させたミュータンス・ストレプトコッキィ群に属する細菌と混合し;
(c) ステップ(b)で得た混合物を、上記の微生物とミュータンス・ストレプトコッキィ群の細菌との凝集体の形成を可能とする条件下でインキュベートし;さらに
(d) ペレットの発生によって凝集体を検出する
ステップでアッセイすることができる。
(a) 上記の微生物を静止期まで増殖させ;
(b) 上記の微生物を、静止期まで増殖させて好適な染色試薬(好ましくは蛍光染色試薬)を用いて染色したミュータンス・ストレプトコッキィ群に属する細菌を混合し;
(c) ステップ(b)で得た混合物を、上記の微生物とミュータンス・ストレプトコッキィ群の細菌との凝集体の形成を可能とする条件下でインキュベートし;さらに
(d) 染色(好ましくは蛍光染色)の検出により凝集体を検出する
ステップでアッセイすることができる。
(i) グルコースから、エムデン-マイヤーホフ経路を経て85%以上の量で乳酸(好ましくは乳酸のL、DまたはDLアイソマー)を生成し;
(ii) 45℃の温度では増殖するが、15℃の温度では増殖せず;
(iii) 長桿形であり;且つ
(iv) 細胞壁中にグリセロールテイコ酸を含む;
(b) ホモ発酵性ラクトバチルス
(i) エムデン-マイヤーホフ経路を経て乳酸(好ましくは乳酸のLまたはDLアイソマー)を生成し;
(ii) 15℃の温度で増殖し、45℃の温度で可変増殖を示し;
(iii) 短桿形またはコリネ型であり;且つ
(iv) 細胞壁中にリビトールおよび/またはグリセロールテイコ酸を含む;
(c) ヘテロ発酵ラクトバチルス
(i) グルコースから、ペントースリン酸経路を経て50%以上の量で乳酸(好ましくは乳酸のDLアイソマー)を生成し;
(ii) 二酸化炭素とエタノールを生成し、
(iii) 15℃または45℃の温度で可変増殖を示し;
(iv) 長桿形または短桿形であり;且つ
(v) 細胞壁中にグリセロールテイコ酸を含む。
(i) D-ラクトースを代謝するが、L-ソルボースおよび/またはD-サッカロースおよび/またはD-イヌリンは代謝しない、
(ii) イヌリンを代謝する、
(iii) L-ソルボースを代謝するが、D-ラクトースおよび/またはD-サッカロースおよび/またはイヌリンは代謝しない、また
(iv) L-ソルボース、D-ラクトースおよびイヌリンを代謝する。
(i) D-ラクトースを代謝するが、L-ソルボース、D-サッカロースおよびイヌリンは代謝しない、
(ii) L-ソルボース、D-ラクトースおよびイヌリンを代謝するが、D-サッカロースは代謝しない、
(iii) L-ソルボースを代謝するが、D-ラクトース、D-サッカロースおよびイヌリンは代謝しない、また
(iv) L-ソルボース、D-ラクトース、D-サッカロースを代謝するが、イヌリンは代謝しない。
A ハッカ油(Olium menthae) 1.2部
アルニカチンキ(Tinctura Arnicae) 3.0部
ミルラチンキ(Tinctura Myrrhae) 3.0部
Tween 5.0部
B 酒精90% 50.0部
C 安息香酸ナトリウム 0.2部
甘味料(例えばアスパルテーム) 0.02部
蒸留水を添加して100部とする。
上記の成分以外に、本発明に従って用いられる乳児用栄養組成物には、栄養組成物中に配合することが望ましい任意の成分(例えば、食物繊維、ヌクレオチド、核酸、香料、および着色料)を配合し得る。
菌株の保存および増殖は、通常の手順に従って行うことができる。例えば、菌株は凍結ストックとして-80℃で保存し得る。1mlの培養液をMRS培地中で静止期(OD600/mL 4〜8)まで増殖させ、500μlの滅菌50%グリセリン溶液と混合して凍結することができる。ミュータンス・ストレプトコッキィの培養液は、TSY培地中で静止期(OD600/mL 1〜2)まで増殖させ、上記のとおりに処理することができる。
菌株の分類学的分類は、これらの炭水化物発酵パターンに従って行った。これは、API 50 CH(bioMerieux社、France)システムを用いて決定し、APILAB PLUSソフトウェア バージョン3.3.3(bioMerieux, France)を用いて分析した。
ラクトバチルス菌とミュータンス・ストレプトコッキィを実施例1に記載のとおりに増殖させた後、蛍光染色を用いてミュータンス・ストレプトコッキィを染色した。このため培養液のOD600を測定した。培養物は、3200xgで5分間の遠心分離によって回収した。そのペレットをPBS緩衝液中に再懸濁した。緩衝液の量は、結果として得られる懸濁液が、製造者の使用説明書に従って調製した2μlのCFDA-SE溶液(Invitrogen社, USA)と混合したこの懸濁液の4.2 mlのOD600を有するように計算した。細胞染色は、この混合物を37℃で2時間インキュベートすることによって行った。染色した細胞は、3200xgで5分間の遠心分離で回収した。この細胞は、その後2mlのPBS緩衝液中に再懸濁した。
このアッセイでは、ラクトバチルス菌とミュータンス・ストレプトコッキィとの混合は、容量比3:1〜60:1(ミュータンス・ストレプトコッキィ:ラクトバチルス菌)で行った。この容量比は、コロニー形成単位の比で1:50〜1:2,5に相当する。
MRSブロス:
MRS混合(Difco社, USA) 55 g/L
pH: 6.5
TSYブロス:
TSY混合(Difco社, USA) 30 g/L
酵母エキス(Deutsche Hefewerke社, Germany) 3 g/L
緩衝液:
PBS緩衝液:
Na2HPO4 *2H20 1.5 g/L
KH2PO4 0.2 g/L
NaCl 8.8 g/L
pHはHClで調整した。
このアッセイでは、各ラクトバチルス菌と、染色した各ミュータンス・ストレプトコッカスとの懸濁液を以下のとおりに混合した:
ストレプトコッカス・ミュータンスDSM 20523とLb-OB-K1(DSM 16667)、ストレプトコッカス・ミュータンスDSM 20523とLb-OB-K2(DSM 16668)、ストレプトコッカス・ミュータンスDSM 20523とLb-OB-K3(DSM 16669)、ストレプトコッカス・ミュータンスDSM 20523とLb-OB-K4(DSM 16670)、ストレプトコッカス・ミュータンスDSM 20523とLb-OB-K5(DSM 16671)、ストレプトコッカス・ミュータンスDSM 20523とLb-OB-K6(DSM 16672)、ストレプトコッカス・ミュータンスDSM 20523とLb-OB-K7(DSM 16673);
ストレプトコッカス・ソブリヌスDSM 20742とLb-OB-K1(DSM 16667)、ストレプトコッカス・ソブリヌスDSM 20742とLb-OB-K2(DSM 16668)、ストレプトコッカス・ソブリヌスDSM 20742とLb-OB-K3(DSM 16669)、ストレプトコッカス・ソブリヌスDSM 20742とLb-OB-K4(DSM 16670)、ストレプトコッカス・ソブリヌスDSM 20742とLb-OB-K5(DSM 16671)、ストレプトコッカス・ソブリヌスDSM 20742とLb-OB-K6(DSM 16672)、ストレプトコッカス・ソブリヌスDSM 20742とLb-OB-K7(DSM 16673);
ストレプトコッカス・クリセツスDSM 20562とLb-OB-K1(DSM 16667)、ストレプトコッカス・クリセツスDSM 20562とLb-OB-K2(DSM 16668)、ストレプトコッカス・クリセツスDSM 20562とLb-OB-K3(DSM 16669)、ストレプトコッカス・クリセツスDSM 20562とLb-OB-K4(DSM 16670)、ストレプトコッカス・クリセツスDSM 20562とLb-OB-K5(DSM 16671)、ストレプトコッカス・クリセツスDSM 20562とLb-OB-K6(DSM 16672)、ストレプトコッカス・クリセツスDSM 20562とLb-OB-K7(DSM 16673);
ストレプトコッカス・ラッティDSM 20564とLb-OB-K1(DSM 16667)、ストレプトコッカス・ラッティDSM 20564とLb-OB-K2(DSM 16668)、ストレプトコッカス・ラッティDSM 20564とLb-OB-K3(DSM 16669)、ストレプトコッカス・ラッティDSM 20564とLb-OB-K4(DSM 16670)、ストレプトコッカス・ラッティDSM 20564とLb-OB-K5(DSM 16671)、ストレプトコッカス・ラッティDSM 20564とLb-OB-K6(DSM 16672)、ストレプトコッカス・ラッティDSM 20564とLb-OB-K7(DSM 16673);
ストレプトコッカス・フェラスDSM 20646とLb-OB-K1(DSM 16667)、ストレプトコッカス・フェラスDSM 20646とLb-OB-K2(DSM 16668)、ストレプトコッカス・フェラスDSM 20646とLb-OB-K3(DSM 16669)、ストレプトコッカス・フェラスDSM 20646とLb-OB-K4(DSM 16670)、ストレプトコッカス・フェラスDSM 20646とLb-OB-K5(DSM 16671)、ストレプトコッカス・フェラスDSM 20646とLb-OB-K6(DSM 16672)、ストレプトコッカス・フェラスDSM 20646とLb-OB-K7(DSM 16673);
ストレプトコッカス・マカカエDSM 20724とLb-OB-K1(DSM 16667)、ストレプトコッカス・マカカエDSM 20724とLb-OB-K2(DSM 16668)、ストレプトコッカス・マカカエDSM 20724とLb-OB-K3(DSM 16669)、ストレプトコッカス・マカカエDSM 20724とLb-OB-K4(DSM 16670)、ストレプトコッカス・マカカエDSM 20724とLb-OB-K5(DSM 16671)、ストレプトコッカス・マカカエDSM 20724とLb-OB-K6(DSM 16672)およびストレプトコッカス・マカカエDSM 20724とLb-OB-K7(DSM 16673)。50μlのラクトバチルス菌懸濁液を、96穴マイクロタイタープレート中の50μlの染色したミュータンス・ストレプトコッキィに加えた。このプレートをフルスピードで12分間ボルテックスした。その後、上記のプレートを500xgで10秒間遠心分離した。上清は注意深く除去して捨てた。ペレットは、100μlのPBS緩衝液中に再懸濁した。
MRSブロス:
MRS混合(Difco社, USA) 55 g/L
pH: 6.5
TSYブロス:
TSY混合(Difco社, USA) 30 g/L
酵母エキス(Deutsche Hefewerke社, Germany) 3 g/L
緩衝液:
PBS緩衝液:
Na2HPO4 *2H20 1.5 g/L
KH2PO4 0.2 g/L
NaCl 8.8 g/L
pHはHClで調整した。
上記のラクトバチルス菌培養液を、実施例1に記載のとおりに増殖させた。
BHI混合(Difco社, USA) 37 g/L
pH: 7.2
実施例7:ラクトバチルス菌の凝集能の温度耐性
上記の細菌を、実施例1に記載のとおりに増殖させた。
上記のラクトバチルス菌を実施例1に記載のとおりに増殖させた。上記のミュータンス・ストレプトコッキィを実施例1および3に記載のとおりに増殖させて染色した。増殖させたラクトバチルス菌培養液を、実施例1に記載のとおり、OD600が2になるまで調整した。1mlの上記の懸濁液を、121℃、2バールで20分間インキュベート(オートクレーブ)した。オートクレーブした培養液を室温まで冷却した後、対照実験を含めて実施例5に記載のとおりに凝集を測定した。熱不活性化させたラクトバチルス菌は、依然として全てのミュータンス・ストレプトコッキィを凝集させた。
上記の細菌を、実施例1に記載のとおりに増殖させた。0.5 mlのラクトバチルス菌と、1.5 mlのストレプトコッカス・ミュータンスを3200*gで10分間の遠心分離によって回収し、上清を捨てた。上記の細胞を、様々なpH値に調整した様々なPBS緩衝液中に、これらの元の容量(それぞれ0.5mlおよび1.5ml)で再懸濁した。これらの緩衝液のpH値は、値7.0から3.0まで0.5pH単位ずつ調整した。培養液を、凝集挙動アッセイに用いる各pH値の緩衝液中に再懸濁した。
上記のラクトバチルス菌を実施例1に記載のとおりに増殖させた。ミュータンス・ストレプトコッキィを実施例1および3に記載のとおりに増殖させて染色した。その後、異なるpH値で凝集をアッセイした。この目的のため、ラクトバチルス菌ならびにストレプトコッキィを、各pHに調整した酢酸緩衝液中に再懸濁した。試験したpH値は4.0、4.5および5.0であった。上記の凝集を、実施例5に記載のとおりにアッセイした。ミュータンス・ストレプトコッキィの凝集は、4.5より低いpH値では起こらなかった。
上記の細菌を、実施例1に記載のとおりに増殖させた。
上記のラクトバチルス菌を実施例1に記載のとおりに増殖させた。ミュータンス・ストレプトコッキィを実施例1および3に記載のとおりに増殖させて染色した。増殖させたラクトバチルス菌培養液を、実施例1に記載のとおり、OD600が2になるまで調整した。1mlの上記の懸濁液を、室温において真空下で2時間凍結乾燥させた。その後、凍結乾燥させたペレットを、1mlのPBS緩衝液中に再懸濁した。凝集は、対照実験を含めて実施例5に記載のとおりに測定した。
上記の細菌を、実施例1に記載のとおりに増殖させた。
上記のラクトバチルス菌を実施例1に記載のとおりに増殖させた。ミュータンス・ストレプトコッキィを実施例1および3に記載のとおりに増殖させて染色した。使用したプロテアーゼは、プロナーゼE、プロテイナーゼK、トリプシン、キモトリプシン(全てSigma社, Germanyから入手)であった。1mlのラクトバチルス菌の複数のアリコートを、3200*gで10分間の遠心分離で細胞を回収し、そのペレットを1mlのPBS緩衝液(pH7.0)中に再懸濁することによってPBS緩衝液中で洗浄した。その後、この細胞を再度上記のとおりに回収し、各プロテアーゼを2.5mg/mLの最終濃度で含むPBS緩衝液(pH 7.0)中に再懸濁した。この懸濁液を37℃で1時間インキュベートした。その後、上記のとおりに細胞を洗浄し、PBS緩衝液(pH7.0)中に再懸濁した。凝集は、対照実験を含めて実施例5に記載のとおりにアッセイした。ミュータンス・ストレプトコッキィに対する上記のラクトバチルス菌の凝集挙動は、上記のプロテアーゼのいずれかを用いた処理によっては変化しなかった。
上記の細菌を、実施例1に記載のとおりに増殖させた。
上記のラクトバチルス菌を実施例1に記載のとおりに増殖させた。ミュータンス・ストレプトコッキィを実施例1および3に記載のとおりに増殖させて染色した。1mlのラクトバチルス菌の複数のアリコートを、上記のとおり1mlの200mM EDTA溶液中で2回洗浄した。その後この細胞を回収し、1mlのPBS緩衝液(pH7.0)中に再懸濁した。
上記の細菌を、実施例1に記載のとおりに増殖させた。
ボランティアらから、新たな唾液をサンプリングした。唾液流は、無糖チューインガムを噛むことによって生じさせた。ボランティアらは、各サンプリング時に15mlの唾液を採取した。新たに採取した唾液は、上記のアッセイ法のため、PBS緩衝液を用いて1:2で希釈した。ラクトバチルス菌とミュータンス・ストレプトコッキィは、実施例1に記載のとおりに培養した。ミュータンス・ストレプトコッキィは、染色処理後、染色した細胞をPBS緩衝液の代わりに唾液中に再懸濁したことを除いては、実施例3に記載のとおりに染色した。凝集は、対照実験を含めて実施例5に記載のとおりに測定した。唾液の存在は凝集を抑制しなかった。
本発明のトローチ剤組成物は、好ましくはDE-C2 36 45 147の第8頁の実施例4に記載のとおりに調製され、ここで、上記の実施例4に記載の成分に加えて、上記の乳酸菌群に属する微生物が、本発明のトローチ剤1mg当たり102〜1012個、好ましくは103〜108個の細胞の量で加えられる。
本発明のトローチ剤組成物は、好ましくはDE-C2 36 45 147の第8頁の実施例5に記載のとおりに調製され、ここで、上記の実施例5に記載の成分に加えて、上記の乳酸菌群に属する微生物が、本発明のトローチ剤1mg当たり102〜1012個、好ましくは103〜108個の細胞の量で加えられる。
本発明の歯磨剤組成物は、好ましくはDE-C2 36 45 147の第8頁の実施例3に記載のとおりに調製され、ここで、上記の実施例3記載の成分に加えて、上記の乳酸菌群に属する微生物が、本発明の歯磨剤1mg当たり102〜1012個、好ましくは103〜108個の細胞の量で加えられる。
本発明のチョークを基剤とする歯磨剤組成物は、好ましくは、教科書“Kosmetik”, W. Umbach(編), 第2版, Thieme Verlag, 1995の第205頁の第7.1.4.4章“Rezepturbeispiel”に記載のとおりに調製され、ここで、第205頁の上記の章に記載の成分に加えて、上記の乳酸菌群に属する微生物が、本発明のチョーク(胡粉)を基剤とする歯磨剤1mg当たり102〜1012個、好ましくは103〜108個の細胞の量で加えられる。
本発明のケイ酸/フッ化ナトリウム歯磨剤組成物に基づくゲル歯磨剤は、好ましくは、教科書“Kosmetik”, W. Umbach(編), 第2版, Thieme Verlag, 1995の第205頁の第7.1.4.4章“Rezepturbeispiel”に記載のとおりに調製され、ここで、第205頁の上記の章に記載の成分に加えて、上記の乳酸菌群に属する微生物が、本発明のケイ酸/フッ化ナトリウムに基づくゲル歯磨剤1mg当たり102〜1012個、好ましくは103〜108個の細胞の量で加えられる。
本発明の歯石に対する歯磨剤組成物は、好ましくは、教科書“Kosmetik”, W. Umbach(編), 第2版, Thieme Verlag, 1995の第206頁の第7.1.4.4章“Rezepturbeispiel”に記載のとおりに調製され、ここで、第206頁の上記の章に記載の成分に加えて、上記の乳酸菌群に属する微生物が、本発明の歯石に対する歯磨剤1mg当たり102〜1012個、好ましくは103〜108個の細胞の量で加えられる。
本発明のチューインガム組成物は、好ましくは、DE-C2 36 45 147の第9頁の実施例6に記載のとおりに調製され、ここで、上記の実施例6に記載の成分に加えて、上記の乳酸菌群に属する微生物が、本発明のチューインガム1mg当たり102〜1012個、好ましくは103〜108個の細胞の量で加えられる。
本発明の濃縮マウスウォッシュ組成物は、好ましくは、教科書“Kosmetik”, W. Umbach(編), 第2版, Thieme Verlag, 1995の第206頁の第7.1.4.4章“Rezepturbeispiel”に記載のとおりに調製され、ここで、第206頁の上記の章に記載の成分に加えて、、上記の乳酸菌群に属する微生物が、本発明の濃縮マウスウォッシュ組成物1ml当たり102〜1013個の細胞の量で加えられる。
フィルムの調製:
1. 水相
水を60℃まで加熱する。
メントールをペパーミント油に溶解させる。
攪拌下で、油性相を水相にゆっくりと混ぜる。
裁断装置を用いて、薄いフィルムを機械的に生成する。
本発明の他の実施形態および用途は、本明細書を考慮し、本明細書に開示される本発明を実施することにより当業者には明らかであろう。本明細書中に引用される全ての参考文献は、いかなる理由にせよ、全ての刊行物、全ての米国および外国の特許ならびに全ての米国および外国の特許出願を含め、参照により具体的且つ完全に援用されるものとする。本明細書および実施例は、単に例示的なものに過ぎず、以下の特許請求の範囲によって示される本発明の真の範囲および精神と共に考慮されることを意図している。
Claims (6)
- ストレプトコッカス・ソブリヌス(Streptococcus sobrinus)に結合することにより前記ストレプトコッカス・ソブリヌス(Streptococcus sobrinus)によって引き起こされる齲蝕を治療または予防するための抗齲蝕原性組成物の調製のための、ラクトバチルス属に属する微生物またはその変異体もしくは誘導体の使用であって、
該ラクトバチルス属に属する微生物またはその変異体もしくは誘導体はミュータンス・ストレプトコッキィ(mutans Streptococci)群に属する細菌に特異的に結合し得ることを特徴とし、
ここで該特異的結合が、
(i) 熱処理に耐性があり、ここで前記熱処理は95℃以上の温度で少なくとも20分にわたるものであり;かつ
(ii) プロテアーゼ処理に耐性があり、ここで前記プロテアーゼ処理はプロナーゼE、プロテイナーゼK、トリプシンおよびキモトリプシンからなる群より選択されるプロテアーゼでの処理であり;かつ
(iii) カルシウム依存性であり;かつ
(iv) 4.5〜8.5のpH範囲内で形成され;かつ
(v) 唾液の存在下で形成される、
ものであり、
ここで前記ラクトバチルス属に属する微生物の誘導体は、前記微生物の不活性形態または前記微生物の断片であり、前記微生物の不活性形態は前記微生物が熱不活性化または凍結乾燥されたものであり、前記断片は膜調製物から取得された膜画分であり、かつ前記不活性形態または前記断片はミュータンス・ストレプトコッキィ(mutans Streptococci)群に属する細菌に特異的に結合し得る能力を保持するものである、
上記使用。 - 特異的結合を、以下のとおり:
(a) 前記微生物を静止期まで増殖させ;
(b) 前記微生物を、静止期まで増殖させたミュータンス・ストレプトコッキィ群に属する細菌と混合し;
(c) ステップ(b)で得た混合物を、前記微生物とミュータンス・ストレプトコッキィ群の細菌との凝集体の形成を可能とする条件下でインキュベートし;さらに
(d) ペレットの発生によって凝集体を検出する
ステップでアッセイすることができる、請求項1に記載の使用。 - 前記ラクトバチルス属に属する微生物が、以下の特性によって3つのサブグループに分けられるホモ発酵性ラクトバチルス、ホモ発酵性ラクトバチルス、またはヘテロ発酵ラクトバチルスのいずれか1つに属するものである、
(a) ホモ発酵性ラクトバチルス
(i) グルコースから、エムデン-マイヤーホフ経路を経て85%以上の量で乳酸を生成し;
(ii) 45℃の温度では増殖するが、15℃の温度では増殖せず;
(iii) 長桿形であり;且つ
(iv) 細胞壁中にグリセロールテイコ酸を含む;
(b) ホモ発酵性ラクトバチルス
(i) エムデン-マイヤーホフ経路を経て乳酸を生成し;
(ii) 15℃の温度で増殖し、45℃の温度で可変増殖を示し;
(iii) 短桿形またはコリネ型であり;且つ
(iv) 細胞壁中にリビトールおよび/またはグリセロールテイコ酸を含む;
(c) ヘテロ発酵ラクトバチルス
(i) グルコースから、ペントースリン酸経路を経て50%以上の量で乳酸を生成し;
(ii) 二酸化炭素とエタノールを生成し、
(iii) 15℃または45℃の温度で可変増殖を示し;
(iv) 長桿形または短桿形であり;且つ
(v) 細胞壁中にグリセロールテイコ酸を含む、
ただし、前記ラクトバチルス属に属する微生物はラクトバチルス・パラカゼイ(Lactobacillus paracasei)ではなくラクトバチルス・ラムノサス(Lactobacillus rhamnosus)でもない、請求項1または2に記載の使用。 - 前記微生物が、ストレプトコッカス・ミュータンス(Streptococcus mutans)、ストレプトコッカス・ソブリヌス(Streptococcus sobrinus)、ストレプトコッカス・クリセツス(Streptococcus cricetus)、ストレプトコッカス・ラッティ(Streptococcus ratti)、ストレプトコッカス・フェラス(Streptococcus ferus)およびストレプトコッカス・マカカエ(Streptococcus macacae)からなる群から選択される1種以上の細菌に結合し得る、請求項1〜3のいずれか1項に記載の使用。
- 前記微生物が、
(a) ストレプトコッカス・ミュータンス血清型c(DSMZ 20523)および/もしくは血清型e(NCTC 10923)および/もしくは血清型f(NCTC 11060)、または
(b) ストレプトコッカス・ソブリヌスDSM 20742、または
(c) ストレプトコッカス・ラッティDSM 20564、または
(d) ストレプトコッカス・クリセツスDSM 20562、または
(e) ストレプトコッカス・フェラスDSM 20646、または
(f) ストレプトコッカス・マカカエDSM 20714
に結合することができる、請求項4に記載の使用。 - 前記抗齲蝕原性組成物が、製薬上または経口的に許容可能な担体または賦形剤をさらに含む医薬組成物である、請求項1〜5のいずれか1項に記載の使用。
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AU2007334850B2 (en) | 2012-06-14 |
WO2008074473A3 (en) | 2008-10-16 |
BRPI0719279A2 (pt) | 2014-03-11 |
RU2446208C2 (ru) | 2012-03-27 |
WO2008074473A2 (en) | 2008-06-26 |
AU2007334850A1 (en) | 2008-06-26 |
RU2009127513A (ru) | 2011-01-27 |
BRPI0719279B1 (pt) | 2018-12-04 |
AU2007334850C1 (en) | 2014-02-13 |
JP5721765B2 (ja) | 2015-05-20 |
EP2094830A2 (en) | 2009-09-02 |
CN104814983A (zh) | 2015-08-05 |
ZA200904963B (en) | 2010-09-29 |
RU2446208C9 (ru) | 2012-11-10 |
US20100047190A1 (en) | 2010-02-25 |
CN101563447A (zh) | 2009-10-21 |
CA2671507A1 (en) | 2008-06-26 |
EP2094830B1 (en) | 2013-04-10 |
KR20090096724A (ko) | 2009-09-14 |
JP2010513350A (ja) | 2010-04-30 |
JP5277172B2 (ja) | 2013-08-28 |
ES2417132T3 (es) | 2013-08-06 |
KR101432336B1 (ko) | 2014-08-20 |
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